Patents by Inventor Yongjun Tu
Yongjun Tu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230242481Abstract: Provided is a preparation method for brivaracetam. The method has a synthetic route as shown below.Type: ApplicationFiled: June 15, 2020Publication date: August 3, 2023Applicant: Zhejiang Tianyu Pharmaceutical Co., Ltd.Inventors: Zhen Wang, Chunlong Ke, Junfeng Liu, Peng Zhang, Qichao Li, Guorong Zhu, Yongjun Tu
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Publication number: 20220388988Abstract: Provided is a preparation method of losartan, which is prepared by reacting a cyano group-containing intermediate represented by formula (I) with an azide reagent in toluene in the presence of a catalyst; wherein, after the reaction is completed, azide ions are removed by means of the following process: adding water to divide the reaction system into three layers, separating the intermediate layer and adding n-butanol to the intermediate layer for dilution, and adding triphenylphosphine to the resulting diluted solution so as to remove residual azide ions from the diluted solution. The preparation method provided by the present invention does not need to use sodium nitrite, thus fundamentally eliminating the formation of genotoxic impurities nitrosamines.Type: ApplicationFiled: January 17, 2020Publication date: December 8, 2022Applicant: Zhejiang Tianyu Pharmaceutical Co., Ltd.Inventors: Zuwei He, Gang Liu, Dequan Su, Ruiyun Lv, Wei Xiao, Zhen Wang, Guorong Zhu, Yongjun Tu
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Patent number: 11375047Abstract: A method of data transmission includes: receiving a first packet, where the first packet includes first compressed data and a first check value, the first compressed data is obtained by compressing first data based on a first compression mode, the first check value is obtained by processing a second check value based on a first check algorithm, the second check value is obtained by processing the first compressed data based on a second check algorithm; obtaining a first check code by processing the first packet based on a third check algorithm; determining, according to a correspondence between the first check code and the first compression mode, that the first compression mode is a compression mode used when the first data is compressed; and obtaining the first data by decompressing, based on a first decompression mode corresponding to the first compression mode, the first compressed data included in the first packet.Type: GrantFiled: September 13, 2018Date of Patent: June 28, 2022Assignee: HUAWEI TECHNOLOGIES CO., LTD.Inventors: Wei Chen, Yihua Zhang, Yongjun Tu, Xin Luo, Kai Qi
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Patent number: 10221145Abstract: The present invention discloses a method for preparing an anti-heart-failure medicine LCZ696. The preparing method comprises the following step (formula (I)): in an organic solvent, a Sacubitril dicyclohexylamine salt reacts with valsartan under the effect of a sodium hydroxide aqueous solution, and the anti-heart-failure medicine LCZ696 is obtained. The preparing method of the present invention is simple in process and omits the procedures of ion exchange from a sodium salt to a calcium salt and hydrochloric acid dissociation in an existing production process, residues of calcium ions are avoided, and the production efficiency is effectively improved.Type: GrantFiled: June 6, 2016Date of Patent: March 5, 2019Assignee: ZHEJIANG TIANYU PHARMACEUTICAL CO., LTD.Inventors: Guorong Zhu, Yongjun Tu, Wenlong Xie, Zhen Wang, Shaojun Xu
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Publication number: 20190014194Abstract: A method of data transmission includes: receiving a first packet, where the first packet includes first compressed data and a first check value, the first compressed data is obtained by compressing first data based on a first compression mode, the first check value is obtained by processing a second check value based on a first check algorithm, the second check value is obtained by processing the first compressed data based on a second check algorithm; obtaining a first check code by processing the first packet based on a third check algorithm; determining, according to a correspondence between the first check code and the first compression mode, that the first compression mode is a compression mode used when the first data is compressed; and obtaining the first data by decompressing, based on a first decompression mode corresponding to the first compression mode, the first compressed data included in the first packet.Type: ApplicationFiled: September 13, 2018Publication date: January 10, 2019Inventors: Wei Chen, Yihua Zhang, Yongjun Tu, Xin Luo, Kai Qi
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Publication number: 20180354915Abstract: The present invention discloses a method for preparing an anti-heart-failure medicine LCZ696. The preparing method comprises the following step (formula (I)): in an organic solvent, a Sacubitril dicyclohexylamine salt reacts with valsartan under the effect of a sodium hydroxide aqueous solution, and the anti-heart-failure medicine LCZ696 is obtained. The preparing method of the present invention is simple in process and omits the procedures of ion exchange from a sodium salt to a calcium salt and hydrochloric acid dissociation in an existing production process, residues of calcium ions are avoided, and the production efficiency is effectively improved.Type: ApplicationFiled: June 6, 2016Publication date: December 13, 2018Inventors: Guorong ZHU, Yongjun TU, Wenlong XIE, Zhen WANG, Shaojun XU
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Patent number: 8664440Abstract: A method for preparing Aliskiren and intermediate thereof, which comprises the following steps: reacting 4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene with magnesium isopropyl chloride and n-BuLi to obtain the compound of formula XXII; reacting the product of methylsulfonylation of the compound of formula XIX with anhydrous LiBr to obtain the compound of formula XXI; obtaining the intermediate of Aliskiren shown as formula XV by reacting the compound of formula XXII with the compound of formula XXI in an ether as the solvent and in the presence of a catalyst containing iron; then reacting the compound of formula XV with the compound of formula VII to obtain the compound of formula XXIII, following removing R1 from the amino group and obtaining Aliskiren shown as formula I.Type: GrantFiled: April 19, 2010Date of Patent: March 4, 2014Assignee: Zhejiang Tianyu Pharmaceutical Co., LtdInventors: Yongjun Tu, Yi Zhang, Rongde Cheng, Lingchao Peng
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Publication number: 20130225841Abstract: A method for preparing Aliskiren and intermediate thereof, which comprises the following steps: reacting 4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene with magnesium isopropyl chloride and n-BuLi to obtain the compound of formula XXII; reacting the product of methylsulfonylation of the compound of formula XIX with anhydrous LiBr to obtain the compound of formula XXI; obtaining the intermediate of Aliskiren shown as formula XV by reacting the compound of formula XXII with the compound of formula XXI in an ether as the solvent and in the presence of a catalyst containing iron; then reacting the compound of formula XV with the compound of formula VII to obtain the compound of formula XXIII, following removing R1 from the amino group and obtaining Aliskiren shown as formula I.Type: ApplicationFiled: April 19, 2010Publication date: August 29, 2013Applicant: Zhejiang Tianyu Pharmaceutical Co., Ltd.Inventors: Yongjun Tu, Yi Zhang, Rongde Cheng, Lingchao Peng
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Patent number: 8045586Abstract: A method provided by the present invention for transmitting overhead information, includes dividing and reforming overhead information into at least two overhead parts, inserting the at least two overhead parts into overhead bytes of at least two corresponding data frames, and transmitting the at least two overhead parts via the at least two data frames which are microwave frames. Overhead information transmitting apparatus and overhead information receiving apparatus are also provided by the present invention. With the method and apparatus of the present invention, the channel bandwidth resources occupied by the overhead bytes or each microwave frame are greatly reduced. If the saved channel bandwidth is used for performing the error correction code on the transmitted information, the code gain is improved and the sensitivity requirement on the receiver is reduced so that the cost of a microwave transmitting system is reduced eventually.Type: GrantFiled: December 17, 2007Date of Patent: October 25, 2011Assignee: Huawei Technologies Co., Ltd.Inventors: Jianbin Huang, Tianxiang Wang, Zhiyong Qiu, Guixue Zhao, Feng Zhang, Jun Feng, Dejun Li, Yongjun Tu, Xiaobin Song