Abstract: Provided are vitamin D3 derivatives of formula (I), pharmaceutical compositions thereof, and pharmaceutical or medical uses thereof for treating metabolic disease, a liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.

Abstract: Provided are vitamin D3 derivatives of formula (I), pharmaceutical compositions thereof, and pharmaceutical or medical uses thereof for treating metabolic disease, a liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.

Abstract: A straddled vehicle including a frame, an electric power generation engine, an electric power generator, front and rear wheels respectively rotatably supported by a front suspension and a rear arm, a motor unit supported by the frame, the front suspension or the rear arm, and including a drive motor that receives electric power generated by the electric power generator to drive the front or rear wheel, a control unit including an inverter controlling the electric power supplied to the drive motor, an engine radiator configured to cool the electric power generation engine, and an electric motor radiator configured to cool the inverter and/or the drive motor, and having a larger cooling area than that of the engine radiator. At least a part of the engine radiator and of the electric motor radiator receive relative wind. The engine radiator and the electric motor radiator are positioned more rearward than a front end of the front wheel.

Abstract: A straddled vehicle, including a vehicle frame structure, a drive unit including a drive motor that receives electric power and outputs driving power, a driving wheel that receives the driving power, and an electric power generation unit. The electric power generation unit includes an electric power generation engine configured to output engine power, and an electric power generator that is fixed to the electric power generation engine and is electrically connected to an electric power transfer medium having flexibility. The electric power generator is configured to convert the engine power into the electric power, and supply the electric power to the drive motor via the electric power transfer medium. The straddled vehicle is series-hybridized by the drive unit and the electric power generation unit. The electric power generation engine is swingably supported, independently of the drive unit, by the vehicle frame structure, such that the engine power is not mechanically supplied to the driving wheel.

Abstract: A straddled vehicle, including a frame structure, a rear arm, a driving wheel rotatably supported by the rear arm, a power source unit, and a drive unit including a gear box, a drive motor and a control unit. The drive motor is arranged with an off-set toward a first direction from a center of the straddled vehicle, without overlapping the power source unit in a side view. The control unit is further in a second direction than the drive motor, and overlaps the drive motor, but does not overlap the power source unit, in the side view. The gear box is further in the second direction than the drive motor, and overlaps the drive motor in the side view. The gear box is also further in the first direction than the control unit, and overlaps with the control unit, but does not overlap the power source unit, in the side view.

Abstract: A straddled vehicle including a frame structure having a frame body, a rear arm swingably supported by the frame structure, a driving wheel rotatably supported by the rear arm, a drive motor supported by the frame structure or the rear arm, and an electric power generation unit supported by the frame body but not by the rear arm. The electric power generation unit includes: an electric power generation engine arranged with an offset toward a first direction from a center of the straddled vehicle with respect to a left-right direction, not overlapping the drive motor in a side view; and an electric power generator further in a second direction, opposite to the first direction, than the electric power generation engine, overlapping the electric power generation engine, but not overlapping the drive motor, in the side view. The electric power generator is driven by the electric power generation engine to generate electric power.

Abstract: A shortening of an initial diagnosis time is achieved, even after an elapse of a predetermined delay time from an ignition switch being switched to an off-state. After the ignition switch is switched to an off-state after an operation of a control device, which drives an electric motor that applies steering assistance force to a steering system, diagnosis of a power supply circuit that supplies power to the control device is carried out, and a diagnosis item to be implemented in a succeeding initial diagnosis is determined based on a result of the diagnosis.

Abstract: A electric power steering control device equipped with a motor having a resolver detection unit includes: an ambient temperature detector for detecting ambient temperature around a portion generating heat by current flow; a motor temperature detector for, based on a signal from the resolver detection unit of the motor, estimating the temperature of the portion generating heat; and an abnormality determiner for comparing the temperature detected by the ambient temperature detector with the temperature detected by the motor temperature detector and determining that the ambient temperature detector is abnormal.

Abstract: A shortening of an initial diagnosis time is achieved, even after an elapse of a predetermined delay time from an ignition switch being switched to an off-state. After the ignition switch is switched to an off-state after an operation of a control device, which drives an electric motor that applies steering assistance force to a steering system, diagnosis of a power supply circuit that supplies power to the control device is carried out, and a diagnosis item to be implemented in a succeeding initial diagnosis is determined based on a result of the diagnosis.

Abstract: Provided are a method for measuring histone methyltransferase activity, a method for screening for compounds that inhibit histone methyltransferase activity, a reagent kit for measuring histone methyltransferase activity, and a kit for screening for compounds that inhibit histone methyltransferase activity. A substrate compound represented by general formula (I): R1-X-K-R2 (I), or a salt thereof, wherein R1 represents a hydrogen atom or a protecting group for an amino terminus; X represents a peptide consisting of 0 or 1 or more amino acid residues; K represents a lysine residue; and R2 represents a dye label linked via an amide bond to the carbonyl terminus of a lysine residue, wherein the cleavage of the amide bond by peptidase changes the fluorescence property or chromogenic property of the dye label, and the methylation of the ? amino group of the lysine residue by the histone methyltransferase decreases susceptibility to peptidase, is used.

Abstract: A electric power steering control device equipped with a motor having a resolver detection unit comprises: an ambient temperature detecting means (33) for detecting ambient temperature around a portion generating heat by current flow; a motor temperature detecting means (32) for, based on a signal from the resolver detection unit (13) of the motor (4), estimating the temperature of the portion generating heat; and an abnormality determining means (34) for comparing the temperature detected by the ambient temperature detecting means with the temperature detected by the motor temperature detecting means and determining that the ambient temperature detecting means is abnormal.

Abstract: Provided are a method for measuring histone methyltransferase activity, a method for screening for compounds that inhibit histone methyltransferase activity, a reagent kit for measuring histone methyltransferase activity, and a kit for screening for compounds that inhibit histone methyltransferase activity. A substrate compound represented by general formula (I): R1—X—K—R2 (I), or a salt thereof, wherein R1 represents a hydrogen atom or a protecting group for an amino terminus; X represents a peptide consisting of 0 or 1 or more amino acid residues; K represents a lysine residue; and R2 represents a dye label linked via an amide bond to the carbonyl terminus of a lysine residue, wherein the cleavage of the amide bond by peptidase changes the fluorescence property or chromogenic property of the dye label, and the methylation of the ? amino group of the lysine residue by the histone methyltransferase decreases susceptibility to peptidase, is used.

Abstract: An engine is operated with air-fuel ratio F/B control interrupted, by regarding an alcohol concentration value ALC1 inputted from outside as a tentative concentration value, and by detecting the rotation-speed fluctuation amount of an engine, the appropriateness of the tentative concentration value is determined. In the case where it is determined that the tentative concentration value is appropriate, an estimated alcohol concentration value ALC2 stored in a storage means is replaced by the tentatively changed alcohol concentration value ALC1.

Abstract: An engine is operated with air-fuel ratio F/B control interrupted, by regarding an alcohol concentration value ALC1 inputted from outside as a tentative concentration value, and by detecting the rotation-speed fluctuation amount of an engine, the appropriateness of the tentative concentration value is determined. In the case where it is determined that the tentative concentration value is appropriate, an estimated alcohol concentration value ALC2 stored in a storage means is replaced by the tentatively changed alcohol concentration value ALC1.