Abstract: The present invention provides a novel compound for effectively preventing nerve damage and protecting nerves, and a preparation method thereof. Besides, the present invention also provides a pharmaceutical composition comprising the novel compound, and a use of the novel compound for preventing nerve damage and protecting nerves.

Abstract: The present disclosure relates to a method for treating a cancer and/or cancer metastasis in a subject comprising administering to the subject irinotecan loaded in a mesoporous silica nanoparticle. The present disclosure also provides a conjugate comprising an agent loaded in a mesoporous silica nanoparticle (MSN) defining at least one pore and having at least one functional group on a sidewall of the at least one pore.

Abstract: An identity certificate may be issued to a blockchain node. The issuance may include issuing a first identity certificate to a first terminal and receiving a second identity certificate issuance request that is from the first terminal. A second identity certificate may be issued to the first terminal, and a third identity certificate issuance request is received from the second terminal. A third identity certificate is issued to the second terminal, so that the second terminal forwards the third identity certificate to the third terminal.

Abstract: An uninterruptible power apparatus is coupled between a power grid and a load. The uninterruptible power apparatus includes a bypass path, a power conversion module, and a control module. The bypass path is coupled to the power grid through a grid terminal, and coupled to the load through a load terminal. The control module turns off a first thyristor and a second thyristor by injecting a second voltage into the load terminal during a forced commutation period. The control module calculates a magnetic flux offset amount based on an error amount between the second voltage and a voltage command, and provides a compensation command in response to the magnetic flux offset amount. The control module controls the DC/AC conversion circuit to provide a third voltage to the load terminal based on the compensation command and the voltage command.

Abstract: Silica-based biomolecule carriers, compositions comprising the same and preparation methods and uses thereof for delivering biomolecules into a cell are provided. The silica-based biomolecule carrier comprises a porous core; a first bioactive moiety; a second bioactive moiety functionally associated with the first bioactive moiety; and linkers for respectively conjugating the first bioactive moiety and the second bioactive moiety to the porous core.

Abstract: The disclosure provides a method for delivering an agent to posterior segment of an eye comprising administrating a pharmaceutical composition comprising the agent and mesoporous silica nanoparticles to the eye. An eye drop and a method for treating an ocular disease in a subject in need of such treatment are also provided.

Abstract: The present disclosure relates to mesoporous silica nanoparticles (MSNs) with specific modifications as drug delivery systems containing both tumor targeting and blood-brain barrier (BBB) penetration properties suitable for cancer treatment and/or CNS disease treatment. The present disclosure also relates to method of preparing MSNs and the MSNs prepared by the method as described herein.

Abstract: The present disclosure relates to PEGylated surface, in particular nano-sized carriers with such surface, in medical applications, such as a drug delivery system. Particularly, the PEGylated nano-sized carriers may solve the immunological issues caused by or related to polyethylene glycol-containing substances.

Abstract: Described herein is a cleaning composition for post-etch or post-ash residue removal from the surface of a semiconductor substrate and a corresponding use of said cleaning composition. Further described is the use of said cleaning composition in combination with one or more oxidants, e.g. for oxidative etching or partial oxidative etching of a layer or mask, comprising or consisting of TiN, preferably in the presence of a tungsten material, on the surface of a semiconductor substrate, and/or for post-etch or post-ash residue removal from the surface of a semiconductor substrate.

Abstract: The present disclosure relates to mesoporous silica nanoparticles having modifications on the surface of the (extended) mesopores, which can be further loaded with one or more types of bioactive ingredients within the (extended) mesopores mesopores, processes of preparing the same and applications of the same.

Abstract: The present disclosure relates to a field of hollow silica nanospheres. Particularly, the present disclosure relates to silica nanoparticles as adjuvant to induce or enhance immune response or as carrier to deliver antigen to a body.

Abstract: The present disclosure relates to mesoporous silica nanoparticles (MSNs) with specific modifications as drug delivery systems containing both tumor targeting and blood-brain barrier (BBB) penetration properties suitable for cancer treatment and/or CNS disease treatment. The present disclosure also relates to method of preparing MSNs and the MSNs prepared by the method as described herein.

Abstract: The present invention relates to hollow silica nanoparticles as a drug delivery system loading bioactive ingredients. Particularly, the present invention relates to silica nanoparticles comprising multi-layered silica shells with one or more bioactive ingredients encapsulated within and their applications in drug delivery; and processes of preparing the same.

Abstract: Silica-based biomolecule carriers, compositions comprising the same and preparation methods and uses thereof for delivering biomolecules into a cell are provided. The silica-based biomolecule carrier comprises a porous core; a first bioactive moiety; a second bioactive moiety functionally associated with the first bioactive moiety; and linkers for respectively conjugating the first bioactive moiety and the second bioactive moiety to the porous core.

Abstract: The present invention relates to hollow silica nanoparticles as a drug delivery system loading bioactive ingredients. Particularly, the present invention relates to silica nanoparticles comprising multi-layered silica shells with one or more bioactive ingredients encapsulated within and their applications in drug delivery; and processes of preparing the same.

Abstract: The present invention provides a composite that consists essentially of a mesoporous silica substrates and silver nanoparticles. In particular, the mesoporous silica substrate comprises a mesoporous silica thin film with perpendicular nanochannels and mesoporous silica nanoparticles with perpendicular nanochannels and the silver nanoparticles non-covalently bond onto surface of the mesoporous silica substrate and have a distribution density of 107-1013 number/cm2 on the surface. The preparing method and antibacterial application of the composite are also disclosed in the present invention.

Abstract: A sensing chip is provided, which includes a substrate and a plurality of nano structures periodically arranged on the substrate, wherein each of the nano structures includes a bottom metal layer disposed on the substrate, a middle dielectric layer disposed on the bottom metal layer, and a top metal layer disposed on the middle dielectric layer. The bottom metal layer has an area that is larger than that of the top metal layer.

Abstract: A sensing chip is provided, which includes a substrate and a plurality of nano structures periodically arranged on the substrate, wherein each of the nano structures includes a bottom metal layer disposed on the substrate, a middle dielectric layer disposed on the bottom metal layer, and a top metal layer disposed on the middle dielectric layer. The bottom metal layer has an area that is larger than that of the top metal layer.

Abstract: Mesoporous carriers for delivering targets into a cell are provided. The mesoporous carriers comprise hollow silica nanospheres (HSN) or mesoporous silica nanoparticles (MSN) and the targets bound to or encapsulated by the hollow silica nanospheres or the mesoporous silica nanoparticles. The targets includes at least two different targets, and the targets may include peptides, proteins, enzymes and/or enzymatic mimetics.

Abstract: A photo-electric device including a photoelectric conversion layer and a plurality of electrodes is provided. The photoelectric conversion layer includes a plurality of inversed pyramid shaped recesses and a plurality of a pyramids, wherein each of the inversed pyramid shaped recesses has at least three first reflection sidewalls, each of the pyramids is located in one of the inversed pyramid shaped recesses respectively, each of the pyramids has at least three second reflection sidewalls, and none of the first reflection sidewall and the second reflection sidewall is located in a same plane. The electrodes are electrically connected to the photoelectric conversion layer.