Patents by Inventor Yong Mao
Yong Mao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240167963Abstract: A visual detection light source and tab detection equipment are described. The visual detection light source is configured to irradiate a side face of a tab portion, and includes a main light source and a supplementary light source; the main light source and the supplementary light source are arc-shaped light sources, the main light source and the supplementary light source are disposed concentrically, and the main light source is disposed outside the supplementary light source; the main light source is configured to irradiate the side face of the tab portion at an inclined irradiation angle; and the supplementary light source is configured to vertically irradiate the side face of the tab portion.Type: ApplicationFiled: July 10, 2023Publication date: May 23, 2024Applicant: CONTEMPORARY AMPEREX TECHNOLOGY CO., LIMITEDInventors: Zhipeng ZHANG, Yuyang Mao, Ping Jiang, Yong Chen
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Publication number: 20240171840Abstract: This application discloses a tab detection mechanism and a tab detection device. The tab detection mechanism may be configured to detect a tab portion on an electrode core. The tab detection mechanism may include a visual camera; a prism disposed below the visual camera and configured to reflect light on a side surface of the tab portion to the visual camera; and a first driver, connected to the visual camera and configured to drive the visual camera to move in a vertical direction. The visual camera is capable of shooting a plurality of images while moving.Type: ApplicationFiled: October 26, 2023Publication date: May 23, 2024Applicant: CONTEMPORARY AMPEREX TECHNOLOGY CO., LIMITEDInventors: Zhipeng ZHANG, Yuyang MAO, Ping JIANG, Yong CHEN
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Publication number: 20240102782Abstract: The invention provides a method for evaluating deep-buried tunnel blasting parameters, and belongs to the technical field of mine engineering. The method comprises: setting multiple diverse blasting schemes; selecting a plurality of test sections with the same geological characteristics, the number of the test sections corresponding to the number of the blasting schemes; blasting the test sections using the blasting schemes, and obtaining diversified monitoring data of each test section; and comparing the diversified monitoring data to select the optimal blasting schemes for the test sections. According to the method for evaluating the deep-buried tunnel blasting parameters, by implementing different blasting schemes in test sections with the same geological characteristics, diversified monitoring data of the test sections are obtained and compared to select the optimal blasting schemes for the test sections, so as to ensure the safety and quality of blasting excavation of deep-buried tunnels.Type: ApplicationFiled: September 5, 2023Publication date: March 28, 2024Inventors: Nuwen Xu, Biao Li, Quanfu Ding, Haoyu Mao, Peiwei Xiao, Xiang Zhou, Xinchao Ding, Yuepeng Sun, Yong Xia, Jun Liu, Zhiqiang Sun
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Publication number: 20240071682Abstract: A neodymium-iron-boron magnet is provided. The neodymium-iron-boron magnet is subject to diffusion and permeation of a heavy rare earth element, the neodymium-iron-boron magnet includes a heavy-rare-earth diffusion region at a surface layer and a core non-diffusion region, and the neodymium-iron-boron magnet has the heavy-rare-earth diffusion region at regions, which have normal directions consistent with three axes of a three-dimensional Cartesian coordinate system, of the surface layer. The present application extends the principle of diffusion from microscopic grains to macroscopic magnets. Diffusion layers of different depths may be obtained by adjusting temperature and time of heat treatment. Through the magnetic hardening of the surface layer of the magnet, the coercive force of the magnet is increased, and the magnet remanence (Br) and the maximum magnetic energy level (BHmax) are very slightly reduced. The producing process is simple, and highly controllable.Type: ApplicationFiled: June 24, 2021Publication date: February 29, 2024Applicant: JL MAG RARE-EARTH (BAOTOU) CO., LTD.Inventors: Minghuo LIAO, Huayun MAO, Yong LIU, Congyao MAO
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Patent number: 11842802Abstract: A patient-trial matching system (100) includes a structuralizer (102) configured to convert input non-structured patient health data and input non-structured clinical trial eligibility criteria into structured patient health data and structured clinical trial eligibility criteria by organizing a content of the non-structured data as known data elements. The patient-trial matching system further includes a semantic matcher (122) configured to match the structured patient health data and the structured clinical trial eligibility criteria based on user input matching criteria and outputs matched results. The patient-trial matching system further includes a ranking engine (126) configured to rank the matched results using ranking criteria (128), which include ranking patients matched to a clinical trial of interest in response to matching to find a group of trial patients and ranking clinical trials matched to a particular patient in response to matching to find a clinical trial.Type: GrantFiled: June 20, 2016Date of Patent: December 12, 2023Assignee: KONINKLIJKE PHILIPS N.V.Inventor: Yong Mao
