Patents by Inventor Yasunobu Iga
Yasunobu Iga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11920123Abstract: A cell analyzing device includes a control circuit. The control circuit acquires data of an observation image. The control circuit specifies a colony of a cultured cell in the observation image. The control circuit calculates a ratio at which the cultured cell occupies a predetermined range included in the observation image as an occupancy rate. The control circuit calculates a size of the colony. The control circuit determines a state of the cultured cell based on the occupancy rate and the size of the colony.Type: GrantFiled: July 15, 2020Date of Patent: March 5, 2024Assignee: Evident CorporationInventors: Yasunobu Iga, Taiji Mine, Yoshinobu Akahori
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Publication number: 20230371817Abstract: An endoscope system according to the present invention includes: an illumination light source that emits illumination light for illuminating an object; a therapeutic light source that emits therapeutic light for causing a photoreactive reagent accumulated in a treatment target site to react; a guide light source that emits guide light having a wavelength shorter than a wavelength band of the therapeutic light source; an imager that captures an optical image, the imager including an optical filter that cuts light in the wavelength band of the therapeutic light and transmits a part of white light, the guide light, and fluorescence emitted by the reagent; a controller that controls emission timings of the illumination light source, the therapeutic light source, and the guide light source; and an image processor that generates an image on the basis of an optical image obtained by light emitted from the illumination light source, the therapeutic light source, and the guide light source, in which the controller cauType: ApplicationFiled: October 24, 2022Publication date: November 23, 2023Applicant: OLYMPUS CORPORATIONInventors: Masaru MIZUNAKA, Yasunobu IGA, Takeshi SUGA, Chikashi OTA
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Patent number: 11493745Abstract: A cell observation system according to the present invention includes: a first image-acquisition device disposed in an incubator and acquires a first image of cells in a culturing vessel; a second image-acquisition device disposed outside the incubator; a processing device connected to the first image-acquisition device and the second image-acquisition device; and a display displays at least a region of the first image, as well as the second image. The second image-acquisition device includes a second image-acquisition unit that acquires a second image of the interior of the culturing vessel, that removed from the incubator. The processing device extracts target cells in the first image, calculates positions at which the extracted target cells are present and stores the positions in the memory, and causes the display to display the positions at which the target cells are present in a superimposed manner on an indication indicating the culturing vessel.Type: GrantFiled: December 22, 2019Date of Patent: November 8, 2022Assignee: Evident CorporationInventors: Takashi Miyoshi, Shinichi Takimoto, Yasunobu Iga, Shintaro Takahashi
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Patent number: 11461892Abstract: A cell observation system according to the present invention includes: a first image-acquisition device disposed in an incubator and acquires a first image of cells in a culturing vessel; a second image-acquisition device disposed outside the incubator; a processing device connected to the first and second image-acquisition devices; and a display. The second image-acquisition device includes a second image-acquisition unit that acquires a second image of the interior of the culturing vessel that removed from the incubator, a support that supports the second image-acquisition unit and the culturing vessel, and a position measuring unit that measures a position between the culturing vessel and the second image-acquisition unit at the time of acquiring the second image. The processing device extracts target cells in the first image, calculates positions of the target cells, and displays the relationship between the positions of the target cells and the second image.Type: GrantFiled: December 22, 2019Date of Patent: October 4, 2022Assignee: Evident CorporationInventors: Takashi Miyoshi, Shinichi Takimoto, Yasunobu Iga, Shintaro Takahashi
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Patent number: 11256898Abstract: A culture information processing device includes: a feature value computing unit that computes growth feature values indicating features of growth characteristics of cells from data acquired in a particular first subculturing process selected from among a plurality of subculturing processes included in a culture period of the cells; a condition setting unit that sets culturing conditions of a second subculturing process one process after the first subculturing process; and an information computing unit that computes, on the basis of the growth feature values computed by the feature value computing unit and the culturing conditions set by the condition setting unit, characteristics-related information related to growth characteristics in the second subculturing process.Type: GrantFiled: March 31, 2020Date of Patent: February 22, 2022Assignee: OLYMPUS CORPORATIONInventors: Taiji Mine, Yasunobu Iga, Yoshinobu Akahori, Koji Sakai, Kazunari Tokuda
