Patents by Inventor Yoichi Iimura
Yoichi Iimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090215771Abstract: The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.Type: ApplicationFiled: June 20, 2008Publication date: August 27, 2009Inventors: Piotr GRACZYK, Afzal KHAN, Gurpreet BHATIA, Yoichi IIMURA
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Publication number: 20090137629Abstract: A method for treatment of a mental disorder containing the step of administering a therapeutically effective amount of a sigma receptor binding agent containing an indanone compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate of them. The variables of formula (I) are recited in the present specification.Type: ApplicationFiled: November 5, 2008Publication date: May 28, 2009Inventors: Yoichi Iimura, Takashi Kosasa, Yoshiharu Yamanishi
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Patent number: 7432375Abstract: The present invention provides novel compounds of formula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.Type: GrantFiled: March 5, 2004Date of Patent: October 7, 2008Assignee: Eisai R & D Management Co., Ltd.Inventors: Piotr Graczyk, Afzal Khan, Gurpreet Bhatia, Yoichi Iimura
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Patent number: 7378425Abstract: The present invention provides an excellent sigma receptor binding agent and/or acetylcholinesterase inhibitor containing an (1-indanone)-(1,2,3,6-tetrahydropyridine) compound. More specifically, it provides an (1-indanone)-(1,2,3,6-tetrahydropyridine) compound represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate thereof: In the formula (I), R1, R2, R3 and R4 are the same as or different from each other.Type: GrantFiled: September 15, 2004Date of Patent: May 27, 2008Assignee: Eisai R & D Management Co., Ltd.Inventors: Yoichi Iimura, Takashi Kosasa, Yoshiharu Yamanishi
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Publication number: 20060270646Abstract: The present invention provides novel compounds of formula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.Type: ApplicationFiled: March 5, 2004Publication date: November 30, 2006Applicant: Eisai Co., Ltd.Inventors: Piotr Graczyk, Afzat Khan, Gurpreet Bhatia, Yoichi Iimura
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Patent number: 7091218Abstract: The present invention provides a novel compound having an excellent acetylcholinesterase inhibitory effect. That is, it provides a compound represented by formula: (wherein R1 and R2 represent substituents), a pharmacologically acceptable salt thereof or hydrates thereof.Type: GrantFiled: September 1, 2000Date of Patent: August 15, 2006Assignee: Eisai Co., Ltd.Inventors: Yoichi Iimura, Takashi Kosasa
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Publication number: 20060084658Abstract: The present invention provides a novel compound having a superior calcium antagonism, in particular, a neuron-selective calcium antagonism. Namely, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, Ar indicates an optionally substituted 5- to 14-membered aromatic ring etc.; the ring A indicates any one ring selected from a piperazine, a homopiperazine, a piperidine and the like; the ring B indicates an optionally substituted C3-14 hydrocarbon ring etc.; E indicates a single bond, a group represented by the formula —CO—, etc.; X indicates a single bond, an oxygen atom etc.; R1 indicates a hydrogen atom, a halogen atom, a hydroxyl group etc.; and D1, D2, W1 and W2 are the same as or different from each other and each represents a single bond or an optionally substituted C1-6 alkylene chain.Type: ApplicationFiled: September 20, 2005Publication date: April 20, 2006Inventors: Noboru Yamamoto, Yuichi Suzuki, Manami Kimura, Tetsuhiro Niidome, Yoichi Iimura, Tetsuyuki Teramoto, Yoshihisa Kaneda, Toshihiko Kaneko, Nobuyuki Kurusu, Daisuke Shinmyo, Yukie Yoshikawa, Slinji Hatakeyama
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Patent number: 6906072Abstract: The present invention provides a novel compound having a superior calcium antagonism, in particular, a neuron-selective calcium antagonism. Namely, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, Ar indicates an optionally substituted 5- to 14-membered aromatic ring etc.; the ring A indicates any one ring selected from a piperazine, a homopiperazine, a piperidine and the like; the ring B indicates an optionally substituted C3-14 on hydrocarbon ring etc.; E indicates a single bond, a group represented by the formula —CO—, etc.; X indicates a single bond, an oxygen atom etc.; R1 indicates a hydrogen atom, a halogen atom, a hydroxyl group etc.; and D1, D2, W1 and W2 are the same as or different from each other and each represents a single bond or an optionally substituted C1-6 alkylene chain.Type: GrantFiled: January 18, 2001Date of Patent: June 14, 2005Assignee: Eisai Co., Ltd.Inventors: Noboru Yamamoto, Yuichi Suzuki, Manami Kimura, Tetsuhiro Niidome, Yoichi Iimura, Tetsuyuki Teramoto, Yoshihisa Kaneda, Toshihiko Kaneko, Nobuyuki Kurusu, Daisuke Shinmyo, Yukie Yoshikawa, Shinji Hatakeyama
