Abstract: The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.

Abstract: An elliptical exerciser includes a frame, first and second magnetic control wheel units, first and second swing levers, first and second transmission rods, first and second guiding mechanisms, first and second pedal rods, and a magnetic mechanism. When the first and second swing levers and the first and second transmission rods are swung forward and rearward synchronously and the first and second pedal rods are pedaled up and down to slide forward and rearward, the first and second pedal rods pivotally connected with bottom ends of the first and second swing levers are to do a tread motion of an elliptical trajectory.

Abstract: An elliptical trainer comprises a frame set, two first transmission rods, two second transmission rods, two footboard assemblies, a holding flywheel assembly, a stand flywheel assembly, and two eccentric link rods. When a user is stepping the two footboard assemblies and taking exercise with elbows on the two second transmission rods, the two footboard assemblies may be stepped up and down to recycle and each second transmission rod may be rotated to reciprocate along an arc and centered in a stand ear. At this time, each drag rod of two stand ears arranged right and left may pull the corresponding eccentric link assembly to rotate 360 degree and the torque of the third flywheel may not overlap each drag rod of each eccentric link assembly vertically. Accordingly, the arrangement of each eccentric link assembly may prevent the swing operation from being stuck to pause or operate unsmoothly.

Abstract: An elliptical exerciser includes a frame, first and second magnetic control wheel units, first and second swing levers, first and second transmission rods, first and second guiding mechanisms, first and second pedal rods, and a magnetic mechanism. When the first and second swing levers and the first and second transmission rods are swung forward and rearward synchronously and the first and second pedal rods are pedaled up and down to slide forward and rearward, the first and second pedal rods pivotally connected with bottom ends of the first and second swing levers are to do a tread motion of an elliptical trajectory.

Abstract: Provided is a semiconductor device including a P-type substrate, a P-type first well region, an N-type second well region, a gate, N-type source and drain regions, a dummy gate and an N-type deep well region. The first well region is in the substrate. The second well region is in the substrate proximate to the first well region. The gate is on the substrate and covers a portion of the first well region and a portion of the second well region. The source region is in the first well region at one side of the gate. The drain region is in the second well region at another side of the gate. The dummy gate is on the substrate between the gate and the drain region. The deep well region is in the substrate and surrounds the first and second well regions. An operation method of the semiconductor device is further provided.

Abstract: Provided is a semiconductor device including a P-type substrate, a P-type first well region, an N-type second well region, a gate, N-type source and drain regions, a dummy gate and an N-type deep well region. The first well region is in the substrate. The second well region is in the substrate proximate to the first well region. The gate is on the substrate and covers a portion of the first well region and a portion of the second well region. The source region is in the first well region at one side of the gate. The drain region is in the second well region at another side of the gate. The dummy gate is on the substrate between the gate and the drain region. The deep well region is in the substrate and surrounds the first and second well regions. An operation method of the semiconductor device is further provided.

Abstract: An exercise machine comprises an oval-shaped structure with a fly wheel, two driving arms, two swing handle and two slidable bars. The fly wheel of the oval-shaped structure simultaneously drives the driving arms and the swing handles, and the slidable bars are pivoted onto the corresponding swing handles and rest on corresponding shafts of the fly wheel such that the movements of the slidable bars are not limited by the driving arms and can be longer than the travel stroke of the fly wheel.

Abstract: An exercise machine comprises an oval-shaped structure, two driving arms, two swing handles and two slidable bars. With the above-mentioned embodiments, following benefits can be obtained, the fly wheel of the oval-shaped structure utilizes the assembling section to be connected an adjusting member, such that the movement strokes can be adjusted.

Abstract: An oval transmission structure utilizes lower ends of swaying moving shafts at two sides thereof to pivot to front ends of push-pull shafts, whose front portions slope to a determined angle. Rear portions of the push-pull shafts offer treadle frames for treadles to dispose with feet. Rear portions of the push-pull shafts further offer a track frame. An assistant device provides a sliding block with a fixing bolt superimposed at a side of the lower portion of the swaying moving shaft. An attached shaft pivoted to a side of the sliding block connects to an axle bolt of a transmission shaft, whose front end axially connects to a crank, whose rear end serially connects to a track wheel and whose middle determined position disposes a sliding wheel thereunder. The reciprocation brought about by the feet, the two cranks axially trigger the front ends of the two transmission shaft for achieving a relative oval action.

Abstract: A transmission structure of a waist twirling exercise machine for body-building and a method thereof includes left and right stepping rods which are obliquely or horizontally connected to a machine base, left and right stepping platforms having left and right shafts inserting through lubricating members provided in through holes of the left and right stepping rods, left and right transmission members having first ends connected to the left and right shafts and second ends provided with eccentric blocks, left and right connecting rods having first ends connected to the eccentric blocks of the left and right transmission members and second ends pivotally connected to either of the machine base and pneumatic cylinders. When the left and right stepping platforms are treaded in turn, the left and right connecting rods subject to their lengths will drive the left and right stepping platforms to turn left and right in turn synchronously, enhancing a waist twirling effect.

