Patents by Inventor Yazhong Pei

Yazhong Pei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted thiophene modulators of intracellular calcium
    Patent number: 7906553
    Abstract: Described herein are compounds of Formula (I) having the structure: where A, J, R1, R4, Z and X are described herein; and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: March 15, 2011
    Assignee: CalciMedica, Inc.
    Inventors: Gonul Velicelebi, Kenneth A. Stauderman, Jeffrey P. Whitten, Yazhong Pei, Jianguo Cao, Zhijun Wang, Evan Rogers, Brian Dyck, Jonathan Grey
  • COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
    Publication number: 20100305200
    Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.
    Type: Application
    Filed: December 10, 2008
    Publication date: December 2, 2010
    Inventors: Gonul Velicelebi, Kenneth A. Stauderman, Frank King, Yazhong Pei, Jeffrey P. Whitten
  • COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
    Publication number: 20100261725
    Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
    Type: Application
    Filed: August 26, 2009
    Publication date: October 14, 2010
    Applicant: CALCIMEDICA, INC.
    Inventors: Gonul Velicelebi, Kenneth A. Stauderman, Jeffrey P. Whitten, Yazhong Pei, Jianguo Cao, Zhijun Wang, Evan Rogers, Brian Dyck, Jonathan Grey
  • INHIBITORS OF STORE OPERATED CALCIUM RELEASE
    Publication number: 20100087415
    Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.
    Type: Application
    Filed: October 5, 2009
    Publication date: April 8, 2010
    Applicant: CALCIMEDICA, INC.
    Inventors: Jeffrey P. Whitten, Yazhong Pei, Kenneth A. Stauderman, Jack Roos
  • COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
    Publication number: 20100056532
    Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
    Type: Application
    Filed: August 26, 2009
    Publication date: March 4, 2010
    Applicant: CalciMedica, Inc.
    Inventors: Gonul Velicelebi, Kenneth A. Stauderman, Jeffrey P. Whitten, Yazhong Pei, Jianguo Cao, Zhijun Wang, Evan Rogers, Brian Dyck, Jonathan Grey
  • COMPOUNDS AND METHODS FOR CYTOPROTECTION
    Publication number: 20080171034
    Abstract: Compounds, compositions and methods for treating degenerative diseases and disorders are disclosed, the compounds having the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein.
    Type: Application
    Filed: October 25, 2007
    Publication date: July 17, 2008
    Applicant: MIGENIX Corp.
    Inventor: Yazhong Pei
  • Compounds and methods for cytoprotection
    Patent number: 7304171
    Abstract: Compounds, compositions and methods for treating degenerative diseases and disorders are disclosed, the compounds having the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein.
    Type: Grant
    Filed: May 26, 2005
    Date of Patent: December 4, 2007
    Assignee: Migenix Corp.
    Inventor: Yazhong Pei
  • Ligands of adenine nucleotide translocase (ant) and compositions and methods related thereto
    Publication number: 20060194825
    Abstract: Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds having structure (I), including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.
    Type: Application
    Filed: December 19, 2003
    Publication date: August 31, 2006
    Applicant: MIGENIX Corp.
    Inventors: Soumitra Ghosh, Yazhong Pei, Xiao-Qing Tang, Spiros Liras, Michael Ahlijanian
  • Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor
    Patent number: 7001729
    Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: February 21, 2006
    Assignee: Migenix Corp.
    Inventors: Christen M. Anderson, Robert E. Davis, William Clevenger, Sandra Eileen Wiley, Scott W. Miller, Tomas R. Szabo, Soumitra S. Ghosh, Walter H. Moos, Yazhong Pei
  • Compounds for inhibiting insulin secretion and methods related thereto
    Publication number: 20060004062
    Abstract: Compounds, compositions and methods for altering insulin secretion, particularly in the context of treatment of subjects having, or suspected of being at risk for having, diabetes mellitus. The compounds have the following struture (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein W1, W2, X, R1, R2, R3, R4, m and n are defined herein.
