Abstract: Coating compositions, methods of producing a cured coating, and articles coated with a cured coating are provided. In an exemplary embodiment, a coating composition includes a crosslinking agent, an acrylic resin, a catalyst, and a catalyst blocker that blocks the catalyst. The crosslinking agent includes an alkylated melamine, and the acrylic resin has a hydroxyl value of from about 5 to about 110 milligrams potassium hydroxide per gram of acrylic resin. The catalyst includes a sulfonic acid, and the catalyst blocker includes an amine with a boiling point of about 300 degrees Celsius or higher.

Abstract: Certain aspects of the present disclosure relate to methods and apparatus for microbial sampling of foods. For example, a method may include providing at least one aggregating sampler at one or more sampling locations, and sampling a production lot of produce or other food items such as meat using the at least one aggregating sampler to create one or more samples that makes up a microbial sampling. Certain aspects of the present disclosure relate to methods and apparatus for microbial sampling of foods. For example, an apparatus, such as a microbial aggregating sampler, may include a covering having a microbial sampling material with a pocket formed in the covering to receive an appendage or a tool for handling of the covering.

Abstract: Manual samplers and sampling methods that facilitate improved dexterity and ease of use and that can be manufacture quickly and cost effectively are provided herein. Such sampler can include sampling sheet(s) with a pocket defined by seams to accommodate a user's entire hand for manual sampling of one or more products, in particular aggregate sampling of multiple products. Samplers can include entry seams to fit along the user's writs to retain the sampler on the user's hand and/or interior seams that engage the user's digits to improve dexterity while contact sampling of uneven surfaces.

Abstract: Solvent-borne coating compositions and methods for forming coated substrates are provided. In one example, a solvent-borne coating composition includes a solvent(s), a colorant(s), a binder including one or more resins, a sag control agent, and a wax dispersion. The sag control agent includes urea crystals that are present in an amount of from about 0.5 wt. % to about 6 wt. % based on the weight of the binder. The wax dispersion includes ethylene vinyl acetate-based wax particles present in an amount of from about 3 wt. % to about 8 wt. % based on the weight of the binder. The solvent-borne coating composition has a non-volatile content of from about 11 to about 30 vol. % based on the volume of the solvent-borne coating composition.

Abstract: Methods and apparatus for improved microbial sampling of foods and sample treatment are provided herein. Such methods may include sampling production lots of produce or other food items such as meat using an aggregating sampler to create one or more samples. Methods and devices that improve concentration of the fluid sample obtained from the aggregate sample include filtering of fluid sample through a filter and/or filter aid materials and lysing target material trapped within the filter and/or filter aid materials to release molecules from targeted microorganisms, which are recovered in a concentrated fluid sample for testing. Sample treatment systems and methods can be automated with various buffer reservoirs and removable cartridges that facilitate controlled flow of fluid sample therethrough to produce a purified, concentrated fluid sample, typically within two hours or less. Such systems can further be configured with removable cartridges and use with sample filter cups and collection cups.

Abstract: Powered sampling systems, devices and methods of surface sampling are provided herein. A portable handheld sampling device can include an actuator operably coupled with a sampling head supporting a sample medium. One or more sensor indicate when a suitable force or pressure is applied by the sampling device as well as the duration of sampling. The actuator can provide movement of the sampling medium, such as rotational movement. The sampling device can provide guidance to a user to facilitate standardized sampling according to a sampling protocol. The sampling device and system can include communication means to facilitate automatic sample logging and period updates of sample protocols. System for creating and managing sampling plans and test results are also provided herein.

Abstract: Sampling probe devices, systems and methods for sampling frozen or solid meltable products. Such systems can include a heating element for placing against the frozen or solid product and a sampler with a cover fabricated at least partly from a microbial sampling medium so the cover absorbs a liquid sample from the product. Methods of sampling include heating the product and contacting the product with the cover until sufficient liquid sample is absorbed by the cover of the sampler. The cover can be weighed after sampling and compared to a before-sampling weight to confirm sufficient liquid was obtained. The sample can be tested as an aggregate sample that is representative of the lot or batch of product being sampled, including testing without an enrichment procedure. Systems utilizing automated heated-sampling plates and radiative heaters are also described.