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Patent number: 6906083Abstract: The present invention provides a novel compound having a superior acetylcholinesterase inhibitory action. It provides a compound represented by the formula: (In the formula, R1 represents a group represented by the formula: (wherein, R3, R4, R5 and R6 are the same as or different from each other and each represents a hydrogen atom, an optionally substituted C1-6 alkoxy group and the like; and m represents an integer from 0 to 6) and the like; and R2 represents a hydrogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C2-6 alkenyl group or an optionally substituted C2-6 alkynyl group), a salt thereof or a hydrate of them.Type: GrantFiled: June 21, 2001Date of Patent: June 14, 2005Assignee: Eisai Co., Ltd.Inventors: Yoichi Iimura, Takashi Kosasa
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Publication number: 20050124642Abstract: The present invention provides an excellent sigma receptor binding agent and/or acetylcholinesterase inhibitor containing an (1-indanone)-(1,2,3,6-tetrahydropyridine) compound. More specifically, it provides an (1-indanone)-(1,2,3,6-tetrahydropyridine) compound represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate thereof: In the formula (I), R1, R2, R3 and R4 are the same as or different from each other.Type: ApplicationFiled: September 15, 2004Publication date: June 9, 2005Applicant: Eisai Co., Ltd.Inventors: Yoichi Iimura, Takashi Kosasa, Yoshiharu Yamanishi
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Publication number: 20050107432Abstract: The present invention provides an indanone derivative and an excellent sigma receptor binding agent comprising an indanone derivative. More specifically, it provides a sigma receptor binding agent comprising an indanone derivative represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate of them.Type: ApplicationFiled: January 22, 2003Publication date: May 19, 2005Inventors: Yoichi Iimura, Takashi Kosasa, Yoshiharu Yamanishi
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Publication number: 20050026895Abstract: The present invention provides a novel compound having a superior acetylcholinesterase inhibitory action. It provides a compound represented by the formula: (In the formula, R1 represents a group represented by the formula: (wherein, R3, R4, R5 and R6 are the same as or different from each other and each represents a hydrogen atom, an optionally substituted C1-6 alkoxy group and the like; and m represents an integer from 0 to 6) and the like; and R2 represents a hydrogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C2-6 alkenyl group or an optionally substituted C2-6 alkynyl group), a salt thereof or a hydrate of them.Type: ApplicationFiled: September 1, 2004Publication date: February 3, 2005Inventors: Yoichi Iimura, Takashi Kosasa
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Publication number: 20040220193Abstract: The present invention provides a novel compound having a superior calcium antagonism, in particular, a neuron-selective calcium antagonism. Namely, it provides a compound represented by the following formula, a salt thereof or a hydrate of them.Type: ApplicationFiled: May 28, 2004Publication date: November 4, 2004Applicant: Eisai Co., Ltd.Inventors: Noboru Yamamoto, Yuichi Suzuki, Manami Kimura, Tetsuhiro Niidome, Yoichi Iimura, Tetsuyuki Teramoto, Yoshihisa Kaneda, Toshihiko Kaneko, Nobuyuki Kurusu, Daisuke Shinmyo, Yukie Yoshikawa, Shinji Hatakeyama
