Patents by Inventor Yasuo Fukagawa
Yasuo Fukagawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8318684Abstract: Seven novel antibiotic substances can be produced by cultivation of a microbial strain which has been isolated from a soil sample and which is designated as Microbispora sp. A 34030 (deposited under an access number FERM BP-10505 in terms of Budapest Treaty). These seven antibiotic substances are named as bispolide A1, bispolide A2, bispolide A3, bispolide B1, bispolide B2a, bispolide B2b and bispolide B3, respectively. These bispolides are each novel compounds which have a chemical structure as collectively represented by the general formula (III) shown below: These bispolides have each a high antibacterial activity against a variety of bacteria, particularly Gram-positive bacteria and their antibiotic-resistant strains, and hence these bispolides each are effective and useful for therapeutically treating bacterial infections of Gram-positive bacteria in humans and animals.Type: GrantFiled: May 15, 2007Date of Patent: November 27, 2012Assignees: Nimura Genetic Solutions Co., Ltd., Forest Research Institute MalaysiaInventors: Keiichi Numata, Noriyuki Okujo, Siew Eim Khor, Lee Li Tan, Annie George, Szu Ting Ng, Chin Jye Tan, Hironobu Iinuma, Yasuo Fukagawa, Kunimoto Hotta, Seiji Shibahara, Shinichi Kondo, Satoshi Nimura
-
Publication number: 20100144658Abstract: Seven novel antibiotic substances could be produced by cultivation of a microbial strain which has been isolated from a soil sample and which is designated as Microbispora sp. A 34030 (deposited under an access number FERM BP-10505 in terms of Budapest Treaty). These seven antibiotic substances are named as bispolide A1, bispolide A2, bispolide A3, bispolide B1, bispolide B2a, bispolide B2b and bispolide B3, respectively. These bispolides are each novel compounds which have a chemical structure as collectively represented by the general formula (III) shown below. These bispolides have each a high antibacterial activity against a variety of bacteria, particularly Gram-positive bacteria and their antibiotic-resistant strains, and hence these bispolides each are effective and useful for therapeutically treating bacterial infections of Gram-positive bacteria in human and animals.Type: ApplicationFiled: May 15, 2007Publication date: June 10, 2010Applicant: MITSUI CHEMICALS, INC.Inventors: Keiichi Numata, Noriyuki Okujo, Siew Eim Khor, Lee Li Tan, Annie George, Szu Ting Ng, Chin Jye Tan, Hironobu Iinuma, Yasuo Fukagawa, Kunimoto Hotta, Seiji Shibahara, Shinichi Kondo, Satoshi Nimura
-
Patent number: 6112390Abstract: A workpiece which is made by integrally combining an outer member and an inner member through hemming is manufactured efficiently in a common apparatus. An outer member and an inner member are combined to alternately subassemble two kinds of workpieces at a common subassembly station. A hemming station is disposed on a downstream side of the subassembly station in a manufacturing line. In this hemming station, a first hemming apparatus for the first kind of workpiece and a second hemming apparatus for the second kind of workpiece are disposed in a side by side relationship with each other. The first kind of workpiece subassembled in the subassembly station and the second kind of workpiece are alternately fed to the first hemming apparatus and the second hemming apparatus by a workpiece feeding robot.Type: GrantFiled: May 20, 1999Date of Patent: September 5, 2000Assignee: Honda Giken Kogyo Kabushiki KaishaInventors: Toshiaki Takeda, Hiroji Chahara, Kazuhiro Terayama, Yasuo Fukagawa, Michihiro Kitahama, Makoto Kanou, Ichiro Oshima, Shinji Fujita