Abstract: An exercise machine comprises an oval-shaped structure, two driving arms, two swing handle and two slidable bars. The fly wheel of the oval-shaped mechanism simultaneously drives the driving arms and the swing handle, and the slidable bars are pivoted onto the assembling portion of the swing handle and rest on the shaft of the fly wheel such that the movements of the slidable bars are not limited by the driving arms and longer the travel stroke of the fly wheel.

Abstract: An oval transmission structure utilizes lower ends of swaying moving shafts at two sides thereof to pivot to front ends of push-pull shafts, whose front portions slope to a determined angle. Rear portions of the push-pull shafts offer treadle frames for treadles to dispose with feet. Rear portions of the push-pull shafts further offer a track frame. An assistant device provides a sliding block with a fixing bolt superimposed at a side of the lower portion of the swaying moving shaft. An attached shaft pivoted to a side of the sliding block connects to an axle bolt of a transmission shaft, whose front end axially connects to a crank, whose rear end serially connects to a track wheel and whose middle determined position disposes a sliding wheel thereunder. The reciprocation brought about by the feet, the two cranks axially trigger the front ends of the two transmission shaft for achieving a relative oval action.

Abstract: A stepping and waist twirling exercise machine includes left and right stepping rods having left and right through holes and left and right stepping platforms having left and right shafts. The shafts are inserted into bearings provided in the through holes. Left and right coil rollers are provided on the shafts. The coil rollers are provided with left and right rope units each having left and right ropes. The ropes have first ends and second ends. The first ends of the ropes are secured to two sides of the coil rollers, respectively. The second ends of the ropes are secured to a frame and a machine base, respectively. When the left and right stepping platforms are stepped downward in turn, the left and right rope units will bring the left and right coil rollers to turn left or right synchronously, providing active or passive stepping and waist twirling exercise.

Abstract: A transmission structure of a waist twirling exercise machine for body-building and a method thereof includes left and right stepping rods which are obliquely or horizontally connected to a machine base, left and right stepping platforms having left and right shafts inserting through lubricating members provided in through holes of the left and right stepping rods, left and right transmission members having first ends connected to the left and right shafts and second ends provided with eccentric blocks, left and right connecting rods having first ends connected to the eccentric blocks of the left and right transmission members and second ends pivotally connected to either of the machine base and pneumatic cylinders. When the left and right stepping platforms are treaded in turn, the left and right connecting rods subject to their lengths will drive the left and right stepping platforms to turn left and right in turn synchronously, enhancing a waist twirling effect.

Abstract: An auxiliary structure to improve efficacy of a fitness equipment includes a pair of swing bars pivoted to a pair of traction bars wherein in turn pivoted to a crank; the crank drives a sprocket and a resistance control wheel for both swing bars to drive both traction bars to travel up, down, back and forth; each pedal is disposed with a roller to travel in a slide attached to the traction bar and is pivoted to a pull-and-push connection bar, which in turn is pivoted to a transmission connection bar; each transmission connection bar is pivoted to a support; each mid section of the transmission connection bar is pivoted to an active connection bar, which in turn is pivoted to the swing bar; and each pedal is dragged by the push-and-pull connection bar driven by the transmission connection bar when both swing bars alternatively swing to drive the transmission connecting bar to increase longitudinal travel ranges of both pedals for providing adequate exercise amount for waist and legs of a user to improve exerci

Abstract: An auxiliary structure to improve efficacy of a fitness equipment includes a pair of swing bars pivoted to a pair of traction bars wherein in turn pivoted to a crank; the crank drives a sprocket and a resistance control wheel for both swing bars to drive both traction bars to travel up, down, back and forth; each pedal is disposed with a roller to travel in a slide attached to the traction bar and is pivoted to a pull-and-push connection bar, which in turn is pivoted to a transmission connection bar; each transmission connection bar is pivoted to a support; each mid section of the transmission connection bar is pivoted to an active connection bar, which in turn is pivoted to the swing bar; and each pedal is dragged by the push-and-pull connection bar driven by the transmission connection bar when both swing bars alternatively swing to drive the transmission connecting bar to increase longitudinal travel ranges of both pedals for providing adequate exercise amount for waist and legs of a user to improve exerci

Abstract: Chair-rotating control mechanism applied to sport apparatus, wherein driven gear sector is to drive the connected eccentric shaft to rotate, chair pivoted with an eccentric shaft is driven by rotating shaft of pedal or decelerating motor, or both of them move together as power source, this control mechanism can be applied to bicycle, exercising bicycle and AB chair to control rotation of chair, so that it can turn around waist and hip of rider when riding on it to do exercise.

Abstract: An electric wheel axle drive structure with automatic clutch function comprised of a direct current drive motor, a driving worm driven into rotation installed at its front side and upper extent, and a driven shaft disposed perpendicularly at the lower extent of the worm, the rotation of which is transferred to wheels conjoined to its outer lateral ends. Sleeved onto the inner section of the driven gear, having an angle that is the same as the spiral angle of the worm and, furthermore, a teeth face width slightly larger than the shaft width of the worm, constituting a contained-type bevel section enmeshment with it, and receiving its driving force is a bevel gear. At the front extent of the bevel gear is a driving mesh disc having distributed laterally faced, annular-shaped, and bi-directional sloped teeth.