Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

Abstract: In order to correctly perform frequency conversion without using a pilot signal from an external system in a CATV system in which an upward signal is converted to a high frequency in-building upward signal using an up-converter and the in-building upward signal is converted to the original upward signal using a down-converter, there is proposed a down-converter provided with a reference oscillation circuit for generating a reference signal with a frequency lower than that of a downward signal or the in-building upward signal. The in-building upward signal is frequency-converted using the reference signal and the reference signal is transmitted to a transmission line of the terminal side. A bi-directional amplifier on the transmission line can not only amplify the downward signal and the in-building upward signal bi-directionally but also transmit the reference signal to an up-converter of the terminal side.

Abstract: The invention provides a stabilized IL-1.alpha. medicinal composition comprising an IL-1.alpha. active substance, serum albumin and a saccharide. The medicinal composition of the invention has very desirable characteristics in terms of the stability of its active ingredient IL-1.alpha. active substance, rendering it stable throughout its processing into various dosage forms, such as freezing and freeze-drying, and for a long time after production under the usual storage conditions, thus being of great utility value in the relevant field.

Abstract: The present invention provides a monoclonal antibody characterized in that the antibody has specific reactivity on human IL-1.beta., and a process for producing the antibody. The invention also provides a method for detection of biologically active human IL-1.beta..

Abstract: The present invention relates to a method for soldering two kinds of parts, parts with leads and chip parts, on one-side printed board, comprising coating a cream solder on a plurality of points of a wiring pattern surface of one-side printed board and coating an adhesive for adhering parts with leads on a non-wiring pattern, adhering parts with leads to said non-wiring pattern surface by said adhesive, passing leads of the parts with leads through lead insert holes of said one-side printed board to insert the same into one cream solder on the wiring pattern surface from the side of the non-wiring pattern surface, mounting chip parts on the other cream solder on said wiring pattern surface, thereafter heating at once the whole cream solder on the wiring pattern to simultaneously reflow-solder the parts with leads and chip parts whereby the parts with leads and the chip parts can be simultaneously soldered by a single reflow soldering step.

Abstract: This invention provides a urokinase complex adsorbable by fibrin characterized in that it comprises heavy chain of high molecular weight urokinase as coupled with heavy chain of plasmin by one or more S-S bonds and a process for preparing the same.

Abstract: This invention provides a process for preparing a fibrin-adsorable protein-urokinase complex characterized by reacting a protein adsorbable by fibrin with urokinase in the presence of a protein coupling reagent represented by the formula ##STR1## wherein R is phenylene or cycloalkylene, A is lower alkylene, B is lower alkylene which may optionally be substituted by lower alkylthio or phenyl-lower alkylthio, and l, m and n are each 0 or 1 provided that l, m and n are not 0 at the same time.The complex is useful as a thrombolytic agent.

Abstract: A light measuring element which is provided with a pulse signal generator for generating pulse signals the duty ratio of which varies in accordance with a coefficient related to the exposure for photographing, a switching element which is driven by the output pulse signals from the pulse signal generator, and a light integrating circuit which includes a photo detector and an integrating capacitor and provides the voltage across the integrating capacitor as a light measure output. The light integrating circuit performs an intermittent light integrating operation by the action of the switching element. The integration period of the light integrating circuit is varied by varying the duty ratio of drive signals to the switching element which are supplied from a pulse signal generator, which duty ratio varies with a coefficient related to the proper exposure for photographing.

Abstract: A series control type automatic flash unit which is capable of achieving completely controlled flashing by controlling electrical energy supplied from a main capacitor to a discharge lamp by means of a first switching element connected in series with the discharge lamp. A series circuit of a second switching element conducted by a light control signal derived from light control means and a commutation capacitor is connected in parallel with the series circuit of the discharge lamp and the first switching element, and the commutation capacitor is charged by charging means in a predetermined polarity. This charging is performed at least prior to the state of commutation, and upon conduction of the second switching element by the light control signal, stored charges of the commutation capacitor are applied via the second switching element to the first switching element to place it in a reverse biased condition. As a consequence, the first switching element is turned OFF to stop lighting of the discharge lamp.