-
Patent number: 5270196Abstract: The present invention relates to an arylsulfatase of microbial origin. The enzyme may be linked to an antibody against a tumor-associated antigen and the resulting conjugate used in conjuction with a sulfated prodrug of a 4'-demethylepipodophyllotoxin glucoside derivative, particularly etoposide in cancer chemotherapy.Type: GrantFiled: January 29, 1992Date of Patent: December 14, 1993Assignee: Bristol-Myers Squibb CompanyInventors: Yosuke Sawada, Tomokazu Ueki, Satoshi Yamamoto, Koji Tomita, Yasuo Fukagawa, Toshikazu Oki
-
Patent number: 4996314Abstract: A compound represented by the formula ##STR1## wherein R.sub.1 represents a lower alkyl group or a lower haloalkyl group; R.sub.2 represents a lower alkyl group, a lower haloalkyl group, an aralkyl group, or a group of the formula --COOR.sub.4 or --SO.sub.2 R.sub.5 in which R.sub.4 represents an aralkyl group or a substituted or unsubstituted alkyl group and R.sub.5 represents an alkyl group or a substituted or unsubstituted aryl group; and R.sub.3 represents a hydrogen atom or a carboxyl protecting group which can be easily split off. This compound is useful in the production of a 6-(disubstituted amino)carbapenem-series antibiotic.The compounds of the formula ##STR2## wherein R.sub.1 and R.sub.2 are as defined above are important intermediates for the synthesis of the compounds of formula (I) and/or the aforesaid di-(substituted amino) carbapenem-series antibiotics.Type: GrantFiled: September 19, 1988Date of Patent: February 26, 1991Assignee: Sanraku IncorporatedInventors: Takeo Yoshioka, Noritaka Chida, Azuma Watanabe, Yasuo Fukagawa, Tomoyuki Ishikura
-
Patent number: 4939248Abstract: This invention provides compounds of the formula ##STR1## wherein Y represents an acetyl, 1-hydroxyethyl or 1-fluoroethyl group, R.sub.1 represents a hydrogen atom or an easily splittable amino-protecting group, and R.sub.2 and R.sub.3 are identical or different and each represents a hydrogen atom, a lower alkyl group, a phenyl group, a benzyl group or a diphenylmethyl group, or R.sub.2 and R.sub.3 together represent a lower alkylene group; and processes for production thereof. These compounds are useful as synthesis intermediates for production of various medicines, particulary carbapenam or carbapenem antibiotics, such as a carbapenem antibiotic of the following formula which has excellent antimicrobial activity and relatively good stability to kidney dehydropeptidase.Type: GrantFiled: August 18, 1988Date of Patent: July 3, 1990Assignee: Sanraku IncorporatedInventors: Takeo Yoshioka, Machiko Watanabe, Yasuo Fukagawa, Tomoyuki Ishikura
-
Patent number: 4933439Abstract: Tylosin derivatives represented by the following general formula (I): ##STR1## [wherein R denotes a hydrogen atom, acetyl, propionyl or a radical of Si(R.sup.2).sub.3 (in which R.sup.2 is a lower alkyl group), and R.sup.1 stands for a hydrogen atom or a radical of Si(R.sup.2 .sub.3 ] are useful as intermediates for the synthesis of 4"-acyl derivatives of tylosin because, after introduction of any desired acyl group at the 4"-hydroxyl group, the silyl protective group can be readily removed without liberation of the acyl group. This invention also provides processes for producing the tylosin derivatives. More specifically, it provides a melthod of selectively protecting 2'- and 4"'-hydroxyl groups of tylosin (those of higher reactivity among the hydroxyl groups involved); a method of selectively protecting only the 4"'-hydroxyl group of tylosin; a method of selectively protecting the 3- and 4"'-hydroxyl groups of 2'-O-acyltylosin; and a method of protecting 3-, 2'- and 4"'-hydroxyl groups of tylosin.Type: GrantFiled: November 17, 1988Date of Patent: June 12, 1990Assignee: Sanraku IncorporatedInventors: Takeo Yoshioka, Azuma Watanabe, Hiroyuki Chiba, Kaichiro Kominato, Kohki Kiyoshima, Yasuo Fukagawa, Hiroshi Tone, Rokuro Okamoto
