Abstract: Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.

Abstract: The present disclosure provides an Industrial Internet of Things system for intelligent repair of manufacturing equipment and a control method. The Industrial Internet of Things system includes a management platform, a sensor network platform, and an object platform interacting in sequence. The object platform is configured as a plurality of manufacturing equipment arranged in sequence according to a process sequence on the assembly line. The management platform is configured to issue self-repair instructions and failure handling instructions corresponding to the intelligent repair method to the corresponding manufacturing equipment through the sensor network platform, so as to realize the automatic repair of manufacturing equipment, reduce the cost of manual troubleshooting, and ensure the normal production and manufacturing of the assembly line.

Abstract: The present disclosure provides a method and a system for regulating pipeline network maintenance based on a smart gas Internet of Things (IoT). The method includes obtaining gas data of at least one faulty pipeline, generating at least one set of candidate maintenance schemes based on the at least one faulty pipeline, determining a recommended maintenance approach for the at least one faulty pipeline based on the at least one set of candidate maintenance schemes and the gas data, determining a set of monitoring point locations based on the recommended maintenance approach, and determining a regulation parameter of a regulation device based on monitoring data of the set of monitoring point locations. The system includes a smart gas user platform, a smart gas service platform, a smart gas safety management platform, a smart gas sensing network platform, and a smart gas object platform interacting in sequence.

Abstract: Detecting analytes using proximity-induced tagmentation, strand invasion, restriction, or ligation is provided herein. In some examples, detecting an analyte includes coupling a donor recognition probe to a first portion of the analyte. The donor recognition probe includes a first recognition element specific to the first portion of the analyte, a first oligonucleotide corresponding to the first portion, and a transposase coupled to the first recognition element and the first oligonucleotide. An acceptor recognition probe is coupled to a second portion of the analyte. The acceptor recognition probe includes a second recognition element specific to the second portion of the analyte and a second oligonucleotide coupled to the second recognition element and corresponding to the second portion. The transposase is used to generate a reporter polynucleotide including the first and second oligonucleotides. The analyte is detected based on the reporter including comprising the first and second oligonucleotides.

Abstract: The present invention relates to the technical field of mine fire prevention and extinguishing, in particular to a liquid nitrogen direct injection and low-temperature foaming intelligent filling system based on mine fire area characteristics and an application method, comprising a liquid nitrogen storage tank, a liquid nitrogen direct injection system and a low-temperature foaming system, wherein the liquid nitrogen storage tank communicates with a liquid nitrogen pressurizing device through a main pipeline; a temperature control unit is arranged on the main pipeline; and the liquid nitrogen pressurizing device is connected with the liquid nitrogen direct injection system and the low-temperature foaming system, respectively, liquid nitrogen is directly injected into a foam liquid, to prepare a low-temperature foam type fire preventing and extinguishing material by means of forced convection, membrane boiling, explosion boiling and nucleate boiling between the liquid nitrogen and water.

Abstract: A method for determining tobacco-specific nitrosamines (TSNAs) in cigarette smoke using one-step clean-up coupled with LC-MS/MS is provided, including the following steps: collecting a particulate matter of mainstream cigarette smoke with a Cambridge filter pad, mixing the particulate matter of mainstream cigarette smoke, an internal standards solution and water in a 50 mL plastic centrifuge tube, and vortexing the resulting mixture at room temperature to allow extraction; transferring an extraction solution after filtration to a new centrifuge tube, adding dichloromethane, and vortexing the resulting mixture; centrifuging to collect a dichloromethane extraction solution in a lower layer to another centrifuge tube, and placing the centrifuge tube in a water bath to remove dichloromethane; dissolving the resulting extraction solution in water, and transferring the resulting solution to an autosampler vial for LC-MS/MS analysis.

