Abstract: [Problem] A compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer is provided. [Solution] The present inventors have studied about a compound that is useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer and have found that a 4-aminoquinazoline compound has an excellent G12D mutant KRAS inhibition activity and can be used as a therapeutic agent for pancreatic cancer, thus completing the present invention. The 4-aminoquinazoline compound of the present invention or a salt thereof can be used as a therapeutic agent for pancreatic cancer.

Abstract: A method for producing polytetrafluoroethylene, which includes polymerizing tetrafluoroethylene in an aqueous medium in the presence of a nucleating agent and a hydrocarbon anionic surfactant to obtain polytetrafluoroethylene. A total amount of the nucleating agent and the hydrocarbon anionic surfactant at the initiation of polymerization is more than 50 ppm based on the aqueous medium.

Abstract: Crystals of the compound represented by formula (1), a method for the production thereof, and a method for producing an antibody-drug conjugate using the crystals.

Abstract: A vehicle brake system includes a switching valve switchable between a first state allowing communication between a first fluid pressure generating device and a frictional brake and a second state allowing communication between a second fluid pressure generating device and the frictional brake. The second fluid pressure generating device generates a fluid pressure by moving a piston with an electric actuator, and has a fluid pressure supply port connected to the switching valve and an atmosphere opening port connected to a reservoir tank. When, due to a failure, the switching valve becomes a third state in which the switching valve makes each of the first fluid pressure generating device and the second fluid pressure generating device communicate with the frictional brake, a control device controls the second fluid pressure generating device to close the atmosphere opening port with the piston.

Abstract: Provided is an improved estimation and identification device that estimates the position of a plurality of identification targets and identifies the plurality of identification targets.

Abstract: An optical cable according to an embodiment of the present disclosure is an optical cable for installation in a microduct, the optical cable including one or more optical-fiber core wires, and a sheath layer covering an outer peripheral side of the one or more optical-fiber core wires. The sheath layer has a density of 2.0 g/cm3 or less. The sheath layer contains an olefin-based resin, a silicone, and a non-halogen flame retardant. A mass ratio of the non-halogen flame retardant to the olefin-based resin is 0.90 to 2.00. A mass ratio of the silicone to the olefin-based resin is 0.005 to 0.100. The olefin-based resin contains a polyethylene, and an ethylene-vinyl acetate copolymer or an ethylene-ethyl acrylate copolymer. The silicone has a weight-average molecular weight of 50,000 to 1,000,000.

Abstract: A vehicle brake system includes a first fluid pressure generating device for generating a fluid pressure according to a brake operating amount, a second fluid pressure generating device for generating a fluid pressure by moving a piston with an electric actuator, and a switching valve switchable between a first state allowing communication between the first fluid pressure generating device and a vehicle behavior stabilizing device and a second state allowing communication between the second fluid pressure generating device and the vehicle behavior stabilizing device. A control device places the switching valve in the second state during execution of automatic brake control, and places the switching valve in the first state when a predetermined abnormality occurs in the vehicle, except that the control device places the switching valve in the second state when an abnormality including inability of the second fluid pressure generating device to generate the fluid pressure occurs.

Abstract: A tire includes a tread portion including a row of blocks arranged in a tire circumferential direction divided by lateral grooves. Each block includes a block tread surface, a first block sidewall surface located on a leading side in a rotation direction of the block, and a leading-side corner portion between the block tread surface and the first block sidewall surface. The leading-side corner portion includes a first portion and a second portion extending in a tire axial direction. The first portion is formed sharper than the second portion. In a plan view of each block, an angle ?1 of the first portion to the tire circumferential direction is larger than an angle ?2 of the second portion to the tire circumferential direction. Each lateral groove has a groove width (A) at the first portion that is larger than a groove width (B) at the second portion.

Abstract: An inkjet head contains a silicon nozzle substrate having an ink channel surface and an ink ejection surface facing the channel surface, and having a nozzle penetrating from the channel surface to the ejection surface; a channel substrate bonded to the channel surface of the silicon nozzle substrate, and including an ink channel and a substrate body that forms the ink channel; and a liquid-repellent film provided on the ejection surface of the silicon nozzle substrate. The channel substrate includes a through channel that penetrates the substrate body so as to face the nozzle, n-number of individual circulation channels that communicate with the through channel, extend in a direction away from the nozzle, and have a portion overlapping the substrate body in a plan view. A positional relationship between each of the individual circulation channels and the nozzle satisfies a specific Expression 1.

Abstract: The present invention causes a holder to hold a plane mirror without causing damage to a reflection layer. Provided is a head-up display comprising a housing, a display device that emits display light, a plane mirror that reflects the display light, and a holder that holds the plane mirror, wherein the plane mirror has a base material, and a reflection layer provided on the base material and including a resin film, and the holder abuts on a portion of the base material in which the reflection layer is not provided.

