Patents by Inventor Yen-Lane Chen
Yen-Lane Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115270Abstract: A device for permanent placement across an atrial appendage ostium in a patient includes a support structure having a contracted delivery configuration and an expanded deployed configuration defining a radially enlarged portion to permanently engage an interior wall of the atrial appendage, a membrane attached to the support structure and configured to extend across the ostium of the atrial appendage when the support structure is in the expanded deployed configuration, and a polymer coating disposed on at least one of the support structure and the membrane, the polymer coating including a direct oral anticoagulant (DOAC) dispersed in a polymer.Type: ApplicationFiled: October 19, 2023Publication date: April 11, 2024Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Steven L. Kangas, Edward Kopesky, Yen-Lane Chen
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Publication number: 20240034741Abstract: Methods are disclosed including methods for crystallizing a material such as a drug. An example method may include combining a nucleation initiator, a surfactant solution, and an amorphous form of a drug to form a drug precursor dispersion/suspension. The method may also include incubating the drug precursor dispersion/suspension to allow the drug to convert from the amorphous form to a crystalline form.Type: ApplicationFiled: October 6, 2023Publication date: February 1, 2024Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: HONGXIA ZENG, JONATHAN PASCAL CHAKY, YEN-LANE CHEN
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Patent number: 11814397Abstract: Methods are disclosed including methods for crystallizing a material such as a drug. An example method may include combining a nucleation initiator, a surfactant solution, and an amorphous form of a drug to form a drug precursor dispersion/suspension. The method may also include incubating the drug precursor dispersion/suspension to allow the drug to convert from the amorphous form to a crystalline form.Type: GrantFiled: March 12, 2021Date of Patent: November 14, 2023Assignee: Boston Scientific Scimed, Inc.Inventors: Hongxia Zeng, Jonathan Pascal Chaky, Yen-Lane Chen
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Publication number: 20230052812Abstract: Medical devices as wells as methods for making and using medical devices are disclosed. An example medical device may include a left atrial appendage device. The left atrial appendage device may include an expandable frame configured to shift between a first configuration and an expanded configuration. A fabric mesh may be disposed along at least a portion of the expandable frame. An anti-thrombogenic coating may be disposed along the fabric mesh.Type: ApplicationFiled: October 14, 2022Publication date: February 16, 2023Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: STEVEN L. KANGAS, EDWARD KOPESKY, YEN-LANE CHEN
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Publication number: 20230011767Abstract: A device for permanent placement across an atrial appendage ostium in a patient includes a support structure having a contracted delivery configuration and an expanded deployed configuration defining a radially enlarged portion to permanently engage an interior wall of the atrial appendage, a membrane attached to the support structure and configured to extend across the ostium of the atrial appendage when the support structure is in the expanded deployed configuration, and a polymer coating disposed on at least one of the support structure and the membrane, the polymer coating including a direct oral anticoagulant (DOAC) dispersed in a polymer.Type: ApplicationFiled: July 8, 2022Publication date: January 12, 2023Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Steven L. Kangas, Edward Kopesky, Yen-Lane Chen
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Patent number: 11484320Abstract: Medical devices as wells as methods for making and using medical devices are disclosed. An example medical device may include a left atrial appendage device. The left atrial appendage device may include an expandable frame configured to shift between a first configuration and an expanded configuration. A fabric mesh may be disposed along at least a portion of the expandable frame. An anti-thrombogenic coating may be disposed along the fabric mesh.Type: GrantFiled: December 17, 2020Date of Patent: November 1, 2022Assignee: Boston Scientific Scimed, Inc.Inventors: Steven L. Kangas, Edward Kopesky, Yen-Lane Chen
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Publication number: 20210300938Abstract: Methods are disclosed including methods for crystallizing a material such as a drug. An example method may include combining a nucleation initiator, a surfactant solution, and an amorphous form of a drug to form a drug precursor dispersion/suspension. The method may also include incubating the drug precursor dispersion/suspension to allow the drug to convert from the amorphous form to a crystalline form.Type: ApplicationFiled: March 12, 2021Publication date: September 30, 2021Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: HONGXIA ZENG, JONATHAN PASCAL CHAKY, YEN-LANE CHEN
