Abstract: Antibodies that bind specifically to glycosylated PD-L1 relative to unglycosylated PD-L1, block binding of PD-L1 to PD-1 and promote internalization and degradation of PD-L1 are provided. Antibodies that recognize specific epitopes on glycosylated PD-L1 protein and that exhibit the dual functions of both blocking the binding of PD-L1 to PD-1 and also facilitating the internalization of PD-L1 on cells are provided. In some aspects, PD-L1 polypeptides comprising glycosylated amino acid residues at amino and carboxy terminal positions of the PD-L1 extracellular domain are also provided. Methods for using such antibodies for the treatment of cancer, particularly PD-L1 positive cancer, are also provided.

Abstract: Disclosed are oxadiazole compounds and pharmaceutically acceptable salts thereof. The compounds and pharmaceutically acceptable salts thereof are specifically suitable for the treatment of neurological diseases such as epilepsy.

Abstract: Disclosed are oxadiazole compounds and pharmaceutically acceptable salts thereof. The compounds and pharmaceutically acceptable salts thereof are specifically suitable for the treatment of neurological diseases such as epilepsy.

Abstract: The present disclosure relates to a method for manufacturing a non-oriented electrical steel sheet and the manufactured non-oriented electrical steel sheet, the method including: heating a slab containing, by wt %, 0.005% or less of C, 2.5 to 4.0% or less of Si, 0.1% or less of P, 0.1 to 2.0% of Al, 0.2 to 2.5% of Mn, 0.003% or less of N, 0.005% or less of Ti and Nb, 0.003% or less of S, 0.005 to 0.025% of V, 0.1% or less of Cu, and a balance of Fe and inevitably mixed impurities, and satisfying the following Expression 1; hot-rolling the slab to manufacture a hot-rolled sheet; cold-rolling the hot-rolled sheet to manufacture a cold-rolled sheet; and performing final annealing on the cold-rolled sheet, wherein [Expression 1] is represented by (51*[C])/12?0.002?[V]?(51*[C])/12+0.004 (in Expression 1, [C] and [V] represent contents (wt %) of C and V, respectively).

Abstract: Provided is a mutant strain having improved aromatic amino acid production capability as a result of inactivation or weakening of activity of glutaminase which is expressed by glutaminase B (glsB) gene.

Abstract: Provided herein are methods for treating cancer using molecules having an antigen binding fragment that immunospecifically binds to BTN1A1 or a BTN1A1 ligand, such as anti-BTN1A1 antibodies or anti-BTN1A1 ligand antibodies. Also provided herein are BTN1A1 ligands, such as Galectin-1, Galectin-9, Neuropilin-2, and B- and T-Lymphocyte Attenuator.

Abstract: Disclosed is a mutant strain having improved aromatic amino acid production capability due to inactivation or weakening of activity of an FMN/FAD exporter protein which is expressed by yeeO gene.

Abstract: Disclosed is a mutant strain having improved aromatic amino acid production capability as a result of the inactivation or weakening of activity of asparaginase which is expressed by ansB gene.

Abstract: A non-oriented electrical steel sheet according to an exemplary embodiment of the present invention includes, by weight %, Si: 2.5 to 6.0%, Al: 0.2 to 3.5%, Mn: 0.2 to 4.5%, Cr: 0.01 to 0.2%, P: 0.005 to 0.08%, Mg: 0.0005 to 0.05%, and a remainder including Fe and inevitable impurities, while satisfying Equation 1 below, and formed with an inner oxidation layer of a 0.2 to 5 ?m thickness inside a base steel sheet. ?2.5?[P]/[Cr]?[Mg]×100?6.5??[Equation 1] (In Equation 1, [P], [Cr], and [Mg] respectively represent a content (by wt %) of P, Cr, and Mg).

Abstract: A semiconductor package and manufacturing method is disclosed. The semiconductor package includes a semiconductor chip having a plurality of chip terminals formed on one surface thereof, a redistribution layer electrically connected to the chip terminal and extending outwardly from a side surface of the chip to electrically connect the chip terminal to an external device, an external pad provided on the insulating layer, formed to be in contact with the redistribution layer exposed from the insulating layer to be electrically connected to the redistribution layer, and exposed to an upper side of the insulating layer; an external connection terminal formed on the external pad and contacting an external device, a protective layer formed to surround at least one surface and a side surface of the chip, and an insulating layer formed to cover the redistribution layer.

Abstract: Antibodies that selectively bind to glycosylated PD-1 relative to unglycosylated PD-1 are provided. In some aspects, PD-1 polypeptides comprising glycosylated amino acid positions are also provided. Methods for making and using such antibodies and polypeptides (e.g., for the treatment of cancer) are also provided.

Abstract: A non-oriented electrical steel sheet according to an exemplary embodiment of the present invention includes 2.0 to 4.0% of Si, 0.05 to 1.5% of Al, 0.05 to 2.5% of Mn, equal to or less than 0.005% of C (excluding 0%), equal to or less than 0.005% of N (excluding 0%), 0.001 to 0.1% of Sn, 0.001 to 0.1% of Sb, 0.001 to 0.1% of P, 0.001 to 0.01% of As, 0.0005 to 0.01% of Se, 0.0005 to 0.01% of Pb, 0.0005 to 0.01% of Bi, a remainder of Fe, and inevitable impurities, as wt %, wherein a Taylor factor (M) of each crystal grain included in a steel sheet is expressed in Formula 1, and an average Taylor factor value of the steel sheet is equal to or less than 2.75: M = ? ? CRSS [ Formula ? ? 1 ] (here, ? is a macro stress, and ?CRSS is a critical resolved shear stress).