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Publication number: 20230065455Abstract: Disclosed are composite materials comprising a porous, carbonated, calcium silicate ceramic having a microstructure comprising interconnected open pores; where the calcium silicate surface defining the pores is partially or completely coated with an amorphous silica layer, and the silica coating comprises an overlayer of calcium carbonate crystals; where the silica coating and calcium carbonate overlayer form a network that interconnects throughout the ceramic microstructure, but do not completely occlude the pores. Also disclosed are methods of forming such composite materials.Type: ApplicationFiled: August 5, 2022Publication date: March 2, 2023Inventors: Richard E. Riman, Berra Beyoglu Siglam, Joachim B. Kohn, Yong Mao
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Patent number: 11594303Abstract: A method (100) for standardizing gene nomenclature, comprising: (i) receiving (110) a source; (ii) tokenizing (120) the source; (iii) comparing (130) a first token to a prefix tree structure with a root node, edges, and leaf nodes; (iv) determining (140) which edge extending from the root node to associated first leaf nodes the first token matches; (v) updating (150) an identification pointer with the location of the first leaf node; (vi) determining (160) which of one or more edges that a second token matches; (vii) updating (170) the identification pointer with the location of the second leaf node; (viii) repeating (172) the determining (160) and updating (170) steps with subsequent tokens until a subsequent token fails to match an edge extending from a leaf node or there is no edge extending from the leaf node; and (ix) providing (180) an identification of a canonical gene name.Type: GrantFiled: August 13, 2019Date of Patent: February 28, 2023Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Samuel Frank Pilato, Alexander Ryan Mankovich, Yong Mao, Woei-Jye Yee, Qingxin Wu, Robbert Christiaan van Ommering, Weijian Qin
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Publication number: 20210319854Abstract: A method (100) for standardizing gene nomenclature, comprising: (i) receiving (110) a source; (ii) tokenizing (120) the source; (iii) comparing (130) a first token to a prefix tree structure with a root node, edges, and leaf nodes; (iv) determining (140) which edge extending from the root node to associated first leaf nodes the first token matches; (v) updating (150) an identification pointer with the location of the first leaf node; (vi) determining (160) which of one or more edges that a second token matches; (vii) updating (170) the identification pointer with the location of the second leaf node; (viii) repeating (172) the determining (160) and updating (170) steps with subsequent tokens until a subsequent token fails to match an edge extending from a leaf node or there is no edge extending from the leaf node; and (ix) providing (180) an identification of a canonical gene name.Type: ApplicationFiled: August 13, 2019Publication date: October 14, 2021Inventors: Samuel Frank Pilato, Alexander Ryan Mankovich, Yong Mao, Woei-Jye Yee, Qingxin Wu, Robbert Christiaan van Ommering, Weijian Qin
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Patent number: 11030324Abstract: A method for assessing risk associated with a request from an inquirer for allele frequency from a database of genetic data, comprising: (i) generating an allele database comprising allele frequency information and request frequency information for each of a plurality of alleles; (ii) generating an inquirer database comprising allele request information about a plurality of inquirers; (iii) receiving a request for genetic data from an inquirer, comprising a request for allele frequency for one or more alleles and an identifier of the inquirer; (iv) updating the request frequency information based on the received request; (v) updating the allele request information for the requesting inquirer; (vi) calculating an allele risk score; (vii) calculating an inquirer risk score; and (viii) assessing, based on the allele risk score and the inquirer risk score, a risk associated with the received request.Type: GrantFiled: November 26, 2018Date of Patent: June 8, 2021Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Jin Qu, Fubiao Xia, Yong Mao, Alexander Ryan Mankovich, Raymond J. Krasinski
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Publication number: 20210158902Abstract: A method (100) for generating a graph-based reference genome, comprising: (i) receiving (120) one or more older versions of a current reference genome, each comprising a plurality of nodes identifying the version of the reference genome and a location within that version for the respective node; (ii) aligning (130) each older version of the reference genome to the current reference genome to generate a graph-based reference genome, wherein the alignment is based on the location information; (iii) extracting (140), from a corpus of references, an allele and contextual information associated with the allele, wherein the respective reference identifies the version of the reference genome and a location of the allele within the version; and (iv) mapping (150) the allele and associated contextual information onto a node of the graph-based reference genome, based on the identified version of the reference genome and the location of the extracted allele within that version.Type: ApplicationFiled: May 20, 2019Publication date: May 27, 2021Inventors: YONG MAO, KOSTYANTYN VOLYANSKYY, NEVENKA DIMITROVA
