Abstract: The present invention provides a new compound which has NK1 receptor antagonist activity, whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to carboxymethyl piperidine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. Wherein, ring A is a benzene ring or the like; ring B is a pyridine ring or the like; R1 is C1-6 alkyl or C1-6 alkoxy; R2 and R3 are a hydrogen atom or methyl; and n is an integral number from 0 to 5.

Abstract: Post-processing apparatus for performing given process subsequently to image forming process by image forming apparatus is disclosed. Post-processing apparatus includes: first ejector which ejects sheet; first tray which temporarily holds sheet; second tray situated downstream of first tray in ejection direction of sheet; a tray driver which moves second tray downwardly from first height position; blower which forms airstream between second tray and lower surface of sheet; and controller which controls blower and tray driver. Controller includes: blower controller which causes blower to blow air over time period in synchronization with first time period from start to end of sheet ejection by first ejector; and tray controller which causes tray driver to move second tray downwardly from first height position after first time period.

Abstract: When a discharge count has exceeded a specified number of sheets, a sheet discharge device executes a process of moving down a discharge tray by a specified quantity and thereafter moving up the discharge tray until a top-surface detection part outputs a top-surface detection signal, while clocking a move-up time lasting from a move-up start of the discharge tray until output of the top-surface detection signal by the top-surface detection part. When the move-up time is equal to or less than a reference time, the sheet discharge device makes a next sheet discharged while the top-surface detection part outputs the top-surface detection signal; on the other hand, when the move-up time is more than the reference time, the sheet discharge device executes a correction process of moving down the discharge tray before making the next sheet discharged.

Abstract: A chain bending limiting attachment includes first bending limiting members and second bending limiting members. The first and second bending limiting members are detachably attached to a chain to be arranged in a series arrangement direction. Each first bending limiting member includes a first engaging portion. When the chain bends in a first direction, the first engaging portion engages with another first bending limiting member adjacent to the first bending limiting member in the series arrangement direction to limit bending of the chain in the first direction. Each second bending limiting member includes a second engaging portion. When the chain bends in a second direction, the second engaging portion engages with another second bending limiting member adjacent to the second bending limiting member in the series direction to limit bending of the chain in the second direction.

Abstract: A problem of the present invention is to provide a new compound which has NK1 receptor antagonist activity, whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to cyclohexyl pyridine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof, wherein, ring A is 4-fluoro-2-methylphenyl or the like; X is a hydrogen atom or the like; R1 is carboxymethyl or the like; R2 is alkyl or the like; Y is 0-2 or the like; U is —N(CH3)COC(CH3)2-3,5-bistrifluoromethylphenyl or the like.

Abstract: A sheet loading device is provided with a sheet ejection portion, a sheet loading portion, a first detection mechanism, a driving device, a second detection mechanism, and a control portion. The driving device drives the sheet loading portion to ascend/descend between an upper surface detection position and a reference position made to descend by a prescribed distance from the upper surface detection position. The second detection mechanism detects that the sheet loading portion is at the reference position. In a case where sheets of the same type are ejected continuously from the sheet ejection portion, the control portion controls beforehand the sheet loading portion to ascend from the reference position to the upper surface detection position and sets a loadable number of sheets of the sheet loading portion in accordance with an ascending time of the sheet loading portion.

Abstract: A sheet stacking device includes a sheet stacking section, pairs of ejection rollers, an airflow generator, and an airflow guide. The airflow guide has a center exhaust port and paired side exhaust ports. An airflow is blown out from the center exhaust port toward a central part of the lower surface of the sheet in a sheet width direction perpendicular to a conveyance direction of the sheet. Airflows are blown out from the respective paired side exhaust ports toward respective sides of the lower surface of the sheet. An amount of the airflow blown out from the center exhaust port is larger than those of the airflows blown out from the respective paired side exhaust ports.

Abstract: A sheet post-processing device of the present disclosure is provided with a punch hole forming device, a processing tray, an ejection tray, a conveyance roller pair, an ejection roller pair, and a stiffening member. In a case where a sheet through which punch holes have been formed is to be ejected on the ejection tray without being subjected to post-processing on the processing tray, in a state where the stiffening member is retracted in a direction away from the sheet, the conveyance roller pair conveys the sheet until at least a tip end thereof reaches on the ejection tray.

Abstract: A sheet loading device is provided with a sheet ejection portion, a sheet loading portion, a first detection mechanism, a driving device, a second detection mechanism, and a control portion. The driving device drives the sheet loading portion to ascend/descend between an upper surface detection position and a reference position made to descend by a prescribed distance from the upper surface detection position. The second detection mechanism detects that the sheet loading portion is at the reference position. In a case where sheets of the same type are ejected continuously from the sheet ejection portion, the control portion controls beforehand the sheet loading portion to ascend from the reference position to the upper surface detection position and sets a loadable number of sheets of the sheet loading portion in accordance with an ascending time of the sheet loading portion.

Abstract: When a discharge count has exceeded a specified number of sheets, a sheet discharge device executes a process of moving down a discharge tray by a specified quantity and thereafter moving up the discharge tray until a top-surface detection part outputs a top-surface detection signal, while clocking a move-up time lasting from a move-up start of the discharge tray until output of the top-surface detection signal by the top-surface detection part. When the move-up time is equal to or less than a reference time, the sheet discharge device makes a next sheet discharged while the top-surface detection part outputs the top-surface detection signal; on the other hand, when the move-up time is more than the reference time, the sheet discharge device executes a correction process of moving down the discharge tray before making the next sheet discharged.

