Abstract: The present invention relates to an attenuated reovirus-based vaccine composition and a use thereof, the attenuated reovirus, according to the present invention, having the 251st to 455th amino acids of a sigma-1 protein of a capsid truncated such that when an epitope of an antigenic protein inducing cancer or infectious disease is introduced to the truncated site of the sigma-1 protein, the epitope of the antigenic protein is stably expressed in a cell, and thus the effect is gained of exhibiting an immune response such as producing a neutralizing antibody or inducing cell-mediated immunity. As such, the present invention is expected to be usefully employable as a vaccine composition for cancer or infectious disease by introducing the epitope of the antigenic protein to the truncated site of the sigma-1 protein of the attenuated reovirus according to the present invention.

Abstract: Provided is a modified reovirus, a pharmaceutical composition thereof, and a method of treating cancer using the same which not only has an excellent anticancer effect on various cancers, including rare cancers, but can also enhance the effect of cancer immunotherapy agents.

Abstract: Provided are a pharmaceutical composition including reovirus or reovirus-treated biological sample as an active ingredient for prevention or treatment of cancer, and a method for prevention or treatment of cancer using same. In addition, provided are a combination use of the pharmaceutical composition and an immune checkpoint inhibitor for treatment of cancer.

Abstract: The present disclosure relates to a composition for preventing, alleviating, or treating an inflammatory disease of the digestive system, particularly, colitis, comprising a reovirus or a variant thereof as an active ingredient.