Abstract: An apparatus for controlled cooling of hot steel plate while constraining and conveying the plate by constraining rolls horizontally which is inexpensive and enabling continuous control of the cooling ability over a broad range, that is, a cooling apparatus for spraying hot steel plate hot rolled and transferred between pairs of constraining rolls with cooling water from pluralities of lines of spray nozzles so as to cool the same, which apparatus has lines of gentle cooling spray nozzles and lines of strong cooling spray nozzles with different orifice shapes and enables continuous control of the cooling ability over a broad range due to the fact that a maximum cooling water impact pressure integrated value of the lines of gentle cooling spray nozzles and a minimum cooling water impact pressure integrated value of the lines of strong cooling spray nozzles are continuous.

Abstract: Disclosed are antibodies (immunoglobulins) and fragments thereof that hydrolyze or bind polypeptide antigens belonging to Staphyloccus aureus, hepatitis C virus, human immunodeficiency virus and Alzheimer's disease. Also disclosed are novel methods to improve the antigen reactivity of the immunoglobulins and to treat a pathophysiological condition using the immunoglobulins as therapeutics.

Abstract: The present invention describes the composition of class and subclass selected pooled human immunoglobulins with catalytic activity, methods of preparation thereof, and therapeutic utility thereof.

Abstract: Provided herein are dual epitope polypeptides and electrophilic analogs thereof having a superantigenic epitope and at least one other epitope effective to induce the production of antibodies with binary specificity for the epitopes on a polypeptide antigen. Also, provided are electrophilic analogs of polyclonal B cell stimulants or lipids, polysaccharides and lipopolysaccharides or nucleotides. In addition, provided herein are methods for increasing production of binary epitope specific antibodies recognizing B cell polypeptide antigens, for stimulating production of antibodies using one or more of the polypeptides or electrophilic analogs and for isolating binary epitope specific antibodies or fragments thereof. Further provided are the antibodies so produced and methods of treating HIV using the same.

Abstract: Improved methods for the production, selection and inhibition of catalytic antibodies are disclosed.

Abstract: The present invention relates to an apparatus for cooling hot steel plate applied for controlled cooling of hot steel plate, obtained by hot rolling, while processing it constrained by constraining rolls and obtaining a steel material excellent and uniform in shape characteristics and provides a method of arranging and setting spray nozzles enabling uniform cooling in a direction perpendicular to processing and provides a method of arranging and setting spray nozzles of a spray cooling apparatus using two or more types of nozzles differing in amounts of water and spray regions to obtain a broad range of adjustment of amounts of water, wherein the spray nozzles are arranged so that a value of an n power of the impact pressures of the cooling water sprayed from the spray on the cooling surface integrated in the processing direction between pairs of constraining rolls becomes within ?20% of the highest value in the direction perpendicular to processing, where, 0.05?n?0.

Abstract: A game machine which uses play items such as cards and which enables the player to play a game seriously and to concentrate in the game so as to win over the opponent is provided according to the present invention. The game machine controls the progress of a game based on data read out from the play items, and issues a new play item for each game played. The game machine includes means for setting a game fee at a discount rate in accordance with the number of previous consecutive wins for the player to try a next post-victory bonus game after winning one game, and means for determining the number of games played based on the outcome (win or loss) of the player's previous games and for issuing new play items collectively to the player by the number corresponding to the determined number of games played.

Abstract: A covalently reactive ligand analogue (CAL) of formula (1): wherein, L1 . . . Lx . . . Lm are components defining a ligand determinant, Lx is a component unit of the ligand determinant selected from the group consisting of an amino acid residue, sugar residue, a fatty acid residue and a nucleotide, L? is a functional group of Lx, Y? is atom, covalent bond or linker, Y? is an optional charged or neutral group Y is a covalently reactive electrophilic group that reacts specifically with a receptor that binds to said ligand determinant, and n is an integer from 1 to 1000 m is an integer from 1 to 30.

Abstract: Improved methods for the production, selection and inhibition of catalytic and covalent antibodies are disclosed.

Abstract: Improved methods for the production, selection and inhibition of catalytic antibodies are disclosed.

Abstract: Improved methods for the production, selection and inhibition of catalytic antibodies are disclosed.

Abstract: Improved methods for the production, selection and inhibition of catalytic antibodies are disclosed.

