Patents by Inventor Yogesh Shantilal Sanghvi

Yogesh Shantilal Sanghvi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Backbone modified oligonucleotide analogues
    Patent number: 6900301
    Abstract: Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique di- and poly-nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: May 31, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Yogesh Shantilal Sanghvi, Jean Jacques Vasseur, Francoise Debart
  • Backbone modified oligonucleotide analogues
    Publication number: 20030045705
    Abstract: Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique di- and poly-nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.
    Type: Application
    Filed: May 22, 2002
    Publication date: March 6, 2003
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Yogesh Shantilal Sanghvi, Jean Jacques Vasseur, Francoise Debart
  • Backbone modified oligonucleotide analogues
    Patent number: 5965721
    Abstract: Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique di- and poly-nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: October 12, 1999
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Yogesh Shantilal Sanghvi, Jean Jacques Vasseur, Francoise Debart
  • Heteroatomic oligonucleoside linkages
    Patent number: 5777092
    Abstract: Oligonucleotide-mimicking macromolecules that have improved nuclease resistance are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligonucleotides with three or four atom linking groups provide unique oligonucleotide-mimicking macromolecules that are useful in regulating RNA expression and in therapeutics. Methods of synthesis and use also are disclosed.
    Type: Grant
    Filed: February 4, 1997
    Date of Patent: July 7, 1998
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Yogesh Shantilal Sanghvi