Patents by Inventor Yasuo Yanagihara
Yasuo Yanagihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8722663Abstract: The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G2-, —N(lower alkyl)-G2-, —NH—CH2-G2-, —N(lower alkyl)-CH2-G2- or —CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O—R2, phenylene-G5-NH—R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O—R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G3-R2 is —O-lower alkylene-R2 or the like; G4-O— is lower alkylene-O— or the like; G5 is lower alkylene; G6 is lower alkylene].Type: GrantFiled: January 28, 2011Date of Patent: May 13, 2014Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Hideki Takasu, Shigekazu Fujita, Shinya Ohtsuka, Toshiyuki Hirose, Yosuke Sato, Satoshi Yamada, Keisuke Miyajima, Koji Sakai, Yutaka Kojima, Kazuo Sekiguchi, Yasuo Yanagihara, Takashi Suzuki, Hideo Tanaka, Kazuhisa Sugiyama, Mitsuhiro Okuno, Takumi Sumida
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Publication number: 20120322807Abstract: The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: Wherein X1 represents a nitrogen atom or a group —CH?, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a groupType: ApplicationFiled: June 18, 2012Publication date: December 20, 2012Inventors: Kazuo Sekiguchi, Takashi Suzuki, Yutaka Ohbuchi, Mitsuhiro Okuno, Naoto Ohi, Kenji Ohnishi, Masaaki Motoyama, Kenji Yoshida, Takeshi Kodama, Kazuhisa Sugiyama, Seiji Akamatsu, Kunihiko Kiyono, Yasuo Yanagihara, Takashi Watanabe, Kazuhiko Hayashi, Hideo Tanaka, Takumi Sumida
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Publication number: 20120283242Abstract: The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G2-, —N(lower alkyl)-G2-, —NH—CH2-G2-, —N(lower alkyl)-CH2-G2- or —CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O—R2, phenylene-G5-NH—R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O—R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G3-R2 is —O-lower alkylene-R2 or the like; G4-O— is lower alkylene-O— or the like; G5 is lower alkylene; G6 is lower alkylene].Type: ApplicationFiled: January 28, 2011Publication date: November 8, 2012Inventors: Hideki Takasu, Shigekazu Fujita, Shinya Ohtsuka, Toshiyuki Hirose, Yosuke Sato, Satoshi Yamada, Keisuke Miyajima, Koji Sakai, Yutaka Kojima, Kazuo Sekiguchi, Yasuo Yanagihara, Takashi Suzuki, Hideo Tanaka, Kazuhisa Sugiyama, Mitsuhiro Okuno, Takumi Sumida
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Publication number: 20120238750Abstract: The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH?; R1 represents a group —Z—R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.Type: ApplicationFiled: February 29, 2012Publication date: September 20, 2012Inventors: Tae FUKUSHIMA, Shuji Matsumura, Noriaki Takemura, Hideaki Satou, Nobuaki Ito, Takuya Shitsuta, Hironori Tsutsui, Michinori Tanaka, Keizo Kan, Hitoshi Nagao, Kenji Watanabe, Kuninori Tai, Takashi Nakagawa, Hideki Takasu, Makoto Sakamoto, Keisuke Miyajima, Satoshi Yamada, Yutaka Kojima, Koichi Yasumura, Naoto Ohi, Mitsuhiro Okuno, Kazuhisa Sugiyama, Kunihiko Kiyono, Takashi Suzuki, Seiji Akamatsu, Takeshi Kodama, Yasuo Yanagihara, Takumi Sumida
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Patent number: 8263599Abstract: An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group —CH?, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.Type: GrantFiled: October 2, 2007Date of Patent: September 11, 2012Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Kazuo Sekiguchi, Takashi Suzuki, Yutaka Ohbuchi, Mitsuhiro Okuno, Naoto Ohi, Kenji Ohnishi, Masaaki Motoyama, Kenji Yoshida, Takeshi Kodama, Kazuhisa Sugiyama, Seiji Akamatsu, Kunihiko Kiyono, Yasuo Yanagihara, Takashi Watanabe, Kazuhiko Hayashi, Hideo Tanaka, Takumi Sumida
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Patent number: 8188277Abstract: The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH?; R1 represents a group —Z—R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.Type: GrantFiled: August 3, 2005Date of Patent: May 29, 2012Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Tae Fukushima, Shuji Matsumura, Noriaki Takemura, Hideaki Satou, Nobuaki Ito, Takuya Shitsuta, Hironori Tsutsui, Michinori Tanaka, Keizo Kan, Hitoshi Nagao, Kenji Watanabe, Kuninori Tai, Takashi Nakagawa, Hideki Takasu, Makoto Sakamoto, Keisuke Miyajima, Satoshi Yamada, Yutaka Kojima, Koichi Yasumura, Naoto Ohi, Mitsuhiro Okuno, Kazuhisa Sugiyama, Kunihiko Kiyono, Takashi Suzuki, Seiji Akamatsu, Takeshi Kodama, Yasuo Yanagihara, Takumi Sumida
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Publication number: 20100210661Abstract: An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group —CH?, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.Type: ApplicationFiled: October 2, 2007Publication date: August 19, 2010Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Kazuo Sekiguchi, Takashi Suzuki, Yutaka Ohbuchi, Mitsuhiro Okuno, Naoto Ohi, Kenji Ohnishi, Masaaki Motoyama, Kenji Yoshida, Takeshi Kodama, Kazuhisa Sugiyama, Seiji Akamatsu, Kunihiko Kiyono, Yasuo Yanagihara, Takashi Watanabe, Kazuhiko Hayashi, Hideo Tanaka, Takumi Sumida
