Abstract: To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R2 is methyl; R3 is a hydrogen atom; and R4 is a group: —CONR5R6 (in which any one of R5 and R6 is a hydrogen atom)].

Abstract: To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R2 is methyl; R3 is a hydrogen atom; and R4 is a group: —CONR5R6 (in which any one of R5 and R6 is a hydrogen atom)].

Abstract: Methods and compositions for treating or preventing type 2 diabetes by inhibiting expression or activity of monoacylglycerol O-acyltransferase 1 (MOGAT1) are disclosed. Also disclosed are methods to identify such compositions.

Abstract: [Problem] To provide a method for packaging a solid body wherein even if a scaling operation is not performed in a vacuum device, a solid body can be easily housed in a packaging material, and further, when the packaging material is sealed, there is no gap between the solid body and the packaging material. [Solution] When a solid body is housed in a packaging material and sealed, a replacement gas having a property of being able to be absorbed in the solid body is intentionally introduced in the packaging material. Thereby, after the sealing, the replacement gas is absorbed in the solid body, and thus, the gap between the solid body and the packaging material becomes smaller, and the solid body is closely attached to the packaging material. When the absorption of the replacement gas is held in the equilibrium state, the volume of the package body remains constant. On the other hand, when the package body is opened, a gap is generated between the solid body and the packaging material.

Abstract: A compound, or its salt, or a solvate thereof having a cPLA2 inhibiting activity having the formula (I): or a pharmaceutical composition, cPLA2 inhibitor and inhibitors of various lipid mediator production containing the same as active ingredients.

Abstract: In an electric power tool, a controller, a capacitor, a terminal stand, a speed change controller, and a switch are arranged at positions offset from the axis of a spindle so as not to overlap the spindle as seen in a direction corresponding to the direction in which the spindle axially extends. The controller, the capacitor, the terminal stand, the speed change controller, and the switch are located so as to overlap a part of a drive motor as seen in a direction orthogonal to the direction in which the spindle axially extends. The controller, the capacitor, the terminal stand, the speed change controller, and the switch are located so as to overlap at least a part of a field as seen in a direction corresponding to the direction in which the spindle axially extends.

Abstract: An apparatus includes a rotatable image heater for heating a recording material, a coil, outside the heater, for generating magnetic flux for heating the heater and having an end outside an end of the heater with respect to the rotational axis direction, a pressor contacting the heater outer surface for forming a nip nipping and conveying the recording material, a metal member for pressing the pressor through the heater and having an end which is located outside the end of the heater and outside an end of the coil with respect to the rotational axis direction, and a magnetic flux confiner disposed inside the heater between the coil and the metal member, for confining the magnetic flux from the coil so as not to extend toward the metal member and having an end located outside the end of the heater with respect to the rotational axis direction.

Abstract: An optical disk drive device has an RF equalizer configured to generate an equalized RF signal by controlling a frequency characteristic of a delay time of an RF signal read out from an optical disk based on a control input signal, a playback clock extractor configured to extract a playback clock for reproducing data recorded on the optical disk from the equalized RF signal, and an RF rate controller configured to generate the control input signal inputted to the RF equalizer, wherein the control input signal is a signal for correcting waveform distortion of the RF signal by controlling the delay time of the RF signal dependent on a frequency of the playback clock.

Abstract: A fixing apparatus which fixes a toner image at a nip portion formed by a belt member and a rotating member controls a deviation of a belt by changing an inclination of a belt supporting member during a fixing operation. During a standby operation in which the belt member and the rotating member are separated from each other, the fixing apparatus stops changing the inclination of the belt supporting member and regulates the deviation of the belt by contacting a flange provided at the belt supporting member and a belt end portion.

Abstract: To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R2 is methyl; R3 is a hydrogen atom; and R4 is a group: —CONR5R6 (in which any one of R5 and R6 is a hydrogen atom)].

Abstract: After a first via hole leading to a ferroelectric capacitor structure are formed in an interlayer insulating film by dry etching, a second via hole to expose part of the ferroelectric capacitor structure is formed in a hydrogen diffusion preventing film so as to be aligned with the first via hole by wet etching, and a via hole constructed by the first via hole and the second via hole communicating with each other is formed.

