Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Abstract: The application provides anti-4-1BB monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Abstract: A combined bio-artificial liver support system, includes branch tubes that are connected in sequence: a blood input branch tube, an upstream tail end, a first plasma separation branch tube comprising at least a first plasma separator, a non-biological purification branch tube comprising at least a plasma perfusion device and a bilirubin adsorber, a biological purification branch tube comprising at least a hepatocyte culture cartridge assembly, and a plasma return branch tube, a downstream tail end of which is set as a blood output end.

Abstract: Embodiments of this application discloses an azimuth estimation method performed at a computing device, the method including: obtaining, in real time, multi-channel sampling signals and buffering the multi-channel sampling signals; performing wakeup word detection on one or more sampling signals of the multi-channel sampling signals, and determining a wakeup word detection score for each channel of the one or more sampling signals; performing a spatial spectrum estimation on the buffered multi-channel sampling signals to obtain a spatial spectrum estimation result, when the wakeup word detection scores of the one or more sampling signals indicates that a wakeup word exists in the one or more sampling signals; and determining an azimuth of a target voice associated with the multi-channel sampling signals according to the spatial spectrum estimation result and a highest wakeup word detection score, thereby improving the accuracy of the azimuth estimation in a voice interaction process.

Abstract: Within several applications the ability to localize an individual within an environment is beneficial. However, existing indoor localization approaches depend upon at least one of two assumptions. First, the subject(s) localization is achieved by localizing a wireless device carried by the subject and second, wireless fingerprints are established for the localization via a site survey being performed before a system can actually localize the subject(s). However, in many application scenarios, neither of the above two assumptions are true, namely that the user is not carrying an active wireless device or that the site has been surveyed. Accordingly, embodiments of the invention provide for subject localization by a dynamic calibration of wireless signals between a receiver and a transmitter, where neither the receiver or transmitter are associated with an electronic device carried or worn by the subject.

Abstract: An approach for protecting container image and runtime data from host access may be presented. Container systems have allowed for more efficient utilization of computing resources, removing the requirement of a hypervisor, and packaging all necessary dependencies within an application. Preventing host access to container image and runtime data can be advantageous for a multitude of reasons. The approach herein may include, flattening a plurality of root file system of a one or more container images into a single layer. The approach may also include generating a container base image for each of the one or more flattened root file system. The approach may include encrypting each of the generated container base images with the flattened root file system.

Abstract: A multi-compartment bed radial flow adsorber capable of realizing large telescopic deformation mainly comprises an adsorber body, the adsorber body consists of an upper seal head, a barrel, a lower seal head and a pressed shell connected with an upper connecting pipe and a lower connecting pipe, the upper seal head and the lower seal head of the shell are each provided with an upper gas inlet and outlet pipe and a lower gas inlet and outlet pipe, a supporting seat is arranged at the bottom in the shell, an adsorption barrel is arranged above the supporting seat and consists of a plurality of concentric barrels with different diameters, a plurality of annular spaces are formed by the concentric barrels with different diameters, different types of adsorbents can be filled in the annular spaces, and the adsorption barrel is composed of a pore plate or a grid.

Abstract: This application discloses a sound acquisition component array, including: two first sound acquisition components, two second sound acquisition components, and two third sound acquisition components. The two second sound acquisition components are located at a first side of a line connecting the two first sound acquisition components, and the two third sound acquisition components are located at a second side of the connecting line that is opposite to the first side of the connecting line; the two second sound acquisition components are symmetrical about a perpendicular bisector of the connecting line, and the two third sound acquisition components are symmetrical about the perpendicular bisector; and a distance between the two first sound acquisition components, a distance between the two second sound acquisition components, and a distance between the two third sound acquisition components are respectively different from one another along a direction defined by the connecting line.

Abstract: This application discloses a method for establishing a call connection, a first terminal, a server, and a storage medium. The method includes: obtaining, by a first terminal, a second vocoder list of a second terminal, the second vocoder list including vocoders supported by the second terminal and with corresponding priorities; determining, by the first terminal, a first vocoder with the highest priority among vocoders that exist in both a first vocoder list of the first terminal and the second vocoder list, the first vocoder list including vocoders supported by the first terminal and with corresponding priorities, and the priorities of the vocoders being positively correlated with audio frequencies in encoding and decoding of the vocoders; and requesting, by the first terminal by using the first vocoder, to establish a first call connection to the second terminal.

Abstract: A call method is provided. The method includes: obtaining at least three paths of voice data transmitted by at least three first terminals, the voice data carrying indication information; selecting at least two paths of target voice data from the at least three paths of voice data according to the indication information of the at least three paths of voice data as obtained; and transmitting the at least two paths of target voice data to a second terminal, the second terminal being configured to decode the at least two paths of target voice data, mix decoded at least two paths of target voice data, and play mixed voice data.