Abstract: Provided is an inkjet head containing a nozzle plate having at least a substrate, wherein the nozzle plate has a liquid-repellent layer on an outermost surface of the substrate on an ink ejection surface side; a liquid-repellent layer base film is provided between the substrate and the liquid-repellent layer; and the liquid-repellent layer base film contains at least silicon (Si) and carbon (C), and having a maximum peak P of a binding energy of a Si2p orbital of a surface portion measured by X-ray photoelectron spectroscopy is in the range represented by the following Formula (1), Formula (1): 99.6 (eV)?P?101.9 (eV).

Abstract: A substrate processing apparatus including a lower jig plate for arranging a substrate which is an object to be pressurized, columnar members supporting the lower jig plate, and a heat dissipating column contacting the lower jig plate directly or indirectly and having a higher heat dissipation property than the columnar members.

Abstract: Provided is a substrate processing apparatus capable applying a uniform load to an object to be pressurized. The substrate processing apparatus includes a lower jig plate 46 for arranging a substrate 2 which is an object to be pressurized, an upper jig plate 44 applying pressure to the substrate 2 arranged to the lower jig plate 46, and a support member 45 supporting the lower jig plate 46 and providing a support force to the lower jig plate 46 in accordance with a in-plane distribution of a load applied to the lower jig plate 46.

Abstract: A substrate processing apparatus 10 having a lower jig plate 46 for arranging a substrate 2 as an object to be pressurized, a support member 45 including an installation portion 52 for installing columnar members 50 supporting the lower jig plate 46, in which the columnar members 50 are placed to the installation portion 52 in accordance with a in-plane distribution of a load applied to the lower jig plate 46.

Abstract: A substrate processing apparatus 10 applies pressure to a substrate 2 which is an object to be pressurized arranged on an upper jig plate 44. The substrate processing apparatus 10 includes a lower jig plate 46 arranged below the upper jig plate 44, an installation base 47 provided on the lower jig plate 46 and the substrate 2 is arranged; and the installation base is temporarily fixed to the installation base 47 in a deformable manner.

Abstract: An inkjet head includes a first and a second channel substrates. At least one of the first and the second channel substrates is formed of silicon. A bonding interface of the first and the second channel substrates is bonded via an adhesive layer. A protective film containing a compound having a Si—C bond is formed on: an ink channel surface formed of silicon among the first and the second channel substrates; and a surface of the channel substrate side formed of silicon in the adhesive layer.

Abstract: There are provided an inkjet head, an inkjet image forming apparatus, a nozzle plate manufacturing method, and an inkjet head manufacturing method capable of improving durability against wiping on an ink discharge surface. The inkjet head includes a nozzle substrate including nozzle holes from which ink is discharged. The nozzle substrate has an irregularity structure formed on an ink discharge surface such that neither ink particles contained in the ink nor a wiping member that wipes the ink discharge surface get caught by the irregularity structure.

Abstract: A pneumatic tire comprises: a tread portion; a pair of sidewall portions; a pair of bead portions each with a bead core embedded therein; a toroidal carcass extending between the bead portions; and a sidewall rubber disposed axially outside the carcass in each of the sidewall portions. The bead portion has a bead bottom surface which contacts with a bead seat of a wheel rim when the tire is mounted thereon. The bead bottom surface comprises an axially inner region including a bead toe and an axially outer region including a bead heel. The axially inner region is formed by a canvas chafer. The axially outer region is formed by the sidewall rubber extended radially inwardly from the sidewall portion.

Abstract: The immediacy is not reduced, and autofocus is not started while the focus position being selected. The image pickup apparatus includes an operation member that selects a position for performing autofocus using a light input device that detects the movement of the finger and instructs the start of autofocus by an operation by the finger. When autofocus being performed, a display object for selecting a position for performing autofocus is displayed on the display unit 28 and the viewfinder in-field display unit 41. The system control unit 50 moves the display object according to the movement amount of the finger detected by the light input device, and starts autofocus at the position of the display object when the operation member is operated. The light input device is disposed below the face, of the operation member, on which the finger is placed.

Abstract: [Object] Provided are a stamp tool whose transport head can be easily shared, a transport device capable of allowing the stamp tool to easily pick up an transport object element disposed on a surface of a substrate from the substrate and transporting the element without being left on the substrate side, and an element array manufacturing method using the same. [Solution] A stamp tool 10 includes a stamp layer 12 allowing an element 32r as an transport object element to detachably adhere thereto, a support plate 14 to which the stamp layer 12 is fixed, and an adapter plate 16 having a mounting surface 16a, the support plate 14 being replaceably attached thereto, and a transport head 22 being allowed to be detachably attached thereon.