Patents by Inventor Yihui Shen

Yihui Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240092884
    Abstract: An anti-ANGPTL3 antibody or an antigen-binding fragment thereof. The present invention provides an anti-ANGPTL3 antibody or an antigen-binding fragment thereof, wherein a heavy chain variable region includes complementarity determining regions (CDRs), including CDR-H1 having an amino acid sequence as set forth in SEQ ID No. 1, CDR-H2 having an amino acid sequence as set forth in SEQ ID No. 2, and CDR-H3 having an amino acid sequence as set forth in SEQ ID No. 3; and the CDRs of a light chain variable region includes CDR-L1 having an amino acid sequence as set forth in SEQ ID No. 4, CDR-L2 having an amino acid sequence as set forth in SEQ ID No. 5, and CDR-L3 having an amino acid sequence as set forth in SEQ ID No. 6. The antibody or the antigen-binding fragment thereof provided in the present invention can specifically recognize ANGPTL3.
    Type: Application
    Filed: March 30, 2021
    Publication date: March 21, 2024
    Applicant: CHILDREN'S HOSPITAL OF FUDAN UNIVERSITY
    Inventors: HONG XU, QIAN SHEN, JIA RAO, YIHUI ZHAI, LI SUN, HAIMEI LIU, QIANYING LV, XINLI HAN
  • Publication number: 20230128716
    Abstract: Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.
    Type: Application
    Filed: August 8, 2022
    Publication date: April 27, 2023
    Inventors: WEI MIN, LU WEI, ZHIXING CHEN, FANGHAO HU, YIHUI SHEN
  • Patent number: 11408894
    Abstract: Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: August 9, 2022
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Wei Min, Lu Wei, Zhixing Chen, Fanghao Hu, Yihui Shen
  • Patent number: 11408892
    Abstract: Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: August 9, 2022
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Wei Min, Lu Wei, Zhixing Chen, Fanghao Hu, Yihui Shen
  • Publication number: 20210068663
    Abstract: Exemplary methods, systems and computer-accessible medium for detecting at least one condition of at least one disease. In particular, it is possible to administer at least one composition to at least one patient, where the at least one composition includes at least one bond-edited compound configured to target at least one of a disease tissue or a pathogen. Further, it is possible to receive information related to the administration of the composition to the patient. It is also possible to detect the at least one bond-edited compound using a Raman scattering arrangement.
    Type: Application
    Filed: September 21, 2020
    Publication date: March 11, 2021
    Inventors: WEI MIN, LU WEI, ZHIXING CHEN, FANGHAO HU, YIHUI SHEN
  • Publication number: 20200200763
    Abstract: Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.
    Type: Application
    Filed: December 17, 2019
    Publication date: June 25, 2020
    Inventors: WEI MIN, LU WEI, ZHIXING CHEN, FANGHAO HU, YIHUI SHEN
  • Publication number: 20180372632
    Abstract: Exemplary methods, systems and computer-accessible medium for detecting at least one condition of at least one disease. In particular, it is possible to administer at least one composition to at least one patient, where the at least one composition includes at least one bond-edited compound configured to target at least one of a disease tissue or a pathogen. Further, it is possible to receive information related to the administration of the composition to the patient. It is also possible to detect the at least one bond-edited compound using a Raman scattering arrangement.
    Type: Application
    Filed: March 21, 2018
    Publication date: December 27, 2018
    Inventors: WEI MIN, LU WEI, ZHIXING CHEN, FANGHAO HU, YIHUI SHEN
  • Publication number: 20160243261
    Abstract: Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.
