Patents by Inventor Yi-Ta Tsai
Yi-Ta Tsai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240133781Abstract: A kit for extracting mycotoxin residues in agricultural products according to the present disclosure includes a pipe, a first powder mixture layer and a second powder mixture layer. The pipe has an output port at the bottom thereof and an input port at the top thereof for inputting a sample solution. The first powder mixture layer is in the form of powder and filled in the pipe. The first powder mixture layer contains cation exchange resin powder, C18 and diatomaceous earth powder. The second powder mixture layer is in the form of powder and filled in the pipe. The second powder mixture layer is located below the first powder mixture layer and above the output port. The second powder mixture layer contains PSA powder, anhydrous magnesium sulfate powder, activated carbon, PLS powder, diatomaceous earth powder and C18 powder. The present disclosure further provides a method of obtaining a primary test liquid from agricultural products using the above kit.Type: ApplicationFiled: June 5, 2023Publication date: April 25, 2024Inventors: HUNG-TA HUA, TSENG-YU TSAI, YI-JIA KU
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Publication number: 20230234033Abstract: A composite solid base catalyst, a manufacturing method thereof and a manufacturing method of glycidol are provided. The composite solid base catalyst includes an aluminum carrier and a plurality of calcium particles. The plurality of calcium particles are supported by the aluminum carrier. Beta basic sites of the composite solid base catalyst are 0.58 mmol/g-3.89 mmol/g.Type: ApplicationFiled: June 14, 2022Publication date: July 27, 2023Inventors: De-Hao TSAI, Yung-Tin PAN, Che-Ming YANG, Ching-Yuan CHANG, Ding-Huei TSAI, Chien-Fu HUANG, Yi-Ta TSAI
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Ammonium salts of 3-(3,5-dibromo-4-hydroxybenzyliden)-5-indo-1,3-dihydroindol-2-one and uses thereof
Patent number: 11304930Abstract: Disclosed herein is a compound of formula (I), which is ammonium salt of GW5074, wherein R1, R2, and R3 are independently hydrogen, alkyl, alkenyl, alkynyl, aryl, or heteroaryl; or R1, R2, R3 and the nitrogen are taken together to form a 6-membered heterocyclyl; and the alkyl, the alkenyl, the alkynyl, the aryl, the heteroaryl, or the 6-membered heterocyclyl is optionally substituted with at least one substituent selected from the group consisting of, —OH, —NH2, and —NRaRb, in which Ra and Rb are independently alkyl, aryl, or heteroaryl. Also disclosed herein is a pharmaceutical kit for the treatment of cancers. The pharmaceutical kit includes, a first formulation comprising a c-Raf inhibitor and a pharmaceutically acceptable carrier; and a second formulation comprising the compound of formula (I) and a pharmaceutically acceptable carrier. Also encompasses herein is a method of treating a subject having a cancer.Type: GrantFiled: July 24, 2019Date of Patent: April 19, 2022Assignee: Metagone Biotech Inc.Inventors: Tai-Lung Cha, Tai-Wei Ly, Yi-Ta Tsai, Sheng-Chieh Lin, Yun Yu -
AMMONIUM SALTS OF 3-(3,5-DIBROMO-4-HYDROXYBENZYLIDEN)-5-INDO-1,3-DIHYDROINDOL-2-ONE AND USES THEREOF
Publication number: 20210283103Abstract: Disclosed herein is a compound of formula (I), which is ammonium salt of GW5074, wherein R1, R2, and R3 are independently hydrogen, alkyl, alkenyl, alkynyl, aryl, or heteroaryl; or R1, R2, R3 and the nitrogen are taken together to form a 6-membered heterocyclyl; and the alkyl, the alkenyl, the alkynyl, the aryl, the heteroaryl, or the 6-membered heterocyclyl is optionally substituted with at least one substituent selected from the group consisting of, —OH, —NH2, and —NRaRb, in which Ra and Rb are independently alkyl, aryl, or heteroaryl. Also disclosed herein is a pharmaceutical kit for the treatment of cancers. The pharmaceutical kit includes, a first formulation comprising a c-Raf inhibitor and a pharmaceutically acceptable carrier; and a second formulation comprising the compound of formula (I) and a pharmaceutically acceptable carrier. Also encompasses herein is a method of treating a subject having a cancer.Type: ApplicationFiled: July 24, 2019Publication date: September 16, 2021Applicant: Metagone Biotech Inc.Inventors: Tai-Lung CHA, Tai-Wei LY, Yi-Ta TSAI, Sheng-Chieh LIN, Yun YU -
Patent number: 10131620Abstract: The present disclosure relates to a recycling method for producing dimethyl carbonate and dimethyl carbonate derivatives. The process is unique in that it produces a by-product that can be re-used in the process as a raw material for repeating the process. For example, when the process is directed to synthesizing dimethyl carbonate, glycerol is used as a starting material. Glycerol is also a by-product produced during formation of dimethyl carbonate, and therefore it can be re-used as starting material to generate more dimethyl carbonate.Type: GrantFiled: October 4, 2016Date of Patent: November 20, 2018Assignee: CHANG CHUN PLASTICS CO., LTD.Inventors: Chien Fu Huang, Yi Ta Tsai
