Patents by Inventor Ying-shu Quan
Ying-shu Quan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10994111Abstract: The present invention provides a drug-holding microneedle array in which a drug is applied and held only on a tip portion of microneedles for quantitatively holding the drug and for preventing the drug from falling away during insertion of the microneedles. The drug-holding microneedle array comprises: a microneedle array having a microneedle substrate 4 and microneedles, the microneedles being positioned in plural on the microneedle substrate 4 and a tip portion 1 of the microneedles projecting via steps 2 and a drug held on the tip portion of the microneedles and the steps 2.Type: GrantFiled: February 10, 2014Date of Patent: May 4, 2021Assignee: COSMED PHARMACEUTICAL CO., LTD.Inventors: Ying-shu Quan, Fumio Kamiyama, Tomoya Yamada
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Publication number: 20210121664Abstract: Provided is an auxiliary tool that makes skin administration of a micro-needle array on which a large number of micro-needles are provided as a result of a progress in fine processing technology more certain. A skin tight-binding device provided with a tight-binding band, and a hole provided on the tight-binding band, in which, when the tight-binding band is fixed to skin, the hole forms a micro-needle patch administration portion, and the skin tight-binding device further provided with a fixing tool that fixes the tight-binding band to the skin.Type: ApplicationFiled: January 23, 2019Publication date: April 29, 2021Inventors: Ying-shu Quan, Fumio Kamiyama
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Publication number: 20210106800Abstract: The invention provides a composition that more effectively and simply realizes lightening and plumping of lips. Provided is a microneedle array for lips applied locally to lips in order to lighten and/or plump the lips, the microneedle array including a water-soluble polymer, in which a microneedle has a height of 50 ?m to 300 ?m, and a tip of the microneedle is a circle having a diameter of 5 to 150 ?m or a plane having the same area.Type: ApplicationFiled: August 17, 2018Publication date: April 15, 2021Inventors: Ying-shu Quan, Fumio Kamiyama, Hiroshi Tanaka, Naoko Kondo
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Publication number: 20210038486Abstract: A cosmetic gel sheet suitable for a cosmetic field or a medical field is provided. The cosmetic gel sheet of the present invention contains carboxy group-containing water-soluble polymer, polyalcohol, and acid as essential constituent components. Carboxy group-containing polysaccharide can be suitably used as the carboxy group-containing water-soluble polymer. Water content in the gel sheet is 30% by weight, but it is more preferable if the water content is 10% by weight or less. In the cosmetic gel sheet of the present invention, the gel sheet can be manufactured by drying an aqueous solution containing carboxy group-containing water-soluble polymer, polyalcohol, and acid as essential components. Wherein, it is desirable that content of the acid in the aqueous solution is adjusted to a value appropriate for setting pH of the aqueous solution to 2.0-4.0.Type: ApplicationFiled: October 21, 2020Publication date: February 11, 2021Inventors: Naoko Kondou, Ying-shu Quan, Fumio Kamiyama
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Publication number: 20210016072Abstract: Provided is a microneedle patch which is easily to be applied on a skin surface. One or more holes are provided inside a protective sheet of the microneedle patch, and one or more cutting lines running from an outer edge of the protective sheet toward the holes are also provided. The cutting lines may be symmetrically arranged on both sides of the hole. Providing an incision on the outer edge of the cutting lines of the protective release sheet facilitates cutting along the cutting lines. In the use of the microneedle patch, both sides of the cutting line of the protective release sheet are held and torn so as to bring out a microneedle array adhesive sheet and apply it on a skin. Then the microneedle array surface is slightly compressed, thereby the microneedle is inserted into the stratum corneum.Type: ApplicationFiled: October 7, 2020Publication date: January 21, 2021Inventors: Ying-shu Quan, Fumio Kamiyama
