Abstract: The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Abstract: Submerged combustion burners having a burner body, a burner tip connected thereto, and a protective cap and/or cladding layer. Submerged combustion melters including the burners and methods of using them to produce molten glass. The burner body has an external conduit and first and second internal conduits substantially concentric therewith, forming first and second annuli for passing a cooling fluid therethrough. The burner tip body is connected to the burner body at ends of the external and second internal conduits. The burner tip and protective cap and/or cladding layer include a generally central flow passage for a combustible mixture, the flow passage defined by an inner wall of the burner tip and protective cap.

Abstract: Submerged combustion burners having a burner body, a burner tip connected thereto, and a protective cap and/or cladding layer. Submerged combustion melters including the burners and methods of using them to produce molten glass. The burner body has an external conduit and first and second internal conduits substantially concentric therewith, forming first and second annuli for passing a cooling fluid therethrough. The burner tip body is connected to the burner body at ends of the external and second internal conduits. The burner tip and protective cap and/or cladding layer include a generally central flow passage for a combustible mixture, the flow passage defined by an inner wall of the burner tip and protective cap.

Abstract: A nonwoven fibrous mat or web forming or treating system is disclosed comprising a movable, permeable wire or belt for carrying the fibrous mat or web over at least one suction tube assembly comprising a primary suction tube having a suction slot at the top of the primary suction tube and an exit tube communicating with the primary suction tube mounted beneath the permeable belt to have the suction slot on or close to the bottom surface of the movable belt. The suction slot is at least 3.6 meters long and up to more than 5.3 meters long, and the exit tube of the suction tube assembly communicates with the primary suction tube through an opening in the primary suction tube, the opening being generally centered around a centerline of the suction slot. This primary suction tube assembly provides a more uniform suction distribution along the suction slot and reduces fouling of the suction slot compared with previous suction tube assemblies.

Abstract: A nonwoven fibrous mat or web forming or treating system is disclosed comprising a movable, permeable wire or belt for carrying the fibrous mat or web over at least one suction tube assembly comprising a primary suction tube having a suction slot at the top of the primary suction tube and an exit tube communicating with the primary suction tube mounted beneath the permeable belt to have the suction slot on or close to the bottom surface of the movable belt. The suction slot is at least 3.6 meters long and up to more than 5.3 meters long, and the exit tube of the suction tube assembly communicates with the primary suction tube through an opening in the primary suction tube, the opening being generally centered around a centerline of the suction slot. This primary suction tube assembly provides a more uniform suction distribution along the suction slot and reduces fouling of the suction slot compared with previous suction tube assemblies.