Abstract: A blockchain-based data processing method, apparatus, and computer-readable medium are provided. Block proposal information is received including a block and a digital signature transmitted by an out-block node. The digital signature is obtained by performing digital signature processing on block header information included in the block. The block header information includes a first Merkel root determined based on transaction data in the block body information. Digest calculation on the block header information is performed to obtain first digest information. De-signature processing is performed on the digital signature to obtain second digest information. A second Merkel root is determined based on the transaction data acquired from the block proposal information when the first digest information and the second digest information are matched. An operation on the block is performed based on a comparison result of the first Merkel root and the second Merkel root.

Abstract: Disclosed generally relates to C5a receptor inhibitors, compositions thereof, methods of use thereof, and methods of preparation thereof.

Abstract: A miniature single-photon fluorescence microscope implantation device and implantation method are disclosed. The implantation device includes: a clamp base defining a clamp slot; a clamp block; and a groove defined in a bottom surface of the clamp slot. An end of the clamp block includes a first protrusion, and a bottom surface of the groove vertically defines a through receiving hole.

Abstract: This invention relates to inhibition of the complement signaling using an anti-C5 antibody or fusion protein thereof. Specifically, the invention relates to methods of treating a complement-mediated disease or complement-mediated disorder in an individual by contacting the individual with an anti-C5 antibody fusion protein thereof.

Abstract: Disclosed are an expansion tool assembly, comprising: an expandable tubular; a guide shoe partially inserted into and connected to the lower end of the expandable tubular; a sealing sleeve arranged in the expandable tubular and connected to the upper end of the guide shoe; an expansion assembly comprising an expansion cone and expansion seat disposed inside the expandable tubular, wherein the lower end of the expansion seat is connected with hooks, which can be rested on the upper end of the sealing sleeve; an upper joint that is connected to the upper end of the expansion seat and can be connected to a drill string. A force transfer path can be established via connection between the expansion seat and sealing sleeve, so that expandable tubular weight is borne on the drill string. Unintentional expansion of the expandable tubular, caused by interaction between expandable tubular and expansion cone, can be avoided.

Abstract: Disclosed are an expansion tool assembly, comprising: an expandable tubular; a guide shoe partially inserted into and connected to the lower end of the expandable tubular; a sealing sleeve arranged in the expandable tubular and connected to the upper end of the guide shoe; an expansion assembly comprising an expansion cone and expansion seat disposed inside the expandable tubular, wherein the lower end of the expansion seat is connected with hooks, which can be rested on the upper end of the sealing sleeve; an upper joint that is connected to the upper end of the expansion seat and can be connected to a drill string. A force transfer path can be established via connection between the expansion seat and sealing sleeve, so that expandable tubular weight is borne on the drill string. Unintentional expansion of the expandable tubular, caused by interaction between expandable tubular and expansion cone, can be avoided.

Abstract: The present invention discloses an expandable liner hanger system comprising a central pipe and an expandable pipe, with an expansion cone provided therebetween the central pipe and expandable pipe in a way that the expansion cone is movable along the central pipe, so that the expandable pipe is expanded; wherein, the expansion cone comprises an expansion cone seat move along the central pipe, and an expansion cone sleeve fitted over the expansion cone seat, the connection between the expansion cone seat and the expansion cone sleeve is configured in a way that the expansion cone sleeve can move upward together with the expansion cone seat along the central pipe so that the expandable pipe is expanded, and the central pipe can drive the expansion cone seat to disengage from the expansion cone sleeve.

Abstract: The present invention discloses an expandable liner hanger system comprising a central pipe and an expandable pipe, with an expansion cone provided therebetween the central pipe and expandable pipe in a way that the expansion cone is movable along the central pipe, so that the expandable pipe is expanded; wherein, the expansion cone comprises an expansion cone seat move along the central pipe, and an expansion cone sleeve fitted over the expansion cone seat, the connection between the expansion cone seat and the expansion cone sleeve is configured in a way that the expansion cone sleeve can move upward together with the expansion cone seat along the central pipe so that the expandable pipe is expanded, and the central pipe can drive the expansion cone seat to disengage from the expansion cone sleeve.

Abstract: The invention relates to an ultralong hydroxyapatite nanowire/microwire, a method of preparing the same, a hydroxyapatite paper comprising the same and a preparation method thereof, and provides an ultralong hydroxyapatite nanowire/microwire having a length of tens to hundreds of micrometers and a diameter of tens to hundreds of nanometers. There is also provided a method of preparing the ultralong hydroxyapatite nanowire/microwire, a hydroxyapatite paper comprising the ultralong hydroxyapatite nanowire/microwire, and a method of preparing the hydroxyapatite paper.

Abstract: The invention relates to an ultralong hydroxyapatite nanowire/microwire, a method of preparing the same, a hydroxyapatite paper comprising the same and a preparation method thereof, and provides an ultralong hydroxyapatite nanowire/microwire having a length of tens to hundreds of micrometers and a diameter of tens to hundreds of nanometers. There is also provided a method of preparing the ultralong hydroxyapatite nanowire/microwire, a hydroxyapatite paper comprising the ultralong hydroxyapatite nanowire/microwire, and a method of preparing the hydroxyapatite paper.

Abstract: The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.

Abstract: The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.

Abstract: The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.

Abstract: The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.

Abstract: The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.