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Patent number: 9782393Abstract: A pharmaceutical composition comprising sorafenib and GW5074. Said combination therapy inhibits cancer cell growth via c-Raf-PP2A-DAPK signaling transduction pathway in either in vitro or in preclinical animal model for orthotopic spontaneous kidney cancer which simulates clinical symptoms. Formation of the bond between c-Raf and GW5074 leads to conformational change which consequently increases the affinity between sorafenib and c-Raf. Binding with the specific drug target facilitates serine 308 dephosphorylation of DAPK by PP2A and induces necrosis in cancer cells. Serine 308 of DAPK protein may also be used as a biomarker for drug screening. This study provides a novel pharmaceutical composition comprising sorafenib and GW5074, a protein complex target consisting of c-Raf and DAPK for drug designing, as well as biomarkers including c-Raf protein, DAPK protein and phosphorylation status of DAPK for drug screening.Type: GrantFiled: June 6, 2016Date of Patent: October 10, 2017Assignee: National Defense Medical CenterInventors: Tai-Lung Cha, Sun-Yran Chang, Guang-Huan Sun, Chung-Chih Lin, Yi-Ta Tsai
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Patent number: 9656943Abstract: The present disclosure relates to a recycling method for producing dimethyl carbonate. The process is unique in that it produces a by-product that can be re-used in the process as a raw material for repeating the process. For example, when the process is directed to synthesizing dimethyl carbonate, glycerol is used as a starting material. Glycerol is also a by-product produced during formation of dimethyl carbonate, and therefore it can be re-used as starting material to generate more dimethyl carbonate.Type: GrantFiled: October 20, 2015Date of Patent: May 23, 2017Assignee: Chang Chun Plastics Co. Ltd.Inventors: Chien Fu Huang, Yi Ta Tsai
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Publication number: 20170107169Abstract: The present disclosure relates to a recycling method for producing dimethyl carbonate. The process is unique in that it produces a by-product that can be re-used in the process as a raw material for repeating the process. For example, when the process is directed to synthesizing dimethyl carbonate, glycerol is used as a starting material. Glycerol is also a by-product produced during formation of dimethyl carbonate, and therefore it can be re-used as starting material to generate more dimethyl carbonate.Type: ApplicationFiled: October 20, 2015Publication date: April 20, 2017Inventors: Chien Fu Huang, Yi Ta Tsai
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Publication number: 20170107170Abstract: The present disclosure relates to a recycling method for producing dimethyl carbonate and dimethyl carbonate derivatives. The process is unique in that it produces a by-product that can be re-used in the process as a raw material for repeating the process. For example, when the process is directed to synthesizing dimethyl carbonate, glycerol is used as a starting material. Glycerol is also a by-product produced during formation of dimethyl carbonate, and therefore it can be re-used as starting material to generate more dimethyl carbonate.Type: ApplicationFiled: October 4, 2016Publication date: April 20, 2017Inventors: Chien Fu Huang, Yi Ta Tsai
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Publication number: 20160339004Abstract: A pharmaceutical composition comprising sorafenib and GW5074. Said combination therapy inhibits cancer cell growth via c-Raf-PP2A-DAPK signaling transduction pathway in either in vitro or in preclinical animal model for orthotopic spontaneous kidney cancer which simulates clinical symptoms. Formation of the bond between c-Raf and GW5074 leads to conformational change which consequently increases the affinity between sorafenib and c-Raf. Binding with the specific drug target facilitates serine 308 dephosphorylation of DAPK by PP2A and induces necrosis in cancer cells. Serine 308 of DAPK protein may also be used as a biomarker for drug screening. This study provides a novel pharmaceutical composition comprising sorafenib and GW5074, a protein complex target consisting of c-Raf and DAPK for drug designing, as well as biomarkers including c-Raf protein, DAPK protein and phosphorylation status of DAPK for drug screening.Type: ApplicationFiled: June 6, 2016Publication date: November 24, 2016Inventors: Tai-Lung CHA, Sun-Yran CHANG, Guang-Huan SUN, Chung-Chih LIN, Yi-Ta TSAI
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Patent number: 9393234Abstract: A pharmaceutical composition comprising sorafenib and GW5074. Said combination therapy inhibits cancer cell growth via c-Raf-PP2A-DAPK signaling transduction pathway in either in vitro or in preclinical animal model for orthotopic spontaneous kidney cancer which simulates clinical symptoms. Formation of the bond between c-Raf and GW5074 leads to conformational change which consequently increases the affinity between sorafenib and c-Raf. Binding with the specific drug target facilitates serine 308 dephosphorylation of DAPK by PP2A and induces necrosis in cancer cells. Serine 308 of DAPK protein may also be used as a biomarker for drug screening. This study provides a novel pharmaceutical composition comprising sorafenib and GW5074, a protein complex target consisting of c-Raf and DAPK for drug designing, as well as biomarkers including c-Raf protein, DAPK protein and phosphorylation status of DAPK for drug screening.Type: GrantFiled: February 9, 2015Date of Patent: July 19, 2016Assignee: NATIONAL DEFENSE MEDICAL CENTERInventors: Tai-Lung Cha, Sun-Yran Chang, Guang-Huan Sun, Chung-Chih Lin, Yi-Ta Tsai