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Publication number: 20200339939Abstract: A cell analyzing device includes a control circuit. The control circuit acquires data of an observation image. The control circuit specifies a colony of a cultured cell in the observation image. The control circuit calculates a ratio at which the cultured cell occupies a predetermined range included in the observation image as an occupancy rate. The control circuit calculates a size of the colony. The control circuit determines a state of the cultured cell based on the occupancy rate and the size of the colony.Type: ApplicationFiled: July 15, 2020Publication date: October 29, 2020Applicant: OLYMPUS CORPORATIONInventors: Yasunobu IGA, Taiji MINE, Yoshinobu AKAHORI
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Publication number: 20200234032Abstract: A culture information processing device includes: a feature value computing unit that computes growth feature values indicating features of growth characteristics of cells from data acquired in a particular first subculturing process selected from among a plurality of subculturing processes included in a culture period of the cells; a condition setting unit that sets culturing conditions of a second subculturing process one process after the first subculturing process; and an information computing unit that computes, on the basis of the growth feature values computed by the feature value computing unit and the culturing conditions set by the condition setting unit, characteristics-related information related to growth characteristics in the second subculturing process.Type: ApplicationFiled: March 31, 2020Publication date: July 23, 2020Applicant: OLYMPUS CORPORATIONInventors: Taiji MINE, Yasunobu IGA, Yoshinobu AKAHORI, Koji SAKAI, Kazunari TOKUDA
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Publication number: 20200126225Abstract: A cell observation system according to the present invention includes: a first image-acquisition device disposed in an incubator and acquires a first image of cells in a culturing vessel; a second image-acquisition device disposed outside the incubator; a processing device connected to the first and second image-acquisition devices; and a display. The second image-acquisition device includes a second image-acquisition unit that acquires a second image of the interior of the culturing vessel that removed from the incubator, a support that supports the second image-acquisition unit and the culturing vessel, and a position measuring unit that measures a position between the culturing vessel and the second image-acquisition unit at the time of acquiring the second image. The processing device extracts target cells in the first image, calculates positions of the target cells, and displays the relationship between the positions of the target cells and the second image.Type: ApplicationFiled: December 22, 2019Publication date: April 23, 2020Applicant: OLYMPUS CORPORATIONInventors: Takashi MIYOSHI, Shinichi TAKIMOTO, Yasunobu IGA, Shintaro TAKAHASHI
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Publication number: 20200124836Abstract: A cell observation system according to the present invention includes: a first image-acquisition device disposed in an incubator and acquires a first image of cells in a culturing vessel; a second image-acquisition device disposed outside the incubator; a processing device connected to the first image-acquisition device and the second image-acquisition device; and a display displays at least a region of the first image, as well as the second image. The second image-acquisition device includes a second image-acquisition unit that acquires a second image of the interior of the culturing vessel, that removed from the incubator. The processing device extracts target cells in the first image, calculates positions at which the extracted target cells are present and stores the positions in the memory, and causes the display to display the positions at which the target cells are present in a superimposed manner on an indication indicating the culturing vessel.Type: ApplicationFiled: December 22, 2019Publication date: April 23, 2020Applicant: OLYMPUS CORPORATIONInventors: Takashi MIYOSHI, Shinichi TAKIMOTO, Yasunobu IGA, Shintaro TAKAHASHI
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Patent number: 10438047Abstract: For the purpose of counting the number of cells within a culture container readily and accurately, a cell analysis device includes a cell-image acquiring unit that acquires an image of cells within a culture container in which the cells are cultured, a usability determining unit that determines whether or not the image acquired by the cell-image acquiring unit is usable, a number-of-cells counting unit that counts the number of cells within the image determined as being usable by the usability determining unit, and a number-of-cells calculating unit that calculates the number of cells within the culture container based on the number of cells counted by the number-of-cells counting unit.Type: GrantFiled: October 5, 2017Date of Patent: October 8, 2019Assignee: OLYMPUS CORPORATIONInventors: Yasunobu Iga, Shinichi Takimoto, Yohei Tanikawa, Yoshinobu Akahori
