Abstract: Embodiments of this application provide a communication method and an apparatus. The method includes: A terminal device measures a downlink reference signal, to obtain third information. The terminal device determines first information and first scenario-related information of a downlink channel based on the third information, and sends the first information and the first scenario-related information to a network device. The network device determines second information based on the first scenario-related information and the first information, where the second information may be considered as reconstructed third information. The third information is reconstructed in the foregoing manner based on the scenario-related information, so that reconstruction precision of the third information can be improved.

Abstract: A communication method and apparatus. A terminal device determines channel state information based on S indexes of S vectors. Each of the S vectors is included in a first vector quantization dictionary. The first vector quantization dictionary includes N1 vectors, where N1 and S are both positive integers. The terminal device sends the channel state information to a network device. Because a vector included in the vector quantization dictionary usually has a relatively large dimension, quantizing channel information by using the first vector quantization dictionary is equivalent to performing dimension expansion on the channel information or maintaining a relatively high dimension. High-precision feedback is implemented by using relatively low signaling overheads.

Abstract: Provided is a binarization method for CT sectional image of fiber package containing artifacts, which includes: performing brightness adjustment on the source image obtained after converting of the HSV image model by using a composite tangent function; creating a planar morphological structural element having a morphology similar to that of a target object to obtain a background image without the target object; obtaining a second intermediate image by a subtraction operation of the first intermediate image and the background image; improving an image contrast of the second intermediate image again to obtain a third intermediate image; and binarizing the third intermediate image by using a local adaptive threshold binarization algorithm and removing a background noise to obtain a final binarized image. The binarization method can improve the uneven brightness of the image under complex illumination, alleviate the artifacts, and strip similar objects from the background with similar gray scales.

Abstract: A method of modulating energy homeostasis in a mammal without eliciting a sexual response by administration of a therapeutically effective amount of a pharmaceutical composition including a melanocortin receptor compound of the formula: where R1 is a bond or a linker unit including from one to six backbone atoms and an unsubstituted naphthalene group, and L, R2, R3 and Rx are as defined in the specification.

Abstract: A thienopyrimidine compound of the formula: wherein R1, R2, R3, and R4 are as defined herein, and methods of use of such compounds for the treatment of melanocortin receptor-associated disorders.

Abstract: Melanocortin receptor-specific peptide combinatorial libraries for forming metallopeptides and metallopeptide combinatorial libraries are provided for use in biological, pharmaceutical and related applications. The combinatorial libraries are constructed of peptides constructed from naturally occurring amino acids, stereoisomers and modifications of such amino acids, non-protein amino acids, post-translationally modified amino acids, enzymatically modified amino acids, or constructs or structures designed to mimic amino acids, in which the peptides are conformationally fixed on complexation of a metal ion-binding portion thereof with a metal ion.

Abstract: Metallopeptides and metallopeptide combinatorial libraries specific for melanocortin receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, in which the peptide, peptidomimetic or construct is conformationally fixed on complexation of a metal ion-binding portion thereof with a metal ion.

Abstract: Method of making metallopeptide combinatorial libraries and metallopeptides are provided, for use in biological, pharmaceutical and related applications. The combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, and include a metal ion-binding region thereof which includes at least one orthogonal sulfur-protecting group, in which the peptide, peptidomimetic or construct is conformationally fixed on deprotection of the sulfur and complexation of the metal ion-binding region with a metal ion. Thereafter the library members may be screened to select those with the desired specificity and affinity.

Abstract: A thienopyrimidine compound of the formula: wherein R1, R2, R3, and R4 are as defined herein, and methods of use of such compounds for the treatment of melanocortin receptor-associated disorders.

Abstract: Metallopeptide combinatorial libraries and methods of making libraries and metallopeptides are provided, for use in biological, pharmaceutical and related applications. The combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, and include a metal ion-binding region thereof which includes at least one orthogonal sulfur-protecting group, in which the peptide, peptidomimetic or construct is conformationally fixed on deprotection of the sulfur and complexation of the metal ion-binding region with a metal ion. Thereafter the library members may be screening to select those with the desired specificity and affinity.