Abstract: [Problem] A compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer is provided. [Solution] The present inventors have studied about a compound that is useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer and have found that a 4-aminoquinazoline compound has an excellent G12D mutant KRAS inhibition activity and can be used as a therapeutic agent for pancreatic cancer, thus completing the present invention. The 4-aminoquinazoline compound of the present invention or a salt thereof can be used as a therapeutic agent for pancreatic cancer.

Abstract: An abnormality determination system applicable to a work machine includes: a stereo camera 22 mounted on a wheel loader having working equipment 10; a position data calculation unit 83 that estimates a position of the working equipment 10 in a captured image of the stereo camera 22 based on a posture of the working equipment 10 when captured by the stereo camera 22; and a determination unit 91 that determines whether the stereo camera 22 is normal based on the estimated position of the working equipment 10.

Abstract: A work machine control device includes a measurement-data acquisition unit that acquires measurement data of a three-dimensional measurement device that is mounted on a work machine including work equipment and measures a three-dimensional shape including a ridgeline of a work target on which the working equipment performs work, and a target calculation unit that calculates and outputs, based on the measurement data regarding the ridgeline of the work target, a distance from the work machine to the work target or an angle of repose of the work target.

Abstract: A compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy is provided. The present inventors have conducted studies on a compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and confirmed that a heteroaryl carboxamide compound has DGK ? (DGKzeta) inhibitory effect, leading to completion of the present invention. The heteroaryl carboxamide compound of the present invention has DGK ? inhibitory effect, and can be used as a therapeutic agent for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy.

Abstract: A control system of a work machine includes: a three-dimensional measurement device 20 that measures a work target of a work machine 1; a detection device 25 that detects the work target; and a working equipment control unit 87 functioning as an intervention control unit that performs intervention control of the work machine 1 when both the three-dimensional measurement device 20 and the detection device 25 have detected the work target.

Abstract: A compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy is provided. The present inventors have conducted studies on a compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and confirmed that a heteroaryl carboxamide compound has DGK ? (DGKzeta) inhibitory effect, leading to completion of the present invention. The heteroaryl carboxamide compound of the present invention has DGK ? inhibitory effect, and can be used as a therapeutic agent for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy.

Abstract: A loading machine control device includes a measurement data acquisition unit acquiring measurement data of a measurement device mounted in a loading machine having working equipment, a target calculation unit calculating, based on the measurement data, a position of an upper end portion of a loading target to which an excavation object excavated by a bucket of the working equipment is loaded, a bucket calculation unit calculating position data of the bucket, an overlap determination unit determining whether the upper end portion of the loading target and the bucket that are in the measurement data overlap each other, and a working equipment control unit controlling the working equipment based on the measured position of the upper end portion of the loading target when it is determined that the upper end portion of the loading target and the bucket that are in the measurement data do not overlap each other.

Abstract: A control device for a loading machine includes a measurement data acquisition unit that acquires measurement data of a measurement device mounted on the loading machine that includes working equipment, a target calculation unit that extracts, from the measurement data, loading target data being measurement data on a loading target on which excavated material excavated by the working equipment is loaded and calculates, based on the loading target data, height data indicating a height of an upper end portion of the loading target and distance data indicating a distance from the loading machine to the loading target, and a working equipment control unit that controls the working equipment based on the height data and the distance data.

Abstract: A work machine includes: a vehicle body front part to which a front wheel is attached; a vehicle body rear part which is coupled to the vehicle body front part through an articulated mechanism and to which a rear wheel is attached; a working equipment coupled to the vehicle body front part; a headlight supported by the vehicle body front part and arranged above the front wheel; and a three-dimensional measurement device arranged on an outer side of the headlight in a vehicle width direction that is in parallel with a rotation axis of the front wheel.

Abstract: A compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer having resistance to anti-PD-1 antibody/anti-PD-L1 antibody therapy is provided. The present inventors have conducted studies on a compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer having resistance to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and found that a pyridazinyl-thiazolecarboxamide compound has DGK ? (DGKzeta) inhibitory effect, leading to completion of the present invention. The pyridazinyl-thiazolecarboxamide compound of the present invention has DGK ? inhibitory effect, and can be used as a therapeutic agent for treatment of cancer related to activation of immune cells or cancer having resistance to anti-PD-1 antibody/anti-PD-L1 antibody therapy.

