Abstract: The Invention relates to a method to utilize the characteristic of a protective agent to incubate singlet oxygen and prolong its lifetime so as to provide abundant singlet oxygen with persistence and thus improve the effect of photodynamic therapy. The composition is composed of a functional substance that can prolong the lifetime of singlet oxygen, an emulsifier and a photosensitizer; the functional substance is emulsified into an emulsion through the emulsifier and delivered into a tumor tissue with the photosensitizer; then the photodynamic therapy can be conducted with the abundant singlet oxygen incubated by the functional substance that can prolong the lifetime of singlet oxygen and thus the effect of photodynamic therapy is improved.

Abstract: The present invention provides preparation methods of protein nanoparticles for in vivo delivery of pharmacologically active agents, wherein said methods are to encase pharmaceutically active agents into proteins or peptides to form nanoparticles by unfolding the protein, and subsequently refolding or assembling the protein to produce a pharmacologically active agent encased within a protein nanoparticle.

Abstract: The present invention provides preparation methods of protein nanoparticles for in vivo delivery of pharmacologically active agents, wherein said methods are to encase pharmaceutically active agents into proteins or peptides to form nanoparticles by unfolding the protein, and subsequently refolding or assembling the protein to produce a pharmacologically active agent encased within a protein nanoparticle.

Abstract: Conjugate of biomacromolecule with bioreductive which can be useful for treating tumor is provided. The biomacromolecule is selected from apo-transferrin, Fe-transferrin, Ru-transferrin, Ti-transferrin, Ga-transferrin, Pt-transferrin, somatostatin, EGF, folacin acid or transcobalamin, and the bioreductive agent is selected from quinones, aromatic nitrogen oxides, fatty nitrogen oxides, heterocyclic nitro compound, transition metal compound. Such conjugate can selectively target the tumor cells, and lower the toxicity of medicines and survivability of tumor cells, so that the conjugate can be used for delivery of anti-tumor compounds or treating tumors.