-
Patent number: 4853407Abstract: Compounds represented by formula ##STR1## wherein Y.sup.1 and Y.sup.2 are identical or different, and respectively denote benzoylamino groups or phthalimide groups. This compound is useful for inhibition of dipeptidase.Type: GrantFiled: May 20, 1988Date of Patent: August 1, 1989Assignee: Sanraku IncorporatedInventors: Norio Shibamoto, Takeo Yoshioka, Yasuo Fukagawa, Tomoyuki Ishikura
-
Patent number: 4812563Abstract: A compound represented by the formula ##STR1## wherein R.sub.1 represents a lower alkyl group or a lower haloalkyl group; R.sub.2 represents a lower alkyl group, a lower haloalkyl group, an aralkyl group, or a group of the formula --COOR.sub.4 or --SO.sub.2 R.sub.5 in which R.sub.4 represents an alkyl group or a substituted or unsubstituted aralkyl group and R.sub.5 represents an alkyl group or a substituted or unsubstituted aryl group; and R.sub.3 represents a hydrogen atom or a carboxyl protecting group which can be easily split off. This compound is useful in the production of a 6-(disubstituted amino)carbapenem-series antibiotic.Type: GrantFiled: March 10, 1987Date of Patent: March 14, 1989Assignee: Sanraku IncorporatedInventors: Takeo Yoshioka, Noritaka Chida, Azuma Watanabe, Yasuo Fukagawa, Tomoyuki Ishikura
-
Patent number: 4778883Abstract: An azetidinone derivative of the formula ##STR1## wherein R.sub.1 represents a formyl group, a carboxyl group, an acetyloxy group or a group of the formula ##STR2## in which R.sub.2 and R.sub.3 each represent a lower alkyl group or together represent a lower alkylene group, and Z represents a hydrogen atom or an amino-protecting group.Type: GrantFiled: February 18, 1987Date of Patent: October 18, 1988Assignee: Sanraku IncorporatedInventors: Takeo Yoshioka, Noritaka Chida, Azuma Watanabe, Yasuo Fukagawa, Tomoyuki Ishikura
-
Patent number: 4528397Abstract: An aminocarboxylic acid derivative represented by the formula ##STR1## wherein R.sub.1 and R.sub.2, independently from each other, represent a hydrogen atom or an alkyl group which may have a substituent, and Y represents --NH-- or --S--, provided that when Y represents --NH--, at least one of R.sub.1 and R.sub.2 represents an alkyl group which may have a substituent. These compounds have excellent inhibitory activity on dipeptidase in animals, and are useful for administration in combination with carbapenem antibiotics.Type: GrantFiled: March 29, 1983Date of Patent: July 9, 1985Assignee: Sanraku-Ocean Co., Ltd.Inventors: Norio Shibamoto, Takeo Yoshioka, Yasuo Fukagawa, Tomoyuki Ishikura
-
Patent number: 4517127Abstract: A compound represented by the following formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxyl group, R.sub.2 represents a group of the formula --CH.sub.2 NO.sub.2, --CN.fwdarw.O or ##STR2## in which A represents a group of the formula ##STR3## in which R.sub.4 represents a hydrogen atom or an alkoxycarbonyl group, R.sub.5 represents a phenyl, alkoxycarbonyl or alkanoyloxymethyl group, R.sub.6 represents an alkyl group and R.sub.7 represents a phenyl, naphthyl, pyridyl, furyl or thienyl group; and R.sub.3 represents a hydrogen atom or a substituted or unsubstituted hydrocarbon group, and a process for production thereof.Type: GrantFiled: December 9, 1983Date of Patent: May 14, 1985Assignee: Sanraku-Ocean Co., Ltd.Inventors: Takeo Yoshioka, Kenichi Yamamoto, Yasuo Fukagawa, Yasutaka Shimauchi, Tomoyuki Ishikura
