Abstract: According to a flow measuring device, first ranges formed by a first plurality of resistors form a single continuous value range on a flow direction coordinate axis. Thus, the first plurality of resistors is limited from being thermally insulated from one another in the flow direction, and thereby detectivity is improved. Also, second ranges formed by a second plurality of resistors form an other single continuous value range on a longitudinal direction coordinate axis. The other continuous value range includes a position that corresponds to a half length of a heating element in a longitudinal direction. As a result, detection difference is obtained at the position, at which a temperature is most optimally detected, and thereby detectivity is further improved.

Abstract: Aminophosphonic acid derivatives (e.g., 2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentylphosphonate monoester) are represented by the following general formula (1): and act as effective S1P receptor modulators while posing less side effects.

Abstract: Aminophosphonic acid derivatives (e.g., 2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentylphosphonate monoester) are represented by the following general formula (1): and act as effective S1P receptor modulators while posing less side effects.

Abstract: In a flow quantity measuring device, each of upstream side and downstream side sensing resistors, which are placed on an upstream side and a downstream side, respectively, of a heating resistor, includes resistor elements, each of which forms a folded path. The folded path has a generally constant width along an entire extent thereof and is returned at each of first and second longitudinal end edges of a sensing area. The heating resistor forms a folded path, which has a generally constant width along an entire extent thereof and is returned at the second longitudinal end edge of the heat generating area. First and second ends of the folded path of the heating resistor projects beyond the first longitudinal end edge of the sensing area on a first side of the flow quantity measuring device.

Abstract: An airflow measuring device includes a sensing portion provided in a bypass passage, which perpendicularly deflects part of air from a main passage to therethrough bypass the part of air. The sensing portion includes a heating resistor energized and dissipate heat to airflow. The sensing portion is configured to measure airflow in the bypass passage based on the heat radiation. The sensing portion further includes a pair of support members erected in the bypass passage to support the heating resistor. The heating resistor of the sensing portion is inclined at a first inclination angle with respect to a direction, which is perpendicular to a flow direction of air in the bypass passage. The heating resistor is inclined toward downstream at an outer streamline of the airflow in the bypass passage.

Abstract: Novel pyrazolopyridine-4-yl pyridazinone derivatives serve as phosphodiesterase inhibitors and are useful compounds for use in pharmaceutical products. Specifically, the compounds of the present invention are pyrazolopyridine-4-yl pyridazinone derivatives represented by the following general formula (1): (Example: 6-(2-ethyl-7-methoxy-pyrazolo[1,5-a]pyridine-4-yl)-5-methyl-4, 5-dihydro-3(2H)-pyridazinone).

Abstract: Provided herein are benzoxazinone compounds of formula I and compositions containing the compounds. The compounds and compositions are useful in the methods of inhibiting the action of serine hydrolase, including neutrophil elastase. In certain embodiments, the compounds and compositions are useful in the prevention, amelioration or treatment of serine hydrolase-mediated diseases.

Abstract: Aminophosphonic acid derivatives (e.g., 2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentylphosphonate monoester) are represented by the following general formula (1): and act as effective S1P receptor modulators while posing less side effects.

Abstract: An amino alcohol derivative represented by the following general formula (1) (for example, (±)-2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentane-1-ol) exhibits strong immunosuppressive effect while causing less side effects:

Abstract: The present invention provides diaryl ether derivatives that exhibit significant immunosuppressive effects with less side effects. The diaryl derivatives of the present invention are represented by the following general formula (1): one example is 2-amino-2-[4-(3-benzyloxyphenoxy)-2-chlorophenyl]propyl-1,3-propanediol.

Abstract: The present invention provides diaryl sulfide derivatives that exhibit significant immunosuppressive effects with less side effects. The diaryl derivatives of the present invention are represented by the following general formula (1): One example is 2-amino-2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]propyl-1,3-propanediol.