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Publication number: 20070270422Abstract: The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH?; R1 represents a group -Z-R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.Type: ApplicationFiled: August 3, 2005Publication date: November 22, 2007Inventors: Tae Fukushima, Shuji Matsumura, Noriaki Takemura, Hideaki Satou, Nobuaki Ito, Takuya Shitsuta, Hironori Tsutsui, Michinori Tanaka, Keizo Kan, Hitoshi Nagao, Kenji Watanabe, Kuninori Tai, Takashi Nakagawa, Hideki Takasu, Makoto Sakamoto, Keisuke Miyajima, Satoshi Yamada, Yutaka Kojima, Koichi Yasumura, Naoto Ohi, Mitsuhiro Okuno, Kazuhisa Sugiyama, Kunihiko Kiyono, Takashi Suzuki, Seiji Akamatsu, Takeshi Kodama, Yasuo Yanagihara, Takumi Sumida
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Patent number: 6107465Abstract: A homogeneous interleukin 1.beta. (IL-1.beta.), its derivative having a modified amino acid sequence of IL-1.beta., a gene coding for said derivative, medical composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.beta. and the derivative.Type: GrantFiled: March 10, 1987Date of Patent: August 22, 2000Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
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Patent number: 5847098Abstract: A homogeneous interleukin 1.beta. (IL-1.beta.), its derivative having a modified amino acid sequence of IL-1.beta., a gene coding for said derivative, medical composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.beta. and the derivative.Type: GrantFiled: June 7, 1995Date of Patent: December 8, 1998Assignee: Otsuka Pharmaceutcal Co., Ltd.Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
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Patent number: 5702698Abstract: Methods are disclosed for promoting production of colony stimulating factor and inhibiting growth of Meth A tumor cells comprising administering a pharmaceutically effective amount of modified IL-1.alpha. to a subject.Type: GrantFiled: June 5, 1995Date of Patent: December 30, 1997Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
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Patent number: 5543140Abstract: Methods for stimulating immunity, inhibiting tumor growth, promoting production of a cytokine, and preventing or inhibiting radiation injury by administration of Interleukin-1.alpha. (IL-1.alpha.) derivatives, are disclosed.Type: GrantFiled: June 1, 1994Date of Patent: August 6, 1996Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
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Patent number: 5371204Abstract: An interleukin-1.alpha. (IL-1.alpha.) derivative having a modified amino acid sequence of IL-1.alpha., a gene coding for said derivative, medicinal composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.alpha..Type: GrantFiled: January 22, 1991Date of Patent: December 6, 1994Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
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Patent number: 5008374Abstract: An interleukin-1.alpha. (IL-1.alpha.) derivative having a modified amino acid sequence of IL-1.alpha., a gene coding for said derivative, medicinal composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.alpha..Type: GrantFiled: March 9, 1987Date of Patent: April 16, 1991Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
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Patent number: 4898818Abstract: This invention provides an antitumor active substance GIF, a process for preparing the same, an antitumor composition containing the substance, a gene coding for GIF, a vector containing the gene and a recombinant microorganism, the substance GIF comprises as its component protein polypeptide A of the following primary structure. ##STR1## wherein X is Cys or Ser and Z is H or a peptide represented by the amino acid sequence ##STR2## or a peptide having the above sequence wherein at least one amino acid is removed from the N terminal or an amino acid.Type: GrantFiled: December 19, 1985Date of Patent: February 6, 1990Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Satoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
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Patent number: 4529336Abstract: A method of distributing powdered or granular material to a plurality of feeding ends in a system having a pressurizing tank for pressurizing and fluidizing a powdered or granular material, a plurality of transportation pipes having one ends constituting discharge nozzles opening above a fluidized bed in the tank and the other ends connected to different feeding ends so as to introduce the material to the feeding ends, and a plurality of booster gas supply pipes for supplying respective transportation pipes with a booster gas. The internal pressure of the tank is controlled by a controller provided with a set valve in accordance with the mean value of the terminal pressures at the feeding ends, the mean value of predetermined set flow rates of the booster gas in the booster gas supplying pipes, and the mean value of predetermined set rates of transportation of material to the feeding ends.Type: GrantFiled: April 6, 1983Date of Patent: July 16, 1985Assignees: Kawasaki Steel Corporation, Denka Consultant & Engineering Co., Ltd.Inventors: Yoshinobu Shinozaki, Motozo Yasuno, Tadaaki Iwamura, Hironari Marushima, Yoshiteru Tagawa, Ryoji Takabe, Takashi Moriyama, Shuzo Fujii, Keiichi Achiba, Hideo Oishi, Yasuo Yanagihara, Yoshiaki Masuda