Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract: Disclosed are compounds of Formula (I) or a salt thereof; wherein: X is N or CH; Q1 is: (i) Cl, Br, I, —CN, —CH3, or —CF3; (ii) a 5-membered heteroaryl selected from pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, and thiadiazolyl; (iii) a 6?membered heteroaryl selected from pyridinyl, pyridazinyl, and pyrimidinyl; or (iv) a bicyclic heteroaryl selected from indolyl, pyrrolopyridinyl, pyrazolopyridinyl and benzo[d]oxazolyl; wherein each of said 5-membered, 6-membered, and bicyclic heteroaryl is substituted with zero to 1 Ra and zero to 1 Rb; and R1, R2, R3, R4, R5, R6, Ra, and Rb are defined herein. Also disclosed are methods of using such compounds as modulators of PI3K, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases.

Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract: Soap compositions including a polymer matrix comprising a first polymer, a polysaccharide that is substantially homogenously distributed within the polymer matrix, and a fatty acid are disclosed.

Abstract: Disclosed are compounds of Formula (I); or a salt thereof; wherein Qi is (i) Cl, Br, I, —CN, —CH3, or —CF3; or (ii) pyrazole, triazole, or pyridinyl, each substituted with R1; Q2 is pyridinyl, indazolyl, isoquinolinyl, or benzo[d]imidazolyl substituted with R2 and R3; and R1, R2, and R3 are defined herein. Also disclosed are methods of using such compounds as modulators of PI3K, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases.

Abstract: Apparatus and methods are described herein for cleaving an optical element at a defined distance from a splice (or other reference point/feature) of the optical element within a desired precision and/or accuracy. In some embodiments, a method includes receiving an indication of a location of a feature in an intermediate optical assembly visible within an image of the intermediate optical assembly. The feature can be for example, a splice. A position of the intermediate optical assembly is translated relative to a cleave unit based on the indication. After translating, the intermediate optical assembly, the intermediate optical assembly is cleaved to form an optical assembly that has an end face at a location disposed at a non-zero distance from the location of the feature. In some embodiments, the location of the feature can be determined with an image recognition system.

Abstract: Disclosed are compounds of Formula (I); or a salt thereof; wherein Qi is (i) Cl, Br, I, —CN, —CH3, or —CF3; or (ii) pyrazole, triazole, or pyridinyl, each substituted with R1; Q2 is pyridinyl, indazolyl, isoquinolinyl, or benzo[d]imidazolyl substituted with R2 and R3; and R1, R2, and R3 are defined herein. Also disclosed are methods of using such compounds as modulators of PI3K, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases.

Abstract: Disclosed are compounds of Formula (I) or a salt thereof; wherein: X is N or CH; Q1 is: (i) Cl, Br, I, —CN, —CH3, or —CF3; (ii) a 5-membered heteroaryl selected from pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, and thiadiazolyl; (iii) a 6?membered heteroaryl selected from pyridinyl, pyridazinyl, and pyrimidinyl; or (iv) a bicyclic heteroaryl selected from indolyl, pyrrolopyridinyl, pyrazolopyridinyl and benzo[d]oxazolyl; wherein each of said 5-membered, 6-membered, and bicyclic heteroaryl is substituted with zero to 1 Ra and zero to 1 Rb; and R1, R2, R3, R4, R5, R6, Ra, and Rb are defined herein. Also disclosed are methods of using such compounds as modulators of PI3K, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases.

Abstract: An online advertising system evaluates advertising opportunities for online advertising publishers. The online advertising system tracks online users via various tracking methods to receive advertising data and user information for the online users. The online advertising system identifies and segments the online users based on segmenting criteria that are associated with some interest topics (e.g., demographical information). The system calculates projected advertising revenue for each audience segment and generates an inventory optimization dashboard based on the calculated revenue. The inventory optimization dashboard helps the advertising publishers better understand the online advertising traffic and better optimize their advertising inventory. For example, the advertising publishers may advertise to specific audience segments which tend to purchase the advertised products or services.

Abstract: Apparatus and methods are described herein for cleaving an optical element at a defined distance from a splice (or other reference point/feature) of the optical element within a desired precision and/or accuracy. In some embodiments, a method includes receiving an indication of a location of a feature in an intermediate optical assembly visible within an image of the intermediate optical assembly. The feature can be for example, a splice. A position of the intermediate optical assembly is translated relative to a cleave unit based on the indication. After translating, the intermediate optical assembly, the intermediate optical assembly is cleaved to form an optical assembly that has an end face at a location disposed at a non-zero distance from the location of the feature. In some embodiments, the location of the feature can be determined with an image recognition system.

