Patents by Inventor Yinzhi FANG

Yinzhi FANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reagents and methods for tetrazine synthesis
    Patent number: 11767302
    Abstract: Disclosed herein are mono- and di-substituted tetrazines and methods of their preparation and converting an oxetanyl ester to a thio-substituted tetrazine, which is then converted to a mono-substituted tetrazine, a di-substituted tetrazine, or a vinylether disubstituted tetrazine.
    Type: Grant
    Filed: October 1, 2021
    Date of Patent: September 26, 2023
    Assignee: UNIVERSITY OF DELAWARE
    Inventors: Joseph M. Fox, William Lambert, Yinzhi Fang, Christopher William am Ende, Subham Mahapatra, Yixin Xie, Chuanqi Wang
  • REAGENTS AND METHODS FOR TETRAZINE SYNTHESIS
    Publication number: 20220106278
    Abstract: Disclosed herein are mono- and di-substituted tetrazines and methods of their preparation and converting an oxetanyl ester to a thio-substituted tetrazine, which is then converted to a mono-substituted tetrazine, a di-substituted tetrazine, or a vinylether disubstituted tetrazine.
    Type: Application
    Filed: October 1, 2021
    Publication date: April 7, 2022
    Applicant: University of Delaware
    Inventors: Joseph M. Fox, William Lambert, Yinzhi Fang, Christopher William am Ende, Subham Mahapatra, Yixin XIE, Chuanqi Wang
  • Methods for inducing bioorthogonal reactivity
    Patent number: 10875840
    Abstract: A method for catalytically converting a dihydrotetrazine 1 into a tetrazine 2, wherein one R group on the dihydrotetrazine 1 is a substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl, or heteroatom-containing group, and the other R group is selected from the group consisting of H and substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl,- or heteroatom-containing groups; 1, 2 wherein the method comprises oxidizing dihydrotetrazine 1 in a reaction medium in the presence of a catalyst and a stoichiometric oxidant.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: December 29, 2020
    Assignee: UNIVERSITY OF DELAWARE
    Inventors: Joseph Fox, Xinqiao Jia, Will Trout, Joel Rosenthal, Han Zhang, Yinzhi Fang, Colin Thorpe, Shuang Liu, Yixin Xie
  • METHODS FOR INDUCING BIOORTHOGONAL REACTIVITY
    Publication number: 20180362504
    Abstract: A method for catalytically converting a dihydrotetrazine 1 into a tetrazine 2, wherein one R group on the dihydrotetrazine 1 is a substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl, or heteroatom-containing group, and the other R group is selected from the group consisting of H and substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl,—or heteroatom-containing groups; 1, 2 wherein the method comprises oxidizing dihydrotetrazine 1 in a reaction medium in the presence of a catalyst and a stoichiometric oxidant.
    Type: Application
    Filed: December 15, 2016
    Publication date: December 20, 2018
    Applicant: University of Delaware
    Inventors: Joseph FOX, Xinqiao JIA, Will TROUT, Joel ROSENTHAL, Han ZHANG, Yinzhi FANG, Colin THORPE, Shuang LIU, Yixin XIE
  • Trans-cycloheptenes and hetero-trans-cycloheptenes for bioorthogonal coupling
    Patent number: 10155777
    Abstract: A substituted trans-cycloheptene according to formula (I); wherein: a) Z and L are each selected from the group consisting of SiR1R2, CH2, CHOH, and CHR2; R1 is phenyl or CH3; R2 is phenyl, CH3, (CH2)nCN, or (CH2)nOH, wherein n is an integer from 1 to 5; Ra and Rb are each individually selected from the group consisting of H, OH, and CH3; and Z and L are not both SiR1R2; or b) Z is BocN, L is CH2, Ra is H, and Rb is H; or c) Z is C=0, L is CH2, Ra is H, and Rb is H.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: December 18, 2018
    Assignee: UNIVERSITY OF DELAWARE
    Inventors: Joseph Fox, Han Zhang, Yinzhi Fang
  • TRANS-CYCLOHEPTENES AND HETERO-TRANS-CYCLOHEPTENES FOR BIOORTHOGONAL COUPLING
    Publication number: 20180072761
    Abstract: A substituted trans-cycloheptene according to formula (I); wherein: a) Z and L are each selected from the group consisting of SiR1R2, CH2, CHOH, and CHR2; R1 is phenyl or CH3; R2 is phenyl, CH3, (CH2)nCN, or (CH2)nOH, wherein n is an integer from 1 to 5; Ra and Rb are each individually selected from the group consisting of H, OH, and CH3; and Z and L are not both SiR1R2; or b) Z is BocN, L is CH2, Ra is H, and Rb is H; or c) Z is C=0, L is CH2, Ra is H, and Rb is H.
    Type: Application
    Filed: April 7, 2016
    Publication date: March 15, 2018
    Applicant: University of Delaware
    Inventors: Joseph FOX, Han ZHANG, Yinzhi FANG