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Publication number: 20150150859Abstract: A pharmaceutical composition comprising sorafenib and GW5074. Said combination therapy inhibits cancer cell growth via c-Raf-PP2A-DAPK signaling transduction pathway in either in vitro or in preclinical animal model for orthotopic spontaneous kidney cancer which simulates clinical symptoms. Formation of the bond between c-Raf and GW5074 leads to conformational change which consequently increases the affinity between sorafenib and c-Raf. Binding with the specific drug target facilitates serine 308 dephosphorylation of DAPK by PP2A and induces necrosis in cancer cells. Serine 308 of DAPK protein may also be used as a biomarker for drug screening. This study provides a novel pharmaceutical composition comprising sorafenib and GW5074, a protein complex target consisting of c-Raf and DAPK for drug designing, as well as biomarkers including c-Raf protein, DAPK protein and phosphorylation status of DAPK for drug screening.Type: ApplicationFiled: February 9, 2015Publication date: June 4, 2015Inventors: Tai-Lung CHA, Sun-Yran CHANG, Guang-Huan SUN, Chung-Chih LIN, Yi-Ta TSAI
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Publication number: 20140357676Abstract: A pharmaceutical composition is provided which includes sorafenib and GW5074. This combination therapy inhibits cancer cell growth via c-Raf-PP2A-DAPK signaling transduction pathway in either an in vitro or pre-clinical animal model for orthotopic spontaneous kidney cancer which simulates clinical symptoms. Formation of the bond between c-Raf and GW5074 leads to conformational change which consequently increases the affinity between sorafenib and c-Raf. Binding with the specific drug target facilitates serine 308 dephosphorylation of DAPK by PP2A and induces necrosis in cancer cells. Serine 308 of DAPK protein may also be used as a biomarker for drug screening. A novel pharmaceutical composition is provided which includes sorafenib and GW5074, a protein complex target consisting of c-Raf and DAPK for drug designing, as well as biomarkers including c-Raf protein, DAPK protein and phosphorylation status of DAPK for drug screening.Type: ApplicationFiled: May 28, 2013Publication date: December 4, 2014Applicant: National Defense Medical CenterInventors: Tai-Lung CHA, Sun-Yran CHANG, Guang-Huan SUN, Chung-Chih LIN, Yi-Ta TSAI
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Patent number: 8155371Abstract: A structure of a voice coil assembly includes a plate, a top board, suspending arms and fixtures. The plate has a top and two opposite sides. The top board is disposed on the top of the plate. The suspending arms extend from the two sides of the plate and are connected to the fixtures. A pair of resilient sections is provided between the suspending arms and the fixtures. The resilient sections are formed in a curved, arcuate or wavy shape. The suspending arm has a cross-section in a flat shape.Type: GrantFiled: March 10, 2008Date of Patent: April 10, 2012Assignee: Hsiuping Institute of TechnologyInventors: Jia-Hroung Wu, Wen-Chi Fu, Wen-Lan Wu, Yi-Ta Tsai, Yong-Siang Chen, Hsiu-Hui Chu, Chyau-Wen Jiang, Yu-Jung Chen
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Publication number: 20090226027Abstract: A structure of a voice coil assembly includes a plate, a top board, suspending arms and fixtures. The plate has a top and two opposite sides. The top board is disposed on the top of the plate. The suspending arms extend from the two sides of the plate and are connected to the fixtures. A pair of resilient sections is provided between the suspending arms and the fixtures. The resilient sections are formed in a curved, arcuate or wavy shape. The suspending arm has a cross-section in a flat shape.Type: ApplicationFiled: March 10, 2008Publication date: September 10, 2009Inventors: Jia-Hroung Wu, Wen-Chi Fu, Wen-Lan Wu, Yi-Ta Tsai, Yong-Siang Chen, Hsiu-Hui Chu, Chyau-Wen Jiang, Yu-Jung Chen
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Publication number: 20090137319Abstract: A command distribution method, and multimedia apparatus and system using the same for playing games are concerned. The game system includes a game platform, a signal transmission module and an audio/video playing device. The audio/video playing device, coupled to the game platform via the signal transmission module, receives a command from the signal transmission module, and processing the command by way of a driver. The command is then transmitted to a data processing engine to be executed so as to generate an output signal. The command distribution method comprises steps of receiving a command from a game platform by an audio/video playing device, identifying a type to which the command corresponds among a plurality of types, and transmitting the command to be processed by a corresponding data processing engine according to the identified type, thereby generating an output signal.Type: ApplicationFiled: November 12, 2008Publication date: May 28, 2009Applicant: MSTAR SEMICONDUCTOR, INC.Inventors: SHIH CHIN LIN, YI TA TSAI, SHAO CHIH WU, CHUAN WEN CHEN, NAI SHENG CHENG