Abstract: The present application provides an antibody fusion protein comprising: i) a multivalent (e.g., bivalent) antibody or antigen-binding fragment thereof specifically recognizing Angiopoietin-2 (Ang2)(“multivalent anti-Ang2 antibody or antigen-binding fragment thereof”), and ii) a vascular endothelial growth factor receptor (VEGFR) component, wherein the multivalent anti-Ang2 antibody or antigen-binding fragment thereof does not inhibit the binding between Ang2 and TEK receptor tyrosine kinase (TIE2). Also provided are methods of making and uses thereof.

Abstract: A tubing-free, sample-to-droplet microfluidic system includes a tubing-free, sample-to-droplet microfluidic chip; a valve control system connected to the tubing-free, sample-to-droplet microfluidic chip; a vacuum system fluidly connected to the tubing-free, sample-to-droplet microfluidic chip; and a droplet formation pressure system fluidly connected to the tubing-free, sample-to-droplet microfluidic chip. A microfluidic chip for a tubing-free, sample-to-droplet microfluidic system includes a tubing-free, sample-to-droplet interface section; a droplet mixing section in fluid connection with the tubing-free, sample-to-droplet interface section to received droplets therefrom; an incubation section in fluid connection with the droplet mixing section to receive droplets therefrom; and a detection section in fluid connection with the incubation section to receive droplets therefrom.

Abstract: The present application discloses a method for operating a memory device. The memory device includes a plurality of rows of repair one-time programmable (OTP) cells and a plurality of rows of main OTP cells. The method includes performing a testing procedure to determine validities of the plurality of rows of repair OTP cells and store repair information to a first part of rows of repair OTP cells that are determined to be valid, and performing a repairing procedure to determine validities of the plurality of rows of repair OTP cells and repair at least one row of main OTP cells that is determined to be invalid in the plurality of rows of main OTP by using a second part of the rows of repair OTP cells that are determined to be valid.

Abstract: A transceiver includes a RF modulator, a filter circuit, a control circuit and a first DC offset compensation circuit. During a first calibration period, the control circuit controls the filter circuit to be connected to the RF modulator with a first phase sequence, such that the RF modulator outputs a first radio frequency signal. During a second calibration period, the control circuit controls the filter circuit to be connected to the RF modulator with a second phase sequence, such that the RF modulator outputs a second radio frequency signal. The second phase sequence is inverted with the first phase sequence. The control circuit is further configured to calculate a first DC offset generated from the filter circuit, and to control the first DC offset compensation circuit to compensate the first DC offset generated from the filter circuit.

Abstract: A method of operating an integrated circuit includes using a first switching device to couple a bio-sensing device to a first signal path, generating, using the bio-sensing device, a bio-sensing signal on the first signal path in response to an electrical characteristic of a sensing film, using a second switching device to couple a temperature-sensing device to a second signal path, and generating, using the temperature-sensing device, a temperature-sensing signal on the second signal path in response to a temperature of the sensing film. The first and second switching devices, the bio-sensing device, the temperature-sensing device, and the sensing film are components of a sensing pixel of a plurality of sensing pixels of the integrated circuit.

Abstract: Disclosed are a computer-implemented method, a system and a computer program product for feature processing. In the computer-implemented method for feature processing, two input features selected from multiple features of each sample in a sample set are projected to one resulting feature by one or more processing units based on a specified curve. The sample set is updated by replacing the two input features with the one resulting feature for each sample in the sample set by one or more processing units. The projecting and the updating for the sample set are repeated by one or more processing units until the number of features of each sample in the sample set reaches a predetermined criterion.

Abstract: A key storage device comprising a first key unit and a second key unit is disclosed. The first key unit is configured to output a first logic value through, comprising: a first setting circuit configured to output a first setting voltage; and a first inverter comprising a first output transistor having a first threshold voltage, configured to receive the first setting voltage and generate the first logic value. The second key unit is configured to output a second logic value through a second node, comprising: a second setting circuit configured to output a second setting voltage; and a second inverter comprising a second output transistor having a second threshold voltage, configured to receive the second setting voltage and generate the second logic value. The absolute value of first threshold voltage is lower than which of the second threshold voltage. The first setting voltage is higher than the second setting voltage.

Abstract: A device includes an integrated circuit die attached to a substrate; a lid attached to the integrated circuit die; a sealant on the lid; a spacer structure attached to the substrate adjacent the integrated circuit die; and a cooling cover attached to the spacer structure, wherein the cooling cover extends over the lid, wherein the cooling cover attached to the lid by the sealant. In an embodiment, the device includes a ring structure on the substrate, wherein the ring structure is between the spacer structure and the integrated circuit die.

Abstract: A device includes a first channel layer, a second channel layer, a gate structure, a source/drain epitaxial structure, and a source/drain contact. The first channel layer and the second channel layer are arranged above the first channel layer in a spaced apart manner over a substrate. The gate structure surrounds the first and second channel layers. The source/drain epitaxial structure is connected to the first and second channel layers. The source/drain contact is connected to the source/drain epitaxial structure. The second channel layer is closer to the source/drain contact than the first channel layer is to the source/drain contact, and the first channel layer is thicker than the second channel layer.