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Patent number: 10385300Abstract: A cell analysis apparatus including: a cell image acquisition unit that acquires an image of cells in a culture vessel in which cells are cultured; a smoothing processing unit that smooths luminance values in the image acquired by the cell image acquisition unit; a minimum-value detecting unit that detects minimum values of the luminance values smoothed by the smoothing processing unit; a smallest-minimum-value extracting unit that extracts smallest minimum values which are the smallest in regions according to the sizes of the cells, from the minimum values detected by the minimum-value detecting unit; a counting unit that counts the number of smallest minimum values extracted by the smallest-minimum-value extracting unit; and a cell-count calculating unit that calculates the number of cells in the culture vessel on the basis of the number of smallest minimum values counted by the counting unit.Type: GrantFiled: July 19, 2017Date of Patent: August 20, 2019Assignee: OLYMPUS CORPORATIONInventors: Yasunobu Iga, Yohei Tanikawa, Shinichi Takimoto, Yoshinobu Akahori
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Publication number: 20190180080Abstract: A cell-state measurement device acquires an image of a culture surface in a vessel formed of an optically transparent material, measures a state of cells being cultured on the culture surface, and includes: a housing including a stage on which the vessel is placed; and an image acquisition unit accommodated in the housing and configured to acquire an image of the cells in the vessel, wherein the image acquisition unit includes: a line sensor including a plurality of light receiving elements linearly arranged; an objective lens disposed between the sensor and the stage; an illuminator illuminating a field of view of the objective lens; and a scanner moving the sensor, wherein the illuminator emits illumination light upward, and wherein the illumination light emitted by the illuminator is reflected downward by the vessel, is transmitted through the culture surface and is incident on the objective lens.Type: ApplicationFiled: February 14, 2019Publication date: June 13, 2019Applicant: Olympus CorporationInventors: Yasunobu IGA, Hitoshi Echigo, Akira Matsushita
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Patent number: 10281704Abstract: Provided is an observation apparatus and an observation method with which it is possible to observe imaging subjects, such as cells or the like, without labeling the imaging subjects and without causing an increase in the apparatus size. Provided is an observation apparatus including: a light-source unit that emits illumination light upward from below a sample; and an image-capturing optical system that has an objective lens that collects transmitted light, which is the illumination light emitted from the light-source unit that has passed through the sample by being reflected above the sample and that captures, below the sample, the transmitted light collected by the objective lens.Type: GrantFiled: May 29, 2017Date of Patent: May 7, 2019Assignee: OLYMPUS CORPORATIONInventors: Shintaro Takahashi, Tadashi Hirata, Yasunobu Iga, Shinichi Takimoto, Takashi Miyoshi
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Patent number: 10136802Abstract: A device for sustained release of optical clearing agent includes a stick-shaped component having at least two supplying passages for supplying gas or liquid formed on the inside with apertures of the supplying passages being formed at positions along the circumference of the lateral surface in the vicinity of the top end of the stick-shaped component respectively, at least two pouch-shaped elastic components placed at positions along the circumference of the lateral surface in the vicinity of the top end of the stick-shaped component respectively to cover the apertures of the supplying passages respectively, an optical clearing agent holding component fixed on the surface of one of the pouch-shaped elastic components and holding optical clearing agent, and a body-fluid absorbing component fixed on the surface of another one of the pouch-shaped elastic components and absorbing body fluid flowing from a target object or dehydrating the target object by osmotic pressure.Type: GrantFiled: August 18, 2015Date of Patent: November 27, 2018Assignee: OLYMPUS CORPORATIONInventors: Yohei Tanikawa, Yasunobu Iga, Shinichi Takimoto
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Publication number: 20180092594Abstract: A fat tissue observation method includes: a process A of applying an optical clearing agent to fat tissue within a body; a process B of heating the fat tissue to reduce a first refractive index of the fat tissue and put the first refractive index close to a second refractive index of the optical clearing agent; and a process C of observing an inside of the fat tissue that the optical clearing agent permeates.Type: ApplicationFiled: December 5, 2017Publication date: April 5, 2018Applicants: OLYMPUS CORPORATION, SARATOV State UniversityInventors: Yohei Tanikawa, Yasunobu Iga, Shinichi Takimoto, Valery V. Tuchin, Elina A. Genina, Alexey N. Bashkatov, Irina Yu. Yanina, Yana V. Tarakanchikova, Georgy S. Terentuk, Polina A. Timoshina, Daria K. Tuchina