Abstract: Provided are a method and apparatus for sending a channel state, a method and apparatus for receiving a channel state and a storage medium. The method for sending a channel state includes following steps: a channel state report for characterizing a channel state comprising a precoding matrix is determined; and the channel state report for characterizing the channel state comprising the precoding matrix is sent, where the channel state report includes: a number of reported coefficients in coefficient matrixes for the precoding matrix and the reported coefficients in the coefficient matrixes for the precoding matrix; where the reported coefficients in the coefficient matrixes for the precoding matrix are used for indicating the precoding matrix.

Abstract: A data processing method implemented by a network interface card device, wherein the method comprises receiving, from a first client, a first access request carrying an access address, detecting whether the first access request has a conflict; and processing the conflict according to a processing policy when the network interface card device detects that the first access request has a conflict.

Abstract: A clock oscillator, a clock oscillator production method and use method, and a chip including the clock oscillator are provided. The clock oscillator includes a resonator, a shock-absorbing material layer, and a base, and at least a part of the shock-absorbing material layer is located between the resonator and the base. In the clock oscillator, the shock-absorbing material layer is added between the resonator and the base, and the shock-absorbing material layer can effectively prevent a mechanical wave from being conducted between the base and the resonator, so that the resonator is protected from external vibration. This can ensure, when there is external vibration, that an output frequency of the resonator is not deteriorated and improve shock absorption performance of the clock oscillator.

Abstract: The embodiment of the present disclosure provides a method and an Internet of Things (IoT) system for safety management of a smart gas underground gas pipeline network. The method is implemented by a smart gas safety management platform and includes: obtaining basic monitoring information of at least one pipeline network partition collected by distributed monitoring components arranged at a plurality of monitoring points; determining at least one key monitoring point and monitoring content of the at least one key monitoring point; determining an inspection plan and a performance allocation plan for the smart gas safety management platform; adjusting the preset monitoring frequency of the distributed monitoring components located at different key monitoring points and at areas surrounding the different key monitoring points; and generating an alarm message to be sent to a user terminal based on an inspection result of the inspection robot.

Abstract: A slurrying device includes a slurrying tank and a rotor stirrer. The rotor stirrer includes a stirring drum, a transmission gear arranged at an end face of the stirring drum configured to face the slurrying tank, and a rotor stirring rod configured to extend from the stirring drum and into the slurrying tank to stir a slurrying liquid in the slurrying tank. The rotor stirring rod is meshed with the transmission gear and configured to revolve along a planar trajectory of the transmission gear while simultaneously rotating. The rotor stirrer further includes a driving device provided at the stirring drum and configured to drive the rotor stirring rod to rotate via the transmission gear.

Abstract: A method for determining a consistency coefficient of a power-law cement grout includes: determining a water-cement ratio of the power-law cement grout; according to engineering practice requirements, determining a time required to determine the consistency coefficient of the power-law cement grout; and obtaining the consistency coefficient of the power-law cement grout. The method is accurate and reliable, requires less calculation, etc.; and has very high practical value and popularization value in environmental protection and ecological restoration.

Abstract: A system for proctoring online exams includes a client-side computing system and a visual analytics system. The client-side computing system includes a camera configured to obtain video data corresponding to a user while taking an exam and one or more input devices configured to obtain interaction data, wherein the interaction data includes mouse movements of the user while taking the exam. The visual analytics system is configured to obtain the video data and the interaction data from the client-side computing system, analyze the exam data to detect abnormal behavior by the user based at least in part on mouse movement data, and generate one or more visualizations of the analyzed exam data to be used in determining whether or not the user has cheated during the exam.

Abstract: The present disclosure relates to use of a Clostridium ghonii spore combined with pembrolizumab in cancer treatment. It is found for the first time that the Clostridium ghonii spore combined with pembrolizumab can significantly improve a curative effect of colon cancer and reduce a dose of the pembrolizumab, and thus is efficient and low-toxic. Oncolysis by Clostridium ghonii can affect immunogenicity of a tumor microenvironment (TME) by various ways, converts an immunosuppressive state of the TME into an immune-activated state, adjusts the immunosuppressive TME, and breaks an immune tolerance. An optimal combination of the Clostridium ghonii spore and the pembrolizumab thoroughly removes about 20% of mouse tumor tissues. A benefit range of patients with tumors treated by a PD-1 antibody is expanded. The combination even has an obvious curative effect on patients failed the treatment by the PD-1 antibody.