Abstract: Herein are disclosed an audio signal processing method and apparatus, an electronic device, and a storage medium. The method includes: obtaining an audio signal acquired by an application while an account logging into the application is in a microphone mute state in a multi-person voice call; obtaining gain parameters, for each of a plurality of audio frames in the audio signal, respectively on a plurality of bands in a first band range; and outputting a prompt message responsive to a determination, based on the gain parameters, that a target voice is contained in the audio signal, the prompt message providing a prompt to disable the microphone mute state of the account.

Abstract: This computer-implemented method for providing an automated prediction of a change of a state of fatigue of a subject carrying out a visual task involving any kind of visual content comprises: providing a plurality of input data, relating to the subject, to a fatigue state change predictive model, wherein the plurality of input data comprises at least one subjective measurement relating to the subject and/or at least one objective measurement relating to the subject and/or at least one other subject-related datum; obtaining, by a processor implementing the model, a value representing a level of change of the state of fatigue of the subject.

Abstract: An audio data processing method is provided. The method includes: obtaining multi-path audio data in an environmental space, obtaining a speech data set based on the multi-path audio data, and separately generating, in a plurality of enhancement directions, enhanced speech information corresponding to the speech data set; matching a speech hidden feature in the enhanced speech information with a target matching word, and determining an enhancement direction corresponding to the enhanced speech information having a highest degree of matching with the target matching word as a target audio direction; obtaining speech spectrum features in the enhanced speech information, and obtaining, from the speech spectrum features, a speech spectrum feature in the target audio direction; and performing speech authentication on the speech hidden feature and the speech spectrum feature that are in the target audio direction based on the target matching word, to obtain a target authentication result.

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Abstract: A system associated with predicting segmentation quality of segmented objects implemented in the analysis of copious image data is disclosed. The system receives a collection of image data related to a particular type of data. The image data is segmented into segmented data portions based on an object associated with the collection of image data. Regions of interest associated with the segmented data portions are determined. The quality of segmentation of the segmented data portions is determined for respective classification of the regions of interest. A classification label is assigned to the regions of interest. Regions of interest are partitioned into sub-regions. Features associated with the sub-regions of the segmented data portions are determined. A training dataset is generated based on the determined features associated with the sub-regions in order to train a classification model based on a predetermined threshold value.

Abstract: A keyword detection method includes: obtaining an enhanced speech signal of a to-be-detected speech signal, the enhanced speech signal corresponding to a target speech speed; performing speed adjustment on the enhanced speech signal to obtain a first speed-adjusted speech signal having a first speech speed, the first speech speed being different from the target speech speed; obtaining a first speech feature signal according to the first speed-adjusted speech signal; obtaining a detection result according to a first keyword detection result corresponding to the first speech feature signal, the detection result indicating whether a target keyword exists in the to-be-detected speech signal; and performing an operation corresponding to the target keyword in response to determining that the target keyword exists according to the detection result.

Abstract: An audio data processing method is provided. The method includes: obtaining multi-path audio data in an environmental space, obtaining a speech data set based on the multi-path audio data, and separately generating, in a plurality of enhancement directions, enhanced speech information corresponding to the speech data set; matching a speech hidden feature in the enhanced speech information with a target matching word, and determining an enhancement direction corresponding to the enhanced speech information having a highest degree of matching with the target matching word as a target audio direction; obtaining speech spectrum features in the enhanced speech information, and obtaining, from the speech spectrum features, a speech spectrum feature in the target audio direction; and performing speech authentication on the speech hidden feature and the speech spectrum feature that are in the target audio direction based on the target matching word, to obtain a target authentication result.

Abstract: A message processing method, applied to a terminal device including a modem, includes: monitoring a running state of the modem, and restarting the modem when it is monitored that the modem crashes; and maintaining a communication connection state, and prohibiting notification of a modem crash message to a user. By maintaining a normal communication state after the modem crashes, it is ensured that the user continues to use the various services of the terminal normally to avoid the interruption of the ongoing business of the user; and the terminal resumes normal operation after the modem is restarted, and the user does not perceive that the modem has ever crashed, thereby maintaining the experience of using the terminal normally all the time.

Abstract: A computer platform is provided that permits selling users to list items for sale and to allow a number of experts to review and verify authenticity of these items. In some embodiments, the system may be capable of queuing items to be listed within a management system, and experts are permitted to review particular items. Also, it is appreciated that certain experts have particular expertise to evaluate items of certain types, and therefore, in some implementations, the system is configured to more accurately match experts with particular items to be reviewed.

Abstract: A method for displaying network identifier information includes: when the mobile terminal is located in a first network cell and the mobile terminal is in an idle state, determining received radio resource configuration information and network information of the first network cell, the radio resource configuration information indicating whether access to a second network is supported, and the network information indicating whether the first network cell has an ability to access the second network; determining a network type based on the radio resource configuration information and the network information, the network type comprising a first network and the second network; and displaying network identifier information corresponding to the network type.