Abstract: Disclosed is a labeled polypeptide that includes a glutamine residue having a side chain represented by formula (I) below: (wherein, (C) represents an ?-carbon of the glutamine residue, X represents a straight chain alkylene group, Y represents a polyethylene glycol chain, Z represents a label, L represents a spacer or an atomic bond, and the polyethylene glycol chain has a molecular weight of 1100 or larger).

Abstract: An in-vehicle building material processing system including: a flat cargo bed formed on a vehicle; rigid members for ensuring flatness with respect to a workpiece-receiving table formed at predetermined section of the cargo bed; clampers for fixing a building material on the workpiece-receiving table; a multi-joint robot provided with a freely swingable cutting means at its tip, which is capable of protruding in a range wider than outer periphery of the workpiece-receiving table; and a control unit having an operation unit for making the multi-joint robot to cut and process the building material desirably, wherein the control unit controls the cutting means to cut and process the building material while controlling at least either of the cutting means and the clampers to avoid a contact of the cutting means and the clampers.

Abstract: The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract: Disclosed is: a fluorescent dye comprising a compound, a tautomer of the compound, or a salt of the compound or the tautomer; a labeled composite substance comprising the fluorescent dye and a composite substance which are bonded to each other; a composition containing the fluorescent dye or the labeled composite substance; and a method for acquiring information about a substance of interest by a super-resolution microscopy.

Abstract: An in-vehicle building material processing system including: a flat cargo bed formed on a vehicle; rigid members for ensuring flatness with respect to a workpiece-receiving table formed at predetermined section of the cargo bed; clampers for fixing a building material on the workpiece-receiving table; a multi-joint robot provided with a freely swingable cutting means at its tip, which is capable of protruding in a range wider than outer periphery of the workpiece-receiving table; and a control unit having an operation unit for making the multi-joint robot to cut and process the building material desirably, wherein the control unit controls the cutting means to cut and process the building material while controlling at least either of the cutting means and the clampers to avoid a contact of the cutting means and the clampers.

Abstract: The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract: The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract: A corrugated paperboard box is provided in which when flaps are bent, a perforated line along which the flaps can be separated from the box is less likely to break. Such a corrugated paperboard box includes a peripheral wall and top flaps, and is formed, at the boundary area between the peripheral wall and the top flaps, with a groove-shaped reverse scoreline recessed on the side of an outer linerboard, and a pair of groove-shaped recesses recessed on the side of an inner linerboard, and extending in parallel to each other so as to sandwich the area in which the reverse scoreline extends. The corrugated paperboard box is further formed, in one of the groove-shaped recesses, with a perforated line along which the top flaps can be separated from the peripheral wall. The top flaps can be bent along the perforated line toward the inner surface of the peripheral wall.

Abstract: A locking receiving portion is defined by a first inclined line extending toward a third panel side on a first panel from a branching point on a fold line between the first panel and a second panel, a second inclined line extending toward the third panel side on the second panel from the branching point, and a cut portion extending between a distal end of the first inclined line and a distal end of the second inclined line. The locking receiving portion extends in an inclined manner between the first panel and the second panel in an assembled state. A locking portion is formed on the third panel, and configured to be locked to a cut portion side of the locking receiving portion in an assembled state.

Abstract: The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract: A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided. Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.

Abstract: The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like. Specifically, the present invention relates to a compound represented by the formula (I) or a salt thereof, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like [in the formula, each symbol is as defined in the specification].

Abstract: A packing box has a bottom panel, end panels raised from first edges of the bottom panel, side panels arranged adjacently to the end panels, edge panels connected to side edges of the end panels via outer panel fold lines, fold-back panels arranged on inner side surfaces of the edge panels, inner panels arranged on inner side surfaces of the end panels, and reinforcing panels continuously formed with the fold-back panels via first fold lines and the inner panels via second fold lines. The reinforcing panel 16 is formed in an inwardly projecting manner between the fold-back panel and the inner panel. Any of the first and second fold lines positioned on a side closer to the outer panel fold line than a projecting top portion is arranged away from the outer panel fold line by a distance.

Abstract: The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect and is useful in the treatment or prevention of obesity, diabetes mellitus, or the like, and a medicament containing the same. Specifically, the present invention relates to a compound represented by the following formula (I) or a salt thereof, and a medicament containing the same [in the formula, each symbol is as defined in the specification].

Abstract: A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided. Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.

Abstract: A box includes a front receiving panel, a bottom surface panel, a rear surface panel, a top surface panel, and a front surface panel that are integrally connected one to another. Each pair of bottom side panels, rear side panels, top side panels, and front side panels are integrally connected to the respective sides of each of the bottom, rear, top, and front surface panels. The front receiving panel, the bottom and rear surface panels, and the bottom and rear side panels constitute a tray portion of the box, with the remaining panels constituting a lid portion of the box. A cut line for separating the lid portion from the tray portion is formed to pass through one or both of the rear surface panel and the top surface panel.

Abstract: The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like. Specifically, the present invention relates to a compound represented by the formula (I) or a salt thereof, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like [in the formula, each symbol is as defined in the specification].

Abstract: The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect and is useful in the treatment or prevention of obesity, diabetes mellitus, or the like, and a medicament containing the same. Specifically, the present invention relates to a compound represented by the following formula (I) or a salt thereof, and a medicament containing the same [in the formula, each symbol is as defined in the specification].

Abstract: A corrugated paperboard box is provided in which when flaps are bent, a perforated line along which the flaps can be separated from the box is less likely to break. Such a corrugated paperboard box includes a peripheral wall and top flaps, and is formed, at the boundary area between the peripheral wall and the top flaps, with a groove-shaped reverse scoreline recessed on the side of an outer linerboard, and a pair of groove-shaped recesses recessed on the side of an inner linerboard, and extending in parallel to each other so as to sandwich the area in which the reverse scoreline extends. The corrugated paperboard box is further formed, in one of the groove-shaped recesses, with a perforated line along which the top flaps can be separated from the peripheral wall. The top flaps can be bent along the perforated line toward the inner surface of the peripheral wall.

Abstract: A construction block and a wall face structure with high durability and versatility are provided. The construction block including: a front face wall and a rear face wall being parallel to each other; a top face wall with a horizontal groove formed for inserting a horizontal reinforcement; side face walls formed with at least one vertical groove for inserting a vertical reinforcement; at least one vertical hole formed between both of the side face walls and closed off by the top face wall and opened at a bottom face; a plurality of protrusions formed on the bottom face in a shape to engage with the horizontal groove; and recessed slits respectively formed in vertical direction on each side face of the front face wall and the rear face wall, is used.