Patents by Inventor Yihui Shen
Yihui Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240092884Abstract: An anti-ANGPTL3 antibody or an antigen-binding fragment thereof. The present invention provides an anti-ANGPTL3 antibody or an antigen-binding fragment thereof, wherein a heavy chain variable region includes complementarity determining regions (CDRs), including CDR-H1 having an amino acid sequence as set forth in SEQ ID No. 1, CDR-H2 having an amino acid sequence as set forth in SEQ ID No. 2, and CDR-H3 having an amino acid sequence as set forth in SEQ ID No. 3; and the CDRs of a light chain variable region includes CDR-L1 having an amino acid sequence as set forth in SEQ ID No. 4, CDR-L2 having an amino acid sequence as set forth in SEQ ID No. 5, and CDR-L3 having an amino acid sequence as set forth in SEQ ID No. 6. The antibody or the antigen-binding fragment thereof provided in the present invention can specifically recognize ANGPTL3.Type: ApplicationFiled: March 30, 2021Publication date: March 21, 2024Applicant: CHILDREN'S HOSPITAL OF FUDAN UNIVERSITYInventors: HONG XU, QIAN SHEN, JIA RAO, YIHUI ZHAI, LI SUN, HAIMEI LIU, QIANYING LV, XINLI HAN
-
Publication number: 20230128716Abstract: Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.Type: ApplicationFiled: August 8, 2022Publication date: April 27, 2023Inventors: WEI MIN, LU WEI, ZHIXING CHEN, FANGHAO HU, YIHUI SHEN
-
Patent number: 11408894Abstract: Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.Type: GrantFiled: December 17, 2019Date of Patent: August 9, 2022Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Wei Min, Lu Wei, Zhixing Chen, Fanghao Hu, Yihui Shen
-
Patent number: 11408892Abstract: Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.Type: GrantFiled: December 18, 2015Date of Patent: August 9, 2022Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Wei Min, Lu Wei, Zhixing Chen, Fanghao Hu, Yihui Shen
-
Publication number: 20210068663Abstract: Exemplary methods, systems and computer-accessible medium for detecting at least one condition of at least one disease. In particular, it is possible to administer at least one composition to at least one patient, where the at least one composition includes at least one bond-edited compound configured to target at least one of a disease tissue or a pathogen. Further, it is possible to receive information related to the administration of the composition to the patient. It is also possible to detect the at least one bond-edited compound using a Raman scattering arrangement.Type: ApplicationFiled: September 21, 2020Publication date: March 11, 2021Inventors: WEI MIN, LU WEI, ZHIXING CHEN, FANGHAO HU, YIHUI SHEN
-
Publication number: 20200200763Abstract: Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.Type: ApplicationFiled: December 17, 2019Publication date: June 25, 2020Inventors: WEI MIN, LU WEI, ZHIXING CHEN, FANGHAO HU, YIHUI SHEN
-
Publication number: 20180372632Abstract: Exemplary methods, systems and computer-accessible medium for detecting at least one condition of at least one disease. In particular, it is possible to administer at least one composition to at least one patient, where the at least one composition includes at least one bond-edited compound configured to target at least one of a disease tissue or a pathogen. Further, it is possible to receive information related to the administration of the composition to the patient. It is also possible to detect the at least one bond-edited compound using a Raman scattering arrangement.Type: ApplicationFiled: March 21, 2018Publication date: December 27, 2018Inventors: WEI MIN, LU WEI, ZHIXING CHEN, FANGHAO HU, YIHUI SHEN
-
Publication number: 20160243261Abstract: Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.Type: ApplicationFiled: December 18, 2015Publication date: August 25, 2016Inventors: WEI MIN, LU WEI, ZHIXING CHEN, FANGHAO HU, YIHUI SHEN
-
Patent number: 8567038Abstract: The invention relates to a vertical axis wind turbine, and in particular to an apparatus and method for transporting the vertical axis wind turbine. The method for transporting the vertical axis wind turbine, including the steps of: employing an apparatus to be a box or frame; situating a generator horizontally in the apparatus; fixing an upper flange and lower flange to a vertical shaft; fixing the base of the generator on the corresponding surface of the apparatus through holes at the base of the generator; and supporting the other end of the vertical shaft by a supporting object.Type: GrantFiled: June 20, 2011Date of Patent: October 29, 2013Inventors: Qiang Yan, Yihui Shen, Dong Zhang, Chaoqi Jiang, Haifeng Niu
-
