Patents by Inventor Yong S. Jong
Yong S. Jong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100172998Abstract: A process for preparing nanoparticles and microparticles is provided. The process involves forming a mixture of a polymer and a solvent, wherein the solvent is present in a continuous phase and introducing the mixture into an effective amount of a nonsolvent to cause the spontaneous formation of microparticles.Type: ApplicationFiled: July 10, 2008Publication date: July 8, 2010Inventors: Edith Mathiowitz, Donald E. Chickering, III, Yong S. Jong, Jules S. Jacob
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Patent number: 7029700Abstract: A process is provided for making dry, micronized particles of an agent, such as a drug. The method includes (a) dissolving a macromolecular material, preferably a polymer, in an effective amount of a solvent, to form a solution; (b) dissolving or dispersing the agent in the solution to form a mixture; (c) freezing the mixture; and (d) drying by vacuum the mixture to form solid particles of the agent dispersed in solid macromolecular material. The micronization in this process occurs directly in a macromolecular matrix and hardening of the particles of agent by solvent removal takes place by lyophilization of the bulk matrix, which stabilizes the drug particles during hardening and prevents coalesence, thereby resulting in smaller final drug particles. The method is particularly preferred for protein agents. The process can be used in conjunction with a standard microencapsulation technique, typically following separation of the agent from the macromolecular matrix.Type: GrantFiled: January 12, 2001Date of Patent: April 18, 2006Assignee: Brown University Research FoundationInventors: Edith Mathiowitz, Yong S. Jong, Jules S. Jacob
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Publication number: 20040220081Abstract: Bioactive agents may be reproducibly converted into particles having diameters in the range of about 5 to about 2000 nanometers (nm). Conversion is accomplished by dissolving the bioactive agent in a solvent for the bioactive agent, and rapidly altering the polarity of the solution to make it a non-solvent for the bioactive agent, for example by diluting the bioactive agent solution with an excess of a liquid that is a non-solvent for the bioactive agent but is miscible with the solvent. Precipitated bioactive agent nanoparticles are collected by centrifugation, filtration or lyophilization. The nanoparticles have a relatively narrow size distribution, and the average diameter can be controlled by choice of solvent and non-solvent. The nanoparticles are typically amorphous. A surfactant may be added to ensure dispersion of the particles when administered. In the preferred embodiment, the bioactive agent is a drug with low aqueous solubility.Type: ApplicationFiled: October 30, 2003Publication date: November 4, 2004Applicant: Spherics, Inc.Inventors: Mark R. Kreitz, Yong S. Jong, Edith Mathiowitz, David J. Enscore, Michael J. Bassett
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Publication number: 20040070093Abstract: A process for preparing nanoparticles and microparticles is provided. The process involves forming a mixture of a polymer and a solvent, wherein the solvent is present in a continuous phase and introducing the mixture into an effective amount of a nonsolvent to cause the spontaneous formation of microparticles.Type: ApplicationFiled: August 12, 2003Publication date: April 15, 2004Applicant: Brown University Research FoundationInventors: Edith Mathiowitz, Donald Chickering, Yong S. Jong, Jules S. Jacob
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Patent number: 6696075Abstract: Methods for inducing a thermoplastic polymer, which can be non-mesogenic, to exhibit liquid crystalline properties have been developed. The method includes the steps of (a) heating the polymer from an initial temperature below its glass transition temperature (Tg) to a temperature greater than its Tg and below its melting temperature (Tm); (b) exposing the polymer to a pressure greater than about 2 metric tons/in2, preferably between about 2 and 10 metric tons/in2, preferably for at least about one minute, while maintaining the temperature greater than its Tg; and (c) cooling the polymer below the Tg while maintaining the elevated pressure. Unlike many prior art transition processes which are reversible, this process provides a liquid crystal state that can be maintained for years at ambient conditions. In a preferred embodiment, the plastics are bioerodible thermoplastic polymers, such as polyanhydrides, some polyesters, polyamides, and polyaromatics.Type: GrantFiled: August 30, 2002Date of Patent: February 24, 2004Assignee: Brown University Research FoundationInventors: Edith Mathiowitz, Jules S. Jacob, Yong S. Jong, Donald E. Chickering, Edwin E. Edwards