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Patent number: 10889408Abstract: To suppress the work cost for the washing of the microneedle and the application of the medicament. A microneedle patch storage tool according to one aspect of the present invention is a microneedle patch storage tool for storing a microneedle patch and comprises a plurality of pallets stacked in a vertical direction, and the two pallets adjacent in the vertical direction constitute one or a plurality of patch holding parts for holding the microneedle patch, and the patch holding part comprises a plurality of lower protrusions arranged in circumferentially divided manner so as to sandwich a peripheral edge part of the microneedle patch in the vertical direction and supporting the peripheral edge part of the microneedle patch from a lower side and a plurality of upper protrusions arranged in circumferentially divided manner and pressing the peripheral edge part of the microneedle patch from an upper side and is opened to at least one of upper and lower directions.Type: GrantFiled: October 6, 2016Date of Patent: January 12, 2021Assignee: COSMED PHARMACEUTICAL CO., LTD.Inventors: Ying-Shu Quan, Ying-Zhe Li, Fumio Kamiyama
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Publication number: 20200376243Abstract: To provide a means which makes it possible to reliably administer a sheet-like water-soluble preparation to skins at various sites and supply water from a back side of the sheet-like water-soluble preparation. A nozzle having at least one hole on an end portion having a plane with a size capable of holding a sheet-like water-soluble preparation, and having concave-convex portions on a portion of the plane excluding the hole; and an applicator for a sheet-like water-soluble preparation, which is composed of a liquid container and the nozzle.Type: ApplicationFiled: March 28, 2018Publication date: December 3, 2020Inventors: Ying-shu Quan, Ying-zhe Li, Kiyotsune Higuchi, Hiroshi Tanaka, Fumio Kamiyama
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Patent number: 10849834Abstract: A cosmetic gel sheet suitable for a cosmetic field or a medical field is provided. The cosmetic gel sheet of the present invention contains carboxy group-containing water-soluble polymer, polyalcohol, and acid as essential constituent components. Carboxy group-containing polysaccharide can be suitably used as the carboxy group-containing water-soluble polymer. Water content in the gel sheet is 30% by weight, but it is more preferable if the water content is 10% by weight or less. In the cosmetic gel sheet of the present invention, the gel sheet can be manufactured by drying an aqueous solution containing carboxy group-containing water-soluble polymer, polyalcohol, and acid as essential components. Wherein, it is desirable that content of the acid in the aqueous solution is adjusted to a value appropriate for setting pH of the aqueous solution to 2.0-4.0.Type: GrantFiled: February 12, 2015Date of Patent: December 1, 2020Assignee: COSMED PHARMACEUTICAL CO., LTD.Inventors: Naoko Kondou, Ying-shu Quan, Fumio Kamiyama
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Patent number: 10821275Abstract: Provided is a microneedle patch which is easily to be applied on a skin surface. One or more holes are provided inside a protective sheet of the microneedle patch, and one or more cutting lines running from an outer edge of the protective sheet toward the holes are also provided. The cutting lines may be symmetrically arranged on both sides of the hole. Providing an incision on the outer edge of the cutting lines of the protective release sheet facilitates cutting along the cutting lines. In the use of the microneedle patch, both sides of the cutting line of the protective release sheet are held and torn so as to bring out a microneedle array adhesive sheet and apply it on a skin. Then the microneedle array surface is slightly compressed, thereby the microneedle is inserted into the stratum corneum.Type: GrantFiled: June 25, 2013Date of Patent: November 3, 2020Assignee: COSMED PHARMACEUTICAL CO., LTD.Inventors: Ying-shu Quan, Fumio Kamiyama
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Publication number: 20200289548Abstract: To develop a novel administration method of a fucoidan-containing hair-growing agent and to provide a means for exerting excellent effects of a fucoidan. A hair-growing agent of the present invention is characterized in that it is composed of a combination of a fucoidan-containing microneedle and a fucoidan-containing liniment. A base of the fucoidan-containing microneedle is preferably a biosoluble polymer. A hair-growing method of the present invention is characterized in that the fucoidan-containing microneedle and the fucoidan-containing liniment are concomitantly used.Type: ApplicationFiled: March 16, 2017Publication date: September 17, 2020Inventors: Ying-shu Quan, Hirofumi Yamashita, Fumio Kamiyama, Akira Yamamoto, Hidemasa Katsumi