Abstract: Certain aspects of the present disclosure relate to methods and apparatus for microbial sampling of foods. For example, a method may include providing at least one aggregating sampler at one or more sampling locations, and sampling a production lot of produce or other food items such as meat using the at least one aggregating sampler to create one or more samples that makes up a microbial sampling. Certain aspects of the present disclosure relate to methods and apparatus for microbial sampling of foods. For example, an apparatus, such as a microbial aggregating sampler, may include a covering having a microbial sampling material with a pocket formed in the covering to receive an appendage or a tool for handling of the covering.

Abstract: Sampling probe devices and methods for sampling frozen or solid meltable products are provided herein. Such devices can include a sampling probe with heating element and a cover fabricated at least partly from a microbial sampling medium that fits over the probe and heating element so that when the heated probe is placed against the frozen or solid product, the cover absorbs a liquid sample from the product. Methods of sampling include heating the probe and contacting the product with the cover until sufficient liquid sample is absorbed by the cover. The cover can be weighed after sampling and compared to a before-sampling weight to confirm sufficient liquid was obtained. The sample can be tested as an aggregate sample that is representative of the lot or batch of product being sampled, including testing without an enrichment procedure. Systems utilizing automated heated-sampling plates and radiative heaters are also described.

Abstract: The present application relates to treating and/or preventing prostate cancer, including metastatic and/or castrate-resistant prostate cancer, in a subject in need of treatment, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotopic derivative, or prodrug thereof, wherein R1, R2, R3, X1, X2, X3, X4, and n are defined herein.

Abstract: Certain aspects of the present disclosure relate to methods and apparatus for microbial sampling of foods. For example, a method may include providing at least one aggregating sampler at one or more sampling locations, and sampling a production lot of produce or other food items such as meat using the at least one aggregating sampler to create one or more samples that makes up a microbial sampling. Certain aspects of the present disclosure relate to methods and apparatus for microbial sampling of foods. For example, an apparatus, such as a microbial aggregating sampler, may include a covering having a microbial sampling material with a pocket formed in the covering to receive an appendage or a tool for handling of the covering.

Abstract: Certain aspects of the present disclosure relate to methods and apparatus for microbial sampling of foods. For example, a method may include providing at least one aggregating sampler at one or more sampling locations, and sampling a production lot of produce or other food items such as meat using the at least one aggregating sampler to create one or more samples that makes up a microbial sampling. Certain aspects of the present disclosure relate to methods and apparatus for microbial sampling of foods. For example, an apparatus, such as a microbial aggregating sampler, may include a covering having a microbial sampling material with a pocket formed in the covering to receive an appendage or a tool for handling of the covering.

Abstract: Solvent-borne coating compositions and methods for forming coated substrates are provided. In one example, a solvent-borne coating composition includes a solvent(s), a colorant(s), a binder including one or more resins, a sag control agent, and a wax dispersion. The sag control agent includes urea crystals that are present in an amount of from about 0.5 wt. % to about 6 wt. % based on the weight of the binder. The wax dispersion includes ethylene vinyl acetate-based wax particles present in an amount of from about 3 wt. % to about 8 wt. % based on the weight of the binder. The solvent-borne coating composition has a non-volatile content of from about 11 to about 30 vol. % based on the volume of the solvent-borne coating composition.