    Type: Application
    Filed: December 18, 2015
    Publication date: August 25, 2016
    Inventors: WEI MIN, LU WEI, ZHIXING CHEN, FANGHAO HU, YIHUI SHEN
  • Patent number: 8567038
    Abstract: The invention relates to a vertical axis wind turbine, and in particular to an apparatus and method for transporting the vertical axis wind turbine. The method for transporting the vertical axis wind turbine, including the steps of: employing an apparatus to be a box or frame; situating a generator horizontally in the apparatus; fixing an upper flange and lower flange to a vertical shaft; fixing the base of the generator on the corresponding surface of the apparatus through holes at the base of the generator; and supporting the other end of the vertical shaft by a supporting object.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: October 29, 2013
    Inventors: Qiang Yan, Yihui Shen, Dong Zhang, Chaoqi Jiang, Haifeng Niu
  • Patent number: 8496433
    Abstract: A wind mill structure of a lift-type vertical axis wind turbine. The lift-type vertical axis wind turbine includes a vertical shaft and the wind mill includes a plurality of blades and supporting arms. The supporting arms hold the blades, and the blades are connected to the vertical shaft via the supporting arms. A setting angle, formed by a chord of the blades and a tangent line that goes through the center of the blades, ranges from ?12° to 12°. An angle, formed by the chord of the blade and the rotatable supporting arm, ranges from 7° to 100°. The wind mill can maintain relatively stable rotation speeds under wind speeds exceeding the rated wind speed by adjusting the angle of the supporting arms, thereby ensuring stable output from the vertical axis wind turbine.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: July 30, 2013
    Inventors: Qiang Yan, Yihui Shen, Dong Zhang, Chaoqi Jiang, Haifeng Niu
  • Patent number: 8390142
    Abstract: A vertical axis wind turbine including: a vertical axis wind mill having a vertical shaft and a generator having a generator rotor shaft, wherein the vertical shaft of the wind mill share the same shaft with the generator rotor shaft. This arrangement simplifies the structure and increases the stability, reliability, and service lifetime of vertical axis wind turbines by making on-site assembly easy and cutting the on-site workload and cost, without undermining the wind resistance capability and safety prompting wider application of vertical axis wind turbines.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: March 5, 2013
    Inventors: Qiang Yan, Yihui Shen, Dong Zhang, Chaoqi Jiang, Haifeng Niu
  • Publication number: 20120003092
    Abstract: A wind mill structure of a lift-type vertical axis wind turbine. The lift-type vertical axis wind turbine includes a vertical shaft and the wind mill includes a plurality of blades and supporting arms. The supporting arms hold the blades, and the blades are connected to the vertical shaft via the supporting arms. A setting angle, formed by a chord of the blades and a tangent line that goes through the center of the blades, ranges from ?12° to 12°. An angle, formed by the chord of the blade and the rotatable supporting arm, ranges from 7° to 100°. The wind mill can maintain relatively stable rotation speeds under wind speeds exceeding the rated wind speed by adjusting the angle of the supporting arms, thereby ensuring stable output from the vertical axis wind turbine.
    Type: Application
    Filed: September 9, 2011
    Publication date: January 5, 2012
    Inventors: Qiang YAN, Yihui SHEN, Dong ZHANG, Chaoqi JIANG, Haifeng NIU
  • Publication number: 20110272224
    Abstract: A brake system for a vertical axis wind turbine including a brake device (3) that is connected with the rotor shaft of generator (1) or vertical shaft (2), brake shoes or brake calipers (4) which are controller by the electromagnetic actuator (11), a friction lining (6), as well as a safety pin (5) and a safety pin electromagnetic actuator (22) that controls the safety pin (5).The brake device (3) is a brake drum or a brake disc. The brake system of the invention is able to reduce the vibration of the vertical axis wind turbine in strong wind conditions effectively without the need of reinforcing the wind turbine's ability to withstand strong winds, thus increasing the safety and reliability of the vertical axis wind turbine. A method for braking a vertical axis wind turbine is also provided.
    Type: Application
    Filed: July 21, 2011
    Publication date: November 10, 2011
    Inventors: Qiang YAN, Yihui SHEN, Dong ZHANG, Chaoqi JIANG, Haifeng NIU
  • Publication number: 20110248510
    Abstract: A vertical axis wind turbine including: a vertical axis wind mill having a vertical shaft and a generator having a generator rotor shaft, wherein the vertical shaft of the wind mill share the same shaft with the generator rotor shaft. This arrangement simplifies the structure and increases the stability, reliability, and service lifetime of vertical axis wind turbines by making on-site assembly easy and cutting the on-site workload and cost, without undermining the wind resistance capability and safety prompting wider application of vertical axis wind turbines.
    Type: Application
    Filed: June 20, 2011
    Publication date: October 13, 2011
    Inventors: Qiang YAN, Yihui SHEN, Dong ZHANG, Chaoqi JIANG, Haifeng NIU
  • Publication number: 20110239460
    Abstract: The invention relates to a vertical axis wind turbine, and in particular to an apparatus and method for transporting the vertical axis wind turbine. The method for transporting the vertical axis wind turbine, including the steps of: employing an apparatus to be a box or frame; situating a generator horizontally in the apparatus; fixing an upper flange and lower flange to a vertical shaft; fixing the base of the generator on the corresponding surface of the apparatus through holes at the base of the generator; and supporting the other end of the vertical shaft by a supporting object.
    Type: Application
    Filed: June 20, 2011
    Publication date: October 6, 2011
    Inventors: Qiang YAN, Yihui SHEN, Dong ZHANG, Chaoqi JIANG, Haifeng NIU