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Publication number: 20200170940Abstract: The invention provides a microneedle array easily applied to an oral cavity and may exert an anesthetic effect according to an application site. Provided are an immediate-acting dental local anesthetic preparation including a microneedle array containing a local anesthetic, in which a needle part dissolves in a mucous membrane when being applied to an oral mucous membrane or gums, the microneedle array containing the local anesthetic, in which a height of a microneedle is 50 ?m or more and 300 ?m or less, a rip of the microneedle is a circle having a diameter of 1 ?m or more and 50 ?m or less or a plane having the same area, and a thickness of a substrate of the microneedle array is 5 ?m or more and 100 ?m or less, and a microneedle patch including the microneedle array and a support provided on a back surface of the microneedle array.Type: ApplicationFiled: November 1, 2018Publication date: June 4, 2020Inventors: Ying-shu Quan, Fumio Kamiyama
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Publication number: 20200164192Abstract: To provide a means capable of applying a water-soluble cosmetic sheet including a microneedle array without using an adhesive sheet.Type: ApplicationFiled: May 21, 2018Publication date: May 28, 2020Inventors: Ying-shu Quan, Hiroshi Tanaka, Naoko Kondou, Fumio Kamiyama
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Patent number: 10589006Abstract: Provided are a microneedle with excellent performance and a method for manufacturing the microneedle. A microneedle array in which a polyglycolic acid is used as a material, crystallinity of the polyglycolic acid is 21% or more and axial contraction rate of tips is 99% or more, and a manufacturing method in which a polyglycolic acid are injection-molded at a cylinder temperature of 230-280° C., a metal mold temperature of 60-130° C., and an injection pressure of 1000-1500 KPa so as to manufacture a microneedle array in which crystallinity of the polyglycolic acid is 21% or more and an axial contraction rate of tips is 99% or more.Type: GrantFiled: December 10, 2015Date of Patent: March 17, 2020Assignee: COSMED PHARMACEUTICAL CO., LTD.Inventors: Ying-shu Quan, Ying-zhe Li, Mio Saito, Shouta Kitaoka, Fumio Kamiyama
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Publication number: 20200009074Abstract: [Problem] To provide a supplement in a new form by which the targeted component is made available for intake other than the oral intake. [Solution] A patch-type supplement composed of a support, a component-containing layer, and a release liner, and the component-containing layer containing a supplement component and an adhesive. The adhesive is preferably an acrylate-based adhesive. A water vapor permeability of the support is preferably not larger than 1000 g/m2×24 hours. The supplement component is preferably made of an aqueous component and an organic component.Type: ApplicationFiled: June 30, 2019Publication date: January 9, 2020Inventors: Hiroshi Tanaka, Ying-shu Quan, Junya Hasegawa, Fumio Kamiyama
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Publication number: 20190358331Abstract: A DDS carrier enabling sustained release of a drug and a production method therefor. Wherein, the drug is retained by a PEG-carboxy group-containing polymer graft. Among polymers, a carboxy group-containing polysaccharide can be suitably used. The PEG-carboxy group-containing polymer graft is a compound prepared by grafting PEG into the carboxy group-containing polysaccharide. When the carboxy group-containing polysaccharide is used, it can be produced by utilizing a condensation reaction of an aminated PEG and a carboxy group-containing polysaccharide in coexistence with a triazine-based condensing agent. Alternatively, the PEG-carboxy group-containing polysaccharide graft can be produced by utilizing a condensation reaction of PEG and a carboxy group-containing polysaccharide in coexistence with an acid.Type: ApplicationFiled: August 9, 2019Publication date: November 28, 2019Inventors: Ying-shu Quan, Tooru Ooya, Rongrong Jiang, Fumio Kamiyama
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Publication number: 20190351207Abstract: To provide a microneedle applicator which can be easily attached with the microneedle patch and is not likely to cause skin infection even when continuously administered to a large number of users. A microneedle patch application device comprising: a movable cylinder having an opening equipped with a clasp or a screw for attaching the microneedle patch case at one end; a case body connected with the other end of the movable cylinder; a piston disposed movably in a direction to the opening of the movable cylinder in the case body; a slide for sliding the piston in an opposite direction to the opening; a slide lock for locking the sliding of the slide in the opposite direction; a spring for applying an impact to the piston by the sliding in the opposite direction and the locking; a safety shaft for suppressing unlocking of the slide lock; and a trigger interlocked with the safety shaft. Although the microneedle patch case at the front end is pressed against a skin, it is replaced for each time of application.Type: ApplicationFiled: January 25, 2018Publication date: November 21, 2019Inventors: Ying-shu Quan, Fumio Kamiyama