Abstract: An airflow meter has a membrane type sensor element. The sensor element is supported on a support member so that a sensing surface of the sensor element is in parallel to the airflow direction. The airflow meter has at least one means for protecting the sensor element from dust such as foreign particles. The protecting means is provided with an obstruction member that is disposed upstream or downstream of the sensor element with respect to the airflow direction. The sensor element is hidden behind the obstruction member. The obstruction member has gradually spreading surfaces and gradually converging surfaces along the airflow direction. Alternatively, the protecting means can be provided with a deflector, a cover member, a flow guide member, an inlet or a dust collector.

Abstract: A process for collecting seeds efficiently and simply at a low cost from a lump consisting of a plurality of seeds having fluffy fibers is provided. The process for collecting seeds includes the steps of disentangling the lump consisting of a plurality of seeds and burning the fluffy fibers after the disentanglement of the lump.

Abstract: In a thermal-type air flow measuring apparatus, a heater is set to a reference temperature which is a predetermined temperature higher than an intake air temperature detector. A flow amount detector is disposed at an upstream side of the heater with respect to a forward direction of an intake air flow. The heater is turned at a plurality of points in a direction perpendicular to the forward direction of the intake air flow and has a predetermined width in the intake air flow direction so that heat transfers less in the intake air flow direction in the heater. If the intake air flow direction reverses, the temperature distribution in the heater also reverses. As a result, an intake air amount varying in response to the air flow direction is detected by comparing the temperature of the flow amount detector with the reference temperature.

Abstract: The present invention provides diaryl sulfide derivatives that exhibit significant immunosuppressive effects with less side effects.

Abstract: The present invention provides diaryl ether derivatives that exhibit significant immunosuppressive effects with less side effects.

Abstract: In a sensor chip for a fluid flow sensor, a thin film portion is formed above a hollow cavity portion while leaving thin film layers formed on the surface of a substrate. A conductor is provided on the inner wall face of a through hole formed to penetrate the substrate to thereby electrically connect a detecting portion constituted by a conductor film in the thin film layers and a substrate conductor portion formed on the rear face side of the through hole. The surface of a circuit board is formed with a control circuit and a base conductor portion electrically connected to the control circuit. The sensor chip and the circuit board are layered and the substrate conductor portion and the base conductor portion are electrically connected.

Abstract: A flow meter is formed with a passage for introducing and carrying air to measure and has a sensing part disposed in the passage for measuring a flow rate of the air. A contraction part is formed on an inner surface of the passage so that the contraction part faces the sensing part. The contraction part narrows the flow of the air flowing near the sensing part. A flat surface of the contraction part is formed in parallel with the surface of the sensing part and at least upstream of the sensing part. Thus, collision of particles against the sensing part and adhesion of contaminants to the sensing pert are inhibited. Meanwhile, the flow rate of the air is measured stably and accurately.

Abstract: A flowmeter includes a heating resistor and a resistive element for detecting the temperature of the heating resistor. The heating resistor is controlled so that the temperature detected by the resistive element approaches a reference temperature determined based on the temperature of the fluid flow. As a result, the temperature of the upstream side of the heating resistor becomes lower than the reference temperature, while the temperature of the downstream side of the heating resistor becomes higher than the reference temperature. Another resistive element is arranged on the upstream side or the downstream side of the heating resistor for detecting the rate of the fluid flow, and the rate and the direction of the fluid flow are detected by comparing the temperature of the resistive element with the reference temperature. This flowmeter is immune to variation in the resistance of the heating resistor.

Abstract: A flow meter is formed with a passage for introducing and carrying air to measure and has a sensing part disposed in the passage for measuring a flow rate of the air. A contraction part is formed on an inner surface of the passage so that the contraction part faces the sensing part. The contraction part narrows the flow of the air flowing near the sensing part. A flat surface of the contraction part is formed in parallel with the surface of the sensing part and at least upstream of the sensing part. Thus, collision of particles against the sensing part and adhesion of contaminants to the sensing pert are inhibited. Meanwhile, the flow rate of the air is measured stably and accurately.