Abstract: There is provided a display substrate, including: a base; light-emitting units on a side of the base; a flat light-shielding functional layer, including a black matrix and a first planarization layer, on a side of the light-emitting units away from the base, light outgoing openings being provided in the black matrix and being in one-to-one correspondence with the light-emitting units, and the first planarization layer at least filling the light outgoing openings; and a color filter layer, including color filter patterns in one-to-one correspondence with the light outgoing openings, on a side of the flat light-shielding functional layer away from the base, an orthographic projection of each color filter pattern on the base covering an orthographic projection of the light outgoing opening corresponding to the color filter pattern on the base. A method for manufacturing a display substrate, a display panel and a display apparatus are further provided.

Abstract: A computer-implemented technique for decomposing semi-structured data is provided. In this technique, metadata for a predetermined number of records can be collected from semi-structured data that includes several records. A structured format is generated based on the metadata and the plurality of records is decomposed with the structured format.

Abstract: The present invention relates to the treatment of herpes simplex virus (HSV) infection using an anti-HSV antibody. In particular, the anti-HSV antibody specifically binds to the glycoprotein D (gD) of herpes simplex virus-1 (HSV-1) and herpes simplex virus-2 (HSV-2). The treatment of the present invention is effective against drug-resistant and/or recurrent HSV infection.

Abstract: An entropy source circuit, comprising: a first adjustable ring oscillator for operating under a first setting or a second setting according to a first control signal, for respectively generating a first oscillation clock signal and a second oscillation clock signal which have different frequencies under the first setting and the second setting; a first sampling circuit, for sampling the first oscillating clock signal according to the sampling frequency to generate first sampling values, or sampling the second oscillating clock signal according to the sampling frequency to generate second sampling values; a first detection circuit detecting a first distribution of the first sampling values; and a control circuit generating the first control signal to switch the first setting to the second setting when the first distribution does not meet a predetermined distribution. The entropy source circuit outputs entropy values according to the first sample value or the second sample value.

Abstract: A sound generator provided in the present disclosure includes a frame, a magnetic circuit unit, and a first vibration unit and a second vibration unit arranged on two sides of the magnetic circuit unit. The magnetic circuit unit includes a first central magnetic yoke in the middle, a central magnet fixed to the first central magnetic yoke, a magnetic component arranged around the central magnet and fixed to the frame, and a connecting portion connecting the first central magnetic yoke to the magnetic component. The central magnet includes a first magnet portion fixed to the first central magnetic yoke and a second magnet portion fixed to the side of the first magnet portion away from the first central magnetic yoke, a projection area of the first magnet portion along a vibrating direction is greater than a projection area of the second magnet portion along the vibrating direction.

Abstract: The present disclosure discloses a sound device includes a frame, a magnet system, and a first vibration system and a second vibration system arranged on two sides of a magnet system. The magnet system includes a first central yoke, a central magnet mounted on the first central yoke, a side yoke surrounding the central magnet and fixed to the frame, and a connection portion connecting the first central yoke and the side yoke. The side yoke includes a first side yoke fixed to the frame and a second side yoke bending and extending from an edge of the first side yoke towards the central magnet; the connection portion connects the first central yoke and the second side yoke. The sound device in the present disclosure has higher magnetic ability and miniaturization ability.

Abstract: Embodiments of the present invention provide computer-implemented methods, computer program products and computer systems. For example, embodiments of the present invention can, in response to receiving information, predict availability of respective services deployed in a cloud environment. Embodiments of the present invention can then calculate an elastic index based on the predicted availability of the respective services.

Abstract: A device includes a first channel layer, a second channel layer, a gate structure, a source/drain epitaxial structure, and a source/drain contact. The first channel layer and the second channel layer are arranged above the first channel layer in a spaced apart manner over a substrate. The gate structure surrounds the first and second channel layers. The source/drain epitaxial structure is connected to the first and second channel layers. The source/drain contact is connected to the source/drain epitaxial structure. The second channel layer is closer to the source/drain contact than the first channel layer is to the source/drain contact, and the first channel layer is thicker than the second channel layer.

Abstract: A random number generator includes a static random number generator, a dynamic entropy source, a counter and a combining circuit. The static random number generator includes an initial random number pool and a static random number pool to output a static random number sequence from one thereof the initial random number pool and the static random number pool. The dynamic entropy source is used to generate a dynamic entropy bit. The counter is used to generate a dynamic random number sequence according to the dynamic entropy bit. The combining circuit is used to output a true random number sequence to a lively random number pool according to the static random number sequence and the dynamic random number sequence. The static random number pool is updated when the lively random number pool is fully updated.

Abstract: An entropy source circuit is provided. The entropy source circuit includes a digital circuit, a determination circuit and a time-to-digital converter (TDC), wherein the determination circuit is coupled to the digital circuit, and the TDC is coupled to the determination circuit. The digital circuit is configured to generate result data at a second time point according to input data received at a first time point, and the determination circuit is configured to perform determination on reference data with dynamic output generated by the digital circuit, to generate a determination result, wherein the reference data is equal to the result data. In addition, the TDC is configured to perform a time-to-digital conversion on a delay of the digital circuit for generating the result data according to the input data with aid of the determination signal, in order to generate entropy data corresponding to the delay.