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Patent number: 10964410Abstract: The present disclosure pertains to a system, a method of using such a system, and a non-transitory computer-readable medium containing instructions to such a system for generating annotated gene fusion data from processing both a patient's DNA and RNA sequence information thereby filtering out weak candidate gene fusions. Thus the annotated gene fusion data contains clinically relevant information and accurate gene fusion detections (low false-positives) for use in clinical and/or R&D settings. The system, method and computer-readable medium allows a user to generate gene fusion data by detecting breakpoints from a patient's DNA-SEQ and RNA-SEQ, creating candidate breakpoint data by combining matching breakpoints from the DNA-SEQ and RNA-SEQ breakpoint data, determining confidence levels of the candidate breakpoint, identifying corresponding gene fusions, and annotating clinically relevant information about the gene fusions.Type: GrantFiled: May 22, 2018Date of Patent: March 30, 2021Assignee: Koninklijke Philips N.V.Inventors: Yong Mao, Nevenka Dimitrova, Kostyantyn Volyanskyy
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Patent number: 10730851Abstract: The application discloses five polymorph forms B, P, F, J, O of (4-((R)-((2S,5R)-4-(3-fluorobenzyl)-(2,5-dimethylpiperazine-1-yl)(3-hydroxyphenyl)methyl)phenyl)(4-methylpiperidine-1-yl)methanone dihydrochloride, preparation methods thereof and application thereof in the manufacture of a medicament for preventing or treating a mood disorder or a disease related to a ? opioid receptor.Type: GrantFiled: November 21, 2016Date of Patent: August 4, 2020Assignee: Yunnan Institute of Materia MedicaInventors: Jingkun Wang, Zhaoyun Zhu, He Song, Min Sun, Tao Cui, Zeren Wang, Zhi Yang, Min Su, Hongbin Liu, Bing Shi, Yong Mao, Huilang Liu, Zeqian Li, Chunmei Zhao, Mei Su, Fang Yuan, Tiancai Zhang, Yong Liu, Kuanren Zhang, Yunlin Wei, Yuehai Shen
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Publication number: 20200234801Abstract: A method (100) for recruiting a patient for a clinical trial, comprising: receiving (110) a dataset comprising information about one or more clinical trials each including patient eligibility criteria; extracting (120) the patient eligibility criteria from each of the clinical trials; converting (130) the patient eligibility criteria to a standardized patient eligibility criterion using a structured clinical trial mark-up language; storing (140) the patient eligibility criterion in a database (862), each of the criterion associated with one or more clinical trials; receiving (150) patient-specific data values about a patient; querying (160) the clinical trial eligibility criteria database using the patient-specific data values to identify eligibility criterion satisfied by the patient-specific data value; identifying (170) a clinical trial associated with the one or more standardized patient eligibility criterion satisfied by a received patient-specific data value; and providing (180) a report of the identifiType: ApplicationFiled: October 5, 2018Publication date: July 23, 2020Inventors: Yong Mao, Woei-Jye Yee, Alexander Ryan Mankovich, Qingxin Wu, Kostyantyn Volyanskyy, Nevenka Dimitrova
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Publication number: 20200024658Abstract: A method and a system for interpreting data between two quantitative genomic datasets are described, wherein datasets are associated with the same disease or condition, for example, samples from the same patient obtained on different genomic platforms with varying data acquisition parameters. The data samples in each of the first and second datasets are rank ordered and the relative distances among the data samples are determined. The value ranks and relative distances are then used to correlate to data samples in the first and second quantitative genomic datasets, with the output provided to a user, such as a clinician or a patient.Type: ApplicationFiled: March 28, 2018Publication date: January 23, 2020Inventors: Kostyantyn Volyanskyy, Nevenka Dimitrova, Yong Mao
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Publication number: 20200020423Abstract: A system and method for providing a prioritized list of clinical trials that are relevant to a patient suffering from an illness or disease, such as cancer, are disclosed. Specifically, a method for conducting an automated, real time clinical trial search and a prioritization analysis is described. The method comprises the steps of conducting an automated full-text clinical trial search based on structuralization of clinical trial eligibility data and knowledge-based inference, initiating a query from the patient's side, and providing a prioritized list of all accessible clinical trials fulfilling a particular query. The system provides better sensitivity, precision and negative predictive value than the current most known clinical trial matching tool: clinicaltrials.gov.Type: ApplicationFiled: September 26, 2017Publication date: January 16, 2020Inventors: Qingxin Wu, Alexander Ryan Mankovich, Abhishek Talluli, Kostyantyn Volyanskyy, Nevenka Dimitrova, Yong Mao, Charles Yee