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Patent number: 6737425Abstract: The invention provides an N,N-substituted cyclic amine compound represented by the following formula (VIII): wherein A represents an aryl group etc.; E represents a group represented by the formula —CO— or a group represented by the formula —CHOH—; G represents an oxygen atom etc.; J represents an aryl group which may be substituted; R1 represents a lower alkyl group etc.; Alk represents a linear or branched lower alkylene group; n, v, w, x and y are independent of each other and each represents 0 or 1; and p represents 2 or 3, or a pharmacologically acceptable salt thereof. The compound of the present invention or a salt thereof is effective to treat a disease against which calcium antagonism is effective.Type: GrantFiled: January 29, 2001Date of Patent: May 18, 2004Assignee: Eisai Co., Ltd.Inventors: Noboru Yamamoto, Makoto Komatsu, Yuichi Suzuki, Koki Kawano, Teiji Kimura, Koichi Ito, Satoshi Nagato, Yoshihiko Norimine, Tetsuhiro Niidome, Tetsuyuki Teramoto, Yoichi Iimura, Shinji Hatakeyama
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Patent number: 6706741Abstract: The present invention provides an excellent acetylcholinesterase inhibitor. That is, it provides an acetylcholinesterase inhibitor comprising a 1-benzylpyridinium salt represented by the following formula: wherein R1, R2, R3 and R4 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a nitrile group, a C1-6 alkyl group, a C1-6 alkoxy group etc.; R5 represents a hydrogen atom, a halogen atom etc.; the partial structure: is a group represented by the formula >C(R6)—CH2— (wherein R6 is a hydrogen atom or a halogen atom) or >C═CH—; X− represents a halide ion or organic sulfonic acid ion; and m is 0 or an integer from 1 to 5.Type: GrantFiled: September 18, 2002Date of Patent: March 16, 2004Assignee: Eisai Co., Ltd.Inventors: Yoichi Iimura, Takashi Kosasa
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Patent number: 6677330Abstract: The present invention provides a novel compound having an excellent acetylcholinesterase inhibitory effect. That is, it provides a 4-substituted piperidine compound fluoride represented by the following formula, a pharmaceutically acceptable salt thereof or hydrates thereof (provided that 1-benzyl-4-[(5,6-dimethoxy-2-fluoro-1-indanon)-2-yl]methylpiperidine, a pharmaceutically acceptable salt thereof and hydrates thereof are excluded). wherein R1 and R2 represent substituents.Type: GrantFiled: August 30, 2001Date of Patent: January 13, 2004Assignee: Eisai Co., Ltd.Inventors: Yoichi Iimura, Takashi Kosasa, Yoshiharu Yamanishi, Hachiro Sugimoto, Yoshio Takeuchi, Tetsuo Shibata, Emiko Suzuki
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Patent number: 6667412Abstract: The present invention provides a novel nitrile compound useful as an intermediate for the production of, for example, N,N-substituted cyclic amine derivatives or phenylacetonitrile derivatives that are useful as a medicine. Specifically it provides a nitrile carboxylic acid compound, nitrile ester compound and nitrile alcohol compound. That is, it provides a nitrile compound represented by the following formula (I): wherein R1 and R2 means substituents; m means 0 or an integer of from 1 to 6; n means 0 or an integer of from 1 to 5; and R3 means carboxyl group, a lower alkoxycarbonyl group or hydroxymethyl group.Type: GrantFiled: August 27, 2001Date of Patent: December 23, 2003Assignee: Eisai Co., Ltd.Inventors: Yuichi Suzuki, Noboru Yamamoto, Koki Kawano, Teiji Kimura, Koichi Ito, Satoshi Nagato, Yoshihiko Norimine, Yoichi Iimura
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Publication number: 20030166925Abstract: The present invention provides a novel compound having a superior acetylcholinesterase inhibitory action.Type: ApplicationFiled: November 25, 2002Publication date: September 4, 2003Inventors: Yoichi Iimura, Takashi Kosasa
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Publication number: 20030069289Abstract: The present invention provides an excellent acetylcholinesterase inhibitor.Type: ApplicationFiled: September 18, 2002Publication date: April 10, 2003Inventors: Yoichi Iimura, Takashi Kosasa
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Patent number: 6277866Abstract: The present invention provides a novel compound useful as a medicament, an acetylcholinesterase inhibitor, and an agent for preventing, treating and improving various kinds of senile dementia, Alzheimer-type senile dementia, cerebrovascular dementia or attention deficit hyperactivity disorder, namely, 1-benzyl-4-[(5,6-dimethoxy-2-fluoro-1-indanone)-2-yl]methylpiperidine represented by the following formula: or a pharmaceutically acceptable salt thereof, and a process for producing the same.Type: GrantFiled: October 27, 1999Date of Patent: August 21, 2001Assignee: Eisai Co., Ltd.Inventors: Yoshio Takeuchi, Norio Shibata, Emiko Suzuki, Yoichi Iimura, Takashi Kosasa, Yoshiharu Yamanishi, Hachiro Sugimoto