Patents by Inventor Yew-Min Tzeng
Yew-Min Tzeng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230143813Abstract: A compound of Formula I compound—Ovatodiolide which is safe and effective to use in a pharmaceutical composition for inhibition of SARS-CoV-2 is provided. The pharmaceutical composition comprising a safe and effective amount of a compound of Formula I compound—Ovatodiolide or pharmaceutically acceptable salts thereof, together with a pharmaceutically acceptable carrier, which has great potential to treat SARS-CoV-2 induced COVID-19 based on a safe and effective amount of a compound of Formula I compound—Ovatodiolide.Type: ApplicationFiled: April 17, 2020Publication date: May 11, 2023Applicants: Peking University Shenzhen Graduate School, CNS Biotek Corp., Gansu Evergreen Pharmaceuticals, Co., Ltd.Inventors: Zhen Yang, Yew-Min Tzeng, Linqi Zhang, Junmin Quan, Qing Chang, Qi Zhang, Chien-Ming Lee
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Publication number: 20180050012Abstract: The present invention is directed to a method for inhibiting growth of ovarian cancer cells in a subject in need thereof, comprising administering to said subject a composition comprising an effective amount of 4-acetyl-antroquinonol B or a pharmaceutical acceptable salt thereof, and a pharmaceutically acceptable carrier.Type: ApplicationFiled: August 8, 2017Publication date: February 22, 2018Applicant: NEW BELLUS ENTERPRISES CO., LTD.Inventors: CHUN-CHIH HUANG, YEW-MIN TZENG, CHI-TAI YEH, Tsang-Hsien Alexander Wu
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Publication number: 20150231105Abstract: This invention provides a method for inhibiting tumor growth caused by cancer stem cells in a subject in need thereof, which comprises administering to the subject an effective amount of 4-acetyl-antroquinonol B.Type: ApplicationFiled: April 23, 2015Publication date: August 20, 2015Applicant: NEW BELLUS ENTERPRISES CO., LTDInventors: Chun-Chih Huang, Chih-Chieh Chen, Lih-Geeng Chen, Yew-Min Tzeng, Chi-Tai Yeh, Tsang-Hsien Alexander Wu
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Method for chemical synthesis of antrocin and use thereof for suppressing non-small cell lung cancer
Patent number: 9045450Abstract: The present invention provides a method for preparing antrocin of pharmaceutically acceptable salts thereof via a series of gold-catalyzed cyclization to construct the (6-6-5) tricyclic core frame. The present invention also provides a use of a composition in preparing drugs for suppressing growth of non-small cell lung cancer cells, wherein the composition comprises an effective amount of antrocin or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier.Type: GrantFiled: August 10, 2011Date of Patent: June 2, 2015Assignees: KAIYEW INVESTMENT CORP., JENISA BIOTECHNOLOGY CORP.Inventors: Zhen Yang, Yew-Min Tzeng, Chuang-Chuang Li, Tuo-Ping Luo, Hang Shi, Chi-Tai Yeh -
METHOD FOR CHEMICAL SYNTHESIS OF ANTROCIN AND USE THEREOF FOR SUPPRESSING NON-SMALL CELL LUNG CANCER
Publication number: 20140350096Abstract: The present invention provides a method for preparing antrocin of pharmaceutically acceptable salts thereof via a series of gold-catalyzed cyclization to construct the (6-6-5) tricyclic core frame. The present invention also provides a use of a composition in preparing drugs for suppressing growth of non-small cell lung cancer cells, wherein the composition comprises an effective amount of antrocin or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier.Type: ApplicationFiled: August 10, 2011Publication date: November 27, 2014Inventors: YEW-MIN TZENG, ZHEN YANG -
Patent number: 8658806Abstract: The present invention relates to a process of preparation of optically active antrocin. At first, to introduce the correct configuration of trans-decalone, alkyl aluminum/TMSCN was used to react with decalenone. The resulting racemic nitrile-decalone was resolved with chiral diol by ketalization to produce two chromatography separable diasteromers. After a simple column chromatography, optically pure compounds were obtained. Formylation was a critical step for the lactone formation. The rest of the synthesis is straight forward through oxidation and olefination. Accordingly, the total synthesis was completed in 10 steps with 7% overall yield from commercially available 6-methoxy-2-tetralone.Type: GrantFiled: September 14, 2012Date of Patent: February 25, 2014Assignee: Deyew Biotech Corp.Inventors: Dar-Fu Tai, Venkatachalam Angamuthu, Yew-Min Tzeng
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Patent number: 8580847Abstract: This subject invention is directed to a method for inhibition of cancer cells, comprising administrating an effective amount of a compound of formula I (Sesquiterpene lactones, antrocin) or pharmaceutically acceptable salts thereof, together with a pharmaceutically acceptable carrier, wherein the cancer cells are selected from colorectal cancer cells, liver cancer cells, lung cancer cells or breast cancer cells.Type: GrantFiled: December 27, 2011Date of Patent: November 12, 2013Assignee: Chaoyang University of TechnologyInventors: Yew-Min Tzeng, Tien-Shen Yang, Chi-Tai Yeh Yeh