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Publication number: 20190270720Abstract: The application discloses five polymorph forms B, P, F, J, O of (4-((R)-((2S,5R)-4-(3-fluorobenzyl)-(2,5-dimethylpiperazine-1-yl)(3-hydroxyphenyl)methyl)phenyl)(4-methylpiperidine-1-yl)methanone dihydrochloride, preparation methods thereof and application thereof in the manufacture of a medicament for preventing or treating a mood disorder or a disease related to a ? opioid receptor.Type: ApplicationFiled: November 21, 2016Publication date: September 5, 2019Applicant: Yunnan Institute of Materia MedicaInventors: Jingkun Wang, Zhaoyun Zhu, He Song, Min Sun, Tao Cui, Zeren Wang, Zhi Yang, Min Su, Hongbin Liu, Bing Shi, Yong Mao, Huilang Liu, Zeqian Li, Chunmei Zhao, Mei Su, Fang Yuan, Tiancai Zhang, Yong Liu, Kuanren Zhang, Yunlin Wei, Yuehai Shen
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Publication number: 20190189248Abstract: Methods, systems and apparatus for detecting subpopulations of constituents of at least one biological organism are disclosed. In accordance with exemplary embodiments, cluster partitions of biological data samples compiled from constituents of at least one biological organism are evaluated (114) by computing inconsistency scores for the partitions based on an inconsistency measure. In addition, for at least one of the plurality of partitions, a non-zero value is allocated to the inconsistency measure of at least one cluster that has only one biological data sample. Further, the subpopulations are identified by selecting the partition of having the minimum inconsistency score as the subpopulations.Type: ApplicationFiled: May 11, 2017Publication date: June 20, 2019Applicant: Koninklijke Philips N.V.Inventors: Konstantin VOLYANSKYY, Nevenka DIMITROVA, Yong MAO
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Publication number: 20190163918Abstract: A method for assessing risk associated with a request from an inquirer for allele frequency from a database of genetic data, comprising: (i) generating an allele database comprising allele frequency information and request frequency information for each of a plurality of alleles; (ii) generating an inquirer database comprising allele request information about a plurality of inquirers; (iii) receiving a request for genetic data from an inquirer, comprising a request for allele frequency for one or more alleles and an identifier of the inquirer; (iv) updating the request frequency information based on the received request; (v) updating the allele request information for the requesting inquirer; (vi) calculating an allele risk score; (vii) calculating an inquirer risk score; and (viii) assessing, based on the allele risk score and the inquirer risk score, a risk associated with the received request.Type: ApplicationFiled: November 26, 2018Publication date: May 30, 2019Inventors: Jin Qu, Fubiao Xia, Yong Mao, Alexander Ryan Mankovich, Raymond J. Krasinski
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Publication number: 20180341746Abstract: The present disclosure pertains to a system, a method of using such a system, and a non-transitory computer-readable medium containing instructions to such a system for generating annotated gene fusion data from processing both a patient's DNA and RNA sequence information thereby filtering out weak candidate gene fusions. Thus the annotated gene fusion data contains clinically relevant information and accurate gene fusion detections (low false-positives) for use in clinical and/or R&D settings. The system, method and computer-readable medium allows a user to generate gene fusion data by detecting breakpoints from a patient's DNA-SEQ and RNA-SEQ, creating candidate breakpoint data by combining matching breakpoints from the DNA-SEQ and RNA-SEQ breakpoint data, determining confidence levels of the candidate breakpoint, identifying corresponding gene fusions, and annotating clinically relevant information about the gene fusions.Type: ApplicationFiled: May 22, 2018Publication date: November 29, 2018Inventors: Yong Mao, Nevenka Dimitrova, Kostyantyn Volyanskyy
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Publication number: 20180330805Abstract: A data-driven integrative visualization system and a method for visualization and exploration of the multi-modal features of a cohort of samples, is disclosed Specifically, a method for providing an interactive computation and visualization front-end of a genomics platform for presenting the complex multiparametric and high dimensional, multi-omic data of a patient with respect to a cohort of samples, that assists the user in understanding the similarities and differences across individual or groups of samples, identify correlation among different features and improve treatment planning and long term patient care, is described. The method may include obtaining and inputting multi-omic data of a patient and/or cohorts, identifying multi-modal feature variations and their relationships, and displaying this information in an interactive circular format on a GUI, from which the user can access further information.Type: ApplicationFiled: May 8, 2018Publication date: November 15, 2018Inventors: Yee Him Cheung, Yong Mao, Nevenka Dimitrova, Nilanjana Banerjee, Johanna Maria de Bont, Jozef Hieronymus Maria Raijmakers, Kostyantyn Volyanskyy