Publication number: 20230115871
Abstract: The present invention relates to the conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.
Type:
Application
Filed:
June 24, 2019
Publication date:
April 13, 2023
Applicant:
Hangzhou DAC Biotech Co., Ltd
Inventors:
Robert Yongxin ZHAO, Qingliang YANG, Linyao ZHAO, Yuanyuan HUANG, Hangbo YE, Shun GAI, Junxiang JIA, Lu BAI, Wenjun LI, Zhixiang GUO, Chen LIN, Jun ZHENG, Huihui GUO, Minjun CAO, Xiangfei KONG, Yong DU, Yifang XU, Xiaomai ZHOU, Hongsheng XIE, Xiuzhen ZHANG, Miaomiao CHEN, Xiaolei LIU, Xiang CAI, Binbin CHEN, Yanlei YANG, Lingli ZHANG
Publication number: 20230057350
Abstract: Provided herein is the conjugation of an amanita toxin compound to a cell-binding molecule with branched linkers for having better targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of an amanita molecule to a cell-binding ligand, as well as methods of using the conjugate in targets treatment of cancer, infection and autoimmune disease.
Type:
Application
Filed:
January 31, 2019
Publication date:
February 23, 2023
Applicant:
Hangzhou DAC Biotech Co., Ltd.
Inventors:
Robert Yongxin ZHAO, Qingliang YANG, Jun LEI, Yuanyuan HUANG, Linyao ZHAO, Hangbo YE, Shun GAI, Mingjun CAO, Qianqian TONG, Lu BAI, Zhixiang GUO, Chengyu YANG, Xiaomai ZHOU, Hongsheng XIE, Yifang XU, Huihui GUO, Junxiang JIA, Jun ZHENG, Cheng LIN, Xiaotao ZHUO, Wenjun LI, Yong DU, Xiangfei KONG, Binbin CHEN, Yanlei YANG, Yanhong TONG, Xiaoxiao CHEN, Yanhua LI, Xiuzheng ZHANG, Juan LAI
Publication number: 20230010108
Abstract: The present invention relates to a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (a dual-linker) containing a 2,3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.
Type:
Application
Filed:
October 12, 2018
Publication date:
January 12, 2023
Applicant:
Hangzhou DAC Biotech Co., Ltd.
Inventors:
Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Linyao ZHAO, Hangbo YE, Xiaotao ZHUO, Chengyu YANG, Jun LEI, Yifang XU, Huihui GUO, Wenjun LI, Shun GAI, Lu BAI, Zhixiang GUO, Junxiang JIA, Jun ZHENG, Xiaomai ZHOU, Hongsheng XIE, Qianqian TONG, Mingjun CHAO, Yanhong TONG, Zhicang YE, Chen LIN, Yanlei YANG, Binbin CHEN
Publication number: 20230001001
Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.
Type:
Application
Filed:
July 30, 2021
Publication date:
January 5, 2023
Applicant:
Hangzhou DAC Biotech Co., Ltd.
Inventors:
Robert Yongxin ZHAO, Yuanyuan HUANG, Qingliang YANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Yifang XU, Huihui GUO, Minjun CHAO, Qianqian TONG, Wenjun LI, Xiang CAI, Xiaomai ZHOU, Hongsheng XIE, Junxiang JIA, Haifeng ZHU, Zhixiang GUO, Shuihong GAO, Chunyan WANG, Chen LIN, Yanlei YANG, Zhicang YE, Jie PENG, Jun XU, Xiaotao ZUO, Qingyu SU