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Publication number: 20180032787Abstract: For the purpose of counting the number of cells within a culture container readily and accurately, a cell analysis device includes a cell-image acquiring unit that acquires an image of cells within a culture container in which the cells are cultured, a usability determining unit that determines whether or not the image acquired by the cell-image acquiring unit is usable, a number-of-cells counting unit that counts the number of cells within the image determined as being usable by the usability determining unit, and a number-of-cells calculating unit that calculates the number of cells within the culture container based on the number of cells counted by the number-of-cells counting unit.Type: ApplicationFiled: October 5, 2017Publication date: February 1, 2018Applicant: OLYMPUS CORPORATIONInventors: Yasunobu IGA, Shinichi TAKIMOTO, Yohei TANIKAWA, Yoshinobu AKAHORI
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Publication number: 20170355949Abstract: It is possible to observe imaging subjects, such as cells or the like, without causing an increase in the apparatus size. Provided is an observation apparatus including: a flat-plate-like stage formed of an optically transparent material on which a container accommodating a sample is placed; a deflecting member that is disposed below the stage and that deflects light coming from the sample on the stage into a substantially horizontal direction; an objective lens that collects the light deflected by the deflecting member; and an image-acquisition device that captures the light collected by the objective lens.Type: ApplicationFiled: August 29, 2017Publication date: December 14, 2017Applicant: OLYMPUS CORPORATIONInventors: Tadashi HIRATA, Shintaro TAKAHASHI, Yasunobu IGA, Shinichi TAKIMOTO
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Publication number: 20170313965Abstract: A cell analysis apparatus including: a cell image acquisition unit that acquires an image of cells in a culture vessel in which cells are cultured; a smoothing processing unit that smooths luminance values in the image acquired by the cell image acquisition unit; a minimum-value detecting unit that detects minimum values of the luminance values smoothed by the smoothing processing unit; a smallest-minimum-value extracting unit that extracts smallest minimum values which are the smallest in regions according to the sizes of the cells, from the minimum values detected by the minimum-value detecting unit; a counting unit that counts the number of smallest minimum values extracted by the smallest-minimum-value extracting unit; and a cell-count calculating unit that calculates the number of cells in the culture vessel on the basis of the number of smallest minimum values counted by the counting unit.Type: ApplicationFiled: July 19, 2017Publication date: November 2, 2017Applicant: OLYMPUS CORPORATIONInventors: Yasunobu IGA, Yohei TANIKAWA, Shinichi TAKIMOTO, Yoshinobu AKAHORI
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Patent number: 9775501Abstract: An endoscope has an insertion portion inserted through a living body, an illumination fiber arranged at a distal end of the insertion portion and irradiates the living body with illumination light, a detection fiber which detects return light from the living body, an actuator which swings a free end of the illumination fiber, and a ferrule which has a through-hole based on a diameter of the illumination fiber and is arranged between the illumination fiber and the actuator. The actuator has an actuator arranged at a first side face of the ferrule and an actuator arranged at a second side face of the ferrule that is different from a face point-symmetric to the first side face with respect to an axial direction of the illumination fiber.Type: GrantFiled: March 11, 2014Date of Patent: October 3, 2017Assignee: OLYMPUS CORPORATIONInventors: Masahiro Yoshino, Tomoki Funakubo, Atsuyoshi Shimamoto, Yasunobu Iga, Mitsuru Namiki
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Publication number: 20170261732Abstract: Provided is an observation apparatus and an observation method with which it is possible to observe imaging subjects, such as cells or the like, without labeling the imaging subjects and without causing an increase in the apparatus size. Provided is an observation apparatus including: a light-source unit that emits illumination light upward from below a sample; and an image-capturing optical system that has an objective lens that collects transmitted light, which is the illumination light emitted from the light-source unit that has passed through the sample by being reflected above the sample and that captures, below the sample, the transmitted light collected by the objective lens.Type: ApplicationFiled: May 29, 2017Publication date: September 14, 2017Applicant: OLYMPUS CORPORATIONInventors: Shintaro TAKAHASHI, Tadashi HIRATA, Yasunobu IGA, Shinichi TAKIMOTO, Takashi MIYOSHI