Patents by Inventor Yasuko Terao
Yasuko Terao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7662574Abstract: The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.Type: GrantFiled: February 2, 2007Date of Patent: February 16, 2010Assignee: Takeda Pharmaceutical Company LimitedInventors: Takuya Watanabe, Kuniko Kikuchi, Yasuko Terao, Yasushi Shintani, Shuji Hinuma, Shoji Fukusumi, Ryo Fujii, Masaki Hosoya, Chieko Kitada
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Patent number: 7608409Abstract: The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.Type: GrantFiled: October 24, 2007Date of Patent: October 27, 2009Assignee: Takeda Pharmaceutical Company LimitedInventors: Takuya Watanabe, Yasuko Terao, Yasushi Shintani, Tetsuya Ohtaki, Kimiko Kanehashi, Chieko Kitada
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Patent number: 7419956Abstract: The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity of the peptide, a compound or its salt obtained by the screening, a drug comprising the compound or its salt, etc. The peptide of the invention and the DNA encoding the same are usable, e.g., for the diagnosis, treatment, prevention, etc. of digestive diseases, etc. Moreover, the peptide of the invention is useful as a reagent for screening a compound or its salt that promotes or inhibits the activity of the protein of the invention.Type: GrantFiled: December 15, 2005Date of Patent: September 2, 2008Assignee: Takeda Pharmaceutical Company LimitedInventors: Tetsuya Ohtaki, Yasushi Masuda, Yoshihiro Takatsu, Takuya Watanabe, Yasuko Terao, Yasushi Shintani, Syuji Hinuma
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Publication number: 20080131976Abstract: The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.Type: ApplicationFiled: October 24, 2007Publication date: June 5, 2008Inventors: Takuya Watanabe, Yasuko Terao, Yasushi Shintani, Tetsuya Ohtaki, Kimiko Kanehashi, Chieko Kitada
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Patent number: 7314754Abstract: The present invention relates to a polynucleotide encoding a human brain-derived G protein coupled receptor protein. The human brain-derived G protein coupled receptor protein is useful: (1) for determination of a ligand to the receptor protein, (2) as an agent for the prevention and/or treatment of diseases associated with dysfunction of the receptor protein, (3) as a genetic diagnostic agent, (4) for quantification of a ligand to the receptor protein, (5) for screening of a compound that alters the binding property between the receptor protein and a ligand, (6) as an agent for the prevention and/or treatment of various diseases, comprising a compound that alters the binding property between the receptor protein and a ligand, (7) for quantification of the receptor protein, (8) for neutralization by antibodies to the receptor protein and (9) for preparation of a non-human animal bearing the DNA encoding the receptor protein.Type: GrantFiled: February 5, 2004Date of Patent: January 1, 2008Assignee: Takeda Pharmaceutical Company LimitedInventors: Takuya Watanabe, Yasuko Terao, Yasushi Shintani
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Publication number: 20070202550Abstract: The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.Type: ApplicationFiled: February 2, 2007Publication date: August 30, 2007Applicant: Takeda Pharmaceutical Company, Ltd.Inventors: Takuya Watanabe, Kuniko Kikuchi, Yasuko Terao, Yasushi Shintani, Shuji Hinuma, Shoji Fukusumi, Ryo Fujii, Masaki Hosoya, Chieko Kitada
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Patent number: 7192723Abstract: The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.Type: GrantFiled: November 21, 2003Date of Patent: March 20, 2007Assignee: Takeda Pharmaceutical Company LimitedInventors: Takuya Watanabe, Kuniko Kikuchi, Yasuko Terao, Yasushi Shintani, Shuji Hinuma, Shoji Fukusumi, Ryo Fujii, Masaki Hosoya, Chieko Kitada
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Patent number: 7045299Abstract: The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity of the peptide, a compound or its salt obtained by the screening, a drug comprising the compound or its salt, etc. The peptide of the invention and the DNA encoding the same are usable, e.g., for the diagnosis, treatment, prevention, etc. of digestive diseases, etc. Moreover, the peptide of the invention is useful as a reagent for screening a compound or its salt that promotes or inhibits the activity of the protein of the invention.Type: GrantFiled: July 17, 2001Date of Patent: May 16, 2006Assignee: Takeda Pharmaceutical Company LimitedInventors: Tetsuya Ohtaki, Yasushi Masuda, Yoshihiro Takatsu, Takuya Watanabe, Yasuko Terao, Yasushi Shintani
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Publication number: 20060088915Abstract: The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity of the peptide, a compound or its salt obtained by the screening, a drug comprising the compound or its salt, etc. The peptide of the invention and the DNA encoding the same are usable, e.g., for the diagnosis, treatment, prevention, etc. of digestive diseases, etc. Moreover, the peptide of the invention is useful as a reagent for screening a compound or its salt that promotes or inhibits the activity of the protein of the invention.Type: ApplicationFiled: December 15, 2005Publication date: April 27, 2006Inventors: Tetsuya Ohtaki, Yasushi Masuda, Yoshihiro Takatsu, Takuya Watanabe, Yasuko Terao, Yasushi Shintani, Syuji Hinuma
