Abstract: The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.

Abstract: A time aligning circuit includes a plurality of buffers, a plurality of delay selectors, a plurality of adjustment symbol generators, and a controller. Each buffer receives an ordered set on a corresponding lane. Each delay selector delays an output of the ordered set of the corresponding buffer. Each adjustment symbol generator outputs an adjustment symbol or the output received from the corresponding delay selector according to an adjustment control signal. When an initial symbol of a designated delay selector is detected but initial symbols of other delay selectors are not received yet, the controller generates the delay control signal to the designated delay selector and generates the adjustment control signal to control a designated adjustment symbol generator corresponding to the designated delay selector in order to output one adjustment symbol until initial signals of all delay selectors are detected.

Abstract: A time aligning circuit includes a plurality of buffers, a plurality of delay selectors, a plurality of adjustment symbol generators, and a controller. Each buffer receives an ordered set on a corresponding lane. Each delay selector delays an output of the ordered set of the corresponding buffer. Each adjustment symbol generator outputs an adjustment symbol or the output received from the corresponding delay selector according to an adjustment control signal. When an initial symbol of a designated delay selector is detected but initial symbols of other delay selectors are not received yet, the controller generates the delay control signal to the designated delay selector and generates the adjustment control signal to control a designated adjustment symbol generator corresponding to the designated delay selector in order to output one adjustment symbol until initial signals of all delay selectors are detected.