Patents by Inventor Yinges Yigzaw

Yinges Yigzaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
    Patent number: 11486883
    Abstract: The invention provides a method for controlling contaminants in biopharmaceutical purification processes by using light scattering and UV absorbance to establish a determinant. The invention makes use of multi-angle light scattering (MALS) and UV as a continuous monitoring system to provide information about the elution peak fractions in real-time instead of conventional pooling methods that rely on a predetermined percent UV peak max value to initiate the pooling process; regardless of product quality.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: November 1, 2022
    Assignee: AMGEN INC.
    Inventors: Arthur C. Hewig, III, Duke H. Phan, Yinges Yigzaw, Robert Bailey
  • METHODS OF REDUCING THE ENZYMATIC HYDROLYSIS ACTIVITY RATE IN A COMPOSITION OBTAINED FROM A PURIFICATION PLATFORM
    Publication number: 20220194980
    Abstract: The present disclosure provides purification platforms comprising a depth filter step and/or a hydrophobic interaction chromatography (HIC) step. Also disclosed herein are methods of using the purification platforms described herein and compositions obtained therefrom, such as pharmaceutical compositions.
    Type: Application
    Filed: November 2, 2021
    Publication date: June 23, 2022
    Inventors: Michael LEISS, Christian Meyer, Alexandra Thomas Morris, Bernhard Spensberger, Yinges Yigzaw, Franziska Edelmann, Roberto Falkenstein, Tobias Graf, Jie Gu, Jeevan Prabhakar
  • PURIFICATION PLATFORMS FOR OBTAINING PHARMACEUTICAL COMPOSITIONS HAVING A REDUCED HYDROLYTIC ENZYME ACTIVITY RATE
    Publication number: 20220135620
    Abstract: The present disclosure provides purification platforms comprising a depth filter step and/or a hydrophobic interaction chromatography (HIC) step and/or a MM-HIC/IEX chromatography step, and are useful for providing a method of reducing a hydrolytic enzyme activity rate of a composition obtained from said purification platforms. Also disclosed herein are methods of using the purification platforms described herein and compositions obtained therefrom, such as pharmaceutical compositions.
    Type: Application
    Filed: October 28, 2021
    Publication date: May 5, 2022
    Inventors: Alex SEAY, Marc WONG, Stephen WOON, Michael LEE, Stefanie KHOO, William O'DWYER, Eileen DUENAS, Yinges YIGZAW, Amy LIM
  • Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
    Patent number: 11293930
    Abstract: The invention provides a method for controlling contaminants in biopharmaceutical purification processes by using light scattering and UV absorbance to establish a determinant. The invention makes use of multi-angle light scattering (MALS) and UV as a continuous monitoring system to provide information about the elution peak fractions in real-time instead of conventional pooling methods that rely on a predetermined percent UV peak max value to initiate the pooling process; regardless of product quality.
    Type: Grant
    Filed: October 7, 2021
    Date of Patent: April 5, 2022
    Assignee: AMGEN INC.
    Inventors: Arthur C. Hewig, III, Duke H. Phan, Yinges Yigzaw, Robert Bailey
  • METHOD FOR USING LIGHT SCATTERING IN REAL TIME TO DIRECTLY MONITOR AND CONTROL IMPURITY REMOVAL IN PURIFICATION PROCESSES
    Publication number: 20220026442
    Abstract: The invention provides a method for controlling contaminants in biopharmaceutical purification processes by using light scattering and UV absorbance to establish a determinant. The invention makes use of multi-angle light scattering (MALS) and UV as a continuous monitoring system to provide information about the elution peak fractions in real-time instead of conventional pooling methods that rely on a predetermined percent UV peak max value to initiate the pooling process; regardless of product quality.
    Type: Application
    Filed: October 7, 2021
    Publication date: January 27, 2022
    Applicant: AMGEN INC.
    Inventors: Arthur C. HEWIG, III, Duke H. PHAN, Yinges YIGZAW, Robert BAILEY
  • METHOD FOR USING LIGHT SCATTERING IN REAL TIME TO DIRECTLY MONITOR AND CONTROL IMPURITY REMOVAL IN PURIFICATION PROCESSES
    Publication number: 20200018771
    Abstract: The invention provides a method for controlling contaminants in biopharmaceutical purification processes by using light scattering and UV absorbance to establish a determinant. The invention makes use of multi-angle light scattering (MALS) and UV as a continuous monitoring system to provide information about the elution peak fractions in real-time instead of conventional pooling methods that rely on a predetermined percent UV peak max value to initiate the pooling process; regardless of product quality.
    Type: Application
    Filed: September 23, 2019
    Publication date: January 16, 2020
    Applicant: AMGEN INC.
    Inventors: Arthur C. HEWIG III, Duke H. PHAN, Yinges YIGZAW, Robert BAILEY
  • Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
    Patent number: 10481164
    Abstract: The invention provides a method for controlling contaminants in biopharmaceutical purification processes by using light scattering and UV absorbance to establish a determinant. The invention makes use of multi-angle light scattering (MALS) and UV as a continuous monitoring system to provide information about the elution peak fractions in real-time instead of conventional pooling methods that rely on a predetermined percent UV peak max value to initiate the pooling process; regardless of product quality.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: November 19, 2019
    Assignee: AMGEN INC.
    Inventors: Arthur C. Hewig, III, Duke H. Phan, Yinges Yigzaw, Robert Bailey
  • PURIFICATION OF MULTISPECIFIC ANTIBODIES
    Publication number: 20190256556
    Abstract: The present invention provides methods of purifying multispecific antibodies. The methods comprise the sequential steps of performing a capture chromatography, a first mixed mode chromatography and a second mixed mode chromatography. In some aspects, the invention provides compositions of multispecific antibodies, which compositions have reduced levels of one or more product-specific impurities and/or process-specific impurities.
    Type: Application
    Filed: December 14, 2018
    Publication date: August 22, 2019
    Applicant: Genentech, Inc.
    Inventors: Glen Scott GIESE, Eva ROSENBERG, Bernard SALLIER, Susanne KONRAD, Wolfgang KOEHNLEIN, Steffen WILLMANN, Agathe BIALAS, Kimberly Ann KALEAS-CARROLL, Yinges YIGZAW
  • METHOD FOR USING LIGHT SCATTERING IN REAL TIME TO DIRECTLY MONITOR AND CONTROL IMPURITY REMOVAL IN PURIFICATION PROCESSES
    Publication number: 20130303732
    Abstract: The invention provides a method for controlling contaminants in biopharmaceutical purification processes by using light scattering and UV absorbance to establish a determinant. The invention makes use of multi-angle light scattering (MALS) and UV as a continuous monitoring system to provide information about the elution peak fractions in real-time instead of conventional pooling methods that rely on a predetermined percent UV peak max value to initiate the pooling process; regardless of product quality.
    Type: Application
    Filed: March 26, 2013
    Publication date: November 14, 2013
    Inventors: Arthur C. Hewig, III, Duke H. Phan, Yinges Yigzaw, Robert Bailey