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Publication number: 20130096324Abstract: The present invention relates to a process of preparation of optically active antrocin. At first, to introduce the correct configuration of trans-decalone, alkyl aluminum/TMSCN was used to react with decalenone. The resulting racemic nitrile-decalone was resolved with chiral diol by ketalization to produce two chromatography separable diasteromers. After a simple column chromatography, optically pure compounds were obtained. Formylation was a critical step for the lactone formation. The rest of the synthesis is straight forward through oxidation and olefination. Accordingly, the total synthesis was completed in 10 steps with 7% overall yield from commercially available 6-methoxy-2-tetralone.Type: ApplicationFiled: September 14, 2012Publication date: April 18, 2013Applicant: DEYEW BIOTECH CORP.Inventors: Dar-fu TAI, Venkatachalam ANGAMUTHU, Yew-min TZENG
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Publication number: 20120100175Abstract: This subject invention is directed to a method for inhibition of cancer cells, comprising administrating an effective amount of a compound of formula I (Sesquiterpene lactones, antrocin) or pharmaceutically acceptable salts thereof, together with a pharmaceutically acceptable carrier, wherein the cancer cells are selected from colorectal cancer cells, liver cancer cells, lung cancer cells or breast cancer cells.Type: ApplicationFiled: December 27, 2011Publication date: April 26, 2012Applicant: CHAOYANG UNIVERSITY OF TECHNOLOGYInventors: Yew-Min Tzeng, Tien-Shen Yang, Chi-Tai Yeh
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Publication number: 20110263700Abstract: This subject invention is directed to a pharmaceutical composition for the inhibition of cancer cells, comprising an effective amount of a compound of formula I (Sesquiterpene lactones, antrocin) or pharmaceutically acceptable salts thereof, together with a pharmaceutically acceptable carrier.Type: ApplicationFiled: April 26, 2010Publication date: October 27, 2011Applicant: CHAOYANG UNIVERSITY OF TECHNOLOGYInventors: Yew-Min Tzeng, Tien-Shen Yang, Chi-Tai Yeh
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Patent number: 6268183Abstract: The invention discloses a two-step process for recovery of thuringiensin, comprising adsorbing the thuringiensin from fermentation broth by calcium silicate, and dissociating the thuringiensin by dibasic sodium phosphate. The resulting thuringiensin can be further purified by using semi-preparative HPLC and electrodialysis to remove the excess salts from the recovered thuringiensin solution.Type: GrantFiled: June 2, 2000Date of Patent: July 31, 2001Assignee: National Science CouncilInventors: Yew-Min Tzeng, Bing-Lan Liu, Shyuan-Shuenn Huang, Cheng-Ming Liu, Hung-Yieng Tsun
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Patent number: 6221223Abstract: Quantitative analysis for thuringiensin by capillary electrophoresis (“CE’) was demonstrated. CE is a suitable separation technique for thuringiensin because of its high resolution, great efficiency, rapid analysis and small consumption of sample. Tryptophan, an aromatic amino acid sharing a similar UV absorptive spectrum as thuringiensin, was used as an internal standard to avoid some inaccurate results caused by the questionable stability of purified thuringiensin. A mixed amount of tryptophan was mixed with varied amount of newly made thuringiensin standards for CE analysis. The electropherograms showed that the peak of tryptophan appeared around 8 minutes, which is 6 minutes earlier than the peak of thuringiensin. The peak area ratio between thuringiensin and tryptophan is proportional to the amount of thuringiensin in the mixture. The linear regression has been established to assess the peak area ratio that can be used to quantify the concentration of thuringiensin.Type: GrantFiled: October 30, 1998Date of Patent: April 24, 2001Inventors: Yew-Min Tzeng, Cheng-Ming Liu
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Patent number: 4889921Abstract: A process of treating meal containing vegetable proteins is disclosed. This process includes the step of extracting the metal with a suitable aqueous solvent in which the vegetable proteins are soluble to obtain an extraction solution. The solubility of the dissolved protein in the extraction solution is then adjusted to precipitate at least some of the protein and therefore obtain a precipitated protein fraction and an unprecipitated protein fraction in solution. The precipitated protein fraction is then separated from the protein fraction in solution, and the unprecipitated protein fraction is separated from the undesirable components in the solution by membrane processing. Each of the protein fractions is then suitably dried to recover the proteins.Type: GrantFiled: April 29, 1987Date of Patent: December 26, 1989Assignee: The University of Toronto Innovations FoundationInventors: Levente L. Diosady, Leon J. Rubin, Yew-Min Tzeng