Patents by Inventor Yosef Rosemberg

Yosef Rosemberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and apparatus for treating tumors using low strength electric fields
    Patent number: 7395112
    Abstract: A method of treating tumor tissue of an individual is provided. The method is effected by applying to cells of the tumor tissue electrical field pulses having a strength, a repetition frequency and a pulse width selected capable of inducing endocytosis mediated cell death thereby treating the tumor tissue.
    Type: Grant
    Filed: June 9, 2002
    Date of Patent: July 1, 2008
    Assignee: Ramot At Tel Aviv University Ltd.
    Inventors: Yona Keisari, Rafl Korenstein, Igor Entin, Yosef Rosemberg
  • Method and apparatus for treating tumors using low strength electric fields
    Publication number: 20080132963
    Abstract: A method of treating tumor tissue of an individual is provided. The method is effected by applying to cells of the tumor tissue electrical field pulses having a strength, a repetition frequency and a pulse width selected capable of inducing endocytosis mediated cell death thereby treating the tumor tissue.
    Type: Application
    Filed: February 1, 2008
    Publication date: June 5, 2008
    Applicant: Ramot At Tel Aviv University Ltd.
    Inventors: Yona Keisari, Rafi Korenstein, Igor Entin, Yosef Rosemberg
  • Method and apparatus for treating tumors using low strength electric fields
    Publication number: 20040158288
    Abstract: A method of treating tumor tissue of an individual is provided. The method is effected by applying to cells of the tumor tissue electrical field pulses having a strength, a repetition frequency and a pulse width selected capable of inducing endocytosis mediated cell death thereby treating the tumor tissue.
    Type: Application
    Filed: November 28, 2003
    Publication date: August 12, 2004
    Inventors: Yona Keisari, Rafl Korenstein, Igor Entin, Yosef Rosemberg
  • Electro-endocytotic therapy as a treatment modality of cancer
    Publication number: 20020198567
    Abstract: There is provided a method for introducing a therapeutic agent into a membrane vesicle, cell, or tissue by exposing the membrane vesicle, cell, or tissue to a low electric field in the presence of the therapeutic agent in an extracellular compartment of the membrane vesicle, cell, or tissue. Also provided is therapy including a low electric field alone or in combination with a therapeutic agent.
    Type: Application
    Filed: June 7, 2001
    Publication date: December 26, 2002
    Inventors: Yona Keisari, Rafi Korenstein, Igor Entin, Yosef Rosemberg
  • Apparatus and method for efficient incorporation of molecules into cells
    Patent number: 5964726
    Abstract: A method and apparatus (20) for introducing molecules and macromolecules into a membrane vesicle, a cell or a tissue by (a) applying a train of low unipolar or alternating voltage pulses to molecules/macromolecules and cells, (b) increase the concentration of the molecules/macromolecules at the surface of the cells, leading to an increased interaction of the molecules/macromolecules with the membrane of the cell while also causing electrophoretic movement of charged proteins and lipids in the cell membrane, and (c) causing the destabilization of the cell membrane whereby the molecules/macromolecules penetrate into the cytosol via an endocytic process and via diffusion through structural defects in the membrane lipid bilayer.The apparatus (20) includes a support plate (36) having apertures (38) for allowing electrodes (22) to pass therethrough. Support tubes (34) located within the apertures (38) slideably surround the electrodes (22).
    Type: Grant
    Filed: April 16, 1997
    Date of Patent: October 12, 1999
    Assignee: RAMOT University Authority for Applied Research and Industrial Development
    Inventors: Rafi Korenstein, Yosef Rosemberg