Abstract: A problem of the present invention is to provide a new compound which has NK1 receptor antagonist activity, whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to cyclohexyl pyridine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof, wherein, ring A is 4-fluoro-2-methylphenyl or the like; X is a hydrogen atom or the like; R1 is carboxymethyl or the like; R2 is alkyl or the like; Y is 0-2 or the like; U is —N(CH3)COC(CH3)2-3,5-bistrifluoromethylphenyl or the like.

Abstract: A problem of the present invention is to provide a new compound which has NK1 receptor antagonist activity, whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to cyclohexyl pyridine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. wherein, ring A is 4-fluoro-2-methylphenyl or the like; X is a hydrogen atom or the like; R1 is carboxymethyl or the like; R2 is alkyl or the like; Y is 0-2 or the like; U is —N(CH3)COC(CH3)2-3,5-bistrifluoromethylphenyl or the like.

Abstract: A sheet post-processing device of the present disclosure is provided with a punch hole forming device, a processing tray, an ejection tray, a conveyance roller pair, an ejection roller pair, and a stiffening member. In a case where a sheet through which punch holes have been formed is to be ejected on the ejection tray without being subjected to post-processing on the processing tray, in a state where the stiffening member is retracted in a direction away from the sheet, the conveyance roller pair conveys the sheet until at least a tip end thereof reaches on the ejection tray.

Abstract: A sheet folding device includes two rollers, a blade, two parallel pins, and two gears. The first and second parallel pins are passed through first and second pin through-holes penetrating through first and second shaft portions in a direction perpendicular to a longitudinal direction of the shaft portions. The first and second gears have first and second shaft through-holes through which the first and second shaft portions are passed, and first and second grooves in which the first and second parallel pins are inserted, respectively. Projection portions formed on inner side wall of the second groove and projecting from both sides of the second shaft portion cause the second parallel pin to closely contact a side wall that is, in the second groove, opposite to the projection portions, and cause the second parallel pin to closely contact a portion of the second pin through-hole.

Abstract: An image forming apparatus includes an apparatus main body, a post-processing device, a first magnetic body, and a second magnetic body. The apparatus main body includes an ejecting part configured to eject a sheet toward an ejecting space. The post-processing device is configured to be slidable between an attached position and a detached position. The post-processing device includes a post-processing part and a movable guide. The movable guide is movable between an ordinary position and an opening position. The first magnetic body magnetically attracts the second magnetic body so as to hold the movable guide at the opening position, in a state where the post-processing device is shifted to the detached position. The first magnetic body separates from the second magnetic body and releases magnetic attraction to the second magnetic body when the post-processing device slides from the detached position to the attached position.

Abstract: [Problem] To provide a novel compound that exhibits an agonistic effect on dopamine D2 receptors. [Solution] The present invention provides a compound represented by the general formula (I): in which R1 is C1-6 alkyl or the like; R2 is hydrogen or the like; R3 and R4 are each hydrogen, C1-6 alkyl, R10R11N—C1-6 alkyl, aralkyl, or the like; R5 and R6 are hydrogen or the like; and R7 is hydrogen or the like, or a pharmaceutically acceptable salt thereof, a pharmaceutical compositions containing same and uses for said compound/salt and composition. The compounds of the present invention exhibit potent dopamine D2 receptor simulating activities and thus are useful as a treating or preventing agent for Parkinson's disease and the like.

Abstract: A problem of the present invention is to provide a new compound which has NK1 receptor antagonist activity, whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to cyclohexyl pyridine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. wherein, ring A is 4-fluoro-2-methylphenyl or the like; X is a hydrogen atom or the like; R1 is carboxymethyl or the like; R2 is alkyl or the like; Y is 0-2 or the like; U is —N(CH3)COC(CH3)2-3,5-bistrifluoromethylphenyl or the like.

Abstract: An image forming apparatus includes an apparatus main body, a post-processing device, a first magnetic body, and a second magnetic body. The apparatus main body includes an ejecting part configured to eject a sheet toward an ejecting space. The post-processing device is configured to be slidable between an attached position and a detached position. The post-processing device includes a post-processing part and a movable guide. The movable guide is movable between an ordinary position and an opening position. The first magnetic body magnetically attracts the second magnetic body so as to hold the movable guide at the opening position, in a state where the post-processing device is shifted to the detached position. The first magnetic body separates from the second magnetic body and releases magnetic attraction to the second magnetic body when the post-processing device slides from the detached position to the attached position.

Abstract: A sheet folding device includes two rollers, a blade, two parallel pins, and two gears. The first and second parallel pins are passed through first and second pin through-holes penetrating through first and second shaft portions in a direction perpendicular to a longitudinal direction of the shaft portions. The first and second gears have first and second shaft through-holes through which the first and second shaft portions are passed, and first and second grooves in which the first and second parallel pins are inserted, respectively. Projection portions formed on inner side wall of the second groove and projecting from both sides of the second shaft portion cause the second parallel pin to closely contact a side wall that is, in the second groove, opposite to the projection portions, and cause the second parallel pin to closely contact a portion of the second pin through-hole.

Abstract: A post-processing unit in an image forming apparatus includes a stapler, an exit tray, a height detector, and a shifting controller. The stapler staples a sheet sheaf. The exit tray is configured to be elevated and lowered and to receive the sheet sheaf stapled by the stapler. The height detector detects a height of the sheet sheaf on the exit tray. The shifting controller shifts the sheet sheaf to be ejected in a situation in which the stapler staples one location at a trailing end of the sheet sheaf in a conveyance direction of the sheet sheaf. The shifting controller shifts the sheet sheaf in a front-rear direction, which is a direction perpendicular to a vertical direction and to the conveyance direction of the sheet sheaf, so that the stapled location in the sheet sheaf on the exit tray matches a detection point of the height detector.