Patents by Inventor Ying Lian
Ying Lian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11988664Abstract: An immunochromatographic detection device adapted for detecting an analyte in a specimen includes a surface-modified cellulose membrane, a detection unit, and a substrate. The surface-modified cellulose membrane includes opposite top and bottom surfaces, cellulose fibers, and an anti-biofouling acrylic copolymer that is bonded to the cellulose fibers. The detection unit is disposed on the top surface of the cellulose membrane, is configured to interact with the specimen, and includes a diffusion layer, a capturing layer, a detection layer, a control line layer, and an absorbent layer. The substrate is disposed on the bottom surface of the surface-modified cellulose membrane.Type: GrantFiled: November 15, 2022Date of Patent: May 21, 2024Assignee: SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Ying-Nien Chou, Mei-Lian Yao
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Publication number: 20240160763Abstract: The disclosure provides a configuration method, data integration method, apparatus, device and storage medium of data integration strategy. The method includes obtaining a data structure of a data source based on an access credential of the data source; and configuring a data structure of an external object for the data structure of the data source, wherein there is a mapping relationship between the data structure of the external object and the data structure of the data source.Type: ApplicationFiled: November 10, 2023Publication date: May 16, 2024Inventors: Xiaoyi Peng, Yaoxuan Wang, Ying Lian
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Publication number: 20240091810Abstract: The present disclosure provides a three-dimensionally arranged nanoparticle film and a preparation method and use thereof, and belongs to the technical field of nanophotonics. The preparation method includes the following steps: coating nanoparticles with hydrophobic molecules, and dispersing in an organic solvent to obtain a modified nanoparticle dispersion; conducting a surface treatment on a three-dimensional template to obtain a hydrophilic three-dimensional template; and adding water to a surface of the hydrophilic three-dimensional template to form a water film, adding the modified nanoparticle dispersion dropwise on a surface of the water film to conduct self-assembly, and removing the water film to obtain a three-dimensionally arranged nanoparticle film with an array structure.Type: ApplicationFiled: March 3, 2022Publication date: March 21, 2024Applicant: TAIYUAN UNIVERSITY OF TECHNOLOGYInventors: Shaoding LIU, Wei GENG, Peng YUE, Lanqi LIAN, Ying YU
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Publication number: 20240086563Abstract: A method for operating a graph database, including receiving, by a computer system, a query to a particular graph database, the query identifying a plurality of vertices of the particular graph database. The method further includes performing, by the computer system, hash operations on two or more of the plurality of vertices to generate respective hash values and dividing, using the respective hash values, the query into a plurality of sub-queries, each corresponding to a subset of the plurality of vertices. The method also includes sending, by the computer system, ones of the plurality of sub-queries to a plurality of database repositories for the particular graph database.Type: ApplicationFiled: November 9, 2022Publication date: March 14, 2024Inventors: Xia Zhang, Pengshan Zhang, Kun Wang, Jiaxin Fang, Jun Li, Xin Wang, Yangxing Liu, Yu Zhang, Changle Lian, Ying Yue, Xiaojun Luan
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Patent number: 9598469Abstract: The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polypeptides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.Type: GrantFiled: December 26, 2013Date of Patent: March 21, 2017Assignees: Novartis Vaccines and Diagnostics, Inc., University of StellenboschInventors: Jan Zur Megede, Susan Barnett, Ying Lian, Susan Engelbrecht, Estrelita Janse Van Rensberg, Thomas J. Scriba
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Publication number: 20140220060Abstract: The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polypeptides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.Type: ApplicationFiled: December 26, 2013Publication date: August 7, 2014Applicant: NOVARTIS VACCINES & DIAGNOSTICS, INC.Inventors: Jan ZUR MEGEDE, Susan BARNETT, Ying LIAN, Susan ENGELBRECHT, Estrelita Janse VAN RENSBERG, Thomas J. SCRIBA
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Publication number: 20120269851Abstract: The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polypeptides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.Type: ApplicationFiled: February 17, 2012Publication date: October 25, 2012Applicants: University of Stellenbosch, NOVARTIS VACCINES & DIAGNOSTICS, INC.Inventors: Jan zur Megede, Susan Barnett, Ying Lian, Susan Engelbrecht, Estrelita Janse van Rensburg, Thomas J. Scriba
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Publication number: 20120269840Abstract: The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.Type: ApplicationFiled: April 27, 2012Publication date: October 25, 2012Applicant: NOVARTIS VACCINES AND DIAGNOSTICS. INC.Inventors: Susan W. BARNETT, Jan ZUR MEGEDE, Indresh SRIVASTAVA, Ying LIAN, Karin HARTOG, Hong LIU, Catherine GREER, Mark SELBY, Christopher WALKER
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Patent number: 8168418Abstract: The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.Type: GrantFiled: April 30, 2010Date of Patent: May 1, 2012Inventors: Susan W Barnett, Jan Zur Megede, Indresh Srivastava, Ying Lian, Karin Hartog, Hong Liu, Catherine Greer, Mark Selby, Christopher Walker