    Type: Application
    Filed: September 13, 2005
    Publication date: January 5, 2006
    Applicant: MitoKor
    Inventors: Yazhong Pei, Soumitra Ghosh, Ian James
  • Ligands of adenine nucleotide translocase (ANT) and compositions and methods related thereto
    Publication number: 20060004093
    Abstract: Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds have the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.
    Type: Application
    Filed: June 7, 2005
    Publication date: January 5, 2006
    Applicants: MIGENIX Corp., Pfizer Inc.
    Inventors: Soumitra Ghosh, Yazhong Pei, Xiao-Qing Tang, Spiros Liras, Michael Ahlijanian
  • Compounds and methods for cytoprotection
    Publication number: 20050267086
    Abstract: Compounds, compositions and methods for treating degenerative diseases and disorders are disclosed, the compounds having the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein.
    Type: Application
    Filed: May 26, 2005
    Publication date: December 1, 2005
    Applicant: MIGENIX Corp.
    Inventor: Yazhong Pei
  • Compounds for inhibiting insulin secretion and methods related thereto
    Patent number: 6958352
    Abstract: Compounds, compositions and methods for altering insulin secretion, particularly in the context of treatment of subjects having, or suspected of being at risk for having, diabetes mellitus. The compounds have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein W1, W2, X, R1, R2, R3, R4, m and n are defined herein.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: October 25, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Yazhong Pei, Soumitra S. Ghosh, Ian William James
  • Ligands of adenine nucleotide translocase (ANT) and compositions and methods related thereto
    Patent number: 6936638
    Abstract: Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds have the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: August 30, 2005
    Assignees: Migenix Corp., Pfizer Inc.
    Inventors: Soumitra S. Ghosh, Yazhong Pei, Xiao-Qing Tang, Spiros J. Liras, Michael K. Ahlijanian
  • Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor.
    Patent number: 6906175
    Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: June 14, 2005
    Assignee: MIGENIX Corp.
    Inventors: Christen M. Anderson, Robert E. Davis, William Clevenger, Sandra Eileen Wiley, Scott W. Miller, Tomas R. Szabo, Soumitra S. Ghosh, Walter H. Moos, Yazhong Pei
  • Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor
    Patent number: 6902908
    Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: June 7, 2005
    Assignee: Migenix Corp.
    Inventors: Christen M. Anderson, Robert E. Davis, William Clevenger, Sandra Eileen Wiley, Scott W. Miller, Tomas R. Szabo, Soumitra S. Ghosh, Walter H. Moos, Yazhong Pei
  • Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor
    Patent number: 6887670
    Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: May 3, 2005
    Assignee: MIGENIX Corp.
    Inventors: Christen M. Anderson, Robert E. Davis, Tomas R. Szabo, Soumitra S. Ghosh, Walter H. Moos, Yazhong Pei
  • PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR
    Publication number: 20050064530
    Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
    Type: Application
    Filed: March 14, 2001
    Publication date: March 24, 2005
    Inventors: Christen Anderson, Robert Davis, Tomas Szabo, Soumitra Ghosh, Walter Moos, Yazhong Pei
  • PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR
    Publication number: 20050019835
    Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
    Type: Application
    Filed: March 14, 2001
    Publication date: January 27, 2005
    Inventors: Christen Anderson, Robert Davis, William Clevenger, Sandra Wiley, Scott Miller, Tomas Szabo, Soumitra Ghosh, Walter Moos, Yazhong Pei
  • PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR
    Publication number: 20050003353
    Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
    Type: Application
    Filed: March 16, 2001
    Publication date: January 6, 2005
    Inventors: Christen Anderson, Robert Davis, William Clevenger, Sandra Wiley, Scott Miller, Tomas Szabo, Soumitra Ghosh, Walter Moos, Yazhong Pei