Patents by Inventor Ying-Fei Wei
Ying-Fei Wei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8372948Abstract: The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: GrantFiled: November 3, 2008Date of Patent: February 12, 2013Assignee: Human Genome Sciences, Inc.Inventors: Jian Ni, Paul E. Young, Joseph J. Kenny, Henrik S. Olsen, Paul A. Moore, Ying-Fei Wei, John M. Greene, Steven M. Ruben, Ding Liu, Paul R. Crocker
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Patent number: 8268979Abstract: A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.Type: GrantFiled: March 10, 2011Date of Patent: September 18, 2012Assignee: Human Genome Sciences, Inc.Inventor: Ying-Fei Wei
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Publication number: 20110224415Abstract: A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.Type: ApplicationFiled: March 10, 2011Publication date: September 15, 2011Applicant: Human Genome Sciences, Inc.Inventor: Ying-Fei Wei
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Patent number: 7927803Abstract: A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.Type: GrantFiled: September 4, 2008Date of Patent: April 19, 2011Assignee: Human Genome Sciences, Inc.Inventor: Ying-Fei Wei
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Patent number: 7838636Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: GrantFiled: June 8, 2007Date of Patent: November 23, 2010Assignee: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Craig A. Rosen, Ying-Fei Wei
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Patent number: 7829293Abstract: The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine ?-15 protein. Chemokine ?-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.Type: GrantFiled: October 2, 2006Date of Patent: November 9, 2010Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Brent L. Kreider, Craig A. Rosen
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Publication number: 20100130417Abstract: The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders, and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptides and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.Type: ApplicationFiled: June 30, 2009Publication date: May 27, 2010Inventors: Ying-Fei Wei, Paul S. Meissner, Jian Ni
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Publication number: 20090311256Abstract: The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: November 3, 2008Publication date: December 17, 2009Applicant: Human Genome Sciences, Inc.Inventors: Jian Ni, Paul E. Young, Joseph J. Kenny, Henrik S. Olsen, Paul A. Moore, Ying-Fei Wei, John M. Greene, Steven M. Ruben, Ding Liu, Paul R. Crocker
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Publication number: 20090088555Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: November 20, 2008Publication date: April 2, 2009Applicant: Human Genome Sciences, Inc.Inventors: David W. LaFleur, Steven M. Ruben, Craig A. Rosen, Paul A. Moore, Yanggu Shi, Hla Kyaw, Ying-Fei Wei
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Patent number: 7511017Abstract: The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.Type: GrantFiled: July 18, 2005Date of Patent: March 31, 2009Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Jian Ni, Reiner L. Gentz, Steven M. Ruben
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Publication number: 20090029380Abstract: A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.Type: ApplicationFiled: September 4, 2008Publication date: January 29, 2009Applicant: Human Genome Sciences, Inc.Inventor: Ying-Fei Wei
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Publication number: 20090005301Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: June 7, 2007Publication date: January 1, 2009Applicant: Human Genome Sciences, Inc.Inventors: Jian Ni, Reinhard Ebner, David W. LaFleur, Paul A. Moore, Henrik S. Olsen, Craig A. Rosen, Steven M. Ruben, Daniel R. Soppet, Paul E. Young, Yanggu Shi, Kimberly A. Florence, Ying-Fei Wei, Charles Florence, Jing-Shan Hu, Yi Li, Hla Kyaw, Carrie L. Fischer, Ann M. Ferrie, Ping Fan, Ping Feng, Gregory A. Endress, Patrick J. Dillon, Kenneth C. Carter, Laurie A. Brewer, Guo-Liang Yu, Zhizhen Zeng, John M. Greene
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Patent number: 7470510Abstract: A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid sequence endcoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, area also disclosed.Type: GrantFiled: February 12, 2003Date of Patent: December 30, 2008Assignee: Human Genome Sciences, Inc.Inventor: Ying-Fei Wei
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Publication number: 20080317756Abstract: The present invention relates to a novel CK?-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-5 protein. CK?-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CK?-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CK?-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.Type: ApplicationFiled: January 22, 2008Publication date: December 25, 2008Inventors: Ying-Fei Wei, Yi Li, Jian Ni, Craig A. Rosen, Steven M. Ruben
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Publication number: 20080226586Abstract: The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine ?-15 protein. Chemokine ?-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.Type: ApplicationFiled: October 2, 2006Publication date: September 18, 2008Applicant: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Brent Kreider, Craig Rosen
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Publication number: 20080051338Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: July 12, 2007Publication date: February 28, 2008Applicant: Human Genome Sciences, Inc.Inventors: George Komatsoulis, Craig Rosen, Steven Ruben, Roxanne Duan, Paul Moore, Yanggu Shi, David LaFleur, Ying-Fei Wei, Jian Ni, Kimberly Florence, Paul Young, Laurie Brewer, Daniel Soppet, Gregory Endress, Reinhard Ebner, Henrik Olsen, Michael Mucenski
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Patent number: 7320869Abstract: The present invention relates to a novel CK?-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK?-5 protein. CK?-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CK?-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CK?-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.Type: GrantFiled: September 13, 2005Date of Patent: January 22, 2008Assignee: Human Genome Sciences, Inc.Inventors: Ying-Fei Wei, Yi Li, Jian Ni, Craig A. Rosen, Steven M. Ruben
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Publication number: 20070203070Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: May 4, 2007Publication date: August 30, 2007Applicant: Human Genome Sciences, Inc.Inventors: Craig Rosen, Steven Ruben, Yi Li, Zhizhen Zeng, Hla Kyaw, Carrie Fischer, Haodong Li, Daniel Soppet, Reiner Gentz, Ying-Fei Wei, Paul Moore, Paul Young, John Greene, Ann Ferrie, Gregg Hastings
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Publication number: 20070172830Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: May 21, 2004Publication date: July 26, 2007Applicant: Human Genome Sciences, Inc.Inventors: Steven Ruben, Kimberly Florence, Jian Ni, Craig Rosen, Kenneth Carter, Paul Moore, Henrik Olsen, Yanggu Shi, Paul Young, Ying-Fei Wei, Laurie Brewer, Daniel Soppet, David LaFleur, Gregory Endress, Reinhard Ebner, Charles Birse
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Patent number: 7247442Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: GrantFiled: May 21, 2004Date of Patent: July 24, 2007Assignee: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Kimberly A. Florence, Jian Ni, Craig A. Rosen, Kenneth C. Carter, Paul A. Moore, Henrik S. Olsen, Yanggu Shi, Paul E. Young, Ying-Fei Wei, Laurie A. Brewer, Daniel R. Soppet, David W. LaFleur, Gregory A. Endress, Reinhard Ebner, Charles E. Birse