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Patent number: 8133494Abstract: The invention relates to polynucleotides encoding modified immunogenic HIV-1 South African subtype C Env polypeptides. The modifications to the Env polypeptides include deletions of V1, V2 and the stem region. The expression cassettes may be used, for example, to express the encoded polypeptide. A recombinant expression system for use in a selected host cell comprising an expression cassette encoding for the modified HIV-1 Env polypeptide is also described.Type: GrantFiled: March 13, 2007Date of Patent: March 13, 2012Assignee: Novartis Vaccine & Diagnostics IncInventors: Jan zur Megede, Susan Barnett, Ying Lian, Susan Engelbrecht, Estrelita Janse van Rensburg, Thomas J. Scriba
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Publication number: 20110110977Abstract: Compositions comprising multivalent and adjuvanted HIV Env glycoproteins are described. Methods of using these compositions for treatment and prevention of HIV are also provided.Type: ApplicationFiled: October 17, 2006Publication date: May 12, 2011Inventors: Susan W. Barnett, Raul Victor Gomez-Roman, Brian Burke, Ying Lian, Indresh K. Srivastava
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Publication number: 20110065146Abstract: The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.Type: ApplicationFiled: April 30, 2010Publication date: March 17, 2011Applicant: NOVARTIS VACCINES AND DIAGNOSTICS, INC.Inventors: Susan W. Barnett, Jan zur Megede, Indresh Srivastava, Ying Lian, Karin Hartog, Hong Liu, Catherine Greer, Mark Selby, Christopher Walker
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Publication number: 20110052632Abstract: The present disclosure relates to novel polynucleotides that encode HIV Env polypeptides. In particular, the disclosure relates to sequences derived from HIV strain Botswana MJ4 encoding Env polypeptides. Compositions comprising these polynucleotides and methods of using these polynucleotides are also disclosed.Type: ApplicationFiled: November 10, 2010Publication date: March 3, 2011Applicant: Novartis Vaccines and Diagnostics, Inc.Inventors: YING LIAN, Jan Zur Megede, Indresh Srivastava, Susan W. Barnett
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Publication number: 20110045017Abstract: This invention is directed to pharmaceutical compositions comprising an HIV antigen and a mucosal adjuvant and methods for raising an immune response in a subject by administering these compositions. Preferably, the pharmaceutical compositions of the invention can be used to treat or prevent HIV infection.Type: ApplicationFiled: November 8, 2010Publication date: February 24, 2011Applicant: NOVARTIS VACCINES AND DIAGNOSTICS, INC.Inventors: YING LIAN, JAN ZUR MEGEDE, INDRESH SRIVASTAVA, SUSAN W. BARNETT
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Publication number: 20100316698Abstract: The present invention relates to polynucleotides encoding immunogenic HIV type C polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell lines, and production of HIV Type C proteins are also described.Type: ApplicationFiled: November 17, 2009Publication date: December 16, 2010Applicants: Novartis Vaccines and Diagnostics, Inc., University of StellenboschInventors: Jan zur Megede, Susan Barnett, Ying Lian, Susan Engelbrecht, Estrelita Janse Van Rensburg
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Patent number: 7718401Abstract: The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.Type: GrantFiled: February 6, 2008Date of Patent: May 18, 2010Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: Susan W. Barnett, Jan zur Megede, Indresh Srivastava, Ying Lian, Karin Hartog, Hong Liu, Catherine Greer, Mark Selby, Christopher Walker
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Patent number: 7618642Abstract: The present invention relates to polynucleotides encoding immunogenic HIV type C polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell lines, and production of HIV Type C proteins are also described.Type: GrantFiled: July 5, 2001Date of Patent: November 17, 2009Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: Jan zur Megede, Susan Barnett, Ying Lian, Susan Engelbrecht, Estrelita Janse van Rensburg
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Publication number: 20090208530Abstract: The present disclosure relates to novel polynucleotides that encode HIV Env polypeptides. In particular, the disclosure relates to sequences derived from HIV strain Botswana MJ4 encoding Env polypeptides. Compositions comprising these polynucleotides and methods of using polynucleotides are also disclosed.Type: ApplicationFiled: February 4, 2009Publication date: August 20, 2009Inventors: Ying Lian, Jan Zur Megede, Indresh Srivastava, Susan W. Barnett
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Publication number: 20080261271Abstract: The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.Type: ApplicationFiled: February 6, 2008Publication date: October 23, 2008Applicant: Novartis Vaccines & Diagnostics, Inc.Inventors: Susan W. Barnett, Jan zur Megede, Indresh Srivastava, Ying Lian, Karin Hartog, Hong Liu, Catherine Greer, Mark Selby, Christopher Walker
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Publication number: 20080095833Abstract: The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.Type: ApplicationFiled: October 15, 2007Publication date: April 24, 2008Applicant: Novartis Vaccines and Diagnostics, Inc.Inventors: Jan Zur Megede, Susan Barnett, Ying Lian