Abstract: A control device for a loading machine includes a measurement data acquisition unit that acquires measurement data of a measurement device mounted on the loading machine that includes working equipment, a target calculation unit that extracts, from the measurement data, loading target data being measurement data on a loading target on which excavated material excavated by the working equipment is loaded and calculates, based on the loading target data, height data indicating a height of an upper end portion of the loading target and distance data indicating a distance from the loading machine to the loading target, and a working equipment control unit that controls the working equipment based on the height data and the distance data.

Abstract: A loading machine control device includes a measurement data acquisition unit acquiring measurement data of a measurement device mounted in a loading machine having working equipment, a target calculation unit calculating, based on the measurement data, a position of an upper end portion of a loading target to which an excavation object excavated by a bucket of the working equipment is loaded, a bucket calculation unit calculating position data of the bucket, an overlap determination unit determining whether the upper end portion of the loading target and the bucket that are in the measurement data overlap each other, and a working equipment control unit controlling the working equipment based on the measured position of the upper end portion of the loading target when it is determined that the upper end portion of the loading target and the bucket that are in the measurement data do not overlap each other.

Abstract: A non-transitory computer-readable storage medium storing therein an editing program for causing a computer to execute a process comprising: when a command has been input in the text of the editing data, starting an application program, and displaying an application image generated by the application program together with the editor image on the preview screen; when a user operation for changing the application image is performed, receiving first application data changed by the application program together with the application image, and insertion position information; inserting the first application data to the insertion position represented by the insertion position information in the text; and when the application data inserted in the editing data have been changed, causing the application program to overwrite changed second application data on the first application data, and transmitting a message to change the application image together with the second application data to the application program.

Abstract: A work machine control device includes a measurement-data acquisition unit that acquires measurement data of a three-dimensional measurement device that is mounted on a work machine including work equipment and measures a three-dimensional shape including a ridgeline of a work target on which the working equipment performs work, and a target calculation unit that calculates and outputs, based on the measurement data regarding the ridgeline of the work target, a distance from the work machine to the work target or an angle of repose of the work target.

Abstract: A work machine control device includes a measurement-data acquisition unit that acquires measurement data of a measurement device that measures a work target, the measurement device being mounted on a work machine including a working equipment, an algorithm selection unit that selects a specific algorithm that processes the measurement data depending on work of the work machine, and a calculation unit that processes the measurement data based on the algorithm selected by the algorithm selection unit to calculate a parameter regarding the work target.

Abstract: A work machine includes: a vehicle body front part to which a front wheel is attached; a vehicle body rear part which is coupled to the vehicle body front part through an articulated mechanism and to which a rear wheel is attached; a working equipment coupled to the vehicle body front part; a headlight supported by the vehicle body front part and arranged above the front wheel; and a three-dimensional measurement device arranged on an outer side of the headlight in a vehicle width direction that is in parallel with a rotation axis of the front wheel.

Abstract: A non-transitory computer-readable storage medium storing therein an editing program for causing a computer to execute a process comprising: when a command has been input in the text of the editing data, starting an application program, and displaying an application image generated by the application program together with the editor image on the preview screen; when a user operation for changing the application image is performed, receiving first application data changed by the application program together with the application image, and insertion position information; inserting the first application data to the insertion position represented by the insertion position information in the text; and when the application data inserted in the editing data have been changed, causing the application program to overwrite changed second application data on the first application data, and transmitting a message to change the application image together with the second application data to the application program.

Abstract: The present invention relates to a cross-linking agent for cross-linking an indole-structure-containing molecule to a desired molecule, the cross-linking agent containing, as an effective component, a radical compound having an N-oxy radical group and a group capable of bonding to the desired molecule.

Abstract: An information processing apparatus includes: a memory; and a processor coupled to the memory, wherein the processor: acquires a plurality of functionalities that a system uses to implement a predetermined idea; searches functionality information, which associates devices with functionalities and associates application programming interfaces (APIs) with functionalities, for one or more devices or one or more APIs having the respective acquired functionalities; generates a plurality of first combinations including at least two ones of the one or more devices and the one or more APIs and having the functionalities; assesses each of the first combinations in accordance with an assessment function in which the first combinations are weighted with particular elements; and presents the first combinations in accordance with assessment values obtained in assessment to select a first combination to be used in the system.

Abstract: An information reception terminal includes a processor configured to acquire meta information from each of a plurality of information distribution terminals existing within a communication range of the information reception terminal. The meta information includes identification information identifying a content distributed by the relevant information distribution terminal. The processor is configured to generate a list of contents on the basis of the meta information acquired from each of the plurality of information distribution terminals. The processor is configured to display the generated list on a display device.