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Publication number: 20210186516Abstract: Medical devices as wells as methods for making and using medical devices are disclosed. An example medical device may include a left atrial appendage device. The left atrial appendage device may include an expandable frame configured to shift between a first configuration and an expanded configuration. A fabric mesh may be disposed along at least a portion of the expandable frame. An anti-thrombogenic coating may be disposed along the fabric mesh.Type: ApplicationFiled: December 17, 2020Publication date: June 24, 2021Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: STEVEN L. KANGAS, EDWARD KOPESKY, YEN-LANE CHEN
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Publication number: 20200093745Abstract: Polymer microspheres for embolizing blood vessels and optionally delivering therapeutic agents are provided.Type: ApplicationFiled: October 9, 2019Publication date: March 26, 2020Inventors: Hongxia Zeng, Steven Kangas, Yen-Lane Chen
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Publication number: 20200038559Abstract: In one aspect, the present disclosure pertains to elutable coating compositions that comprise an excipient comprising a bio-degradable or bio-stable polymer selected from a poly(lactic-co-glycolic acid) (PLGA) or methyl cellulose (MCC), a binding agent; a therapeutic agent. In some embodiments, the elutable coating compositions further comprise a solvent, in which case such compositions may be, for example, applied to a substrate in the form of a layer and subsequently dried, thereby forming an elutable coating on the substrate.Type: ApplicationFiled: July 30, 2019Publication date: February 6, 2020Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: HONGXIA ZENG, JONATHAN PASCAL CHAKY, MING DANG, YEN-LANE CHEN
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Patent number: 10471012Abstract: Polymer microspheres for embolizing blood vessels and optionally delivering therapeutic agents are provided. The microspheres include PLGA 50:50 and/or Ptx, and are generally formed by emulsion means.Type: GrantFiled: January 4, 2016Date of Patent: November 12, 2019Assignee: Boston Scientific Scimed, Inc.Inventors: Hongxia Zeng, Steven L. Kangas, Yen-Lane Chen
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Patent number: 10098650Abstract: A system and method for treating atherosclerotic plaque. The system includes a first catheter including an expandable balloon and a second catheter including a lumen in fluid communication with a distal hole. The method includes inserting the first catheter into a body lumen adjacent to a plaque formation, and deploying a balloon from the first catheter adjacent to the plaque formation. In addition, the method includes inserting the second catheter adjacent to the first catheter, and routing the distal end portion of second catheter along at least a portion of the deployed balloon of the first catheter. Further, the method includes routing at least a portion of the second catheter into a subintimal space adjacent to the atherosclerotic plaque. Furthermore, the method includes injecting a therapeutic agent into the subintimal space adjacent to the atherosclerotic plaque.Type: GrantFiled: June 9, 2015Date of Patent: October 16, 2018Assignee: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Steven L. Kangas, Yen-Lane Chen
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Patent number: 10080821Abstract: Drug delivery balloons have densely packed crystals of small particle size of the drug thereon. An amorphous drug coating is applied to a balloon surface and annealed to provide the crystals. The balloon surface is nucleated to induce formation of drug crystals in the annealing step to provide the crystals in high density with small size.Type: GrantFiled: June 14, 2010Date of Patent: September 25, 2018Assignee: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Steve Kangas, Michael Sean Owens, Jon Patterson, Dave Ekberg, Erik Haun, Eric Henderson, Aaron Foss, Yen-Lane Chen
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Publication number: 20160262917Abstract: A medical device includes a tubular network of struts including a bioerodible polymer. The tubular network can include a plurality of bands and a plurality of connector struts. Each band can include a plurality of peaks between adjacent band struts. Each band can be connected to one or more adjacent bands by at least two connector struts at a plurality of connector intersections. The bioerodible polymer can include a plurality of polymer chains functionalized with a photo active group.Type: ApplicationFiled: March 10, 2016Publication date: September 15, 2016Inventors: JOHN J. CHEN, STEVEN L. KANGAS, YEN-LANE CHEN, HONGXIA ZENG, RAGHAV GOEL
