Patents by Inventor Yiru Dai

Yiru Dai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PREPARATION METHOD FOR 3BETA-ARACHIDYLAMIDO-7ALPHA, 12ALPHA, 5BETA-CHOLAN-24-CARBOXYLIC ACID
    Publication number: 20120277448
    Abstract: A method for preparing 3?-arachidylamido-7?,12?,5?-cholan-24-carboxylic acid represented by the following formula V is disclosed, which includes the following steps: converting cholic acid to the compound of formula III by acylation reaction and azidation reaction, reducing the compound of formula III to the compound of formula IV and in the end acylating the compound of formula IV with arachidoyl chloride to get the compound of formula V. The method avoids the use of protection groups.
    Type: Application
    Filed: November 25, 2010
    Publication date: November 1, 2012
    Applicants: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, TOPHARMAN SHANGHAI CO., LTD.
    Inventors: Xiangrui Jiang, Lijun Guo, Yiru Dai, Jianfeng Li, Jin Suo, Rongxia Zhang, Zheng Liu
  • Process for preparing montelukast and precursors thereof
    Publication number: 20060223999
    Abstract: The present invention provides a process for stereoselectively reducing 2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]-phenyl]-3-oxopropyyl]benzoic-acid methyl ester, to produce to produce methyl 2-[3-(S)-[3-[2-(7-chloro-2-quinolinyl)-ethenyl]phenyl]-3-hydroxypropyl]benzoate, and a process for producing montelukast or a salt thereof. The present invention further provides a process for purifying methyl 2-[3-(S)-[3-[2-(7-chloro-2-quinolinyl)-ethenyl]phenyl]-3-hydroxypropyl]benzoate. The reduction process of the present invention uses a chiral reagent and can produce the desired reduction product in high enantiomeric excess (ee).
    Type: Application
    Filed: May 10, 2006
    Publication date: October 5, 2006
    Applicant: CHEMAGIS LTD.
    Inventors: Jingshan Shen, Yiru Dai, Joseph Kaspi