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Publication number: 20190344062Abstract: To provide a practical microneedle preparation which solves a problem that, even if a tip portion of the microneedle could be quantitatively coated with the drug, the drug remained in the stratum corneum when actually applying the microneedle array as a transdermal absorption preparation. A microneedle array having needles with a length of 350 ?m to 900 ?m, and a tip apex diameter of 20 ?m to 100 ?m, including drug-coated portions, and comprising a non-biosoluble polymer as a base, wherein a lower end of each drug-coated portion is 200 ?m or more away from a root of the needle.Type: ApplicationFiled: December 28, 2017Publication date: November 14, 2019Inventors: Ying-shu Quan, Mio Saito, Hirofumi Yamashita, Fumio Kamiyama
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Publication number: 20190283933Abstract: To suppress the work cost for the washing of the microneedle and the application of the medicament. A microneedle patch storage tool according to one aspect of the present invention is a microneedle patch storage tool for storing a microneedle patch and comprises a plurality of pallets stacked in a vertical direction, and the two pallets adjacent in the vertical direction constitute one or a plurality of patch holding parts for holding the microneedle patch, and the patch holding part comprises a plurality of lower protrusions arranged in circumferentially divided manner so as to sandwich a peripheral edge part of the microneedle patch in the vertical direction and supporting the peripheral edge part of the microneedle patch from a lower side and a plurality of upper protrusions arranged in circumferentially divided manner and pressing the peripheral edge part of the microneedle patch from an upper side and is opened to at least one of upper and lower directions.Type: ApplicationFiled: October 6, 2016Publication date: September 19, 2019Applicant: COSMED PHARMACEUTICAL CO.,LTD.Inventors: Ying-shu QUAN, Ying-zhe LI, Fumio KAMIYAMA
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Publication number: 20190142707Abstract: A cosmetic gel sheet suitable for a cosmetic field or a medical field is provided. The cosmetic alcogel sheet of the present invention comprises: a water-soluble nonwoven fabric or a water-soluble film; and an alcogel which is laminated on it and contains carboxy group-containing water-soluble polymer, polyalcohol and acid as essential components, and the sheet is characterized in that the water content of the gel is 30% by mass or less. It is more preferred that the carboxy group-containing water-soluble polymer is carboxy group-containing polysaccharides, and the polyalcohol is glycerin. The cosmetic alcogel sheet of the present invention can be manufactured by: drying an aqueous solution containing carboxy group-containing water-soluble polymer, polyalcohol and acid as essential components on a releasable sheet to manufacture gel, and then laminating the gel on a water-soluble nonwoven fabric or a water-soluble film.Type: ApplicationFiled: April 28, 2017Publication date: May 16, 2019Inventors: Ying-shu Quan, Naoko Kondou, Fumio Kamiyama
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Publication number: 20190099590Abstract: Providing a patch case that is easily attached to a microneedle applicator, easily separable from the microneedle patch upon insertion and disposable for use. The main feature of the patch case according to the present invention is characterized in that it is made of a thermoplastic polymer and is capable of holding a microneedle patch comprising a support film which can be heat-sealed with the thermoplastic polymer. Preferably, the thermoplastic polymer of the body and the fusible material of the support film are both polyolefins or both are the same thermoplastic polymer. In addition, if the patch case is attached to the front of the applicator. sanitary situation can be maintained even with continuous use of the applicator, since the applicator does not contact the skin of the recipient.Type: ApplicationFiled: March 16, 2017Publication date: April 4, 2019Applicant: COSMED PHARMACEUTICAL CO., LTD.Inventors: Ying-shu Quan, Kiyotsune Higuchi, Fumio Kamiyama