Abstract: The present disclosure relates to the field of medicine. In particular, it relates to novel antisense oligonucleotides that prevent or reduce exon 8 skipping in the SLC26A4 gene during pre-mRNA splicing, and their use in the treatment of Pendred Syndrome.

Abstract: The present disclosure relates to the field of medicine. In particular, it relates to novel antisense oligonucleotides that prevent or reduce exon 8 skipping in the SLC26A4 gene during pre-mRNA splicing, and their use in the treatment of Pendred Syndrome.

Abstract: The present disclosure relates to the field of medicine. In particular, it relates to novel antisense oligonucleotides that prevent or reduce exon 8 skipping in the SLC26A4 gene during pre-mRNA splicing, and their use in the treatment of Pendred Syndrome.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

Abstract: A movable system includes a movable platform that includes a motorized drive to cause the movable platform to move in position, and a compartment located in an interior part of the movable platform; and an LIDAR system mounted to the movable platform including a probe fiber laser module located on the movable platform and producing pulsed probe laser light and scan the pulsed probe laser light out for optically sensing presence of one or more objects in the surrounding area based on detection of reflected probe laser light from the one or more objects. The probe fiber laser module includes a base laser module located inside the enclosure of the compartment and remote laser modules distributed at the platform instrument holding portions to scan the pulsed probe laser light out for optically sensing presence of one or more objects in the surrounding area.

Abstract: A movable system includes a movable platform that includes a motorized drive to cause the movable platform to move in position, and a compartment located in an interior part of the movable platform; and an LIDAR system mounted to the movable platform including a probe fiber laser module located on the movable platform and producing pulsed probe laser light and scan the pulsed probe laser light out for optically sensing presence of one or more objects in the surrounding area based on detection of reflected probe laser light from the one or more objects. The probe fiber laser module includes a base laser module located inside the enclosure of the compartment and remote laser modules distributed at the platform instrument holding portions to scan the pulsed probe laser light out for optically sensing presence of one or more objects in the surrounding area.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

Abstract: The present disclosure provides a doped fiber amplifier and a working method thereof. The doped fiber amplifier including a seed source inputting signal light, a first isolator connected with the seed source, a coupler connected with the first isolator, a pump laser and a doped fiber connected with the coupler, a second isolator connected with the doped fiber, an optical splitter connected with the second isolator, and a connection head connected with the optical splitter. The connection head outputs a signal light of the seed source.

Abstract: The present disclosure provides an array-type light source light-splitting device and a light splitting method thereof. The array-type light source light-splitting device includes a seed source inputting signal light, an optical fiber amplifier connected with the seed source, and a light splitter connected with the optical fiber amplifier. The light splitter includes N paths of optical fibers. N is a natural number. The light splitter splits the signal light of the seed source into N paths and outputs them. The light splitter splits the signal light of the seed source into multi-path signal light and outputs them, meanwhile the power is amplified by the optical fiber amplifier of each path to become the multi-path signal light and outputs them. A repetition rate of the 1550 nm laser is able to reach megahertz.

Abstract: Disclosed herein are compounds, compositions and methods for treatment of diseases and disorders, including spinal muscular atrophy.

Abstract: An optical comb filter, comprising an input/output collimator (50), an output collimator (60), a spectroscope (10), and first, second and third GT resonant cavities (20, 30, 40), wherein each GT resonant cavity comprises a transparent solid block coated with a membrane layer and a spacing part, a through hole is provided on the transparent solid block, and the transparent solid block and the spacing part form a hollow cavity; and rectangular orientation of an insertion loss curve is realized, and the bandwidth utilization rate is high.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

Abstract: A tunable PLC optical filter having sequentially connected thermally tunable Mach-Zehnder (MZ) interferometers is described. The cascade of MZ interferometers, each having a free spectral ranges matching ITU frequency grid spacing, are tuned so as to have a common passband centered on the frequency of the signal being selected, while having at least one of the stopbands centered on any other ITU frequency. Any other optical channel that may be present at any other ITU frequency is suppressed as a result. Another MZ interferometer in series with the cascade of interferometers including an asymmetric or variable coupler, is tuned to have low transmission at the center frequency of the selected optical channel.

Abstract: A coating of a random copolymer of acrylamide and a second monomer, e.g. glycidoxylmethacrylate, for a silica surface is described. The coating is applied to chromatographic support structures having silica based surfaces. The coating is functionalized to produce protein chromatography matrices that are particularly useful for extracting trace amounts of biomarker molecules from biological samples.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

Abstract: A tunable PLC optical filter having sequentially connected thermally tunable Mach-Zehnder (MZ) interferometers is described. The cascade of MZ interferometers, each having a free spectral ranges matching ITU frequency grid spacing, are tuned so as to have a common passband centered on the frequency of the signal being selected, while having at least one of the stopbands centered on any other ITU frequency. Any other optical channel that may be present at any other ITU frequency is suppressed as a result. Another MZ interferometer in series with the cascade of interferometers including an asymmetric or variable coupler, is tuned to have low transmission at the center frequency of the selected optical channel.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

Abstract: A self-assembled engineered lattice of nanometer-scale silica particles, or other suitable particles generally resembling regularly-sized spheres, is configured in a separation bed for electrophoresis, isoelectric focusing, chromatography, or other voltage-induced separation of analytes. After separation, the analytes are immobilized on the separation bed and then ionized using matrix-assisted laser desorption/ionization (MALDI) for use with a mass spectrometer. The nanoparticles can be coated with polymers that activate to immobilize the analytes or assist with MALDI. The separation can occur in two dimensions.

Abstract: An optical comb filter, comprising an input/output collimator (50), an output collimator (60), a spectroscope (10), and first, second and third GT resonant cavities (20, 30, 40), wherein each GT resonant cavity comprises a transparent solid block coated with a membrane layer and a spacing part, a through hole is provided on the transparent solid block, and the transparent solid block and the spacing part form a hollow cavity; and rectangular orientation of an insertion loss curve is realized, and the bandwidth utilization rate is high.