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Patent number: 6677313Abstract: The invention involves methods and products for oral gene therapy. Genes under the control of promoters are protectively contained in microparticles and delivered to cells in operative form, thereby obtaining noninvasive gene delivery for gene therapy.Type: GrantFiled: October 3, 2000Date of Patent: January 13, 2004Assignee: Brown University Research FoundationInventors: Edith Mathiowitz, Yong S. Jong, Gerardo Carino, Jules S. Jacob
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Publication number: 20030228367Abstract: Methods for inducing a thermoplastic polymer, which can be non-mesogenic, to exhibit liquid crystalline properties have been developed. The method includes the steps of (a) heating the polymer from an initial temperature below its glass transition temperature (Tg) to a temperature greater than its Tg and below its melting temperature (Tm); (b) exposing the polymer to a pressure greater than about 2 metric tons/in2, preferably between about 2 and 10 metric tons/in2, preferably for at least about one minute, while maintaining the temperature greater than its Tg; and (c) cooling the polymer below the Tg while maintaining the elevated pressure. Unlike many prior art transition processes which are reversible, this process provides a liquid crystal state that can be maintained for years at ambient conditions. In a preferred embodiment, the plastics are bioerodible thermoplastic polymers, such as polyanhydrides, some polyesters, polyamides, and polyaromatics.Type: ApplicationFiled: August 30, 2002Publication date: December 11, 2003Applicant: Brown University Research FoundationInventors: Edith Mathiowitz, Jules S. Jacob, Yong S. Jong, Donald E. Chickering, Edwin E. Edwards
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Patent number: 6616869Abstract: A process for preparing nanoparticles and microparticles is provided. The process involves forming a mixture of a polymer and a solvent, wherein the solvent is present in a continuous phase and introducing the mixture into an effective amount of a nonsolvent to cause the spontaneous formation of microparticles.Type: GrantFiled: May 11, 2001Date of Patent: September 9, 2003Assignee: Brown University Research FoundationInventors: Edith Mathiowitz, Donald Chickering, III, Yong S. Jong, Jules S. Jacob
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Publication number: 20030104068Abstract: A process is provided for making dry, micronized particles of an agent, such as a drug. The method includes (a) dissolving a macromolecular material, preferably a polymer, in an effective amount of a solvent, to form a solution; (b) dissolving or dispersing the agent in the solution to form a mixture; (c) freezing the mixture; and (d) drying by vacuum the mixture to form solid particles of the agent dispersed in solid macromolecular material. The micronization in this process occurs directly in a macromolecular matrix and hardening of the particles of agent by solvent removal takes place by lyophilization of the bulk matrix, which stabilizes the drug particles during hardening and prevents coalesence, thereby resulting in smaller final drug particles. The method is particularly preferred for protein agents. The process can be used in conjunction with a standard microencapsulation technique, typically following separation of the agent from the macromolecular matrix.Type: ApplicationFiled: April 30, 2002Publication date: June 5, 2003Applicant: Brown University Research FoundationInventors: Edith Mathiowitz, Yong S. Jong, Jules S. Jacob
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Publication number: 20030082236Abstract: A process is provided for making dry, micronized particles of an agent, such as a drug. The method includes (a) dissolving a macromolecular material, preferably a polymer, in an effective amount of a solvent, to form a solution; (b) dissolving or dispersing the agent in the solution to form a mixture; (c) freezing the mixture; and (d) drying by vacuum the mixture to form solid particles of the agent dispersed in solid macromolecular material. The micronization in this process occurs directly in a macromolecular matrix and hardening of the particles of agent by solvent removal takes place by lyophilization of the bulk matrix, which stabilizes the drug particles during hardening and prevents coalesence, thereby resulting in smaller final drug particles. The method is particularly preferred for protein agents. The process can be used in conjunction with a standard microencapsulation technique, typically following separation of the agent from the macromolecular matrix.Type: ApplicationFiled: January 12, 2001Publication date: May 1, 2003Inventors: Edith Mathiowitz, Yong S. Jong, Jules S. Jacob