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Publication number: 20060057663Abstract: The present invention provides a human-derived protein or a salt thereof, a DNA encoding the same, a method for determination of ligand to the protein, a screening method/kits for a compound or its salt that alters a binding property between ligand and the protein, and the like. The human-derived protein or a DNA encoding the same of the present invention can be used in (1) determination of ligand to the protein of the present invention, (2) a prophylactic/therapeutic agent for diseases associated with dysfunction of the protein of the present invention, (3) a screening of a compound (agonist, antagonist, etc.) that alters a binding property between the protein and the ligand of the present invention, and the like.Type: ApplicationFiled: July 6, 2001Publication date: March 16, 2006Inventors: Masanori Miwa, Takashi Ito, Natsuki Ikeda, Yasuko Terao, Yasushi Shintani, Nobuyuki Miyajima
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Publication number: 20050240008Abstract: The present invention relates to a novel protein containing a peptide having a ligand activity to a G-protein copuled receptor protein; amides, esters, salts of the peptides; and drugs containing the same.Type: ApplicationFiled: March 29, 2001Publication date: October 27, 2005Inventors: Tetsuya Ohtaki, Yasushi Shintani, Yasuko Terao, Satoshi Kumano
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Publication number: 20040180407Abstract: The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.Type: ApplicationFiled: February 5, 2004Publication date: September 16, 2004Inventors: Takuya Watanabe, Yasuko Terao, Yasushi Shintani
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Publication number: 20040132073Abstract: The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.Type: ApplicationFiled: November 21, 2003Publication date: July 8, 2004Inventors: Takuya Watanabe, Kuniko Kikuchi, Yasuko Terao, Yasushi Shintani, Shuji Hinuma, Shuji Fukusumi, Ryo Fujii, Masaki Hosoya, Chieko Kitada
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Publication number: 20040101956Abstract: The present invention intends to provide a novel protein, which is useful in a screening of agonist/antagonist, etc.Type: ApplicationFiled: May 29, 2003Publication date: May 27, 2004Inventors: Yasuko Terao, Yasushi Shintani
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Publication number: 20040077535Abstract: The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity of the peptide, a compound or its salt obtained by the screening, a drug comprising the compound or its salt, etc.Type: ApplicationFiled: September 29, 2003Publication date: April 22, 2004Inventors: Tetsuya Ohtaki, Yasushi Masuda, Yoshihiro Takatsu, Takuya Watanabe, Yasuko Terao, Yasushi Shintani, Syuji Hinuma
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Publication number: 20040048314Abstract: The present invention is intended to provide therapeutic/prophylactic agents and diagnostic for digestive diseases, etc.Type: ApplicationFiled: August 1, 2003Publication date: March 11, 2004Inventors: Tetsuya Ohtaki, Yasushi Masuda, Yoshihiro Takatsu, Takuya Watanabe, Yasuko Terao, Yasushi Shintani, Syuji Hinuma
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Patent number: 6699965Abstract: G Protein-coupled receptor proteins originating in the vicinity of rat brain stem and human brain or salts thereof, or peptide fragments thereof or amides, esters or salts of the same; ligands thereto; a method/kit for screening compounds capable of altering the binding properties of the ligands to the G protein-coupled receptor proteins; the compounds or salts thereof obtained by the above screening; antibodies against the G protein-coupled receptor proteins, etc.Type: GrantFiled: April 26, 2001Date of Patent: March 2, 2004Assignee: Takeda Chemical Industries, Ltd.Inventors: Takuya Watanabe, Yasuko Terao, Yasushi Shintani, Tetsuya Ohtaki, Kimiko Kanehashi, Chieko Kitada
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Publication number: 20040029224Abstract: The present invention provides a novel G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as that represented by SEQ ID NO: 5 or salts thereof, and a polynucleotide encoding the same. The present invention also provides a use such as pharmaceuticals, etc.Type: ApplicationFiled: November 21, 2002Publication date: February 12, 2004Inventors: Yasuko Terao, Hideki Matsui, Yasushi Shintani
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Publication number: 20040029178Abstract: The present invention intends to provide a novel protein useful for a screening of agonists/antagonists. Specifically, the present invention provides rat- and mouse-derived protein or its salt, DNA encoding the protein, a determination method of ligand to the protein, a screening method and a screening kit for a compound that alters a binding property between ligand and the protein, a compound or its salt obtainable by the screening, and the like.Type: ApplicationFiled: May 30, 2003Publication date: February 12, 2004Inventors: Yasuko Terao, Yasushi Shintani, Mioko Harada, Yukio Shimomura, Masaaki Mori