Abstract: An ultrahigh-pressure acid-fracturing isodiametric hose assembly, comprising a hose body and a metal joint. The metal joint comprises an inner tube, a first outer tube the inner tube, and a second outer tube. The first outer tube and the second outer tube each is an independent pressing part. An external groove is provided at an outer wall of the inner tube. An end of the first outer tube comprises an internal ridge which matches the external groove for snapping. The terminal of the inner tube comprises a connecting portion. An outer wall of the inner tube comprises a first protrusion, and an inner wall of the first outer tube comprises a second protrusion engaging with the first protrusion. The hose body is clamped between the first protrusion and the second protrusion that are engaged. An inner wall of the second outer tube comprises multiple micro-protrusions.

Abstract: An ultra-wideband electromagnetic band gap (EBG) structure includes multiple EBG units in an array. Each EBG unit includes a power plane, a dielectric substrate and a ground plane from top to bottom. The power plane includes a patch, a coupled complementary split ring resonator (C-CSRR) and a plurality of semi-improved Z-bridge structures. Each edge of the patch is provided with a semi-improved Z-bridge structure. The C-CSRR is provided within a ring formed by the semi-improved Z-bridge structures. The Z-bridge structure includes a first horizontal branch, a first vertical branch, a second horizontal branch and a second vertical branch connected in sequence. The second vertical branch is connected to the patch. First horizontal branches of adjacent EBG units are connected to each other. A circuit board including the aforementioned EBG structure is also provided.

Abstract: Embodiments of the disclosure provide a circuit, chip, system, and method for eliminating random perturbation. The circuit includes a weight calculating module for receiving digital signals and random perturbation digital quantity, using least mean square error algorithm to calculate weight deviation iteration coefficient based on digital signal and digital quantity, and updating perturbation weight in real-time according to weight deviation iteration coefficient; and a perturbation eliminating module for eliminating perturbation signal in output digital signal of quantizer according to perturbation weight updated in real-time and updating perturbation weight in real-time according to weight deviation iteration coefficient, and then calculating current perturbation weight in real time to realize self-calibration of perturbation weight.

Abstract: Disclosed in the present disclosure is a method for extracting and separating various components from flaxseed meal based on a subcritical composite solvent, including the following steps: adding an extraction agent to flaxseed meal for subcritical extraction to obtain a crude flax lignan extract and crude flaxseed oil in one step, where the extraction agent includes n-butane and anhydrous ethanol at a volume ratio of 1:1; adding n-hexane to the crude flaxseed oil for fractional extraction, and conducting rotary evaporation to obtain flaxseed oil; and subjecting the flaxseed meal used to hot water extraction to obtain flaxseed gum. In the present disclosure, the subcritical composite solvent used in an extraction process can replace a large number of organic reagents used in a traditional extraction process, and has the characteristics of good solvent effect, environmental friendliness, recyclability, and low burden on the environment.

Abstract: An industrial internet of things system for intelligent production control is provided, comprising: a user platform, a service platform, a management platform, a sensor network platform, and an object platform. The user platform modifies production line parameters based on an instruction of the user, generates a first instruction, and sends it to the management platform through the transformation of the service platform. The object platform collects production link data of each production link of products and transmits it to the management platform. The management platform modifies work order parameters based on a second instruction transformed by the service platform, generates a third instruction, and determines whether devices corresponding to the plurality of production links are abnormal based on the production link data.

Abstract: A pixel circuit, a display panel and a method for driving the pixel circuit. The pixel circuit includes a first light emission control module and a gate initialization module. The first light emission control module includes a control terminal, a first terminal and a second terminal, where the control terminal of the first light emission control module is electrically connected with a first light emission control signal, the first terminal of the first light emission control module is electrically connected with a first power signal, and the second terminal of the first light emission control module is electrically connected to the first electrode of the drive transistor.