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Publication number: 20020155146Abstract: Methods for inducing a thermoplastic polymer, which can be non-mesogenic, to exhibit liquid crystalline properties have been developed. The method includes the steps of (a) heating the polymer from an initial temperature below its glass transition temperature (Tg) to a temperature greater than its Tg and below its melting temperature (Tm); (b) exposing the polymer to a pressure greater than about 2 metric tons/in2, preferably between about 2 and 10 metric tons/in2, preferably for at least about one minute, while maintaining the temperature greater than its Tg; and (c) cooling the polymer below the Tg while maintaining the elevated pressure. Unlike many prior art transition processes which are reversible, this process provides a liquid crystal state that can be maintained for years at ambient conditions. In a preferred embodiment, the plastics are bioerodible thermoplastic polymers, such as polyanhydrides, some polyesters, polyamides, and polyaromatics.Type: ApplicationFiled: March 13, 2000Publication date: October 24, 2002Inventors: Edith Mathiowitz, Jules S. Jacob, Donald E. Chickering, Yong S. Jong, Edwin E. Edwards
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Patent number: 6465002Abstract: Methods for inducing a thermoplastic polymer, which can be non-mesogenic, to exhibit liquid crystalline properties have been developed. The method includes the steps of (a) heating the polymer from an initial temperature below its glass transition temperature (Tg) to a temperature greater than its Tg and below its melting temperature (Tm); (b) exposing the polymer to a pressure greater than about 2 metric tons/in2, preferably between about 2 and 10 metric tons/in2, preferably for at least about one minute, while maintaining the temperature greater than its Tg; and (c) cooling the polymer below the Tg while maintaining the elevated pressure. Unlike many prior art transition processes which are reversible, this process provides a liquid crystal state that can be maintained for years at ambient conditions. In a preferred embodiment, the plastics are bioerodible thermoplastic polymers, such as polyanhydrides, some polyesters, polyamides, and polyaromatics.Type: GrantFiled: March 13, 2000Date of Patent: October 15, 2002Assignee: Brown University Research FoundationInventors: Edith Mathiowitz, Jules S. Jacob, Yong S. Jong, Donald E. Chickering, III, Edwin E. Edwards
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Publication number: 20020110538Abstract: The invention relates to methods and products for preventing and treating tumors. In particular the invention relates to the use of slow release microparticles containing cytokines, which are directly injected into a tumor, in order to treat the tumor, e.g., cause tumor regression or to prevent tumor growth or metastasis.Type: ApplicationFiled: December 27, 2000Publication date: August 15, 2002Applicant: Health Research, Inc.Inventors: Edith Mathiowitz, Yong S. Jong, Nejat K. Egilmez, Richard B. Bankert, Jules S. Jacob
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Publication number: 20010043914Abstract: The invention relates to methods and products for preventing and treating tumors. In particular the invention relates to the use of slow release microparticles containing IL-12, which are directly injected into a tumor, in order to treat the tumor or to prevent tumor growth or metastasis.Type: ApplicationFiled: December 27, 2000Publication date: November 22, 2001Inventors: Edith Mathiowitz, Yong S. Jong, Jules S. Jacob, Nejat K. Egilmez, Richard B. Bankert
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Patent number: 6248720Abstract: The invention involves methods and products for oral gene therapy. Genes under the control of promoters are protectively contained in microparticles and delivered to cells in operative form, thereby obtaining noninvasive gene delivery for gene therapy.Type: GrantFiled: July 3, 1996Date of Patent: June 19, 2001Assignee: Brown University Research FoundationInventors: Edith Mathiowitz, Yong S. Jong, Gerardo Carino, Jules S. Jacob
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Patent number: 6235224Abstract: A process for preparing nanoparticles and microparticles is provided. The process involves forming a mixture of a polymer and a solvent, wherein the solvent is present in a continuous phase and introducing the mixture into an effective amount of a nonsolvent to cause the spontaneous formation of microparticles.Type: GrantFiled: November 18, 1999Date of Patent: May 22, 2001Assignee: Brown University Research FoundationInventors: Edith Mathiowitz, Donald Chickering, III, Yong S. Jong, Jules S. Jacob
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Patent number: 6143211Abstract: A process for preparing nanoparticles and microparticles is provided. The process involves forming a mixture of a polymer and a solvent, wherein the solvent is present in a continuous phase and introducing the mixture into an effective amount of a nonsolvent to cause the spontaneous formation of microparticles.Type: GrantFiled: July 3, 1996Date of Patent: November 7, 2000Assignee: Brown University FoundationInventors: Edith Mathiowitz, Donald Chickering, III, Yong S. Jong, Jules S. Jacob