Patent number: 8496433Abstract: A wind mill structure of a lift-type vertical axis wind turbine. The lift-type vertical axis wind turbine includes a vertical shaft and the wind mill includes a plurality of blades and supporting arms. The supporting arms hold the blades, and the blades are connected to the vertical shaft via the supporting arms. A setting angle, formed by a chord of the blades and a tangent line that goes through the center of the blades, ranges from ?12° to 12°. An angle, formed by the chord of the blade and the rotatable supporting arm, ranges from 7° to 100°. The wind mill can maintain relatively stable rotation speeds under wind speeds exceeding the rated wind speed by adjusting the angle of the supporting arms, thereby ensuring stable output from the vertical axis wind turbine.Type: GrantFiled: September 9, 2011Date of Patent: July 30, 2013Inventors: Qiang Yan, Yihui Shen, Dong Zhang, Chaoqi Jiang, Haifeng Niu
-
Patent number: 8390142Abstract: A vertical axis wind turbine including: a vertical axis wind mill having a vertical shaft and a generator having a generator rotor shaft, wherein the vertical shaft of the wind mill share the same shaft with the generator rotor shaft. This arrangement simplifies the structure and increases the stability, reliability, and service lifetime of vertical axis wind turbines by making on-site assembly easy and cutting the on-site workload and cost, without undermining the wind resistance capability and safety prompting wider application of vertical axis wind turbines.Type: GrantFiled: June 20, 2011Date of Patent: March 5, 2013Inventors: Qiang Yan, Yihui Shen, Dong Zhang, Chaoqi Jiang, Haifeng Niu
-
Publication number: 20120003092Abstract: A wind mill structure of a lift-type vertical axis wind turbine. The lift-type vertical axis wind turbine includes a vertical shaft and the wind mill includes a plurality of blades and supporting arms. The supporting arms hold the blades, and the blades are connected to the vertical shaft via the supporting arms. A setting angle, formed by a chord of the blades and a tangent line that goes through the center of the blades, ranges from ?12° to 12°. An angle, formed by the chord of the blade and the rotatable supporting arm, ranges from 7° to 100°. The wind mill can maintain relatively stable rotation speeds under wind speeds exceeding the rated wind speed by adjusting the angle of the supporting arms, thereby ensuring stable output from the vertical axis wind turbine.Type: ApplicationFiled: September 9, 2011Publication date: January 5, 2012Inventors: Qiang YAN, Yihui SHEN, Dong ZHANG, Chaoqi JIANG, Haifeng NIU
-
Publication number: 20110272224Abstract: A brake system for a vertical axis wind turbine including a brake device (3) that is connected with the rotor shaft of generator (1) or vertical shaft (2), brake shoes or brake calipers (4) which are controller by the electromagnetic actuator (11), a friction lining (6), as well as a safety pin (5) and a safety pin electromagnetic actuator (22) that controls the safety pin (5).The brake device (3) is a brake drum or a brake disc. The brake system of the invention is able to reduce the vibration of the vertical axis wind turbine in strong wind conditions effectively without the need of reinforcing the wind turbine's ability to withstand strong winds, thus increasing the safety and reliability of the vertical axis wind turbine. A method for braking a vertical axis wind turbine is also provided.Type: ApplicationFiled: July 21, 2011Publication date: November 10, 2011Inventors: Qiang YAN, Yihui SHEN, Dong ZHANG, Chaoqi JIANG, Haifeng NIU
-
Publication number: 20110248510Abstract: A vertical axis wind turbine including: a vertical axis wind mill having a vertical shaft and a generator having a generator rotor shaft, wherein the vertical shaft of the wind mill share the same shaft with the generator rotor shaft. This arrangement simplifies the structure and increases the stability, reliability, and service lifetime of vertical axis wind turbines by making on-site assembly easy and cutting the on-site workload and cost, without undermining the wind resistance capability and safety prompting wider application of vertical axis wind turbines.Type: ApplicationFiled: June 20, 2011Publication date: October 13, 2011Inventors: Qiang YAN, Yihui SHEN, Dong ZHANG, Chaoqi JIANG, Haifeng NIU
-
Publication number: 20110239460Abstract: The invention relates to a vertical axis wind turbine, and in particular to an apparatus and method for transporting the vertical axis wind turbine. The method for transporting the vertical axis wind turbine, including the steps of: employing an apparatus to be a box or frame; situating a generator horizontally in the apparatus; fixing an upper flange and lower flange to a vertical shaft; fixing the base of the generator on the corresponding surface of the apparatus through holes at the base of the generator; and supporting the other end of the vertical shaft by a supporting object.Type: ApplicationFiled: June 20, 2011Publication date: October 6, 2011Inventors: Qiang YAN, Yihui SHEN, Dong ZHANG, Chaoqi JIANG, Haifeng NIU