Abstract: The present invention relates to the field of biomedicine, particularly to double-stranded RNA molecules targeting CKIP-1 and uses thereof, particularly to use of the double-stranded RNA molecules for the treatment of inflammatory diseases such as arthritis, particularly rheumatoid arthritis.

Abstract: Techniques of this disclosure are directed to enable a computing device to process voice queries and provide query answers even when the computing device and vehicle do not have internet connectivity. According to the disclosed techniques, a computing device may detect a query via input devices of the computing device and output a query answer determined based on the detected query. Rather than directly querying a remote computing system, various aspects of the techniques of this disclosure may enable the computing device to use a query answer cache to generate the query answer. The query answer cache may include predicted queries and query answers retrieved from a query answer cache of a remote computing system, thereby enabling the computing device to respond to the detected queries while experiencing unreliable internet connection.

Abstract: The present disclosure relates to the field of early warning for geological disasters, and discloses an early warning method for icefall-caused moraine lake outburst disasters, which aims at solving the problems of low early warning precision and difficulty in implementation in an early warning solution of the prior art. The method includes: S1, calculating topographic parameters of moraine lakes and upstream glaciers thereof, and filtering a moraine lake to undertake focal monitoring; S2, calculating a freezing-thawing cycle index and a regional accumulated temperature index of an upstream glacier region for the moraine lake to undertake focal monitoring, S3, calculating a catastrophic climate determination factor TG-year, wherein if the catastrophic climate determination factor TG-year satisfies a corresponding catastrophic climate determination condition, an early warning condition is satisfied, otherwise the early warning condition is not satisfied; and S4, implementing early warning.

Abstract: The present invention is directed to a sensor device detecting movement of mouth or tongue associated with bruxism and/or sleep apnea. The present invention is also directed to a system for treating sleep apnea in a patient in need thereof, comprising a sensing component and a stimulation component, the sensing component comprising one or more wireless sensors for collecting one or more vital signs of the patient and/or tongue muscle movements of the patient, the sensing component being in wireless communication with a control system, and wherein the stimulation component comprises (i) an implantable body configured to deliver energy to one of a nerve or muscle, and (ii) a wearable appliance inductively coupled to the implanted body, the wearable portion configured to receive signals from the control system, wherein the sensing component comprises the sensor device of the present invention.

Abstract: The present disclosure relates to at least one method for ascertaining at least one attribute of pressure vessel wall. A method comprises: while a pressure vessel, which comprises a wall having an outer surface and an inner surface, is operating: ascertaining a current wavelength shift of a first fiber Bragg grating (FBG) sensor disposed at a first outer surface location on the pressure vessel; and ascertaining a current thickness of the wall at the first outer surface location by: computing a vector based on a time series of the current wavelength shift, or a derivative of the time series, or a derivative of the current wavelength shift; providing the vector to a predetermined regression model; and using the regression model, ascertaining the current thickness of the wall.

Abstract: Non-human animal models of non-alcoholic fatty liver disease (NAFLD) are provided. Compositions and methods for producing the non-human animal models and uses of the non-human animal models to screen and evaluate agents for treating or preventing NAFLD are also provided.

Abstract: A serial isolated communication method, applied to a transmitter of a serial isolated communication system, includes: obtaining isolated communication data to be transferred; encoding isolated communication data with more than two bits into corresponding data pulse signals according to a preset encoding rule, wherein a group of data pulse signals include a positive pulse, a negative pulse, and a delay of 0 or N pulse widths between the positive pulse and the negative pulse, and N?1; and transferring the data pulse signals to a receiver. A serial isolated communication method, applied to a receiver of a serial isolated communication system, includes: receiving data pulse signals transferred from a transmitter; decoding the data pulse signals into the isolated communication data according to a preset decoding rule; and obtaining the isolated communication data. Serial isolated communication device and system are further provided.

Abstract: A serial isolated communication method, applied to a transmitter of a serial isolated communication system, includes: obtaining isolated communication data to be transferred; encoding isolated communication data with more than two bits into corresponding data pulse signals according to a preset encoding rule, wherein a group of data pulse signals include a positive pulse, a negative pulse, and a delay of 0 or N pulse widths between the positive pulse and the negative pulse, and N?1; and transferring the data pulse signals to a receiver. A serial isolated communication method, applied to a receiver of a serial isolated communication system, includes: receiving data pulse signals transferred from a transmitter; decoding the data pulse signals into the isolated communication data according to a preset decoding rule; and obtaining the isolated communication data. Serial isolated communication device and system are further provided.

Abstract: Techniques of this disclosure are directed to enable a computing device to process voice queries and provide query answers even when the computing device and vehicle do not have internet connectivity. According to the disclosed techniques, a computing device may detect a query via input devices of the computing device and output a query answer determined based on the detected query. Rather than directly querying a remote computing system, various aspects of the techniques of this disclosure may enable the computing device to use a query answer cache to generate the query answer. The query answer cache may include predicted queries and query answers retrieved from a query answer cache of a remote computing system, thereby enabling the computing device to respond to the detected queries while experiencing unreliable internet connection.

