Abstract: Disclosed herein are methods and compositions useful for identification of potential therapeutic agents for the treatment of a NF1- or RAS-associated disorder. Disclosed herein are also methods and compositions useful for the treatment of a NF1- or RAS-associated disorder.

Abstract: An aqueous extract of Larrea tridentata useful in the control of phytopathogens that attack commercial crops, functionalized to increase the ratio of quinones of nordihydroguaiaretic acid.

Abstract: An aqueous extract of Larrea tridentata useful in the control of phytopathogens that attack commercial crops, functionalized to increase the ratio of quinones of nordihidroguayaretic acid.

Abstract: Provided herein are vinylogous thioester compounds and methods for using the compounds.

Abstract: Isoxazoloanthrones and a method for treating disorders associated or caused by Ras deregulation or dysregulation, for example, disorders associated with alterations in the neurofibromin 1 gene such as Neurofibromatosis Type 1, and proliferative disorders such as glioblastoma are provided.

Abstract: Provided herein are vinylogous thioester compounds and methods for using the compounds.

Abstract: Isoxazoloanthrones and a method for treating disorders associated or caused by Ras deregulation or dysregulation, for example, disorders associated with alterations in the neurofibromin 1 gene such as Neurofibromatosis Type 1, and proliferative disorders such as glioblastoma are provided.

Abstract: An improved footwear device is user customizable permitting selective alteration of the footwear appearance. Each footwear device is made from layers of rubber or similar footwear material. A first layer forms a bottom (outsole) that impacts the pathway surface. A second layer or insole forms a working surface to protect the user foot from impacts, pathway contours and debris. The cosmetic alteration portion of the device comprises three loops formed from a single strand of fabric such as cotton or similar material. This strand is threaded through three strategically positioned holes perforating the second or insole layer; then, the strand is folded in such a fashion that three loops are formed, one for each hole. Next, the two layers are adhesively attached one to another so as to form a completed device. A strip of material is then threaded through the protruding loops so as to change the footwear's appearance.

Abstract: The instant disclosure relates to compositions that may be useful as therapeutic agents for the treatment of disorders associated or caused by Ras deregulation or dysregulation, for example, disorders associated with alterations in the NF1 gene such as neurofibromatosis type I, fungal infections such as those caused by Candida albicans, and proliferative disorders such as glioblastoma.

Abstract: The instant disclosure relates to compositions that may be useful as therapeutic agents for the treatment of disorders associated or caused by Ras deregulation or dysregulation, for example, disorders associated with alterations in the NF1 gene such as neurofibromatosis type I, fungal infections such as those caused by Candida albicans, and proliferative disorders such as glioblastoma.

Abstract: Disclosed herein are compositions useful for identification of potential therapeutic agents for the treatment of a disorder associated with RAS deregulation or dysregulation. The compositions may be a yeast cell having one or more mutations in an IRA gene or an ERG gene. Also disclosed are methods of using these compositions.

Abstract: The present invention relates to the isolation of gene sequences encoding mammalian cell cycle checkpoints, as well as the expression of the encoded proteins using recombinant DNA technology. The expressed proteins are used to generate specific antibodies and to inhibit the growth of cells. The human checkpoint gene sequences are used as a probe for a portion of the chromosome associated with tumors and other malignancies, as well as growth and/or development deficiencies.

Abstract: The present invention relates to the isolation of gene sequences encoding mammalian cell cycle checkpoints, as well as the expression of the encoded proteins using recombinant DNA technology. The expressed proteins are used to generate specific antibodies and to inhibit the growth of cells. The human checkpoint gene sequences are used as a probe for a portion of the chromosome associated with tumors and other malignancies, as well as growth and/or development deficiencies.

Abstract: The present invention relates to the isolation of gene sequences encoding mammalian cell cycle checkpoints, as well as the expression of the encoded proteins using recombinant DNA technology. The expressed proteins are used to generate specific antibodies and to inhibit the growth of cells. The human checkpoint gene sequences are used as a probe for a portion of the chromosome associated with tumors and other malignancies, as well as growth and/or development deficiencies.

Abstract: The present invention relates to the isolation of gene sequences encoding mammalian cell cycle checkpoints, as well as the expression of the encoded proteins using recombinant DNA technology. The expressed proteins are used to generate specific antibodies and to inhibit the growth of cells. The human checkpoint gene sequences are used as a probe for a portion of the chromosome associated with tumors and other malignancies, as well as growth and/or development deficiencies.