Patents by Inventor Yasumasa Dekishima
Yasumasa Dekishima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230025343Abstract: The present invention provides a carbonyl reductase having the activity of reducing a carbonyl group-containing compound to convert the compound into an optically active compound, and a production method of an optically active compound using the enzyme. Specifically, a carbonyl reductase having one or more mutations in which the 54th aspartic acid, the 157th methionine, the 170th alanine, the 211th isoleucine, the 214th methionine, and the 249th methionine are each substituted by other specific amino acid in the amino acid sequence shown in SEQ ID NO: 1 or a homologue of the amino acid sequence, and a production method of an optically active compound using the same are provided.Type: ApplicationFiled: November 20, 2020Publication date: January 26, 2023Applicant: API CORPORATIONInventors: Takanobu IURA, Yasumasa DEKISHIMA, Takeshi SAKAMOTO, Mari HARA, Hirotoshi HIRAOKA, Harald GRĂ–GER, Jieun CHOI
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Publication number: 20190315696Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.Type: ApplicationFiled: June 17, 2019Publication date: October 17, 2019Applicant: API CORPORATIONInventors: Naoyuki WATANABE, Tomoko MAEDA, Yasumasa DEKISHIMA, Hiroshi KAWABATA, Masaki NAGAHAMA
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Patent number: 10377722Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.Type: GrantFiled: May 19, 2017Date of Patent: August 13, 2019Assignee: API CORPORATIONInventors: Naoyuki Watanabe, Tomoko Maeda, Yasumasa Dekishima, Hiroshi Kawabata, Masaki Nagahama, Kosuke Ito
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Patent number: 10087473Abstract: A method for producing cis-5-hydroxy-L-pipecolic acid, the method comprising allowing a 2-oxoglutarate-dependent L-pipecolic acid hydroxylase to act on L-pipecolic acid to generate cis-5-hydroxy-L-pipecolic acid, wherein the 2-oxoglutarate-dependent L-pipecolic acid hydroxylase comprises the polypeptide (A), (B) or (C) below: (A) a polypeptide comprising the amino acid sequence represented by SEQ ID NO: 4 or 11; (B) a polypeptide comprising the amino acid sequence represented by SEQ ID NO: 4 or 11 except that one or several amino acids are deleted, substituted, and/or added, which polypeptide has 2-oxoglutarate-dependent L-pipecolic acid hydroxylase activity; or (C) a polypeptide comprising an amino acid sequence with an identity of not less than 60% to the amino acid sequence represented by SEQ ID NO: 4 or 11, which polypeptide has 2-oxoglutarate-dependent L-pipecolic acid hydroxylase activity.Type: GrantFiled: November 2, 2015Date of Patent: October 2, 2018Assignee: API CORPORATIONInventors: Ryoma Miyake, Yasumasa Dekishima
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Publication number: 20170306367Abstract: A method for producing cis-5-hydroxy-L-pipecolic acid, the method comprising allowing a 2-oxoglutarate-dependent L-pipecolic acid hydroxylase to act on L-pipecolic acid to generate cis-5-hydroxy-L-pipecolic acid, wherein the 2-oxoglutarate-dependent L-pipecolic acid hydroxylase comprises the polypeptide (A), (B) or (C) below: (A) a polypeptide comprising the amino acid sequence represented by SEQ ID NO: 4 or 11; (B) a polypeptide comprising the amino acid sequence represented by SEQ ID NO: 4 or 11 except that one or several amino acids are deleted, substituted, and/or added, which polypeptide has 2-oxoglutarate-dependent L-pipecolic acid hydroxylase activity; or (C) a polypeptide comprising an amino acid sequence with an identity of not less than 60% to the amino acid sequence represented by SEQ ID NO: 4 or 11, which polypeptide has 2-oxoglutarate-dependent L-pipecolic acid hydroxylase activity.Type: ApplicationFiled: November 2, 2015Publication date: October 26, 2017Applicant: API CORPORATIONInventors: Ryoma MIYAKE, Yasumasa DEKISHIMA
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Publication number: 20170305867Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.Type: ApplicationFiled: May 19, 2017Publication date: October 26, 2017Applicant: API CORPORATIONInventors: Naoyuki WATANABE, Tomoko MAEDA, Yasumasa DEKISHIMA, Hiroshi KAWABATA, Masaki NAGAHAMA, Kosuke ITO
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Publication number: 20160347718Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.Type: ApplicationFiled: February 6, 2015Publication date: December 1, 2016Applicants: API CORPORATION, API CORPORATIONInventors: Naoyuki WATANABE, Yasumasa DEKISHIMA, Masaki NAGAHAMA, Tomoko MAEDA, Takashi OHTANI, Kosuke ITO, Hiroshi KAWABATA
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Patent number: 9061991Abstract: It is an object of the present invention to provide a novel method for producing (1R,2S)/(1S,2R)-1-amino-1-alkoxycarbonyl-2-vinylcyclopropane which is useful as a synthetic intermediate of therapeutic agents for hepatitis C and a synthetic intermediate thereof. According to the present invention, when a trans-2-butene derivative having a leaving group at each of the 1- and 4-positions is reacted with a malonic ester in the presence of a base, a specific amount of an alkali metal alkoxide or an alkali metal hydride is used as the base, and further a specific amount of a malonic ester is used to produce a cyclopropane diester, and further, chiral or achiral 1-amino-1-alkoxy-carbonyl-2-vinylcyclopropane and a salt thereof are synthesized using the cyclopropane diester.Type: GrantFiled: February 16, 2011Date of Patent: June 23, 2015Assignee: API CORPORATIONInventors: Yuuki Asuma, Tatsuya Suzuki, Jun Takehara, Tsugihiko Hidaka, Kuniko Asada, Ryoma Miyake, Yasumasa Dekishima, Hiroshi Kawabata