Abstract: Methods and devices for non-invasively assessing lethality and/or cross contamination of a process. In some embodiments, an aggregating sampler is used, such as a fixture catcher, to obtain samples before, after and/or during the process. In some embodiments, an isolated packet of bacteria is exposed to the active elements of the process without contacting the product. In other embodiments, a method to measure lethality using microgenomic analysis is reported. In still other embodiments, a procedure is reported to use the knowledge from a microgenomic process to use direct qPCR for identified genera species to measure cross contamination. These metrics have special utility in the validation of wash water performance but may have utility is assessing process performance when unpackaged product is treated as for blanching and irradiation. Process performance can include verification of process delivery or for research.

Abstract: Powered sampling systems, devices and methods of surface sampling are provided herein. A portable handheld sampling device can include an actuator operably coupled with a sampling head supporting a sample medium. One or more sensor indicate when a suitable force or pressure is applied by the sampling device as well as the duration of sampling. The actuator can provide movement of the sampling medium, such as rotational movement. The sampling device can provide guidance to a user to facilitate standardized sampling according to a sampling protocol. The sampling device and system can include communication means to facilitate automatic sample logging and period updates of sample protocols. System for creating and managing sampling plans and test results are also provided herein.

Abstract: A coating composition for coating a substrate is provided herein. The coating composition includes a first polymer including a first polymer-bound moiety having an acid-functional group, or a derivative thereof. The coating composition further includes a second polymer including a second polymer-bound moiety having an amine-functional group. The coating composition further includes a solvent. The first polymer is substantially free of amine-functional groups and the second polymer is substantially free of acid-functional groups, or derivatives thereof. The acid-functional groups and the amine-functional groups are substantially reactive to each other at least after application of the coating composition to the substrate.

Abstract: Systems and methods for sampling within a conveyance system are provided herein, such systems and methods being particularly useful in batch sampling of food products for a targeted biological agent. In one aspect, the sampling system includes a conveyance system and one or more sampling devices positioned along a conveyance path such that at least one portion of the batch contacts a sampling medium of the one or more sampling devices. In another aspect, sampling devices are provided that allow a sampling member to be secured in a sampling position for batch testing and readily removed after sampling and tested. The systems, devices and methods herein provide improved sampling coverage of the entire batch and reduce waste and inefficiency as compared to conventional batch sampling methods.

Abstract: A method of forming a multilayer coating on a substrate is provided. The multilayer coating exhibits reduced strike-in and mottling. The method includes the steps of providing the substrate including a primer disposed thereon, applying a basecoat composition on the primer, applying a clearcoat composition on the basecoat composition, and curing the basecoat composition and the clearcoat composition to form the multilayer coating on the substrate. The basecoat composition includes a film forming resin, a pigment, and about 5% to about 75% by weight on binder of a cyclic lactone modified branched acrylic polymer having a hydroxyl monomer content of about 1% to 65% by weight, all or part of which has been reacted with a cyclic lactone, and having a weight average molecular weight (Mw) of about 10,000 to about 150,000 g/mol.

Abstract: Certain aspects of the present disclosure relate to methods and apparatus for microbial sampling of foods. For example, a method may include providing at least one aggregating sampler at one or more sampling locations, and sampling a production lot of produce or other food items such as meat using the at least one aggregating sampler to create one or more samples that makes up a microbial sampling. Certain aspects of the present disclosure relate to methods and apparatus for microbial sampling of foods. For example, an apparatus, such as a microbial aggregating sampler, may include a covering having a microbial sampling material with a pocket formed in the covering to receive an appendage or a tool for handling of the covering.

Abstract: Certain aspects of the present disclosure relate to methods and apparatus for microbial sampling of foods. For example, a method may include providing at least one aggregating sampler at one or more sampling locations, and sampling a production lot of produce or other food items such as meat using the at least one aggregating sampler to create one or more samples that makes up a microbial sampling. Certain aspects of the present disclosure relate to methods and apparatus for microbial sampling of foods. For example, an apparatus, such as a microbial aggregating sampler, may include a covering having a microbial sampling material with a pocket formed in the covering to receive an appendage or a tool for handling of the covering.