Abstract: A fuel-injection method and an apparatus provides an output timing of an injection command signal so that fuel-injection timing is matched with a basic desired injection timing, to reduce exhaust gases and engine performance, by filtering waveforms of the detected common rail pressure to obtain pressure data, calculating an approximate straight line from the pressure data, spanning from a preselected time to a time T3 of at least the first smallest value after the start of the pressure drop in the common rail pressure, and defining a time, at which the difference between the pressure data and an approximate straight line Ld is the largest value, as the timing T2 of the start of the pressure drop in the common rail pressure, then calculating the time lag &Dgr;Td that spans from the output timing To of injection command signal to the fuel-injection timing

Abstract: A common-rail fuel injection system is disclosed, which calculates a mean value of common-rail pressures that remain pulsating after pressure drop due to any fuel injection, and considers the mean value to be a net common-rail pressure after fuel injection thereby finding with accuracy an amount of fuel to be injected. The common-rail pressure kept constant before the beginning of the fuel injection starts pulsating due to a pressure surge or oil hammer resulting from the fuel injection. The mean value is derived from the common-rail pressures sensed over a time interval for data sampling, which starts with the beginning of the command pulse. The mean value may be considered to be an approximation close to the net common-rail pressure that has fallen due to the fuel injection. The amount of fuel injected, as given depending on a net amount of pressure drop from the pressure before any fuel injection to the mean value, may be found accurately irrespective of characteristic deviation every injector.

Abstract: A fuel-injection method and an apparatus provides an output timing of an injection command signal so that fuel-injection timing is matched with a basic desired injection timing, to reduce exhaust gases and engine performance, by filtering waveforms of the detected common rail pressure to obtain pressure data, calculating an approximate straight line from the pressure data, spanning from a preselected time to a time T3 of at least the first smallest value after the start of the pressure drop in the common rail pressure, and defining a time, at which the difference between the pressure data and an approximate straight line Ld is the largest value, as the timing T2 of the start of the pressure drop in the common rail pressure, then calculating the time lag &Dgr; Td that spans from the output timing T0 of injection command signal to the fuel-injection timing T1.

Abstract: A thin film magnetic head includes a gap layer which may be made of a SiON film to increase Young's modulus E to about 123.3 (GPa) or more. As a result, the gap layer is less pushed from a surface facing a recording medium in the height direction during lapping of the surface facing the recording medium, thereby decreasing the amount of protrusion of the gap layer from the facing surface as compared with a conventional magnetic head.

Abstract: In a fuel-injection method and an apparatus therefor, an output timing of a injection command signal is decided in such a manner that a fuel-injection timing is in matching with a basic desired injection timing, thereby to help ensure the improvement in the exhaust gases performance ˜of the engine. The invention includes the apparatus to perform the steps of obtaining pressure data by filtering waveforms of the detected common rail pressure, calculating an approximate straight line Ld by the pressure data from a preselected time to a time T3 of at least the first smallest value after the start of the pressure drop, and defining a time, at which a difference between a pressure data and an approximate straight line Ld is the largest value, as the timing T2 of the start of the pressure drop. Based on the time T2, a time lag &Dgr;Td is calculated, that spans from an output timing T0 of injection command signal to a fuel-injection timing T1.

Abstract: The common-rail type fuel injection method of this invention injects a small amount of fuel during the deceleration of engine to swiftly accomplish reductions in the common rail pressure and the engine revolution speed, thus reducing the amount of NOx at the end of the deceleration. The basic fuel injection amount Qb is determined from the accelerator control input Acc and the engine revolution speed Ne (step S10). When the actual pressure Pf of the common rail is higher than the target pressure Pf.sub.0 by more than a predetermined value .alpha.

Abstract: This invention determines the output timing of the injection command signal to each of the injectors so that the fuel injection timing agrees with the basic target injection timing even when there are variations in the fuel injection timing among the injectors, and thereby improves the exhaust emission performance of the engine. The time T.sub.2 of an intersection between the straight line Lp representing an average Pa of the common rail pressure before it starts to fall and the first-degree approximation straight line Ld having a maximum inclination of fall of the common rail pressure is determined as the timing at which the common rail pressure starts to fall. Based on the time T.sub.2 and the average pressure Pa, the delay time .DELTA.Td which elapses from the output timing T.sub.0 of the injection command signal to each of the injectors to the actual fuel injection timing T.sub.1 is calculated. The output timing T.sub.0 for the injection command signal is determined as an instant the delay time .DELTA.

Abstract: A fuel-injection system for an engine is disclosed for accomplishing a minute fuel injection by learning the minimum conductive duration to electronic devices for the beginning of the minute fuel injection. A controller unit may output at a time Tp a command pulse of an actuating current that is applied to solenoid-operated valves to make injectors to carry out the fuel injection. After a definite length of time T.sub.0 has elapsed, a common rail pressure begins decreasing from a mean value P.sub.0, which is kept until then. The controller unit changes incrementally the conductive duration Pwp of the command pulse for a pilot injection from the minimal conductive duration, and identifies the timing of the beginning of the fuel injection with the timing when an area Ar of pressure reduction is over a preselected value. In case the desired amount of fuel to be injected is too minute, the controller unit may calculate the conductive duration dependently on the minimum command pulse width.