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Publication number: 20130096339Abstract: It is an object of the present invention to provide a novel method for producing (1R,2S)/(1S,2R)-1-amino-1-alkoxycarbonyl-2-vinylcyclopropane which is useful as a synthetic intermediate of therapeutic agents for hepatitis C and a synthetic intermediate thereof. According to the present invention, when a trans-2-butene derivative having a leaving group at each of the 1- and 4-positions is reacted with a malonic ester in the presence of a base, a specific amount of an alkali metal alkoxide or an alkali metal hydride is used as the base, and further a specific amount of a malonic ester is used to produce a cyclopropane diester, and further, chiral or achiral 1-amino-1-alkoxy-carbonyl-2-vinylcyclopropane and a salt thereof are synthesized using the cyclopropane diester.Type: ApplicationFiled: February 16, 2011Publication date: April 18, 2013Applicant: API CORPORATIONInventors: Yuuki Asuma, Tatsuya Suzuki, Jun Takehara, Tsugihiko Hidaka, Kuniko Asada, Ryoma Miyake, Yasumasa Dekishima, Hiroshi Kawabata
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Patent number: 7659409Abstract: The object of the present invention is to provide 3-hydroxy-3-(2-thienyl)propionamides useful as synthesis intermediates of pharmaceutical preparations and the like and a method for obtaining optically active 3-amino-1-(2-thienyl)-1-propanols using the same with high reaction yield, high optical yield and industrially low cost. According to the present invention, 3-amino-1-(2-thienyl)-1-propanols are obtained by carrying out asymmetric reduction of a ?-ketocarbonyl compound having thiophene ring in the presence of a catalyst constituted from a compound of a group VIII or IX metal in the periodic table (e.g., a ruthenium compound) and an asymmetric ligand represented by a specified optically active diamine derivative (e.g., a diphenylethylenediamine derivative), or using a cell, a treated product of said cell or the like of a microorganism, and as occasion demands, carrying out amidation of the ester group and then carrying out reduction of the amido group.Type: GrantFiled: September 20, 2004Date of Patent: February 9, 2010Assignee: Mitsubishi Chemical CorporationInventors: Jun Takehara, Jingping Qu, Kazuaki Kanno, Hiroshi Kawabata, Yasumasa Dekishima, Makoto Ueda, Kyoko Endo, Takeshi Murakami, Tomoko Sasaki, Hisatoshi Uehara, Youichi Matsumoto, Shihomi Suzuki
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Publication number: 20080233621Abstract: It is an object of the present invention to provide an inexpensive and efficient industrial method for obtaining (S)-2-pentanol, (S)-2-hexanol, 1-methylalkyl malonic acid and 3-methyl carboxylic acid at a high optical purity. The present invention provides a method of producing (S)-2-pentanol or (S)-2-hexanol which comprises allowing certain types of microorganisms or transformed cells, a product obtained by treating said microorganisms or cells, a culture solution of said microorganisms or cells, and/or a crude purified product or purified product of a carbonyl reductase fraction obtained from said microorganisms or cells, to act on 2-pentanone or 2-hexanone.Type: ApplicationFiled: February 4, 2005Publication date: September 25, 2008Applicant: API CorporationInventors: Yasumasa Dekishima, Hiroshi Kawabata, Hirotoshi Hiraoka, Makoto Ueda, Hisatoshi Uehara
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Publication number: 20050107621Abstract: The object of the present invention is to provide 3-hydroxy-3-(2-thienyl)propionamides useful as synthesis intermediates of pharmaceutical preparations and the like and a method for obtaining optically active 3-amino-1-(2-thienyl)-1-propanols using the same with high reaction yield, high optical yield and industrially low cost. According to the present invention, 3-amino-1-(2-thienyl)-1-propanols are obtained by carrying out asymmetric reduction of a ?-ketocarbonyl compound having thiophene ring in the presence of a catalyst constituted from a compound of a group VIII or IX metal in the periodic table (e.g., a ruthenium compound) and an asymmetric ligand represented by a specified optically active diamine derivative (e.g., a diphenylethylenediamine derivative), or using a cell, a treated product of said cell or the like of a microorganism, and as occasion demands, carrying out amidation of the ester group and then carrying out reduction of the amido group.Type: ApplicationFiled: September 20, 2004Publication date: May 19, 2005Applicant: MITSUBISHI CHEMICAL CORPORATIONInventors: Jun Takehara, Jingping Qu, Kazuaki Kanno, Hiroshi Kawabata, Yasumasa Dekishima, Makoto Ueda, Kyoko Endo, Takeshi Murakami, Tomoko Sasaki, Hisatoshi Uehara, Youichi Matsumoto, Shihomi Suzuki