Abstract: To provide the compounds inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic disease, inflammatory disease or immunologic disease. The compound is pyridinylpyrazolo-pyrimidinone compound represented by the following formula (IA) or (IB): especially, R1 is cyclohexyl or cycloheptyl group, R2 is methyl; R3 is a group: —NR5R6 or —S(O)0-2R8;hydrogen atom; nitro group; cyano group; a halogen atom; heteroaryl group; and R4 is methoxy or ethoxy group.

Abstract: To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R2 is methyl; R3 is a hydrogen atom; and R4 is a group: —CONR5R6 (in which any one of R5 and R6 is a hydrogen atom)].

Abstract: The size of particles is detected accurately and at low cost even when there are few microparticles as impurities included in a liquid. Provided is a method of detecting a size of particles in a liquid by detecting diffraction fringes appearing due to the particles in the liquid by a light detection portion. Diffraction fringes are detected by a first light detection portion and a second light detection portion that are separated along the flow direction of the liquid. A peak time difference (T2) that is a difference between times at which peak values appear in a detection signal from the first and second light detection portion is measured, and an area (SQ) based on the waveform of the detection signal is measured. The sizes of the particles included in the liquid are detected based on the peak time differences (T2) and the areas (SQ) that were measured.

Abstract: An optical disc drive device has an FE signal generator which generates a focus error signal, a TE signal generator which generates a tracking error signal, a return beam detector which detects a return beam reflected by an optical disc after irradiated by an optical pickup to generate a return beam level signal, a return beam gain setting part which sets amplitude adjustment amount of the return beam level signal so that a signal level of the return beam level signal generated by the return beam detector coincides with a predetermined reference level, an FE gain setting part which sets amplitude adjustment amount of the focus error signal in accordance with the signal level of the return beam level signal adjusted by the return beam gain setting part so that a signal amplitude of the focus error signal is constant, and a TE gain setting part which sets amplitude adjustment amount of the tracking error signal in accordance with the signal level of the return beam level signal adjusted by the return beam gain

Abstract: An image heating apparatus includes an endless belt for heating an image on a recording material in a nip and a pressing pad for pressing the belt from an inner surface thereof in the nip. A sheet-like member is provided to cover the pressing pad, providing for sliding movement relative to the belt. A lubricant absorbing member for suppressing swelling of the pressing pad by absorbing a lubricant applied on an inner surface of the belt, with the lubricant absorbing member covered by the sheet-like member.

Abstract: After a first via hole leading to a ferroelectric capacitor structure are formed in an interlayer insulating film by dry etching, a second via hole to expose part of the ferroelectric capacitor structure is formed in a hydrogen diffusion preventing film so as to be aligned with the first via hole by wet etching, and a via hole constructed by the first via hole and the second via hole communicating with each other is formed.

Abstract: The size of particles is detected accurately and at low cost even when there are few microparticles as impurities included in a liquid. Provided is a method of detecting a size of particles in a liquid by detecting diffraction fringes appearing due to the particles in the liquid by a light detection portion. Diffraction fringes are detected by a first light detection portion and a second light detection portion that are separated along the flow direction of the liquid. A peak time difference (T2) that is a difference between times at which peak values appear in a detection signal from the first and second light detection portion is measured, and an area (SQ) based on the waveform of the detection signal is measured. The sizes of the particles included in the liquid are detected based on the peak time differences (T2) and the areas (SQ) that were measured.

Abstract: A pickup control device includes a servo system which processes a first signal for error control read from an optical disk to generate a servo control signal. A clock signal is synchronized with the rotation of the optical disk. Two memories store a frequency component at or lower than a predetermined frequency contained in the first signal and a rotational frequency component contained in the first signal. A first adder adds data from the first memory to the first signal and a second adder, in synchronization with the clock signal, data from the memories to generate a second signal. A correction unit writes into the second memory the frequency component or the rotational frequency component and reads data and supplies data to the first adder, and reads and updates data stored in the first memory.

Abstract: An optical disk drive device has an RF equalizer configured to generate an equalized RF signal by controlling a frequency characteristic of a delay time of an RF signal read out from an optical disk based on a control input signal, a playback clock extractor configured to extract a playback clock for reproducing data recorded on the optical disk from the equalized RF signal, and an RF rate controller configured to generate the control input signal inputted to the RF equalizer, wherein the control input signal is a signal for correcting waveform distortion of the RF signal by controlling the delay time of the RF signal dependent on a frequency of the playback clock.