-
Patent number: 4508648Abstract: Novel phosphoric ester of antibiotic OA-6129 presented by the formula ##STR1## wherein R is a hydrogen atom, hydroxyl or hydroxysulfonyloxy, and its salts and the preparation method thereof.Type: GrantFiled: September 24, 1982Date of Patent: April 2, 1985Assignee: Sanraku-Ocean Co., Ltd.Inventors: Katsuro Kubo, Takeo Yoshioka, Mitsuyasu Okabe, Yasuo Fukagawa, Tomoyuki Ishikura
-
Patent number: 4451401Abstract: A compound represented by the following formula ##STR1## wherein R represents a hydrogen atom or a methyl group,R.sup.1 represents a hydrogen atom or an ester residue, andR.sup.2 and R.sup.3 represent hydrogen atoms respectively, or taken together, a group of the formula ##STR2## in which each of R.sup.4 and R.sup.5 represents a hydrogen atom, a lower alkyl group or a phenyl group,and its salt; and a process for the production thereof.Type: GrantFiled: July 1, 1982Date of Patent: May 29, 1984Assignee: Sanraku-Ocean Co., Ltd.Inventors: Mitsuyasu Okabe, Takeo Yoshioka, Yasuo Fukagawa, Rokuro Okamoto, Kageaki Kouno, Tomoyuki Ishikura
-
Patent number: 4438201Abstract: A novel enzyme, amidohydrolase, having the ability to depantothenylate antibiotic OA-6129A represented by the following formula ##STR1## but no substantial ability to deacetylate antibiotic PS-5 represented by the following formula ##STR2##Type: GrantFiled: July 1, 1982Date of Patent: March 20, 1984Assignee: Sanraku-Ocean Co., Ltd.Inventors: Katsuro Kubo, Yasuo Fukagawa, Tomoyuki Ishikura
-
Patent number: 4426390Abstract: A compound of the formula ##STR1## wherein R.sub.1 represents a hydrogen atom, --OH or --OSO.sub.3 H, and R.sub.2 represents a hydrogen atom or an unsubstituted or substituted benzyl group; and a salt thereof; processes for production thereof by fermentation; and uses thereof as antimicrobial agents.Type: GrantFiled: September 29, 1981Date of Patent: January 17, 1984Assignee: Sanraku-Ocean Co., Ltd.Inventors: Mitsuyasu Okabe, Takeo Yoshioka, Yasuo Fukagawa, Rokuro Okamoto, Kageaki Kouno, Tomoyuki Ishikura
-
Patent number: 4368203Abstract: A novel antibiotic substance of the formula ##STR1## wherein R.sub.1 is CH.sub.3 and R.sub.2 is --CH.sub.2 --CH.sub.2 -- or R.sub.1 is H and R.sub.2 is --CH.dbd.CH--; and R.sub.3 represents hydrogen, lower alkyl or triphenylmethyl,and including the salts of the compound of formula (I) wherein R.sub.3 is hydrogen, said antibiotic substance having strong antibiotic activity and .beta.-lactamase inhibiting effect, and a method for producing the same by aerobic cultivation of Streptomyces A271.Type: GrantFiled: October 10, 1978Date of Patent: January 11, 1983Assignee: Sanraku-Ocean Co., Ltd.Inventors: Kazuhiko Okamura, Shoji Hirata, Yasushi Okumura, Yasuo Fukagawa, Yasutaka Shimauchi, Tomoyuki Ishikura, Kageaki Kouno, Joseph Lein
-
Patent number: 4318916Abstract: A novel antibiotic substance and derivatives thereof, having strong antibiotic activity and .beta.-lactamase inhibiting effect and a method for producing the same by aerobic cultivation of Streptomyces A 271.Type: GrantFiled: March 2, 1978Date of Patent: March 9, 1982Assignee: Sanraku-Ocean Co., Ltd.Inventors: Kazuhiko Okamura, Shoji Hirata, Yasushi Okumura, Yasuo Fukagawa, Yasutaka Shimauchi, Tomoyuki Ishikura, Kageaki Kouno, Joseph Lein