Abstract: Compositions containing biomass, an ionic liquid, and an amide are described herein. Methods of their preparation and use in extracting and processing biomass are also described herein. Further described herein are films and fibers prepared from the compositions. Methods of recovering the ionic liquids used to process the biomass are also provided.

Abstract: Apparatus and methods are described herein for cleaving an optical element at a defined distance from a splice (or other reference point/feature) of the optical element within a desired precision and/or accuracy. In some embodiments, a method includes receiving an indication of a location of a feature in an intermediate optical assembly visible within an image of the intermediate optical assembly. The feature can be for example, a splice. A position of the intermediate optical assembly is translated relative to a cleave unit based on the indication. After translating, the intermediate optical assembly, the intermediate optical assembly is cleaved to form an optical assembly that has an end face at a location disposed at a non-zero distance from the location of the feature. In some embodiments, the location of the feature can be determined with an image recognition system.

Abstract: Disclosed is a process for forming films, fibers, and beads comprising a chitinous mass, for example, chitin, chitosan obtained from one or more biomasses. The disclosed process can be used to prepare films, fibers, and beads comprising only polymers, i.e., chitin, obtained from a suitable biomass, or the films, fibers, and beads can comprise a mixture of polymers obtained from a suitable biomass and a naturally occurring and/or synthetic polymer. Disclosed herein are the films, fibers, and beads obtained from the disclosed process. This Abstract is presented solely to aid in searching the subject matter disclosed herein and is not intended to define, limit, or otherwise provide the full scope of the disclosed subject matter.

Abstract: In some embodiments, an apparatus includes a formation member that defines a passageway configured to receive therein at least a portion of an optical fiber that includes a stripped portion to be recoated. The passageway defines at least in part a recoat cross-sectional width of the stripped portion of the optical fiber to be recoated. A nozzle is coupled to the formation member and configured to dispense a recoat material into the passageway when the nozzle is moved relative to the stripped portion of the optical fiber when the stripped portion of the optical fiber is disposed at least partially within the passageway such that the recoat material is dispensed on and surrounds the stripped portion of the optical fiber. In some embodiments, the apparatus includes a controller that can control the flow rate of the recoat material dispensed by the nozzle.

Abstract: An array substrate is disclosed. The array substrate comprises a plurality of gate lines, a plurality of data lines, and a plurality of pixel units defined by the gate lines and the data lines and arranged in an array, each of the pixel units comprising a thin film transistor (TFT) for switching the pixel unit and a driving electrode for driving liquid crystal, and the driving electrode being formed with slit-shaped openings. The two corresponding pixel units respectively provided on two sides of the gate line are different from each other in structure, and the pixel unit on one side of the gate line can be obtained by rotating the pixel unit on the other side of the gate line by 180° respect to the central point of the section of the gate line between the two pixel units.

Abstract: Compositions containing biomass, an ionic liquid, and an amide are described herein. Methods of their preparation and use in extracting and processing biomass are also described herein. Further described herein are films and fibers prepared from the compositions. Methods of recovering the ionic liquids used to process the biomass are also provided.

Abstract: Disclosed is a process for forming films, fibers, and beads comprising a chitinous mass, for example, chitin, chitosan obtained from one or more biomasses. The disclosed process can be used to prepare films, fibers, and beads comprising only polymers, i.e., chitin, obtained from a suitable biomass, or the films, fibers, and beads can comprise a mixture of polymers obtained from a suitable biomass and a naturally occurring and/or synthetic polymer. Disclosed herein are the films, fibers, and beads obtained from the disclosed process. This Abstract is presented solely to aid in searching the subject matter disclosed herein and is not intended to define, limit, or otherwise provide the full scope of the disclosed subject matter.

Abstract: In some embodiments, an optical fiber assembly apparatus includes a signal fiber having a substantially constant outer diameter, a proximal portion, and a distal portion. The proximal portion has a waveguide structure configured to propagate an optical signal having a first mode field diameter and the distal portion has a waveguide structure configured to propagate the optical signal having the first mode field diameter at a proximal end of the distal portion and has an expanded waveguide structure configured to propagate the optical signal having a second mode field diameter at a distal end of the distal portion. The optical fiber assembly includes a lens fiber having a proximal end. The proximal end of the lens fiber is fused to the distal end of the distal portion of the signal fiber. The lens fiber is configured to propagate an optical signal through a nominally homogenous region.

Abstract: Disclosed herein are compositions and methods that involve ionic liquids and biomass. In one aspect, the disclosure relates to ionic liquid systems for the processing of biomass, their components and/or derivatives, and mixtures thereof.

Abstract: The invention relates to purinone derivatives useful in treating disorders that are mediated by adenosine receptor function, including neurodegenerative diseases and inflammation.