Abstract: A signal transmitting circuit and a signal receiving circuit for serial communication, and an electronic device are provided. The signal transmitting circuit includes a control module, a first transmitter, a second transmitter, a first differential pin, and a second differential pin, wherein the control module is configured to control the first transmitter to output a first signal via the first differential pin, and control the second transmitter to output a second signal via the second differential pin to record target information with a target signal after differentiating between the first signal and the second signal; and wherein if the target information includes data information and instant information, the data information is recorded in the target signal with a third signal with a first frequency while recording the instant information with a fourth signal with a second frequency, the first frequency is different from the second frequency.

Abstract: A manufacturing system for an inkjet printing flexible display device includes a substrate input module, a substrate transferring module, a printing module, a post-printing processing module, a solid content detection module, a film packaging printing module, a film formation detection module, a substrate output module. At the same time, the functional modules are highly integrated and optimized in structure and layout. The manufacturing system for the inkjet printing flexible display device is suitable for industrial production and are adopted to monitor the manufacturing process by using a plurality of detection modules.

Abstract: A signal transmitting circuit and a signal receiving circuit for serial communication, and an electronic device are provided. The signal transmitting circuit includes a control module, a first transmitter, a second transmitter, a first differential pin, and a second differential pin, wherein the control module is configured to control the first transmitter to output a first signal via the first differential pin, and control the second transmitter to output a second signal via the second differential pin to record target information with a target signal after differentiating between the first signal and the second signal; and wherein if the target information includes data information and instant information, the data information is recorded in the target signal with a third signal with a first frequency while recording the instant information with a fourth signal with a second frequency, the first frequency is different from the second frequency.

Abstract: A manufacturing system for an inkjet printing flexible display device includes a substrate input module, a substrate transferring module, a printing module, a post-printing processing module, a solid content detection module, a film packaging printing module, a film formation detection module, a substrate output module. At the same time, the functional modules are highly integrated and optimized in structure and layout. The manufacturing system for the inkjet printing flexible display device is suitable for industrial production and are adopted to monitor the manufacturing process by using a plurality of detection modules.

Abstract: A method of predicting if a subject has an Activated B Cell-like (ABC) subtype or a non-ABC subtype of Diffuse Large B-Cell Lymphoma (DLBCL), comprising (a) obtaining a sample from the subject; (b) measuring the expression levels of CD10, MUM1, FOXP1, and optionally Bcl-6; (c) determining a composite score based on the expression levels of CD10, MUM1, and FOXP1, and optionally Bcl-6; and (d) predicting if the subject has an ABC subtype or a non-ABC subtype of DLBCL based on the composite score.

Abstract: The present disclosure relates to materials and methods for evaluating prostate cancer using binding entities (such as antibodies) that bind to the N-terminus and the C-Terminus of androgen receptor. Prostate samples are histochemically labeled for the N-terminus and the C-Terminus of androgen receptor, and a ratio between the binding of the N- and C-terminal antibodies is determined.

Abstract: The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into a linear discrimination analysis where the linear discrimination analysis normalizes the Biomarkers against a reference; and imposes a cut-off which optimizes sensitivity and specificity of each Biomarker, weights the prevalence of the carcinomas and selects a tissue of origin determining origin based on highest probability determined by the linear discrimination analysis or determining that the carcinoma is not derived from a particular set of carcinomas; and optionally measuring Biomarkers specific for one or more additional different carcinoma, and repeating the steps for additional Biomarkers.

Abstract: Methods are disclosed for the identification of gene sets that are differentially expressed in PBMCs of patients diagnosed with a pre-diabetic disease state and overt type II diabetes. 3 gene and 10 gene signatures are shown to accurately predict a diabetic disease state in a patient. The application also described kits for the rapid diagnosis of diabetic disease states in patients at a point of care facility.

Abstract: The disclosed edge-blocker oligonucleotide based AS-NEPB-PCR method amplifies allele specific DNA (or RNA) while dramatically blocking amplification of wild type (WT) DNA (or RNA). The AS-NEPB-PCR design allows ready modification of an existing PCR reaction setup with an edge-blocker oligonucleotide together with an allele specific primer complementary to the mutant sequence to achieve allele specific amplification. The method simplifies assay optimization procedures and achieved sensitivity sufficient to detect a signal present at 0.1% level with close to 100% specificity, which is useful in detecting SNP or genetic mutations. The method was used to detect three different genetic mutations in cancer, in KRAS, BRAF, and EGFR, with three different types of modified edge-blocker oligonucleotides (phosphate, inverted dT and amino-C7). It was possible to detect one copy of mutant DNA in 1000-copy of normal DNA background of a heterogeneous sample, and was far more sensitive than the other blocking method.

Abstract: Circulating Endothelial Cells are isolated from patient blood and gene expression of the cells is analyzed to assess a medical condition or the tissue of origin of the cell. Kits for conducting the method are also provided.

Abstract: A remote node for a wavelength-division-multiplexed passive optical network (WDM PON). The remote node comprises means for receiving uplink optical signals from one or more optical network units of the WDM PON; a broadband reflector for reflecting a self-seeding portion of the respective uplink optical signals to the respective uplink light sources; and wherein the reflector comprises a gain medium and is configured for receiving a pump optical signal from a central office of the WDM PON for amplifying the self seeding portion of the respective uplink optical signal.