Patents by Inventor Yollete V. GUILLEN SCHLIPPE

Yollete V. GUILLEN SCHLIPPE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Directed evolution of multivalent glycopeptides that tightly bind to target proteins
    Patent number: 11345912
    Abstract: The invention relates to a method for selecting a glycopolypeptide that binds to a target protein, the method including the steps of providing a pool of glycopolypeptides fused via puromycin linker to an encoding mRNA-cDNA duplex; combining the pool with a target protein to form a mixture; incubating the mixture for a period of time sufficient to allow any target protein to bind to one or more of the glycopolypeptides, thereby forming glycopolypeptide-target protein complexes; and isolating from the mixture the glycopolypeptide-target protein complexes, thereby identifying a plurality of selected glycopolypeptides.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: May 31, 2022
    Assignee: BRANDEIS UNIVERSITY
    Inventors: Isaac J. Krauss, Satoru Horiya, Yollete V. Guillen Schlippe
  • DIRECTED EVOLUTION OF MULTIVALENT GLYCOPEPTIDES THAT TIGHTLY BIND TO TARGET PROTEINS
    Publication number: 20200102555
    Abstract: The invention relates to a method for selecting a glycopolypeptide that binds to a target protein, the method including the steps of providing a pool of glycopolypeptides fused via puromycin linker to an encoding mRNA-cDNA duplex; combining the pool with a target protein to form a mixture; incubating the mixture for a period of time sufficient to allow any target protein to bind to one or more of the glycopolypeptides, thereby forming glycopolypeptide-target protein complexes; and isolating from the mixture the glycopolypeptide-target protein complexes, thereby identifying a plurality of selected glycopolypeptides.
    Type: Application
    Filed: December 12, 2019
    Publication date: April 2, 2020
    Inventors: Isaac J. Krauss, Satoru Horiya, Yollete V. Guillen Schlippe
  • Directed evolution of multivalent glycopeptides that tightly bind to target proteins
    Patent number: 10544412
    Abstract: The invention relates to a method for selecting a glycopolypeptide that binds to a target protein, the method including the steps of providing a pool of glycopolypeptides fused via puromycin linker to an encoding mRNA-cDNA duplex; combining the pool with a target protein to form a mixture; incubating the mixture for a period of time sufficient to allow any target protein to bind to one or more of the glycopolypeptides, thereby forming glycopolypeptide-target protein complexes; and isolating from the mixture the glycopolypeptide-target protein complexes, thereby identifying a plurality of selected glycopolypeptides.
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: January 28, 2020
    Assignees: Brandeis University, The General Hospital Corporation
    Inventors: Isaac J. Krauss, Satoru Horiya, Yollete V. Guillen Schlippe
  • DIRECTED EVOLUTION OF MULTIVALENT GLYCOPEPTIDES THAT TIGHTLY BIND TO TARGET PROTEINS
    Publication number: 20160304858
    Abstract: The invention relates to a method for selecting a glycopolypeptide that binds to a target protein, the method including the steps of providing a pool of glycopolypeptides fused via puromycin linker to an encoding mRNA-cDNA duplex; combining the pool with a target protein to form a mixture; incubating the mixture for a period of time sufficient to allow any target protein to bind to one or more of the glycopolypeptides, thereby forming glycopolypeptide-target protein complexes; and isolating from the mixture the glycopolypeptide-target protein complexes, thereby identifying a plurality of selected glycopolypeptides.
    Type: Application
    Filed: December 2, 2014
    Publication date: October 20, 2016
    Inventors: Isaac J. KRAUSS, Satoru HORIYA, Yollete V. GUILLEN SCHLIPPE