Abstract: A bypass switch for a STATCOM and an HVDC of the present invention is characterized by: a switch body having a column; a switch head which is coupled to the column and in which a sliding part is provided so as to be slidable up and down; a sliding part which is inserted into the switch head; a driven latch which is inserted into the sliding part and fixed to a driving shaft penetrating therethrough; a driving latch which is coupled to an end of the driving shaft exposed to the outside of the switch head, and which is provided to be driven by a solenoid; a stop coupled to the front of the switch head so as to limit movement of the driven latch; a pressure bearing which is inserted into a lower portion of the sliding part and coupled thereto by a bearing pin; an elastic body provided between the sliding part and the switch body; and a rod coupled to an upper portion of the sliding part so as to be insulated by an insulator.

Abstract: Antibodies that selectively bind to glycosylated PD-1 relative to unglycosylated PD-1 are provided. In some aspects, PD-1 polypeptides comprising glycosylated amino acid positions are also provided. Methods for making and using such antibodies and polypeptides (e.g., for the treatment of cancer) are also provided.

Abstract: Disclosed is a pulling compensation apparatus for a vehicle including: a main body part capable of loading a power engine of the vehicle and goods or carrying people; a transfer part transferring the main body part; a sensor part sensing a height and a slope of the main body part, pulling due to motion inertia and an obstacle to transmit a signal; a controller embedded with a computer receiving the signal of the sensor part; and a pulling reduction part controlled by the controller to reduce the pulling and shocks of the main body part. The pulling reduction part varies the height to reduce the pulling and shocks of the main body part when the pulling of the main body part and the obstacle are sensed by the sensor part.

Abstract: A non-oriented electric steel sheet includes 2.5 wt % to 3.1 wt % of Si, 0.1 wt % to 1.3 wt % of Al, 0.2 wt % to 1.5 wt % of Mn, 0.008 wt % or less of C (excluding 0 wt %), 0.005 wt % or less of S (excluding 0 wt %), 0.005 wt % or less of N (excluding 0 wt %), 0.005 wt % or less of Ti (excluding 0 wt %), 0.001 wt % to 0.07 wt % of Mo, 0.001 wt % to 0.07 wt % of P, 0.001 wt % to 0.07 wt % of Sn, and 0.001 wt % to 0.07 wt % of Sb, in which a remainder includes Fe and inevitable impurities, an average crystal grain diameter is 70 ?m to 150 ?m, the non-oriented electric steel sheet satisfies Equations (1) and (2), 0.32?([Al]+[Mn])/[Si]?0.5??[Equation 1] 0.025?[Mo]+[P]+[Sn]+[Sb]?0.15??[Equation 2] (here, a bracket denotes the contents (wt %) of each element).

Abstract: The present disclosure relates to an L-amino acid-producing E. coli mutant strain or Corynebacterium glutamicum mutant strain having enhanced L-amino acid productivity, and a method of producing L-amino acid using the same. The L-amino acid-producing E. coli mutant strain and Corynebacterium glutamicum mutant strain according to the present disclosure exhibit an enhanced ability to produce L-amino acid, such as L-tryptophan, L-phenylalanine, L-tyrosine, L-glutamine, L-lysine, L-arginine, L-valine, L-leucine, L-isoleucine, L-threonine, L-histidine, L-serine, or L-citrulline, compared to parent strains thereof, and are capable of producing a high concentration of L-amino acid in high yield.

Abstract: Provided herein are molecules, such as antibodies, that selectively bind to glycosylated BTLA (B- and T-lymphocyte attenuator) relative to unglycosylated BTLA. Methods for making and using such molecules are also provided, including methods for treating or diagnosing cancer. In some embodiments, the anti-glycosylated BTLA antibodies provided herein can immunospecifically bind to glycosylated wild-type BTLA (WT). In some embodiments, the anti-glycosylated BTLA antibodies provided herein can immunospecifically bind to one or more BTLA double mutants that retain only a single glycosylation site at BTLA N75, N94 or N110. In some embodiments, the anti-glycosylated BTLA antibodies provided herein show only background binding, if any, to a BTLA triple mutant, that retains none of BTLA's N75, N94, or N110 0-glycosylation sites.

Abstract: A non-oriented electrical steel sheet according to an embodiment of the present invention includes, in wt %, Si at 0.2 to 4.3%, Mn at 0.05 to 2.5%, Al at 0.1 to 2.1%, Bi at 0.0001 to 0.003%, Ga at 0.0001 to 0.003%, and the balance of Fe and inevitable impurities.

Abstract: A non-oriented electrical steel sheet according to an embodiment of the present invention includes: in wt %, C at 0.004 wt % or less (excluding 0 wt %), Si at 2.5 to 4.0 wt %, P at 0.1 wt % or less (excluding 0 wt %), Al at 0.3 to 2.0 wt %, N at 0.003 wt % or less (excluding 0 wt %), S at 0.003 wt % or less (excluding 0 wt %), Mn at 0.15 to 2.5 wt %, Cr at 0.5 wt % (excluding 0 wt %), and the balance including Fe and other impurities unavoidably added thereto; satisfies the following Equation 1; and has an average grain size of 20 ?m or less. [Mn]?1450×[S]?0.8??[Equation 1] (In Equation 1, [Mn] and [S] represent a content (wt %) of Mn and S, respectively.