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Publication number: 20160220490Abstract: Polymer microspheres for embolizing blood vessels and optionally delivering therapeutic agents are provided. The microspheres include PLGA 50:50 and/or Ptx, and are generally formed by emulsion means.Type: ApplicationFiled: January 4, 2016Publication date: August 4, 2016Applicant: Boston Scientific Scimed, Inc.Inventors: Hongxia Zeng, Steven L. Kangas, Yen-Lane Chen
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Publication number: 20150351782Abstract: A system and method for treating atherosclerotic plaque. The system includes a first catheter including an expandable balloon and a second catheter including a lumen in fluid communication with a distal hole. The method includes inserting the first catheter into a body lumen adjacent to a plaque formation, and deploying a balloon from the first catheter adjacent to the plaque formation. In addition, the method includes inserting the second catheter adjacent to the first catheter, and routing the distal end portion of second catheter along at least a portion of the deployed balloon of the first catheter. Further, the method includes routing at least a portion of the second catheter into a subintimal space adjacent to the atherosclerotic plaque. Furthermore, the method includes injecting a therapeutic agent into the subintimal space adjacent to the atherosclerotic plaque.Type: ApplicationFiled: June 9, 2015Publication date: December 10, 2015Inventors: Steven L. Kangas, Yen-Lane Chen
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Publication number: 20150250772Abstract: A medical device having a polymer-free outer surface layer comprising a crystalline drug selected from the group consisting of everolimus, tacrolimus, sirolimus, zotarolimus, biolimus, and rapamycin. The device may be produced by a method comprising the steps of providing a medical device; applying a solution of the drug to said portion of the outer surface to form a coating of amorphous drug; and vapor annealing the drug with a solvent vapor to form crystalline drug; wherein a seed layer of a crystalline form of said drug having a maximum particle size of about 10 ?m or less is applied to at least said portion of the outer surface of the device before or after applying the drug solution, but before vapor annealing the amorphous coating.Type: ApplicationFiled: May 22, 2015Publication date: September 10, 2015Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Steven L. Kangas, James Q. Feng, Hongxia Zeng, Yen-Lane Chen
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Publication number: 20150238736Abstract: A catheter system includes a catheter having a first balloon and a second balloon. The first balloon is longitudinally offset from the second balloon along the length of the catheter. The first and second balloons both have expanded and unexpanded states. The second balloon has a drug coating. The catheter system has a first configuration, a second configuration, and a third configuration. In the first configuration, the first balloon is in the unexpanded state and the second balloon is in the unexpanded state. In the second configuration, the first balloon is in the expanded state and the second balloon is in the unexpanded state. In the third configuration, the first balloon is in the expanded state and the second balloon is in the expanded state.Type: ApplicationFiled: February 27, 2015Publication date: August 27, 2015Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Hongxia Zeng, Yen-Lane Chen, Steven L. Kangas
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Publication number: 20150182732Abstract: A catheter comprises a medical balloon having a drug coating. The drug coating comprises drug crystals on a surface of the balloon. The majority of the drug crystals on the surface of the balloon are oriented drug crystals which extend within 5° of a predetermined, non-zero common angle relative to the surface of the balloon from which the crystals extend.Type: ApplicationFiled: December 29, 2014Publication date: July 2, 2015Applicant: Boston Scientific Scimed, Inc.Inventors: Hongxia Zeng, Yen-Lane Chen, Steven L. Kangas
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Patent number: 9056152Abstract: A medical device having a polymer-free outer surface layer comprising a crystalline drug selected from the group consisting of everolimus, tacrolimus, sirolimus, zotarolimus, biolimus, and rapamycin. The device may be produced by a method comprising the steps of providing a medical device; applying a solution of the drug to said portion of the outer surface to form a coating of amorphous drug; and vapor annealing the drug with a solvent vapor to form crystalline drug; wherein a seed layer of a crystalline form of said drug having a maximum particle size of about 10 ?m or less is applied to at least said portion of the outer surface of the device before or after applying the drug solution, but before vapor annealing the amorphous coating.Type: GrantFiled: September 23, 2011Date of Patent: June 16, 2015Assignee: Boston Scientific Scimed, Inc.Inventors: Steve Kangas, James Feng, Yen-Lane Chen, Maggie Zeng